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Impaired muscle glycogen resynthesis after eccentric exercise
Abstract
Eight men performed 10 sets of 10 eccentric contractions of the knee extensor muscles with one leg [eccentrically exercised leg (EL)]. The weight used for this exercise was 120% of the maximal extension strength. After 30 min of rest the subjects performed two-legged cycling [concentrically exercised leg (CL)] at 74% of maximal O2 uptake for 1 h. In the 3 days after this exercise four subjects consumed diets containing 4.25 g CHO/kg body wt, and the remainder were fed 8.5 g CHO/kg. All subjects experienced severe muscle soreness and edema in the quadriceps muscles of the eccentrically exercised leg. Mean (+/- SE) resting serum creatine kinase increased from a preexercise level of 57 +/- 3 to 6,988 +/- 1,913 U/l on the 3rd day of recovery. The glycogen content (mmol/kg dry wt) in the vastus lateralis of CL muscles averaged 90, 395, and 592 mmol/kg dry wt at 0, 24, and 72 h of recovery. The EL muscle, on the other hand, averaged 168, 329, and 435 mmol/kg dry wt at these same intervals. Subjects receiving 8.5 g CHO/kg stored significantly more glycogen than those who were fed 4.3 g CHO/kg. In both groups, however, significantly less glycogen was stored in the EL than in the CL.
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“isolated eccentric exercise (29) or exhaustive running (14) was associated with reduced rates of muscle glycogen restoration during 24 and 72 h of post-exercise recovery”
From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [29]
In the citing paper
“glycogen synthesis in damaged muscles might be partially overcome by increased amounts of CHO intake during the first 24 h after exercise (29).”
From Postexercise muscle glycogen resynthesis in humans. (2017) · cites this paper as [29]
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Items 101–173 of 173
Avogadro, P., Kyröläinen, H., & Belli, A. (2004) · European Journal of Applied Physiology · doi:10.1007/s00421-004-1200-8 · Cited by 12
“However, this last hypothesis is still under debate (Friden et al. 1983; O’Reilly et al. 1987; Costill et al. 1990).”
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“It has also been established that glycogen resynthesis is inhibited across the initial 48 h period post eccentric exercise (Costill et al. 1990; O’Reilly et al. 1987) and this may inXuence IMCL accumulation (Stannard and Johnson 2006).”
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“Metabolic studies of human muscle further indicates that eccentric activity rapidly depletes fast-twitch fibers of glycogen when performed above VO 2max (15, 23), uses significantly more muscle glycogen than concentric activity at similar intensities (38), and impairs glycogen uptake post-exercise compared to muscle d…”
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“Data from studies that employed eccentric exercise demonstrated that muscle glycogen levels were lower 24 h [5, 12] up to 10 days after eccentric exercise [15] compared with immediately post-exercise.”
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“Muscle glycogen resynthesis is markedly impaired after eccentric exercise (O'Reilly et al. 1987; Costill et al. 1990).”
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BackgroundA Survey of Resistance Training Practices Among Physique Competitors During Peak Week
Homer, K. A., Cross, M. R., & Helms, E. R. (2024) · The Journal of Strength and Conditioning Research · doi:10.1519/jsc.0000000000004869 · Cited by 3
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BackgroundEffects of Lower Extremity Alignment During Barbell Squat Training on Muscle Volumes
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Metadata
- Authors
- Costill, D. L., Pascoe, D. D., Fink, W. J., Robergs, R. A., Barr, S. I., & Pearson, D.
- Affiliations
- Ball State University (US)
- ORCID
- Robergs, R. A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1990-07-01
- Volume
- 69
- Issue
- 1
- Pages
- 46-50
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2097845617
- Cited by
- 173
- References
- 0
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 4 · 2023: 4 · 2022: 4 · 2021: 6 · 2020: 5 · 2019: 4 · 2018: 6 · 2017: 7 · 2016: 7 · 2015: 5 · 2014: 5 · 2013: 9 · 2012: 7
- FWCI
- 2.08
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion)
- Faculty of Health
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
- Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
- Keywords
- muscle glycogen resynthesis, eccentric exercise, post-exercise recovery, carbohydrate intake, creatine kinase, delayed onset muscle soreness, muscle edema, vastus lateralis, knee extensors
- MeSH terms
- Adult, Dietary Carbohydrates, Glycogen, Humans, Male, Muscle Contraction, Muscles, Time Factors, Exercise
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