Cited by 180Obstructive Sleep Apnea ResearchNeuroscience of respiration and sleepHormonal and reproductive studies

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Influence of testosterone on breathing during sleep

Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., White, D. P.·1986·Journal of Applied Physiology

DOI 10.1152/jappl.1986.61.2.618

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Abstract

Apneas and hypopneas during sleep occur more frequently in men than women. Disordered breathing is also reported to increase in hypogonadal men following testosterone administration. This suggests a hormonal influence on sleeping respiratory pattern. We therefore studied respiratory rhythm during sleep in 11 hypogonadal males both on and off testosterone-replacement therapy. In four subjects the anatomy (computerized tomography) and airflow resistance of the upper airway were also determined on both occasions. Sleep stage distribution and duration were unchanged following androgen administration. However, both apneas and hypopneas increased significantly during testosterone replacement so that the total number of disordered breathing events (apneas + hypopneas) per hour of sleep rose from 6.4 +/- 2.1 to 15.4 +/- 7.0 (P less than 0.05). This was a highly variable event with some subjects demonstrating large increases in apneas and hypopneas when androgen was replaced, whereas others had little change in respiration during sleep. Upper airway dimensions, on the other hand, were unaffected by testosterone. These results suggest that testosterone contributes to sleep-disordered breathing through mechanisms independent of anatomic changes in the upper airway.

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Authors: Schneider, B. K., Pickett, C. K., Zwillich, C. W., Weil, J. V., McDermott, M. T., Santen, R. J., Varano, L. A., & White, D. P.
ORCID: Santen, R. J.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1986-08-01
Volume: 61
Issue: 2
Pages: 618-623
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1986.61.2.618
OpenAlex: W1929790158
Cited by: 179
References: 19
Citations by year: 2026: 2 · 2025: 2 · 2023: 7 · 2022: 3 · 2021: 4 · 2020: 4 · 2019: 3 · 2018: 5 · 2017: 6 · 2016: 8 · 2015: 2 · 2014: 4 · 2013: 8 · 2012: 5
FWCI: 0.72
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (AG04491)
National Heart, Lung, and Blood Institute (HL-01316)
Topics: Health Sciences › Medicine › Physiology (medical) › Obstructive Sleep Apnea Research
Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroscience of respiration and sleep
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords: testosterone, sleep-disordered breathing, apnea, hypopnea, hypogonadism, testosterone replacement therapy, androgens, upper airway resistance, upper airway anatomy, respiratory rhythm, sex differences
MeSH terms: Arousal, Humans, Hypogonadism, Male, Middle Aged, Respiration, Sleep, Sleep Apnea Syndromes, Testosterone

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Influence of testosterone on breathing during sleep

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