Cited by 304Thermoregulation and physiological responsesElectrolyte and hormonal disordersCardiovascular and exercise physiology

The DOI matches its Crossref record.

Role of osmolality and plasma volume during rehydration in humans

Nose, H., Mack, G. W., Shi, X. R., Nadel, E. R.·1988·Journal of Applied Physiology

DOI 10.1152/jappl.1988.65.1.325

Open this paper in CoChat — free account

Abstract

To determine how the sodium content of ingested fluids affects drinking and the restoration of the body fluid compartments after dehydration, we studied six subjects during 4 h of recovery from 90-110 min of a heat [36 degrees C, less than 30% relative humidity (rh)] and exercise (40% maximal aerobic power) exposure, which caused body weight to decrease by 2.3%. During the 1st h, subjects rested seated without any fluids in a thermoneutral environment (28 degrees C, less than 30% rh) to allow the body fluid compartments to stabilize. Over the next 3 h, subjects rehydrated ad libitum using tap water and capsules containing either placebo (H2O-R) or 0.45 g NaCl (Na-R) per 100 ml water. During the 3-h rehydration period, subjects restored 68% of the lost water during H2O-R, whereas they restored 82% during Na-R (P less than 0.05). Urine volume was greater in H2O-R than in Na-R; thus only 51% of the lost water was retained during H2O-R, whereas 71% was retained during Na-R (P less than 0.05). Plasma osmolality was elevated throughout the rehydration period in Na-R, whereas it returned to the control level by 30 min in H2O-R (P less than 0.05). Changes in free water clearance followed changes in plasma osmolality. The restoration of plasma volume during Na-R was 174% of that lost. During H2O-R it was 78%, which seemed to be sufficient to diminish volume-dependent dipsogenic stimulation.(ABSTRACT TRUNCATED AT 250 WORDS)

Integrity signals

Registry

Crossref · 10.1152/jappl.1988.65.1.325

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 101–200 of 300

Compositional Aspects of Beverages Designed to Promote Hydration Before, During, and After Exercise: Concepts Revisited
Pérez-Castillo, Í. M., Williams, J. A. S., Chicharro, J. L., Mihic, N., Rueda, R., Bouzamondo, H., & Horswill, C. A. (2023) · Nutrients · doi:10.3390/nu16010017 · Cited by 47
“In subjects dehydrated to 2.3% BML after exercising in the heat, the ad libitum intake of a 0.45% NaCl solution was shown to restore pre-dehydration plasma volume values within 20 min, while 60 min was needed when consuming water alone [224,225].”
MethodInfluential
Effect of a Carbohydrate-Electrolyte Beverage, Lemon Tea, or Water on Rehydration During Short-Term Recovery From Exercise
Wong, S. H., & Chen, Y. (2011) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.21.4.300 · Cited by 37
“However, high sodium content can make a drink unpalatable (Nose et al., 1988; Wemple, Lamb, & McKeever, 1997).”
Background
Children's Perceptual Responses to Ingesting Drinks of Different Compositions during and Following Exercise in the Heat
Meyer, F., Bar‐Or, O., & Wilk, B. (1995) · International Journal of Sport Nutrition · doi:10.1123/ijsn.5.1.13 · Cited by 36
Tear Osmolarity in the Diagnosis of Systemic Dehydration and Dry Eye Disease
Bron, A. J., & Willshire, C. (2021) · Diagnostics · doi:10.3390/diagnostics11030387 · Cited by 36
Effect of varying the concentrations of carbohydrate and milk protein in rehydration solutions ingested after exercise in the heat
James, L. J., Evans, G. H., Madin, J., Scott, D., Stepney, M., Harris, R., Stone, R., & Clayton, D. J. (2013) · British Journal Of Nutrition · doi:10.1017/s0007114513000536 · Cited by 35
“As with high-concentration glucose solutions((18)), the potential slower delivery of water to the peripheral circulation with a solution containing casein protein might offset the reduction in serum osmolality that occurs with the ingestion of a large volume of a dilute solution((19)).”
Background
Role of Whole Foods in Promoting Hydration after Exercise in Humans
Sharp, R. L. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719664 · Cited by 35
“Despite availability of adequate fluids, people generally do not drink enough to fully compensate for sweat losses [7,13].”
Background
Water drinking causes a biphasic change in blood composition in humans
Endo, Y., Torii, R., Yamazaki, F., SAGAWA, S., Yamauchi, K., Tsutsui, Y., Morikawa, T., & Shiraki, K. (2001) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240100555 · Cited by 33
Postexercise rehydration in man: the effects of carbohydrate content and osmolality of drinks ingested ad libitum
Evans, G. H., Shirreffs, S. M., & Maughan, R. J. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-065 · Cited by 33
“The avoidance of a large fall in plasma osmolality or large increases in extracellular fluid volume is therefore of benefit in maintaining circulating vasopressin concentrations and prevent a diuresis (Nose et al. 1988b).”
Background
Enhanced renal Na+reabsorption by carbohydrate in beverages during restitution from thermal and exercise-induced dehydration in men
Kamijo, Y., Ikegawa, S., Okada, Y., Masuki, S., Okazaki, K., Uchida, K., Sakurai, M., & Nosé, H. (2012) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00588.2011 · Cited by 33
The effect of post-exercise drink macronutrient content on appetite and energy intake
Clayton, D. J., Stensel, D. J., Watson, P., & James, L. J. (2014) · Appetite · doi:10.1016/j.appet.2014.07.013 · Cited by 32
A metered intake of milk following exercise and thermal dehydration restores whole-body net fluid balance better than a carbohydrate–electrolyte solution or water in healthy young men
Seery, S., & Jakeman, P. M. (2016) · British Journal Of Nutrition · doi:10.1017/s0007114516002907 · Cited by 33
“1 h), results in enhanced diuresis and failure to restore net fluid balance (NFB) within 4–6 h((8,9,11)).”
Effects of Rooibos Tea, Bottled Water, and a Carbohydrate Beverage on Blood and Urinary Measures of Hydration After Acute Dehydration
Utter, A. C., Quindry, J. C., Emerenziani, G. P., & Valiente, J. S. (2010) · Research in Sports Medicine · doi:10.1080/15438620903321102 · Cited by 32
“Previous studies have demonstrated the importance of glucose-electrolyte beverages in the recovery of plasma volume when compared with plain water (Nose et al. 1988; Shirreffs and Maughan 1998).”
Background
Fluid and Electrolyte Homeostasis During and Following Exercise: Hormonal and Non-Hormonal Factors
Wade, C. E., Freund, B. J., & Claybaugh, J. R. (1989) · Springer eBooks · doi:10.1007/978-1-4613-0585-9_1 · Cited by 32
The Effect of Pre-Exercise Hyperhydration on Exercise Performance, Physiological Outcomes and Gastrointestinal Symptoms: A Systematic Review
Jardine, W. T., Aisbett, B., Kelly, M. K., Burke, L. M., Ross, M. L., Condo, D., Périard, J. D., & Carr, A. J. (2023) · Sports Medicine · doi:10.1007/s40279-023-01885-2 · Cited by 32
“Sodium is a positively charged ion (Na + ) that is the main contributor to plasma osmolality [31] and plays a crucial role in determining the flow of fluids in the intra-and extracellular compartments [24].”
Background
Effects of Commercially Formulated Water on the Hydration Status of Dehydrated Collegiate Wrestlers
Valiente, J. S., Utter, A. C., Quindry, J. C., & Nieman, D. C. (2009) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e3181bac56e · Cited by 31
“However, the addition of sodium chloride (77 mmol l(21)) to plain water will stimulate the drive to drink and increase the fluid retained by reducing urine output (18).”
BackgroundInfluential
A Review of Fluid and Hydration in Competitive Tennis
Kovacs, M. S. (2008) · International Journal of Sports Physiology and Performance · doi:10.1123/ijspp.3.4.413 · Cited by 30
Exercise in the heat: Strategies to minimize the adverse effects on performance
Terrados, N., & Maughan, R. (1995) · Journal of Sports Sciences · doi:10.1080/02640419508732278 · Cited by 30
Fluid balance and renal response following dehydrating exercise in well-trained men and women
Stachenfeld, N. S., Gleim, G. W., Zabetakis, P. M., & Nicholas, J. A. (1996) · European Journal of Applied Physiology · doi:10.1007/bf00242277 · Cited by 30
Potential impact of a 500-mL water bolus and body mass on plasma osmolality dilution
Sollanek, K. J., Kenefick, R. W., Cheuvront, S. N., & Axtell, R. S. (2011) · European Journal of Applied Physiology · doi:10.1007/s00421-011-1833-3 · Cited by 29
Effect of whey protein isolate on rehydration after exercise
James, L. J., Mattin, L. R., Aldiss, P., Adebisi, R., & Hobson, R. M. (2014) · Amino Acids · doi:10.1007/s00726-014-1680-8 · Cited by 28
“space) to a rehydration drink prevents the decline in serum sodium concentration and osmolality that occurs with the ingestion of a low-sodium drink (Nose et al. 1988), and consequently reduces urine production (Nose et al.”
Background
Sodium-induced hyperhydration decreases urine output and improves fluid balance compared with glycerol- and water-induced hyperhydration
Savoie, F. A., Dion, T., Asselin, A., & Goulet, E. D. B. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0243 · Cited by 28
“Sodium is the most abundant extracellular cation, and therefore a primary determinant of plasma osmolality and extracellular fluid volume (Nose et al. 1988).”
Background
Body mass management of lightweight rowers: nutritional strategies and performance implications
Slater, G., Rice, A., Jenkins, D. G., & Hahn, A. G. (2014) · British Journal of Sports Medicine · doi:10.1136/bjsports-2014-093918 · Cited by 28
Effectiveness of Exercise-Heat Acclimation for Preventing Heat Illness in the Workplace
Yamazaki, F. (2013) · Journal of UOEH · doi:10.7888/juoeh.35.183 · Cited by 27
Effects of ingesting a sports drink during exercise and recovery on subsequent endurance capacity
LEE, J. K. W., Nio, A. Q. X., Ang, W. H., Law, L. Y. L., & Lim, C. L. (2011) · European Journal of Sport Science · doi:10.1080/17461391.2010.487115 · Cited by 28
“Nose et al. (1988) reported an acute fall in serum osmolality with the ingestion of water and placebo, which stimulated diuresis.”
Background
Rehydration following exercise: effects of administration of water versus an isotonic oral rehydration solution (ORS)
MARLIN, D. J., SCOTT, C. M., Mills, P. C., et al. (1998) · The Veterinary Journal · doi:10.1016/s1090-0233(98)80060-9 · Cited by 26
Electrolyte vs. glucose‐electrolyte isotonic solutions for oral rehydration therapy in horses
Monreal, L., GARZóN, N., Espada, Y., et al. (1999) · Equine Veterinary Journal · doi:10.1111/j.2042-3306.1999.tb05259.x · Cited by 26
The influence of beverage composition and gastrointestinal function on fluid and nutrient availability during exercise
Rehrer, N. J., Brouns, F. J. P. H., Beckers, E. J., & Saris, W. H. M. (1994) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/j.1600-0838.1994.tb00421.x · Cited by 26
The Interrelationship of Research in the Laboratory and the Field to Assess Hydration Status and Determine Mechanisms Involved in Water Regulation During Physical Activity
Stachenfeld, N. S. (2014) · Sports Medicine · doi:10.1007/s40279-014-0155-0 · Cited by 26
“However, a weakness of the dehydration protocol is that exerciseinduced dehydration does not isolate the independent contributions of volume and osmoreceptors to the overall thirst or AVP responses because both are changing simultaneously [29, 34, 40].”
Background
Milk Protein and the Restoration of Fluid Balance after Exercise
James, L. J. (2012) · Medicine and sport science/Medicine and sport · doi:10.1159/000341958 · Cited by 24
Nutrition in Combat Sports
Burke, L. M., & Cox, G. R. (2008) · Springer eBooks · doi:10.1007/978-1-84800-354-5_1 · Cited by 25
Efficacy of Ingesting an Oral Rehydration Solution after Exercise on Fluid Balance and Endurance Performance
Fan, P. W., Burns, S. F., & LEE, J. K. W. (2020) · Nutrients · doi:10.3390/nu12123826 · Cited by 24
“During recovery, the inclusion of sodium offers several advantages over plain water: (i) it sustains the osmotic drive to drink [34] thereby promoting better voluntary fluid intake [40]; (ii) maintains greater plasma and extracellular fluid volumes [41]; (iii) lowers urine output; and (iv) blunts further declines in p…”
BackgroundInfluential
CrossRef Listing of Deleted DOIs
Unnithan, V. B., & Goulopoulou, S. (2007) · CrossRef Listing of Deleted DOIs · doi:10.1007/s11932-004-0017-x · Cited by 23
Up in the Air: Evidence of Dehydration Risk and Long-Haul Flight on Athletic Performance
Zubac, D., Stella, A. B., & Morrison, S. A. (2020) · Nutrients · doi:10.3390/nu12092574 · Cited by 22
“Briefly, under well-controlled conditions [38], USG is argued to be a superior dehydration marker (at lower levels of dehydration, ~2%), compared to blood indices primarily due to the body fluid regulatory homeostatic mechanisms, including plasma volume defense pathways [39].”
Background
Investigating the Nutritional and Recovery Habits of Tennis Players
Fleming, J., Naughton, R. J., & Harper, L. D. (2018) · Nutrients · doi:10.3390/nu10040443 · Cited by 27
“Consuming water alone during exercise can increase urine output alongside the rapid reduction in plasma sodium concentration, thus negatively impacting the body’s fluid balance [36,37].”
Background
Effects of hypertonicity on water intake in the elderly: An age-related failure
Dyke, M. M., Davis, K. M., Clark, B. A., et al. (1997) · Geriatric Nephrology and Urology · doi:10.1023/a:1008252032016 · Cited by 22
Use of Salivary Osmolality to Assess Dehydration
Smith, D. L., Shalmiyeva, I., DeBlois, J. P., & Winke, M. R. (2011) · Prehospital Emergency Care · doi:10.3109/10903127.2011.614044 · Cited by 23
The Role of Salt and Glucose Replacement Drinks in the Marathon
Murray, B. (2007) · Sports Medicine · doi:10.2165/00007256-200737040-00021 · Cited by 22
Marathon running: physiological and chemical changes accompanying late-race functional deterioration
Cade, R., Packer, D., Zauner, C., et al. (1992) · European Journal of Applied Physiology · doi:10.1007/bf00602353 · Cited by 22
Change in hydration indices associated with an increase in total water intake of more than 0.5 L/day, sustained over 4 weeks, in healthy young men with initial total water intake below 2 L/day
Stookey, J. D., Hamer, J., & Killilea, D. W. (2017) · Physiological Reports · doi:10.14814/phy2.13356 · Cited by 21
“Ad libitum water intake is subject to unconscious, involuntary dehydration, where individuals drink to satiety but a water deficit remains (Nose et al. 1988a,b; Greenleaf 1992).”
Background
Multivariate statistical analysis comparing sport and energy drinks
Amendola, C., Iannilli, I., Restuccia, D., Santini, I., & Vinci, G. (2004) · Innovative Food Science & Emerging Technologies · doi:10.1016/j.ifset.2004.01.006 · Cited by 21
Hydration Efficacy of a Milk Permeate-Based Oral Hydration Solution
Berry, C. W., Wolf, S. T., Murray, B., & Kenney, W. L. (2020) · Nutrients · doi:10.3390/nu12051502 · Cited by 21
“These solutions are designed to maintain or improve hydration status by promoting drinking, absorption of fluid from the small intestine via activation of sodium-glucose transporters [10], and retention of fluid within the body and the vascular compartment [11,12].”
Background
Hydration in the Pediatric Athlete — How to Guide Your Patients
Bergeron, M. F. (2015) · Current Sports Medicine Reports · doi:10.1249/jsr.0000000000000179 · Cited by 21
“This particularly occurs when plain water or very low-sodium fluid is consumed alone (36).”
Background
Blood and Urine Responses to Ingesting Fluids of Various Salt and Glucose Concentrations
Frey, M., Riddle, J. M., Charles, J. B., et al. (1991) · The Journal of Clinical Pharmacology · doi:10.1002/j.1552-4604.1991.tb03643.x · Cited by 21
Recommendations for Treatment of Hyponatraemia at Endurance Events
Hsieh, M. (2004) · Sports Medicine · doi:10.2165/00007256-200434040-00003 · Cited by 20
Control of water intake in thermally dehydrated rats
Barney, C. C., & West, D. R. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90333-y · Cited by 21
Scientific basis for a milk permeate-based sports drink – A critical review
Berry, C. W., Murray, B., & Kenney, W. L. (2021) · International Dairy Journal · doi:10.1016/j.idairyj.2021.105296 · Cited by 20
Rehydration and Recovery After Exercise
Shirreffs, S. M. (2000) · doi:10.1002/9780470693766.ch19 · Cited by 22
Efficacy of ice slurry and carbohydrate–electrolyte solutions for firefighters
Tabuchi, S., Horie, S., Kawanami, S., et al. (2021) · Journal of Occupational Health · doi:10.1002/1348-9585.12263 · Cited by 19
Fluid, energy and nutrient recovery via ad libitum intake of different fluids and food
Campagnolo, N., Iudakhina, E., Irwin, C. G., Schubert, M. M., Cox, G. R., LEVERITT, M. D., & Desbrow, B. (2017) · Physiology & Behavior · doi:10.1016/j.physbeh.2017.01.009 · Cited by 19
Heat Illness during Working and Preventive Considerations from Body Fluid Homeostasis
Kamijo, Y., & Nosé, H. (2006) · Industrial Health · doi:10.2486/indhealth.44.345 · Cited by 19
Special issues and concerns for the high school- and college-aged athletes
Martin, T. J., & Martin, J. S. (2002) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(02)00004-4 · Cited by 19
“hypotonic replacement fluids [12,13,79], which may result in intracellular electrolyte imbalances, may be a contributing factor.”
Background
A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 3: Heat and cold tolerance during exercise
Notley, S. R., Mitchell, D., & Taylor, N. A. S. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05276-3 · Cited by 19
Influence of Nutrient Intake after Weigh-In on Lightweight Rowing Performance
Slater, G., Rice, A. J., Sharpe, K., Jenkins, D. G., & Hahn, A. G. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000240319.16029.5f · Cited by 18
“Not only does dietary sodium assist in maintaining serum OSM and sodium concentrations (17), which, in turn, maintains the drive to drink (18), it also stimulates glucose absorption in the small intestine via the active cotransport of sodium and glucose (11).”
Background
Compartmental water management of Marwari sheep during dehydration and rehydration
Kataria, N., & Kataria, A. K. (2007) · University of Zagreb University Computing Centre (SRCE) · Cited by 18
Fluid, energy, and nutrient recovery via ad libitum intake of different commercial beverages and food in female athletes
McCartney, D., Irwin, C. G., Cox, G. R., & Desbrow, B. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0176 · Cited by 17
“…observation is 487 consistent with results from previous experiments suggesting that the consumption of food (providing energy and 488 nutrients) enhances fluid retention (Maughan et al. 1996; Pryor et al. 2015) by delaying gastric emptying and 489 attenuating osmotic diuresis (Nose et al. 1988).”
BackgroundResult
Interactions between body fluid homeostasis and thermoregulation in humans
Nosé, H., Kamijo, Y., & Masuki, S. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00025-4 · Cited by 17
Fluid balance and hydration status in combat sport Olympic athletes: a systematic review with meta-analysis of controlled and uncontrolled studies
Zubac, D., Paravlic, A. H., Reale, R., Jelaska, I. D., Morrison, S. A., & Ivančev, V. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-01937-2 · Cited by 17
Environmental Conditions Affecting the Athlete
Thein, L. A. (1995) · Journal of Orthopaedic and Sports Physical Therapy · doi:10.2519/jospt.1995.21.3.158 · Cited by 17
A Compositional Analysis of a Common Acetic Acid Solution With Practical Implications for Ingestion.
Dale, R. B., Leaver-Dunn, D., & Bishop, P. (2003) · PubMed Central · Cited by 16
A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 2: physiological measurements
Notley, S. R., Mitchell, D., & Taylor, N. A. S. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05284-3 · Cited by 15
Qualitative and/or Quantitative Drinking Water Recommendations for Pediatric Obesity Treatment
Stookey, J. D. (2014) · Journal of Obesity & Weight loss Therapy · doi:10.4172/2165-7904.1000232 · Cited by 15
“Physiologic signals, such as suppressed thirst and involuntary dehydration, and environmental or social cues that discourage drinking water are known barriers to drinking water [60-63].”
Background
Effect of prehydration on nasal mucociliary clearance in low relative humidity
Oozawa, H., Kimura, H., Noda, T., Hamada, K., Morimoto, T., & Majima, Y. (2011) · Auris Nasus Larynx · doi:10.1016/j.anl.2011.04.002 · Cited by 14
Hyperthermia and dehydration: their independent and combined influences on physiological function during rest and exercise
van den Heuvel, A. M. J., Haberley, B. J., Hoyle, D. J. R., Croft, R. J., Peoples, G. E., & Taylor, N. A. S. (2020) · European Journal of Applied Physiology · doi:10.1007/s00421-020-04493-4 · Cited by 15
Systemic but not local rehydration restores dehydration-induced changes in pulmonary function in healthy adults
Marshall, H. L., Gibson, O. R., Romer, L. M., Illidi, C. R., Hull, J. H., & Kippelen, P. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00311.2020 · Cited by 15
“That previous studies (30, 31) have evidenced restoration of plasma volume and extracellular osmolality (i.”
Background
Carbohydrate Electrolyte Solutions Enhance Endurance Capacity in Active Females
Sun, F., Wong, S. H., Chen, S.-H., & Poon, E. T. (2015) · Nutrients · doi:10.3390/nu7053739 · Cited by 15
“Because the ingestion of plain water may decrease plasma osmolality and sodium concentration, so as to stimulate the production of urine and reduce the urge to drink [17], it may not be appropriate for consumption during endurance exercise.”
Background
The effects of repeated ingestion of high and low glucose–electrolyte solutions on gastric emptying and blood 2H2O concentration after an overnight fast
Evans, G. H., Shirreffs, S. M., & Maughan, R. J. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002169 · Cited by 15
“However, the rapid appearance of ingested water in the circulation can lead to an increased urine output due to acute reductions in circulating fluid retention hormone concentration((16,17)), which would be considered undesirable for the maintenance of fluid balance.”
Background
Electrolyte supplementation during severe energy restriction increases exercise capacity in the heat
James, L. J., Mears, S. A., & Shirreffs, S. M. (2015) · European Journal of Applied Physiology · doi:10.1007/s00421-015-3254-1 · Cited by 14
Effect of Exercise Intensity on Subsequent Gastric Emptying Rate in Humans
Evans, G. H., Watson, P., Shirreffs, S. M., & Maughan, R. J. (2015) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2015-0110 · Cited by 14
“Sodium composition (Shirreffs & Maughan, 1998) of an ingested drink appears to have a large influence on water retention after exercise as a result of the effect on plasma osmolality and arginine vasopressin response (Nose et al., 1988).”
Background
Hydration Status Assessment Techniques and Their Applicability Among Olympic Combat Sports Athletes: Literature Review
Zubac, D., Marušič, U., & Karninčić, H. (2016) · Strength and conditioning journal · doi:10.1519/ssc.0000000000000236 · Cited by 15
“Notably, it is well established that soon after the dehydrating exercise, half of the reduced PV is recovered even if no fluid is ingested, possibly due to the body’s ability to shift fluid from the intracellular to the intravascular space (43).”
Background
Health Hazards to Park Rangers from Excessive Heat at Grand Canyon National Park
Krake, A. M., McCullough, J. M., & King, B. S. (2003) · Applied Occupational and Environmental Hygiene · doi:10.1080/10473220301364 · Cited by 14
Effects of protein addition to carbohydrate–electrolyte solutions on postexercise rehydration
Li, L., Wong, S. H., & Sun, F. (2015) · Journal of Exercise Science & Fitness · doi:10.1016/j.jesf.2014.11.001 · Cited by 13
“41 A 6% reduction in PV was observed immediately after exercise in the present study.”
Background
Efficacy of Glucose or Amino Acid–Based Commercial Beverages in Meeting Oral Rehydration Therapy Goals After Acute Hypertonic and Isotonic Dehydration
Cheuvront, S. N., Kenefick, R. W., Charkoudian, N., Mitchell, K. M., Luippold, A. J., Bradbury, K. E., & Vidyasagar, S. (2018) · Journal of Parenteral and Enteral Nutrition · doi:10.1002/jpen.1142 · Cited by 14
Effect of Preexercise Electrolyte Ingestion on Fluid Balance in Men and Women
Johannsen, N. M., Lind, E., King, D. S., & Sharp, R. L. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181a82940 · Cited by 13
“(23) who found greater net fluid gain with the addition of NaCl to ingested water during recovery.”
Background
Dietary Requirements for Ultra-Endurance Exercise
Singh, A. K., Pelletier, P. A., & Deuster, P. A. (1994) · Sports Medicine · doi:10.2165/00007256-199418050-00002 · Cited by 13
Hydration Is More Important Than Exogenous Carbohydrate Intake During Push-to-the-Finish Cycle Exercise in the Heat
Berry, C. W., Wolf, S. T., Cottle, R. M., & Kenney, W. L. (2021) · Frontiers in Sports and Active Living · doi:10.3389/fspor.2021.742710 · Cited by 12
“, 2001), encouraging retention of fluid within the body and the vascular compartment (Nose et al., 1988; Shirreffs et al., 2007), and replacement of fluid and electrolytes lost via sweat (American College of Sports et al.”
Background
RBC deformability and amino acid concentrations after hypo-osmotic challenge may reflect chronic cell hydration status in healthy young men
Stookey, J. D., Klein, A., Hamer, J., Chi, C., Higa, A., Ng, V., Arieff, A. I., Kuypers, F. A., Larkin, S. K., Perrier, E. T., et al. (2013) · Physiological Reports · doi:10.1002/phy2.117 · Cited by 12
A Sodium Drink Enhances Fluid Retention During 3 Hours of Post-Exercise Recovery When Ingested With a Standard Meal
Evans, G. H., Miller, J., Whiteley, S., & James, L. J. (2017) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.2016-0196 · Cited by 13
“The addition of sodium to a 83 rehydration drink increases plasma osmolality (Nose et al. 1988) and enhances post-exercise 84 rehydration in a dose-dependent manner (Maughan and Leiper 1995; Shirreffs and Maughan 85 1998; Merson et al. 2008).”
BackgroundMethod
The Ergogenics of Fluid and Electrolyte Balance
Hosey, R. G., & Glazer, J. L. (2004) · Current Sports Medicine Reports · doi:10.1249/00149619-200408000-00008 · Cited by 11
Hidratación y ejercicio físico
Rosés, J. M., & Pujol, P. (2006) · Apunts Sports Medicine · doi:10.1016/s1886-6581(06)70013-5 · Cited by 12
Restoration of Fluid and Electrolyte Balance After Exercise
Shirreffs, S. M. (2001) · Canadian Journal of Applied Physiology · doi:10.1139/h2001-057 · Cited by 12
A century of exercise physiology: concepts that ignited the study of human thermoregulation. Part 4: evolution, thermal adaptation and unsupported theories of thermoregulation
Notley, S. R., Mitchell, D., & Taylor, N. A. S. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05262-9 · Cited by 12
Oral Rehydration Beverages for Treating Exercise-Associated Dehydration: A Systematic Review, Part I. Carbohydrate-Electrolyte Solutions
Borra, V., Brier, N. D., Berry, D. C., Zideman, D. A., Singletary, E. M., Buck, E. D. J. D., & _, _. (2023) · Journal of Athletic Training · doi:10.4085/1062-6050-0682.22 · Cited by 12
The optimal sports drink
Shirreffs, S. M. (2003) · Schweizerische Zeitschrift für Sportmedizin und Sporttraumatologie · Cited by 15
Plasma compartment filling after exercise or heat exposure
Jimenez, C., Koulmann, N., Mischler, I., Allevard, A. M., LAUNAY, J.-C., Savourey, G., & Melin, B. (2002) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200210000-00014 · Cited by 10
Fluid balance and exercise performance.
Singh, R. (2003) · PubMed · Cited by 11
Ad Libitum Fluid Intake and Plasma Responses After Pickle Juice, Hypertonic Saline, or Deionized Water Ingestion
Allen, S. T., Miller, K. C., Albrecht, J. M., Garden-Robinson, J., & Salafia, E. H. B. (2013) · Journal of Athletic Training · doi:10.4085/1062-6050-48.5.04 · Cited by 10
“A dding sodium (Naþ) to drinks improves rehydration(1,2) and ad libitum fluid consumption in hypohydrated individuals.(3) Furthermore, drinks containing Naþ can more effectively restore plasma volume and plasma sodium concentration ([Na]p) than drinks without Naþ.”
Background
Effect of Preexercise Soup Ingestion on Water Intake and Fluid Balance During Exercise in the Heat
Johannsen, N. M., Sullivan, Z. M., Warnke, N. R., Smiley‐Oyen, A. L., King, D. S., & Sharp, R. L. (2013) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.23.3.287 · Cited by 9
RETRACTED: Acute and sub-acute toxicological evaluation of lyophilized Nymphaea x rubra Roxb. ex Andrews rhizome extract
Kumar, K., Sharma, S., Kumar, A., Bhardwaj, P., Barhwal, K. K., & Hota, S. K. (2017) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2017.04.008 · Cited by 9
“Dehydration has been well reported to increase plasma osmolality through decrease in plasma volume (Nose et al., 1985).”
Background
Retracted
EXERCISE AND SWEATING
Ogawa, T. (1996) · 体力科學 · doi:10.7600/jspfsm1949.45.289 · Cited by 9
Oral Rehydration Beverages for Treating Exercise-Associated Dehydration: A Systematic Review, Part II. The Effectiveness of Alternatives to Carbohydrate-Electrolyte Drinks
Brier, N. D., Borra, V., Berry, D. C., Zideman, D. A., Singletary, E. M., Buck, E. D. J. D., & _, _. (2023) · Journal of Athletic Training · doi:10.4085/1062-6050-0686.22 · Cited by 8
Alterations to Kidney Physiology during Cardiopulmonary Bypass—A Narrative Review of the Literature and Practical Remarks
Udzik, J., Pacholewicz, J., Biskupski, A., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12216894 · Cited by 8
“Experimental studies indicate that in this kind of dehydration, the ICF deﬁcits can persist even after three hours of ad libitum rehydration [85].”
Background
Dehydration and Thermal Strain in Junior Tennis
Bergeron, M. F. (2009) · American Journal of Lifestyle Medicine · doi:10.1177/1559827609334973 · Cited by 8
Hypohydration attenuates increases in creatinine clearance to oral protein loading and the renal hemodynamic response to exercise pressor reflex
Chapman, C. L., Holt, S. M., O’Connell, C. T., Brazelton, S. C., Medved, H. N., Howells, W. A. B., Reed, E. L., Needham, K. W., Halliwill, J. R., & Minson, C. T. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00728.2023 · Cited by 7
The Influence of Rehydration Mode After Exercise Dehydration on Cardiovascular Function
McDermott, B. P., Casa, D. J., Lee, E. C., Yamamoto, L. M., Beasley, K. N., Emmanuel, H., Pescatello, L. S., Kraemer, W. J., Anderson, J. M., Armstrong, L. E., et al. (2013) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0b013e318295d548 · Cited by 7
“The oropharyngeal reflex was likely responsible for decreased thirst in the IV + OR trial, and this is supported with differences when oral fluid was added to IV (13,30).”
BackgroundInfluential
Plasma volume expansion 24-hours post-exercise: effect of doubling the volume of replacement fluid.
Kay, B., O’Brien, B. J., & Gill, N. D. (2005) · PubMed · Cited by 7
Practical Nutrition Strategies to Support Basketball Performance during International Short-Term Tournaments: A Narrative Review
Esen, Ö., Rozwadowski, K., Čepička, L., Gabrys, T. T., & Karayiğit, R. (2022) · Nutrients · doi:10.3390/nu14224909 · Cited by 10
Effet d'une boisson bicarbonatée sodée sur les adaptations physiologiques à l'effort
Richard, R., Jimenez, L., Duvallet, A. L., et al. (2000) · Science & Sports · doi:10.1016/s0765-1597(00)87998-8 · Cited by 6
Influence of acute fluid loading on stress-induced hemoconcentration and cardiovascular reactivity
Patterson, S., Tomasulo, M. M. V., Shanholtzer, B. A., & Patterson, C. A. (2008) · Journal of Behavioral Medicine · doi:10.1007/s10865-008-9162-7 · Cited by 6
“For example, a hypotonic fluid such as water (*4 mOsm/kg) causes electrolytes to be osmotically drawn from the intestinal blood vessels into the lumen of the digestive tract to increase osmolality of the fluid before it can be absorbed into the blood stream, while a hypertonic fluid causes water to be drawn into the d…”
Background
Influence de la composition des boissons et de la fonction gastro-intestinale sur la biodisponibilité des liquides et des substances nutritives pendant l'exercice physique. Revue de la littérature
Beckers, E. J., Rehrer, N. J., Brouns, F. J. P. H., & Saris, W. H. M. (1992) · Science & Sports · doi:10.1016/s0765-1597(05)80182-0 · Cited by 5
The Effect of Hypo-Hydration on Mood and Cognition Is Influenced by Electrolyte in a Drink and Its Colour: A Randomised Trial
Cousins, A. L., Young, H. A., Thomas, A. G., & Benton, D. (2019) · Nutrients · doi:10.3390/nu11092002 · Cited by 6
“377 Water alone does not efficiently replace lost fluid as it reduces the sodium concentration in plasma 378 so that the reduced osmolality stimulates diuresis [24].”
Background

Authors: Nose, H., Mack, G. W., Shi, X. R., & Nadel, E. R.
Affiliations: John B. Pierce Laboratory (US)
ORCID: Mack, G. W.
Shi, X. R.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1988-07-01
Volume: 65
Issue: 1
Pages: 325-331
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1988.65.1.325
OpenAlex: W2157430501
Cited by: 304
References: 0
Citations by year: 2026: 4 · 2025: 4 · 2024: 8 · 2023: 10 · 2022: 2 · 2021: 9 · 2020: 7 · 2019: 6 · 2018: 9 · 2017: 11 · 2016: 4 · 2015: 10 · 2014: 23 · 2013: 16 · 2012: 8
FWCI: 2.44
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (HL 20634)
Topics: Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords: rehydration, plasma osmolality, plasma volume, sodium intake, dehydration, free water clearance, urine output, water retention, thirst, body fluid compartments
MeSH terms: Adult, Algorithms, Blood Volume, Body Weight, Dehydration, Electrolytes, Physical Exertion, Hot Temperature, Humans, Male, Osmolar Concentration, Sodium, Thirst, Urine, Water

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Role of osmolality and plasma volume during rehydration in humans

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks