The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Influence of testosterone on breathing during sleep
Abstract
Apneas and hypopneas during sleep occur more frequently in men than women. Disordered breathing is also reported to increase in hypogonadal men following testosterone administration. This suggests a hormonal influence on sleeping respiratory pattern. We therefore studied respiratory rhythm during sleep in 11 hypogonadal males both on and off testosterone-replacement therapy. In four subjects the anatomy (computerized tomography) and airflow resistance of the upper airway were also determined on both occasions. Sleep stage distribution and duration were unchanged following androgen administration. However, both apneas and hypopneas increased significantly during testosterone replacement so that the total number of disordered breathing events (apneas + hypopneas) per hour of sleep rose from 6.4 +/- 2.1 to 15.4 +/- 7.0 (P less than 0.05). This was a highly variable event with some subjects demonstrating large increases in apneas and hypopneas when androgen was replaced, whereas others had little change in respiration during sleep. Upper airway dimensions, on the other hand, were unaffected by testosterone. These results suggest that testosterone contributes to sleep-disordered breathing through mechanisms independent of anatomic changes in the upper airway.
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“two randomized controlled trials show that testosterone therapy can acutely (within 2–3 weeks) induce sleep-disordered breathing [126, 127].”
From Sleep, testosterone and cortisol balance, and ageing men (2022) · cites this paper as [126]
Citations
Cites
Guilleminault, C., Tilkian, A., & Dement, W. C. (1976) · Annual Review of Medicine · doi:10.1146/annurev.me.27.020176.002341 · Cited by 1,812
Interaction of sleep state and chemical stimuli in sustaining rhythmic ventilation
Skatrud, J. B., & Dempsey, J. A. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.3.813 · Cited by 343
Ventilatory Control in Myxedema and Hypothyroidism
Zwillich, C. W., Pierson, D. J., Hofeldt, F. D., Lufkin, E. G., & Weil, J. V. (1975) · New England Journal of Medicine · doi:10.1056/nejm197503272921302 · Cited by 292
Self-citationMIDGLEY, A. R., & NISWENDER, G. D. (1970) · European Journal of Endocrinology · doi:10.1530/acta.0.065s320 · Cited by 269
Obstructive Sleep Apnea Syndrome Induced by Testosterone Administration
Sandblom, R. E., Matsumoto, A. M., Schoene, R. B., Lee, K. A., Giblin, E. C., Bremner, W. J., & Pierson, D. J. (1983) · New England Journal of Medicine · doi:10.1056/nejm198303033080908 · Cited by 205
Pharyngeal resistance in normal humans: influence of gender, age, and obesity
White, D. P., Lombard, R. M., Cadieux, R. J., & Zwillich, C. W. (1985) · Journal of Applied Physiology · doi:10.1152/jappl.1985.58.2.365 · Cited by 183
Self-citationEffects of progesterone on chemosensitivity in normal men.
Cw, Z., Mr, N., Fd, S., & Weil, J. V. (1978) · PubMed · Cited by 178
Self-citationSleep-disordered breathing and nocturnal oxygen desaturation in postmenopausal women
Block, A. J., Wynne, J. W., & Boysen, P. G. (1980) · The American Journal of Medicine · doi:10.1016/0002-9343(80)90502-1 · Cited by 173
Pathogenesis of apneas in hypersomnia-sleep apnea syndrome.
Önal, E., Lopata, M., & O'Connor, T. (1982) · PubMed · doi:10.1164/arrd.1982.125.2.167 · Cited by 129
Kenyon, A. T., Knowlton, K., Sandiford, I., Koch, F. C., & Lotwin, G. (1940) · Endocrinology · doi:10.1210/endo-26-1-26 · Cited by 125
Cited by
Sorted by citations
Prevalence of Sleep-disordered Breathing in Women
BIXLER, E. O., VGONTZAS, A. N., LIN, H.-M., TEN HAVE, T., REIN, J., VELA-BUENO, A., & KALES, A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.163.3.9911064 · Cited by 1,598
Pathophysiology of Adult Obstructive Sleep Apnea
Eckert, D. J., & Malhotra, A. (2008) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200707-114mg · Cited by 719
Risks of testosterone-replacement therapy and recommendations for monitoring.
Rhoden, E. L., & Morgentaler, A. (2004) · New England Journal of Medicine · doi:10.1056/nejmra022251 · Cited by 705
Sex differences in sleep: impact of biological sex and sex steroids
Mong, J. A., & Cusmano, D. M. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0110 · Cited by 578
Andropause: clinical implications of the decline in serum testosterone levels with aging in men
Matsumoto, A. M. (2002) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/57.2.m76 · Cited by 490
Metadata
- Authors
- Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., & White, D. P.
- ORCID
- Santen, R. J.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1986-08-01
- Volume
- 61
- Issue
- 2
- Pages
- 618-623
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1929790158
- Cited by
- 179
- References
- 19
- Citations by year
- 2026: 2 · 2025: 2 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 5
- FWCI
- 0.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG04491)
- National Heart, Lung, and Blood Institute (HL-01316)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- testosterone, sleep-disordered breathing, apnea, hypopnea, hypogonadism, testosterone replacement therapy, androgens, upper airway resistance, upper airway anatomy, respiratory rhythm, sex differences
- MeSH terms
- Arousal, Humans, Hypogonadism, Male, Middle Aged, Respiration, Sleep, Sleep Apnea Syndromes, Testosterone
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