The DOI matches its Crossref record; 81 of the 83 references it cites were found in a registry or an index.
HIF-1: mediator of physiological and pathophysiological responses to hypoxia
Abstract
All organisms can sense O 2 concentration and respond to hypoxia with adaptive changes in gene expression. The large body size of mammals necessitates the development of multiple complex physiological systems to ensure adequate O 2 delivery to all cells under normal conditions. The transcriptional regulator hypoxia-inducible factor 1 (HIF-1) is an essential mediator of O 2 homeostasis. HIF-1 is required for the establishment of key physiological systems during development and their subsequent utilization in fetal and postnatal life. HIF-1 also appears to play a key role in the pathophysiology of cancer, cardiovascular disease, and chronic lung disease, which represent the major causes of mortality among industrialized societies. Genetic or pharmacological modulation of HIF-1 activity in vivo may represent a novel therapeutic approach to these disorders.
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“ROS can damage TCA-cycle enzymes, especially aconitase and α-ketoglutarate dehydrogenase (62, 168, 249, 250, 277).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [277]
Citations
Cites
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Self-citationThe tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
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Self-citationRole of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
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Purification and Characterization of Hypoxia-inducible Factor 1
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2 of the 83 references couldn’t be matched to a known paper.
Research works printed but not linked: 8
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Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
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Epstein, A. C. R., Gleadle, J. M., McNeill, L. A., Hewitson, K. S., O'Rourke, J., Mole, D. R., Mukherji, M., Metzen, E., Wilson, M. I., Dhanda, A., et al. (2001) · Cell · doi:10.1016/s0092-8674(01)00507-4 · Cited by 3,333
VEGF in signaling and disease: beyond discovery and development
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Metadata
- Authors
- Semenza, G. L.
- Affiliations
- Johns Hopkins University (US)
- Corresponding author
- Semenza, Gregg L.
- ORCID
- Semenza, Gregg L.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2000-04-01
- Volume
- 88
- Issue
- 4
- Pages
- 1474-1480
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2143343444
- Cited by
- 1,822
- References
- 83
- Citations by year
- 2026: 28 · 2025: 54 · 2024: 53 · 2023: 55 · 2022: 67 · 2021: 77 · 2020: 62 · 2019: 55 · 2018: 76 · 2017: 85 · 2016: 78 · 2015: 83 · 2014: 72 · 2013: 78 · 2012: 74
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01dk039869-16)
- National Heart, Lung, and Blood Institute (R01HL55338, R01HL055338)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01 DK39869)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Health Sciences › Medicine › Hematology › Erythropoietin and Anemia Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Keywords
- HIF-1, hypoxia, oxygen homeostasis, oxygen sensing, transcriptional regulation, gene expression, fetal development, postnatal development, cancer, cardiovascular disease, chronic lung disease
- MeSH terms
- Animals, Hypoxia, DNA-Binding Proteins, Gene Expression Regulation, Humans, Mammals, Nuclear Proteins, Oxygen, Transcription Factors, Hypoxia-Inducible Factor 1, Hypoxia-Inducible Factor 1, alpha Subunit
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