Muscle glucose transport: interactions of in vitro contractions, insulin, and exercise
Abstract
Exercise increases permeability of muscle to glucose. Normally, the effects of exercise and a maximal insulin stimulus on glucose transport are additive. However, the combined effect on rat epitrochlearis muscle permeability to 3-O-methylglucose (3-MG) of a maximal insulin stimulus followed by in vitro contractile activity of 1.24 +/- 0.06 mumol.10 min-1.ml intracellular water-1 was no greater than that of either stimulus alone. We found that this absence of an additive effect was caused by prolonged exposure to an unphysiologically high insulin concentration (20,000 microU/ml for 60 min), which, in addition to stimulating glucose transport, appears to prevent further increases in permeability to glucose. When the treatments were reversed and muscles were first stimulated to contract and then incubated with 20,000 microU/ml insulin, 3-MG uptake (mumol.10 min-1.ml intracellular water-1) increased from a control value of 0.26 +/- 0.03 to 1.80 +/- 0.15, compared with 1.04 +/- 0.06 for contractile activity alone, 1.21 +/- 0.08 for insulin, and 1.88 +/- 0.11 for exercise (swimming) plus insulin. Swimming plus in vitro contractile activity did not have a greater effect than contractile activity alone. Our results provide evidence that 1) the effect of exercise on muscle permeability to glucose is mediated solely by a process associated with contractile activity, and 2) it is advisable to avoid the use of unphysiologically high insulin concentrations in studies designed to elucidate in vivo actions of insulin.
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Insulin is additive to contraction in stimulating glucose uptake.
“3) Insulin is additive to contraction in stimulating glucose uptake [109,110].”
From AMPK and Exercise: Glucose Uptake and Insulin Sensitivity (2013) · cites this paper as [109]
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Henriksen, E. J., Bourey, R. E., Rodnick, K. J., Koranyi, L. I., Permutt, M. A., & Holloszy, J. O. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.4.e593 · Cited by 432 · see citing works
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Balon, T. W., Nadler, J. L., & Jasman), (. T. T. A. O. A. (1997) · Journal of Applied Physiology · doi:10.1152/jappl.1997.82.1.359 · Cited by 393 · see citing works
Ploug, T., van Deurs, B., Ai, H., Cushman, S. W., & Ralston, E. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.142.6.1429 · Cited by 302 · see citing works
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The Exercise-Induced Growth Hormone Response in Athletes
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“[70,71] It appears to be a combination of the intensity,[80] Much of the stimulus for protein synthesis seems duration,[81] frequency[82] and mode[54] of exercise to occur through IGF-1 with just modest contribu- that determines the EIGR.”
BackgroundAMPK and Exercise: Glucose Uptake and Insulin Sensitivity
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“3) Insulin is additive to contraction in stimulating glucose uptake [109,110].”
BackgroundLee, A. D., Hansen, P. A., & Holloszy, J. O. (1995) · FEBS Letters · doi:10.1016/0014-5793(95)00147-2 · Cited by 234 · see citing works
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Coderre, L., Kandror, K. V., Vallega, G., & Pilch, P. F. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.46.27584 · Cited by 195 · see citing works
Role of Akt substrate of 160 kDa in insulin-stimulated and contraction-stimulated glucose transport
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Roles of TBC1D1 and TBC1D4 in insulin- and exercise-stimulated glucose transport of skeletal muscle
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BackgroundSelf-citationRegulation of glucose transport into skeletal muscle
Holloszy, J. O., & Hansen, P. A. (1996) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/3-540-61343-9_8 · Cited by 151 · see citing works
Self-citationInfluence of resistance exercise training on glucose control in women with type 2 diabetes
Fenicchia, L. M., Kanaley, J. A., Azevedo, J. L., Miller, C. S., Weinstock, R. S., Carhart, R. L., & Ploutz-Snyder, L. L. (2004) · Metabolism · doi:10.1016/j.metabol.2003.10.007 · Cited by 146 · see citing works
Cartee, G. D. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00416.2015 · Cited by 140 · see citing works
Self-citationEffects of captopril on glucose transport activity in skeletal muscle of obese Zucker rats
Henriksen, E. J., & Jacob, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90276-7 · Cited by 137 · see citing works
The Insulin-Sensitive Glucose Transporter
Bimbaum, M. J. (1992) · International review of cytology · doi:10.1016/s0074-7696(08)62678-9 · Cited by 133 · see citing works
Terada, S., Yokozeki, T., Kawanaka, K., Ogawa, K., Higuchi, M., Ezaki, O., & Tabata, I. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.6.2019 · Cited by 134 · see citing works
“This is evidenced by findings that the maximal effects of insulin and contractions or hypoxia on sugar transport (3, 19) and GLUT-4 translocation to the cell surface (16) are additive.”
BackgroundA forty-year memoir of research on the regulation of glucose transport into muscle
Holloszy, J. O. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00463.2002 · Cited by 135 · see citing works
“(13), we found that when epitrochlearis muscles were incubated with 20 mU/ml insulin for 60 min after either a bout of exercise or electrical stimulation, the effects of contractions and insulin on 3-MG transport were completely additive.”
MethodSelf-citationRegulation of Carbohydrate and Fat Metabolism During and After Exercise
Holloszy, J. O., & Kohrt, W. M. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001005 · Cited by 129 · see citing works
Self-citationFunai, K., Schweitzer, G. G., Sharma, N., Kanzaki, M., & Cartee, G. D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00194.2009 · Cited by 119 · see citing works
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Cartee, G. D., & Holloszy, J. O. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.2.e390 · Cited by 113 · see citing works
Self-citationRegulation of glucose transport in skeletal muscle 1
Barnard, R. J., & YOUNGREN, J. F. (1992) · The FASEB Journal · doi:10.1096/fasebj.6.14.1426762 · Cited by 100 · see citing works
Kawanaka, K., Nolte, L. A., Han, D., Hansen, P. A., & Holloszy, J. O. (2000) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.2000.279.6.e1311 · Cited by 98 · see citing works
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BackgroundSelf-citationActivation of glucose transport in skeletal muscle by phospholipase C and phorbol ester
Henriksen, E. J., Rodnick, K. J., & Holloszy, J. O. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)88218-0 · Cited by 93 · see citing works
Self-citationSinacore, D. R., & Gulve, E. A. (1993) · Physical Therapy · doi:10.1093/ptj/73.12.878 · Cited by 83 · see citing works
Postexercise glucose uptake and glycogen synthesis in skeletal muscle from GLUT4‐deficient mice
Ryder, J. W., Kawano, Y., Galuska, D., Fahlman, R., Wallberg‐Henriksson, H., Charron, M. J., & Zierath, J. R. (1999) · The FASEB Journal · doi:10.1096/fasebj.13.15.2246 · Cited by 81 · see citing works
“Insulin and prior exercise have an additive effect on glucose transport in skeletal muscle (14, 34, 46).”
BackgroundCalorie restriction increases cell surface GLUT-4 in insulin-stimulated skeletal muscle
Dean, D. J., Brozinick, J. T., Cushman, S. W., & Cartee, G. D. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.6.e957 · Cited by 81 · see citing works
“The maximal effect of insulin on glucose transport is additive with contractile activity (13) or hypoxia (8), and wortmannin [a specific phosphatidylinositol 3-kinase (PI3K) inhibitor] entirely prevents insulin-, but not contraction- or hypoxiastimulated glucose transport (30, 43).”
BackgroundSelf-citationFunai, K., & Cartee, G. D. (2009) · Diabetes · doi:10.2337/db08-1477 · Cited by 76 · see citing works
“Nevertheless, Wortmannin can clearly eliminate contractionstimulated increases in pAkt and PAS-AS160 in rat epitrochlearis muscle, which begs the question: How can activation of Akt and PAS-AS160 be important for insulinstimulated glucose transport, but not contraction-stimulated glucose transport? A similar paradox i…”
BackgroundSelf-citationBrozinick, J. T., Etgen, G. J., Yaspelkis, B. B., & Ivy, J. L. (1994) · Biochemical Journal · doi:10.1042/bj2970539 · Cited by 75 · see citing works
Acute altitude-induced hypoxia suppresses plasma glucose and leptin in healthy humans
Kelly, K. R., Williamson, D. L., Fealy, C. E., Kriz, D. A., Krishnan, R. K., Huang, H., Ahn, J., Loomis, J. L., & Kirwan, J. P. (2009) · Metabolism · doi:10.1016/j.metabol.2009.07.014 · Cited by 74 · see citing works
“It is also known that insulin and hypoxia stimulate glucose transporter (GLUT) 4–mediated glucose transport via separate signaling pathways [3,6-8].”
BackgroundReversal of enhanced muscle glucose transport after exercise: roles of insulin and glucose
Gulve, E. A., Cartee, G. D., Zierath, J. R., Corpus, V. M., & Holloszy, J. O. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.259.5.e685 · Cited by 73 · see citing works
Self-citationContraction-induced increase in muscle insulin sensitivity: requirement for a serum factor
Gao, J., Gulve, E. A., & Holloszy, J. O. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.2.e186 · Cited by 62 · see citing works
Self-citationExercise, Hypoglycemia, and Type 1 Diabetes
Basu, R., Johnson, M. L., Kudva, Y. C., & Basu, A. (2014) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2014.0097 · Cited by 56 · see citing works
Effects of ovariectomy and exercise training on muscle GLUT-4 content and glucose metabolism in rats
Hansen, P. A., McCarthy, T. J., Pasia, E. N., Spina, R. J., & Gulve, E. A. (1996) · Journal of Applied Physiology · doi:10.1152/jappl.1996.80.5.1605 · Cited by 56 · see citing works
Effects of phenylarsine oxide on stimulation of glucose transport in rat skeletal muscle
Henriksen, E. J., & Holloszy, J. O. (1990) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1990.258.4.c648 · Cited by 45 · see citing works
Self-citationThe Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action
McGarrah, R. W., Slentz, C. A., & Kraus, W. E. (2016) · Current Cardiology Reports · doi:10.1007/s11886-016-0797-7 · Cited by 44 · see citing works
Zhao, J. P., Lin, H., Jiao, H., & Song, Z. (2008) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2008.10.106 · Cited by 43 · see citing works
“Both insulin and exercise stimulate glucose transport (Constable et al., 1988).”
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Gulve, E. A., Henriksen, E. J., Rodnick, K. J., Youn, J. H., & Holloszy, J. O. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.264.3.e319 · Cited by 43 · see citing works
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Exercise and insulin stimulate skeletal muscle glucose transport through different mechanisms
Sternlicht, E., Barnard, R. J., & Grimditch, G. K. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.2.e227 · Cited by 35 · see citing works
Effects of high-intensity intermittent swimming on glucose transport in rat epitrochlearis muscle
Kawanaka, K., Tabata, I., Tanaka, A., & Higuchi, M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.6.1852 · Cited by 34 · see citing works
“In the present study, 120-min-long, low-intensity swimming reduced muscle glycogen concentration to a lower level and activated glucose transport to a greater extent than did ten 10-s-long in vitro tetani (Tables 2 and 3), whereas a previous study (3) reported that low-intensity swimming with the same duration activat…”
BackgroundInfluentialRabGAPs in skeletal muscle function and exercise
Espelage, L., Al‐Hasani, H., & Chadt, A. (2019) · Journal of Molecular Endocrinology · doi:10.1530/jme-19-0143 · Cited by 33 · see citing works
Contractile activity restores insulin responsiveness in skeletal muscle of obese Zucker rats
Dolan, P. L., Tapscott, E. B., Dorton, P. J., & Dohm, G. L. (1993) · Biochemical Journal · doi:10.1042/bj2890423 · Cited by 32 · see citing works
Funai, K., & Cartee, G. D. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90838.2008 · Cited by 32 · see citing works
“For example, combining maximally effective insulin and contractile activity results in an essentially additive increase in glucose transport (7, 19), and concentrations of the phosphatidylinositol 3-kinase inhibitor wortmannin that completely inhibit insulin-stimulated glucose transport do not alter contraction-stimul…”
BackgroundSelf-citationBlair, D. R., Funai, K., Schweitzer, G. G., & Cartee, G. D. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.91003.2008 · Cited by 31 · see citing works
Self-citationInsulin and nitric oxide stimulates glucose transport in human placenta
Acevedo, C. G., Márquez, J. L., Rojas, S., & Bravo, I. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.09.039 · Cited by 30 · see citing works
Polymyxin B inhibits stimulation of glucose transport in muscle by hypoxia or contractions
Henriksen, E. J., Sleeper, M., Zierath, J. R., & Holloszy, J. O. (1989) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1989.256.5.e662 · Cited by 30 · see citing works
Self-citationA role for calcium/calmodulin kinase in insulin stimulated glucose transport
Wright, D. C., Fick, C. A., Olesen, J. B., Lim, K., Barnes, B. R., & Craig, B. W. (2003) · Life Sciences · doi:10.1016/j.lfs.2003.06.041 · Cited by 28 · see citing works
Cartee, G. D., Arias, E. B., Yu, C. S., & Pataky, M. W. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00289.2016 · Cited by 27 · see citing works
Self-citationCastorena, C. M., Arias, E. B., Sharma, N., Bogan, J. S., & Cartee, G. D. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00466.2014 · Cited by 27 · see citing works
Self-citationThe role of exercise and hypoxia on glucose transport and regulation
Soo, J., Raman, A., Lawler, N. G., Goods, P. S. R., Deldicque, L., Girard, O., & Fairchild, T. J. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05135-1 · Cited by 25 · see citing works
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BackgroundAl‐Khalili, L., Krook, A., Zierath, J. R., & Cartee, G. D. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00161.2004 · Cited by 24 · see citing works
“Similar to in vivo exercise, electrically stimulated contractile activity by isolated rat skeletal muscle in serum-free buffer also results in a substantial increase in insulin-independent glucose transport (8), and this effect is largely reversed within hours (5, 9, 11).”
BackgroundSelf-citationWright, D. C., & Sutherland, L. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h07-155 · Cited by 23 · see citing works
Ambery, A. G., Tackett, L., Penque, B. A., Brozinick, J. T., & Elmendorf, J. S. (2017) · Physiological Reports · doi:10.14814/phy2.13363 · Cited by 23 · see citing works
“For some time it has been known that muscle contractions stimulate GLUT4-mediated glucose uptake independent of insulin (Constable et al. 1988; Douen et al. 1990; Ryder et al. 2001).”
BackgroundPerfused rat hindlimb is suitable for skeletal muscle glucose transport measurements
Wojtaszewski, J. F. P., Jakobsen, A. B., Ploug, T., & Richter, E. A. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.1.e184 · Cited by 23 · see citing works
Physiological Bases for the Treatment of the Physically Active Individual with Diabetes
Wasserman, D. H., & Abumrad, N. N. (1989) · Sports Medicine · doi:10.2165/00007256-198907060-00003 · Cited by 23 · see citing works
The Daily Management of Athletes with Diabetes
MacKnight, J. M., Mistry, D. J., Pastors, J. G., Holmes, V. F., & Rynders, C. A. (2009) · Clinics in Sports Medicine · doi:10.1016/j.csm.2009.02.005 · Cited by 23 · see citing works
Glucose utilization during exercise: influence of endurance training
Wojtaszewski, J. F. P., & Richter, E. A. (1998) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.1998.0322e.x · Cited by 21 · see citing works
Regulation of Muscle Glucose Uptake In Vivo
Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070227 · Cited by 19 · see citing works
Eblenkamp, M., BÖTTCHER, U., Thomas, J., Löken, C., Ionescu, I., Rose, H., Kammermeier, H., & Fischer, Y. (1996) · Life Sciences · doi:10.1016/0024-3205(96)00270-6 · Cited by 19 · see citing works
Richter, E. A. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp120120 · Cited by 25 · see citing works
Fiber type-selective exercise effects on AS160 phosphorylation
Wang, H., Arias, E. B., Oki, K., Pataky, M. W., Almallouhi, J. A., & Cartee, G. D. (2019) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00528.2018 · Cited by 16 · see citing works
Self-citationMuscle glucose uptake is effectively activated by ischemia in type 2 diabetic subjects.
Niklasson, M., Holmäng, A. B., Sjöstrand, M., Strindberg, L., & Lönnroth, P. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1178 · Cited by 16 · see citing works
Structural biomechanics modulate intramuscular distribution of locally delivered drugs
Wu, P. I., & Edelman, E. R. (2008) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2008.06.025 · Cited by 15 · see citing works
“While studies have investigated how strain or contraction in whole muscles affects total uptake of glucose (Aslesen et al., 2001, Constable et al., 1988, Holloszy and Narahara, 1965, Ihlemann et al., 2001, Ihlemann et al., 1999, 2000), lactate (McDermott and Bonen, 1994), phosphate (Abraham and…”
BackgroundMorishima, T., & Goto, K. (2014) · SpringerPlus · doi:10.1186/2193-1801-3-370 · Cited by 14 · see citing works
“transporter (GLUT) 4-mediated glucose transport via several signaling pathways (Constable et al. 1988; Ploug et al. 1987; Cartee et al. 1991; Youn et al. 1994).”
BackgroundInfluentialCortright, R. N., Azevedo, J. L., Hickey, M. S., Tapscott, E. B., & Dohm, G. L. (1997) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(97)00072-4 · Cited by 13 · see citing works
The historical context and scientific legacy of John O. Holloszy
Hagberg, J. M., Coyle, E. F., Baldwin, K. M., Cartee, G. D., Fontana, L., Joyner, M. J., Kirwan, J. P., Seals, D. R., & Weiss, E. P. (2019) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00669.2018 · Cited by 13 · see citing works
Self-citationKlarod, K., Philippe, M., Gatterer, H., & Burtscher, M. (2017) · Sport Sciences for Health · doi:10.1007/s11332-017-0392-3 · Cited by 13 · see citing works
Mechanism of hypoxia-stimulated glucose transport in rat skeletal muscle: potential role of glycogen
Reynolds, T., Brozinick, J. T., Rogers, M. A., & Cushman, S. W. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.274.5.e773 · Cited by 12 · see citing works
“However, these same laboratories have also reported the contrary (7, 11, 28).”
BackgroundEffects of alkaline pH on the stimulation of glucose transport in rat skeletal muscle
Ren, J., Youn, J. H., Gulve, E. A., Henriksen, E. J., & Holloszy, J. O. (1993) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(93)90289-c · Cited by 12 · see citing works
Self-citationPostexercise Skeletal Muscle Glucose Transport Is Normal in Kininogen-Deficient Rats
Schweitzer, G. G., & Cartee, G. D. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31820a7f65 · Cited by 11 · see citing works
“A single exercise session can stimulate glucose transport in the absence of insulin (insulin-independent), and it can also increase insulin's ability to increase glucose transport (insulin-dependent) (7,8,10).”
Self-citationContraction stimulates muscle glucose uptake independent of atypical PKC
Yu, H., FUJII, N. L., Toyoda, T., An, D., Farese, R. V., Leitges, M., Hirshman, M. F., Mul, J. D., & Goodyear, L. J. (2015) · Physiological Reports · doi:10.14814/phy2.12565 · Cited by 10 · see citing works
“…and muscle contractile activity also cause GLUT4 translocation, it is well established that the initiating signaling molecules that mediate this process are distinct from that of insulin (Ploug et al. 1987; Constable et al. 1988; Douen et al. 1990; Hayashi et al. 1998; Lemieux et al. 2000).”
BackgroundLee, I. H., Lee, Y. J., Seo, H.-B., Kim, Y. S., Nam, J., Jeon, B.-D., & Kwon, T.-D. (2018) · Physical Activity and Nutrition · doi:10.20463/jenb.2018.0004 · Cited by 10 · see citing works
Voluntary exercise improves glycemia in non-obese diabetic (NOD) mice
Keller, J. B., Bevier, W. C., Jovanovic‐Peterson, L., et al. (1993) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(93)90129-s · Cited by 8 · see citing works
Larsen, R. N., Taylor, F., Dempsey, P. C., McNarry, M. A., Rickards, K., Sethi, P., Homer, A. R., Cohen, N. D., Owen, N. G., Kumareswaran, K., et al. (2024) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2024.0146 · Cited by 7 · see citing works
“As muscle contractions induce glucose uptake even in the absence of insulin, 31,32 it is likely that regular activity breaks would reduce beta-cell demand in insulin resistant states (e.g., typical of T2D) resulting in a fall in circulating insulin; whereas in states of absolute insulin de fi ciency…”
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Kim, J., Arias, E. B., & Cartee, G. D. (2006) · The Journal of Physiological Sciences · doi:10.2170/physiolsci.rp009406 · Cited by 6 · see citing works
Self-citationFitzgerald, L. S., Bremner, S. N., Ward, S. R., Cho, Y., & Schenk, S. (2024) · Function · doi:10.1093/function/zqae035 · Cited by 5 · see citing works
Acute exercise and caffeine improve insulin-induced hypoglycemia in normal and malnourished rats
Babata, L. K. R., Malta, A., de Godoi, V. A. F., & Pedrosa, M. M. D. (2015) · Acta Scientiarum Biological Sciences · doi:10.4025/actascibiolsci.v37i1.22776 · Cited by 3 · see citing works
Exercise and Diabetic Neuropathy
LeBrasseur, N. K., & Fielding, R. A. (1998) · Humana Press eBooks · doi:10.1007/978-1-4612-1816-6_16 · Cited by 3 · see citing works
Post-exercise muscle glycogen repletion in horses
Hyyppä, S. (2007) · Jukuri (Natural Resources Institute Finland (Luke)) · Cited by 2 · see citing works
Booz, G. W., & Bianchi, C. P. (1992) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/0005-2736(92)90076-x · Cited by 2 · see citing works
Endurance exercise: a model of physiological integration
Calderón‐Montero, F. J., Ramos-Álvarez, J. J., & Capellá, I. L. (2021) · Archivos de medicina del deporte: revista de la Federación Española de Medicina del Deporte y de la Confederación Iberoamericana de Medicina del Deporte · doi:10.18176/archmeddeporte.00062 · Cited by 1 · see citing works
de Barros, M. C. (2009) · doi:10.11606/d.5.2009.tde-08092009-144855 · Cited by 1 · see citing works
Glund, S. (2007) · Figshare
MacKrell, J. G. (2013) · Deep Blue (University of Michigan)
Nutrient and energy sensing in skeletal muscle
Deshmukh, A. S. (2009) · Figshare · Cited by 1 · see citing works
Sparks, M. (1995) · Victoria University Research Repository (Victoria University)
Harfmann, B. D. (2015) · UKnowledge (University of Kentucky)
Loyd, C. (2014) · OhioLink ETD Center (Ohio Library and Information Network)
Richter, E. A. (1995) · Comprehensive physiology · doi:10.1002/j.2040-4603.1995.tb01717.x
“The two physiologically relevant stimuli of membrane glucose transport capacity in muscle are insulin and contractions (79, 108, 109, 135, 136, 155, 161, 162, 251,271,273,274,300,365).”
Regulation of Muscle Glucose Uptake In Vivo
Mandarino, L. J., Bonadonna, R. C., McGuinness, O. P., Halseth, A. E., & Wasserman, D. H. (2001) · Comprehensive physiology · doi:10.1002/j.2040-4603.2001.tb01473.x
Carbohydrate metabolism and the beta-adrenergic system in disuse muscle atrophy.
Kirby, C. R. (1990) · UA Campus Repository (The University of Arizona)
- Authors
- Constable, S. H., Favier, R. J., Cartee, G. D., Young, D. A., & Holloszy, J. O.
- Affiliations
- Washington University in St. Louis (US)
- ORCID
- Cartee, G. D.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1988-06-01
- Volume
- 64
- Issue
- 6
- Pages
- 2329-2332
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2337102266
- Cited by
- 99
- References
- 0
- Citations by year
- 2024: 2 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 1 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 3
- FWCI
- 1.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (2t32am007011-12)
- National Institute on Aging (AG 00078)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK-18986)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- muscle glucose transport, insulin, physical activity, 3-O-methylglucose uptake, epitrochlearis muscle, swimming training, insulin resistance
- MeSH terms
- Animals, Biological Transport, Active, Physical Exertion, Insulin, Male, Mannitol, Methylglucosides, Methylglycosides, Muscle Contraction, Muscles, Rats, Inbred Strains, Reference Values, Swimming, 3-O-Methylglucose, Rats, In Vitro Techniques
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