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Cited by 117Muscle metabolism and nutritionCardiovascular and exercise physiologyAdipose Tissue and Metabolism

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Acetylcarnitine formation during intense muscular contraction in humans

Harris, R. C., Foster, C. V., Hultman, E.·1987·Journal of Applied Physiology
DOI 10.1152/jappl.1987.63.1.440
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Abstract

To study the changes in carnitine during intense muscular effort subjects underwent 4 min intermittent electrical stimulation of the quadriceps femoris muscle and on a separate occasion performed 4 min exercise on a bicycle ergometer. Biopsies of the vastus lateralis muscle were taken at rest and after 2 and 4 min of stimulation or exercise. Resting mean muscle total carnitine content was 20.0 mmol/kg dry muscle. Approximately 77% was free carnitine and 19% acetylcarnitine. Four minutes of stimulation or intense exercise did not effect total carnitine but did result in a marked fall in free carnitine and almost equivalent rise in acetylcarnitine. The results indicate that acetylcarnitine is a major metabolite formed during intense muscular effort and that carnitine may function in the regulation of the acetyl-CoA/CoA ratio by buffering excess production of acetyl units.

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Crossref · 10.1152/jappl.1987.63.1.440

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Metadata

Authors
Harris, R. C., Foster, C. V., & Hultman, E.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
1987-07-01
Volume
63
Issue
1
Pages
440-442
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.1987.63.1.440
OpenAlex
W2173556929
Cited by
117
References
0
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2021: 3 · 2020: 1 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 4
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Applied Physiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
  • Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Keywords
acetyl-L-carnitine, carnitine metabolism, free carnitine, neuromuscular electrical stimulation, physical activity, quadriceps, vastus lateralis, skeletal muscle
MeSH terms
Acetylcarnitine, Adult, Carnitine, Electric Stimulation, Humans, Kinetics, Male, Muscle Contraction, Muscles

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