The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
High dietary sodium chloride consumption may not induce body fluid retention in humans
Abstract
A commonly accepted hypothesis is that a chronically high-sodium diet expands extracellular volume and finally reaches a steady state where sodium intake and output are balanced whereas extracellular volume is expanded. However, in a recent study where the main purpose was to investigate the role of natriuretic peptides under day-to-day sodium intake conditions (Heer M, Drummer C, Baisch F, and Gerzer R. Pflügers Arch 425: 390-394, 1993), our laboratory observed increases in plasma volume without any rise in extracellular volume. To scrutinize these results that were observed as a side effect, we performed a controlled, randomized study including 32 healthy male test subjects in a metabolic ward. The NaCl intake ranged from a low level of 50 meq NaCl/day to 200, 400, and 550 meq/day, respectively. Plasma volume dose dependently increased (P < 0.01), being elevated by 315 +/- 37 ml in the 550-meq-NaCl-intake group. However, in contrast to the increased plasma volume, comparable to study I, total body water did not increase. In parallel, body mass also did not increase. Mean corpuscular volume of erythrocytes, as an index for intracellular volume, was also unchanged. We conclude from the results of these two independently conducted studies that under the chosen study conditions, in contrast to present opinions, high sodium intake does not induce total body water storage but induces a relative fluid shift from the interstitial into the intravascular space.
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“The gains of this controller must be chosen to reproduce the ultimate effect of this mechanism: maintenance of CNa at equilibrium levels (±1 mmol/L) after a perturbation such as an increase in Na intake.42, 43”
From A Quantitative Systems Physiology Model of Renal Function and Blood Pressure Regulation: Model Description (2017) · cites this paper as [43]
Citations
Cites
Textbook of Medical Physiology
Guyton, A. C., & Hall, J. E. (1966) · Annals of Internal Medicine · doi:10.7326/0003-4819-64-6-1363_2 · Cited by 9,760
Interstitial-lymphatic mechanisms in the control of extracellular fluid volume
Aukland, K., & Reed, R. K. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.1 · Cited by 938
Roche, A. F., Heymsfield, S. B., & Lohman, T. G. (2005) · Medical Entomology and Zoology · Cited by 743
Age as a determinant of renal sodium conservation in normal man.
Kirkendall, A. M., Connor, W. E., Abboud, F. M., Rastogi, S., Anderson, T. A., & Fry, M. M. (1976) · PubMed · Cited by 429
The effect of increased salt intake on blood pressure of chimpanzees
Denton, D. A., Weisinger, R. S., Mundy, N. I., Wickings, E. J., Dixson, A. F., Moisson, P., Pingard, A. M., Shade, R. E., Carey, D., Ardaillou, R., et al. (1995) · Nature Medicine · doi:10.1038/nm1095-1009 · Cited by 414
Nutrition, an integrated approach
Pike, R., & Brown, M. L. (1975) · Medical Entomology and Zoology · Cited by 244
Strauss, M. B. (1958) · A M A Archives of Internal Medicine · doi:10.1001/archinte.1958.00260210013003 · Cited by 161
Divergent hemodynamic and hormonal responses to varying salt intake in normotensive subjects.
Overlack, A., Ruppert, M., Kolloch, R. E., Göbel, B. O., Kraft, K., Diehl, J., Schmitt, W., & Stumpe, K. O. (1993) · Hypertension · doi:10.1161/01.hyp.22.3.331 · Cited by 127
Effects of an acute saline infusion on fluid and electrolyte metabolism in humans
Drummer, C., Gerzer, R., Heer, M. A., Molz, B., Bie, P., Schlossberger, M., Stadaeger, C., Röcker, L., Strollo, F., Heyduck, B., et al. (1992) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1992.262.5.f744 · Cited by 121
3 Regulation of vasopressin secretion
Baylis, P. H. (1989) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(89)80006-0 · Cited by 93
Research works printed but not linked: 4
- Heer M., C., 1992, Acta Physiol Scand, 144, 13
- Kirkendall WM, 1976, J Lab Clin Med, 87, 418
- Kojima S, 1987, Clin Exp Theory Pract, 9, 1243
- Szabo G, 1982, Lymphology, 15, 175
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Machnik, A., Neuhofer, W., Jantsch, J., Dahlmann, A., Tammela, T., Machura, K., Park, J.-K., Beck, F.-X., Müller, D. N., Derer, W., et al. (2009) · Nature Medicine · doi:10.1038/nm.1960 · Cited by 969
Sodium Intake and Hypertension
Grillo, A., Salvi, L., Coruzzi, P., Salvi, P., & Parati, G. (2019) · Nutrients · doi:10.3390/nu11091970 · Cited by 819
“However, rigorous studies have demonstrated that sodium may accumulate in the body without a concomitant retention of water, both in humans [51] and in experimental models [52].”
BackgroundLinks Between Dietary Salt Intake, Renal Salt Handling, Blood Pressure, and Cardiovascular Diseases
Meneton, P., Jeunemaı̂tre, X., de Wardener, H. E., & MacGregor, G. A. (2005) · Physiological Reviews · doi:10.1152/physrev.00056.2003 · Cited by 719
From space to Earth: Advances in human physiology from 20 years of bed rest studies (1986–2006)
Pavy-Le Traon, A., Heer, M., Narici, M. V., Rittweger, J., & Vernikos, J. (2007) · European Journal of Applied Physiology · doi:10.1007/s00421-007-0474-z · Cited by 658
“Heer et al. (2000) have shown that high salt intake leads to sodium storage without concomitant fluid retention.”
BackgroundDisorders of Plasma Sodium — Causes, Consequences, and Correction
Sterns, R. H. (2014) · New England Journal of Medicine · doi:10.1056/nejmra1404489 · Cited by 643
Metadata
- Authors
- Heer, M., Baisch, F., Kropp, J., Gerzer, R., & Drummer, C.
- Affiliations
- Deutsches Zentrum für Luft- und Raumfahrt e. V. (DLR) (DE)
- Technische Universität Dresden (DE)
- Venue
- American Journal of Physiology-Renal Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 278
- Issue
- 4
- Pages
- F585-F595
- ISSN
- 1522-1466 (ISSN-L)
- 1931-857X
- OpenAlex
- W2140024548
- Cited by
- 285
- References
- 25
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 6 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 14 · 2019: 19 · 2018: 16 · 2017: 21 · 2016: 6 · 2015: 17 · 2014: 11 · 2013: 5 · 2012: 7
- FWCI
- 6.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- American Journal of Physiology-Renal Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Sodium Intake and Health
- Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Keywords
- high sodium intake, dietary salt, plasma expansion, extracellular volume, total body water, fluid retention, fluid shifts, interstitial fluid, mean corpuscular volume, natriuretic peptides, sodium balance
- MeSH terms
- Adult, Blood Pressure, Blood Volume, Body Fluid Compartments, Body Fluids, Body Water, Body Weight, Diet, Sodium-Restricted, Diuresis, Electrolytes, Hormones, Humans, Male
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