Cited by 302Cardiovascular and exercise physiologyExercise and Physiological ResponsesAngiogenesis and VEGF in Cancer

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Angiogenic growth factor mRNA responses in muscle to a single bout of exercise

Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., Wagner, P. D.·1996·Journal of Applied Physiology

DOI 10.1152/jappl.1996.81.1.355

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Abstract

A major adaptation to exercise is new capillary formation in skeletal muscle. On the basis of angiogenesis in tumors and during development, several angiogenic growth factors may be involved, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), and transforming growth factor-beta 1 (TGF-beta 1). In 9-wk-old female Wistar rats, mRNA expression for these three growth factors in gastrocnemius muscle was examined by quantitative Northern analysis after a single 1-h run at 15 or 20 m/min at 10 degrees incline in room air. A third group ran at 15 m/min in 12% O2, and resting control groups were included at inspired O2 fractions of 0.21 and 0.12. Exercise significantly increased mRNA levels two- to fourfold, which was evident over the first 4 h postexercise; by 8 and 24 h, mRNA levels returned to baseline. For all three factors, mRNA levels were significantly higher after exercise at 20 than at 15 m/min. Hypoxia at rest doubled VEGF and TGF-beta 1 message but had no effect on bFGF. Hypoxic exercise further raised VEGF mRNA levels but had no effect on the other factors. We suggest that VEGF, bFGF, and TGF-beta 1 may be involved in the angiogenic response to exercise and that reduced intracellular PO2 (as occurs during normoxic exercise) may be part of the stimulus to such growth factor production.

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“Its expression can be induced in a wide variety of cell types and tissues [143], including muscle fibers [144, 145], myofibroblasts [146], endothelial cells [119, 147], and vascular smooth muscle cells [132].”

Authors: Breen, E. C., Johnson, E. C., Wagner, H., Tseng, H. M., Sung, L. A., & Wagner, P. D.
Affiliations: University of California San Diego (US)
ORCID: Breen, E. C.
Wagner, P. D.
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 1996-07-01
Volume: 81
Issue: 1
Pages: 355-361
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/jappl.1996.81.1.355
OpenAlex: W2137609684
Cited by: 302
References: 0
Citations by year: 2026: 3 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 5 · 2021: 8 · 2020: 7 · 2019: 6 · 2018: 5 · 2017: 5 · 2016: 15 · 2015: 21 · 2014: 13 · 2013: 13 · 2012: 13
FWCI: 22.86
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl046910-04)
National Heart, Lung, and Blood Institute (P01HL017731, 2-PO1-HL-17731, 5-RO1-HL-46910)
Topics: Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Health Sciences › Medicine › Physiology (medical) › Exercise and Physiological Responses
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
Keywords: exercise-induced angiogenesis, angiogenic factors, vascular endothelial growth factor, basic fibroblast growth factor, TGF-β1, hypoxic exercise, hypoxia, intracellular oxygen tension, mRNA expression, gastrocnemius, single bout exercise
MeSH terms: Animals, Hypoxia, Physical Exertion, Female, Half-Life, RNA, Messenger, Blotting, Northern, Transforming Growth Factor beta, Fibroblast Growth Factor 2, Endothelial Growth Factors, Rats, Wistar, In Situ Hybridization, Muscle, Skeletal, Rats

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Angiogenic growth factor mRNA responses in muscle to a single bout of exercise

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