The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging
Abstract
The purpose of this study was to determine whether enzymatic and histochemical characteristics of human skeletal muscle are altered with aging. Tissues from the vastus lateralis (VL) and gastrocnemius were analyzed for citrate synthase (CS) activity and fiber type in 55 sedentary men (age range 18–80 yr). In this population, CS activity in the gastrocnemius was negatively related to age ( r = −0.32, P < 0.05); there was no relationship in the VL. Treadmill-determined maximal oxygen consumption was positively related ( r = 0.40, P < 0.05) to CS in the gastrocnemius but not in the VL. CS activity in the gastrocnemius was 24% lower in the oldest (≥60 yr, n = 10) vs. the youngest (≤30 yr; n = 12) men; there was no change in CS activity in the VL with aging. No changes in fiber type were evident with age in either muscle. These data suggest a reduction in oxidative enzyme activity in human skeletal muscle with the aging process; this relationship may be muscle-group specific.
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Cites
Human aging, muscle mass, and fiber type composition.
Evans, W. J., & Lexell, J. (1995) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/50a.special_issue.11 · Cited by 1,308
Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M. (1983) · Muscle & Nerve · doi:10.1002/mus.880060809 · Cited by 582 · cited 3×
“Again, the literature is controversial as in the vastus lateralis an increase in the relative percentage of type I fibers (22, 27) or no change (1, 2, 12, 21, 24, 25) in fiber type has been reported with aging.”
BackgroundMethodMcCully, K. K., Fielding, R. A., Evans, W. J., Leigh, J. S., & Posner, J. D. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.2.813 · Cited by 288
Cited by
Sarcopenia: Aging-Related Loss of Muscle Mass and Function
Larsson, L., Degens, H., Li, M., Salviati, L., Lee, Y. I., Thompson, W., Kirkland, J. L., & Sandri, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00061.2017 · Cited by 1,797
Decline in skeletal muscle mitochondrial function with aging in humans
Short, K. R., Bigelow, M. L., Kahl, J., Singh, R., Coenen-Schimke, J., Raghavakaimal, S., & Nair, K. S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501559102 · Cited by 1,333
Effects of Resistance Training on Older Adults
Hunter, G. R., McCarthy, J. P., & Bamman, M. M. (2004) · Sports Medicine · doi:10.2165/00007256-200434050-00005 · Cited by 764
Oxidative capacity and ageing in human muscle
Conley, K. E., Jubrias, S. A., & Esselman, P. C. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-1-00203.x · Cited by 651
Short, K. R., Vittone, J. L., Bigelow, M. L., Proctor, D. N., Rizza, R. A., Coenen-Schimke, J. M., & Nair, K. S. (2003) · Diabetes · doi:10.2337/diabetes.52.8.1888 · Cited by 631
Metadata
- Authors
- Houmard, J. A., Weidner, M. L., Gavigan, K. E., Tyndall, G. L., Hickey, M. S., & Alshami, A.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 1998-10-01
- Volume
- 85
- Issue
- 4
- Pages
- 1337-1341
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2134002692
- Cited by
- 158
- References
- 3
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging. https://app.cochat.ai/papers/10.1152/jappl.1998.85.4.1337
- The paper
- Houmard, J. A., Weidner, M. L., Gavigan, K. E., Tyndall, G. L., Hickey, M. S., & Alshami, A. (1998). Fiber type and citrate synthase activity in the human gastrocnemius and vastus lateralis with aging. Journal of Applied Physiology. https://doi.org/10.1152/jappl.1998.85.4.1337
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
