Distribution of different fiber types in human skeletal muscles: Effects of aging studied in whole muscle cross sections
Abstract
The effects of aging on the total number and size of fibers, and the proportion and distribution of type 1 (slow twitch) and type 2 (fast twitch) fibers were studied in cross sections (15 μ thick) of autopsied whole m. vastus lateralis from two age groups. Each group consisted of six, previously physically healthy males (mean age 72 ± 1 years and 30 ± 6 years, respectively). The size of the muscles of the older individuals was 18% smaller ( P < 0.01) and the total number of fibers was 25% lower ( P < 0.01) than those of the young individuals (mean number 364,000 ± 50,000 vs 478,000 ± 56,000). There was, however, no significant difference in the mean fiber size (indirectly determined) orthe proportion of the two fiber types, though a preferential reduction in type 2 fiber number in the aged individuals was seen. The relative occurrence of the fiber types at various depths in the aged muscles was found to be more even than in muscles from the young individuals. The results suggest that the aging atrophy in m. vastus lateralis , at least up to the age of 70, is primarily the result of a loss of fibers.
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During aging, changes in contractile efficiency of muscle fibers and tissue quality, such as pericellular fat infiltration, may contribute to altered muscle function.
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- Authors
- Lexell, J., Henriksson‐Larsén, K., Winblad, B., & Sjöström, M.
- Affiliations
- Umeå University (SE)
- Corresponding author
- Lexell, Jan
- Venue
- Muscle & Nerve
- Publisher
- Wiley
- Published
- 1983-10
- Volume
- 6
- Issue
- 8
- Pages
- 588-595
- ISSN
- 0148-639X (ISSN-L)
- 1097-4598
- OpenAlex
- W2028656620
- Cited by
- 582
- References
- 23
- Citations by year
- 2026: 11 · 2025: 9 · 2024: 22 · 2023: 13 · 2022: 25 · 2021: 34 · 2020: 15 · 2019: 17 · 2018: 13 · 2017: 14 · 2016: 19 · 2015: 23 · 2014: 19 · 2013: 16 · 2012: 22
- FWCI
- 2.54
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Muscle & Nerve (publishedVersion)
- PubMed (publishedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Muscle metabolism and nutrition
- Keywords
- skeletal muscle aging, fiber type distribution, vastus lateralis, muscle atrophy, fiber number, fiber diameter, muscle cross-section, age-related muscle loss
- MeSH terms
- Adult, Aged, Aging, Arteriosclerosis, Cell Count, Humans, Ischemia, Male, Muscles, Nerve Degeneration
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