Hypoxia-inducible factor 1: master regulator of O2 homeostasis

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

Forsythe, J. A., Jiang, B.-H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., & Semenza, G. L. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.9.4604 · Cited by 3,981 · see citing works

A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

Semenza, G. L., & Wang, G. L. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.12.5447 · Cited by 2,617 · see citing works

Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

Iyer, N. V., Kotch, L. E., Agani, F., Leung, S. W., Laughner, E., Wenger, R. H., Gassmann, M., Gearhart, J. D., Lawler, A. M., Yu, A. Y., et al. (1998) · Genes & Development · doi:10.1101/gad.12.2.149 · Cited by 2,476 · see citing works

Purification and Characterization of Hypoxia-inducible Factor 1

Wang, G. L., & Semenza, G. L. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.3.1230 · Cited by 2,069 · see citing works

Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1.

Semenza, G., Roth, P. H., Fang, H. M., & Wang, G. L. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31580-6 · Cited by 1,892 · see citing works

Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1

Semenza, G. L., Jiang, B.-H., Leung, S. W., Passantino, R., Concordet, J.-P., Maire, P., & Giallongo, A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.51.32529 · Cited by 1,752 · see citing works

Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works

Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

Tian, H., McKnight, S. L., & Russell, D. W. (1997) · Genes & Development · doi:10.1101/gad.11.1.72 · Cited by 1,351 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

Activation of Hypoxia-inducible Transcription Factor Depends Primarily upon Redox-sensitive Stabilization of Its α Subunit

Huang, E. L., Arany, Z. P., Livingston, D. M., & Bunn, H. F. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.50.32253 · Cited by 1,190 · see citing works

Dimerization, DNA Binding, and Transactivation Properties of Hypoxia-inducible Factor 1

Jiang, B.-H., Rue, E., Wang, G. L., Roe, R., & Semenza, G. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.30.17771 · Cited by 1,106 · see citing works

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084 · see citing works

Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia

Levy, A. P., Levy, N. S., Wegner, S. A., & Goldberg, M. A. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.22.13333 · Cited by 1,066 · see citing works

Hypoxia Regulates Vascular Endothelial Growth Factor Gene Expression in Endothelial Cells

Liu, Y., Cox, S. R., Morita, T., & Kourembanas, S. (1995) · Circulation Research · doi:10.1161/01.res.77.3.638 · Cited by 1,044 · see citing works

A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the <i>VEGF</i> expression and is potentially involved in lung and vascular development

Ema, M., Taya, S., Yokotani, N., Sogawa, K., Matsuda, Y., & Fujii-Kuriyama, Y. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.9.4273 · Cited by 1,016 · see citing works

Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene.

Semenza, G. L., Nejfelt, M. K., Chi, S. M., & Antonarakis, S. E. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.13.5680 · Cited by 990 · see citing works

Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia.

Wang, G. L., & Semenza, G. L. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80571-7 · Cited by 863 · see citing works

Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia

Lee, P. J., Jiang, B.-H., Chin, B. Y., Iyer, N. V., Alam, J., Semenza, G. L., & Choi, A. K. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.9.5375 · Cited by 782 · see citing works

Abnormal angiogenesis and responses to glucose and oxygen deprivation in mice lacking the protein ARNT

Maltepe, E., Schmidt, J. V., Baunoch, D., Bradfield, C. A., & Simon, M. C. (1997) · Nature · doi:10.1038/386403a0 · Cited by 781 · see citing works

Desferrioxamine induces erythropoietin gene expression and hypoxia- inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction

Wang, G., & Semenza, G. (1993) · Blood · doi:10.1182/blood.v82.12.3610.3610 · Cited by 766 · see citing works

Transactivation and Inhibitory Domains of Hypoxia-inducible Factor 1α

Jiang, B.-H., Zheng, J. Z., Leung, S. W., Roe, R., & Semenza, G. L. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.31.19253 · Cited by 629 · see citing works

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

Melillo, G., Musso, T., Sica, A., Taylor, L. S., Cox, G. W., & Varesio, L. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1683 · Cited by 626 · see citing works

Hypoxia-induced Transcriptional Activation and Increased mRNA Stability of Vascular Endothelial Growth Factor in C6 Glioma Cells

Ikeda, E., Achen, M. G., Breier, G., & Risau, W. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.34.19761 · Cited by 593 · see citing works

Hypoxic Regulation of Lactate Dehydrogenase A

Firth, J. D., Ebert, B. L., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.36.21021 · Cited by 576 · see citing works

Hypoxia and Mitochondrial Inhibitors Regulate Expression of Glucose Transporter-1 via Distinct Cis-acting Sequences

Ebert, B. L., Firth, J. D., & Ratcliffe, P. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.49.29083 · Cited by 569 · see citing works

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

Jiang, B., Agani, F. H., Passaniti, A., & Semenza, G. L. (1997) · PubMed · Cited by 532 · see citing works

Activation of Hypoxia-inducible Factor-1; Definition of Regulatory Domains within the α Subunit

Pugh, C. W., O'Rourke, J. F., Nagao, M., Gleadle, J., & Ratcliffe, P. J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.17.11205 · Cited by 526 · see citing works

Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3' enhancer.

Firth, J. D., Ebert, B. L., Pugh, C. W., & Ratcliffe, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.14.6496 · Cited by 525 · see citing works

Characterization of a Subset of the Basic-Helix-Loop-Helix-PAS Superfamily That Interacts with Components of the Dioxin Signaling Pathway

Hogenesch, J. B., Chan, W. K., Jackiw, V., Brown, R. C., Gu, Y.-Z., Pray-Grant, M. G., Perdew, G. H., & Bradfield, C. A. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.13.8581 · Cited by 514 · see citing works

Induction of Vascular Endothelial Growth Factor by Hypoxia Is Modulated by a Phosphatidylinositol 3-Kinase/Akt Signaling Pathway in Ha-ras-Transformed Cells Through a Hypoxia Inducible Factor-1 Transcriptional Element

Mazure, N. M., Chen, E. Y., Laderoute, K. R., & Giaccia, A. J. (1997) · Blood · doi:10.1182/blood.v90.9.3322 · Cited by 498 · see citing works

Activation of hypoxia-inducible factor 1α: posttranscriptional regulation and conformational change by recruitment of the Arnt transcription factor

Kallio, P. J., Pongratz, I., Gradin, K., McGuire, J., & Poellinger, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.11.5667 · Cited by 415 · see citing works

In VivoExpression of mRNAs Encoding Hypoxia-Inducible Factor 1

Wiener, C. M., Booth, G., & Semenza, G. L. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.1199 · Cited by 413 · see citing works

Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1

Rolfs, A., Kvietikova, I., Gassmann, M., & Wenger, R. H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.32.20055 · Cited by 401 · see citing works

HRF, a putative basic helix-loop-helix-PAS-domain transcription factor is closely related to hypoxia-inducible factor-1α and developmentally expressed in blood vessels

Flamme, I., Fröhlich, T., von Reutern, M., Kappel, A., Damert, A., & Risau, W. (1997) · Mechanisms of Development · doi:10.1016/s0925-4773(97)00674-6 · Cited by 366 · see citing works

ARNT-Deficient Mice and Placental Differentiation

Kozak, K. R., Abbott, B., & Hankinson, O. (1997) · Developmental Biology · doi:10.1006/dbio.1997.8758 · Cited by 328 · see citing works

Hypoxia induces type II NOS gene expression in pulmonary artery endothelial cells via HIF-1

Palmer, L. A., Semenza, G. L., Stoler, M. H., & Johns, R. A. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.274.2.l212 · Cited by 327 · see citing works

The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

Wood, S. M., Gleadle, J., Pugh, C. W., Hankinson, O., & Ratcliffe, P. J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.25.15117 · Cited by 289 · see citing works

cDNA Cloning and Tissue-Specific Expression of a Novel Basic Helix-Loop-Helix/PAS Factor (Arnt2) with Close Sequence Similarity to the Aryl Hydrocarbon Receptor Nuclear Translocator (Arnt)

Hirose, K., Morita, M., Ema, M., Mimura, J., Hamada, H., Fujii, H., Saijo, Y., Gotoh, O., Sogawa, K., & Fujii‐Kuriyama, Y. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.4.1706 · Cited by 271 · see citing works

Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

Pugh, C. W., Tan, C., Jones, R. W., & Ratcliffe, P. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.23.10553 · Cited by 255 · see citing works

In vitro analysis of Ah receptor domains involved in ligand-activated DNA recognition.

Dolwick, K. M., Swanson, H. I., & Bradfield, C. A. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.18.8566 · Cited by 239 · see citing works

Effect of Protein Kinase and Phosphatase Inhibitors on Expression of Hypoxia Inducible Factor 1

Wang, G. L., Jiang, B., & Semenza, G. L. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2674 · Cited by 230 · see citing works

Role of hydrogen peroxide in hypoxia-induced erythropoietin production

Fandrey, J., Frede, S., & JELKMANN, W. E. B. (1994) · Biochemical Journal · doi:10.1042/bj3030507 · Cited by 226 · see citing works

Enhancer element at the 3'-flanking region controls transcriptional response to hypoxia in the human erythropoietin gene

Beck, I., Ramirez, S., Weinmann, R. S., & Caro, J. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98438-3 · Cited by 206 · see citing works

Cellular Respiration during Hypoxia

Chandel, N. S., Budinger, G. R. S., Choe, S. H., & Schumacker, P. T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18808 · Cited by 189 · see citing works

Selection and Analysis of a Mutant Cell Line Defective in the Hypoxia-inducible Factor-1 α-Subunit (HIF-1α)

Wood, S. M., Wiesener, M. S., Yeates, K. M., Okada, N., Pugh, C. W., Maxwell, P. H., & Ratcliffe, P. J. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.14.8360 · Cited by 189 · see citing works

The Human Hypoxia-Inducible Factor 1α Gene:HIF1AStructure and Evolutionary Conservation

Iyer, N. V., Leung, S. W., & Semenza, G. L. (1998) · Genomics · doi:10.1006/geno.1998.5416 · Cited by 176 · see citing works

Effect of Altered Redox States on Expression and DNA-Binding Activity of Hypoxia-Inducible Factor 1

Wang, G. L., Jiang, B., & Semenza, G. L. (1995) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1995.2005 · Cited by 174 · see citing works

Induction of Phosphoglycerate Kinase 1 Gene Expression by Hypoxia

Li, H., Ko, H. P., & Whitlock, J. P. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.35.21262 · Cited by 173 · see citing works

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B., Davis, L. E., Kimberly, D. J., Hohimer, A. R., & Semenza, G. L. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70433-8 · Cited by 145 · see citing works

Nucleotide Sequence, Chromosomal Assignment and mRNA Expression of Mouse Hypoxia-Inducible Factor-1α

Wenger, R. H., Rolfs, A., Marti, H. H., Guénet, J., & Gassmann, M. (1996) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1996.0845 · Cited by 122 · see citing works

Hemodynamics and organ blood flow in fetal sheep subjected to chronic anemia

Davis, L. E., & Hohimer, A. R. (1991) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1991.261.6.r1542 · Cited by 101 · see citing works

Absolute Requirement of Aryl Hydrocarbon Receptor Nuclear Translocator Protein for Gene Activation by Hypoxia

Salceda, S., Beck, I., & Caro, J. (1996) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1996.0469 · Cited by 93 · see citing works

The Murine Sim-2 Gene Product Inhibits Transcription by Active Repression and Functional Interference

Moffett, P., Reece, M., & Pelletier, J. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.9.4933 · Cited by 92 · see citing works

Diphenylene Iodonium Inhibits the Induction of Erythropoietin and Other Mammalian Genes by Hypoxia

Gleadle, J., Ebert, B. L., & Ratcliffe, P. J. (1995) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1995.092_c.x · Cited by 87 · see citing works

Cobalt and desferrioxamine reveal crucial members of the oxygen sensing pathway in HepG2 cells

Ehleben, W., Porwol, T., Fandrey, J., Kummer, W., & Acker, H. (1997) · Kidney International · doi:10.1038/ki.1997.67 · Cited by 83 · see citing works

Cobalt chloride and desferrioxamine antagonize the inhibition of erythropoietin production by reactive oxygen species

Fandrey, J., Frede, S., Ehleben, W., Porwol, T., Acker, H., & JELKMANN, W. E. B. (1997) · Kidney International · doi:10.1038/ki.1997.68 · Cited by 77 · see citing works

Mouse Hypoxia-Inducible Factor-1α Is Encoded by Two Different mRNA Isoforms: Expression From a Tissue-Specific and a Housekeeping-Type Promoter

Wenger, R. H., Rolfs, A., Spielmann, P., Zimmermann, D. R., & Gassmann, M. (1998) · Blood · doi:10.1182/blood.v91.9.3471 · Cited by 75 · see citing works

Angiogenesis by gene therapy: a new horizon for myocardial revascularization?

Lewis, B. S. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00170-3 · Cited by 73 · see citing works

The Mouse Gene for Hypoxia‐Inducible Factor‐1α

Wenger, R. H., Rolfs, A., Kvietikova, I., Spielmann, P., Zimmermann, D. R., & Gassmann, M. (1997) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1997.t01-1-00155.x · Cited by 47 · see citing works

Cardiac Expressions of HIF-1α and HLF/EPAS, Two Basic Loop Helix/PAS Domain Transcription Factors Involved in Adaptative Responses to Hypoxic Stresses

Ladoux, A., & Frelin, C. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.7708 · Cited by 45 · see citing works

Molecular characterization of the murine Hif-1 alpha locus.

Luo, G., Gu, Y.-Z., Jain, S. R., Chan, W. K., Carr, K. M., Hogenesch, J. B., & Bradfield, C. A. (1997) · Europe PMC (PubMed Central) · Cited by 44 · see citing works

Angiogenesis in cancer and other diseases

Carmeliet, P., & Jain, R. K. (2000) · Nature · doi:10.1038/35025220 · Cited by 9,070 · see citing works

Why Do Cancers Have High Aerobic Glycolysis?

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Differential Roles of Hypoxia-Inducible Factor 1α (HIF-1α) and HIF-2α in Hypoxic Gene Regulation

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HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia

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Adipose Tissue Hypoxia in Obesity and Its Impact on Adipocytokine Dysregulation

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Loss of <i>PTEN</i> facilitates HIF-1-mediated gene expression

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Placental Origins of Chronic Disease

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Ecto-5′-Nucleotidase (CD73) Regulation by Hypoxia-Inducible Factor-1 Mediates Permeability Changes in Intestinal Epithelia

Synnestvedt, K., Furuta, G. T., Comerford, K. M., Louis, N., Karhausen, J., Eltzschig, H. K., Hansen, K. R., Thompson, L. F., & Colgan, S. P. (2002) · Journal of Clinical Investigation · doi:10.1172/jci0215337 · Cited by 660 · see citing works

Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway

Cullinan, S. B., & Diehl, J. A. (2006) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2005.09.018 · Cited by 554 · see citing works

Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis

Sonveaux, P., Copetti, T., De Saedeleer, C. J., Végran, F., Verrax, J., Kennedy, K. M., Moon, E. J., Dhup, S., Danhier, P., Frérart, F., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033418 · Cited by 536 · see citing works

Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

Furuta, G. T., Turner, J. R., Taylor, C. T., Hershberg, R. M., Comerford, K., Narravula, S., Podolsky, D. K., & Colgan, S. P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1027 · Cited by 449 · see citing works

Intracellular localisation of human HIF-1α hydroxylases:implications for oxygen sensing

Metzen, E., Berchner-Pfannschmidt, U., Stengel, P., Marxsen, J. H., Stolze, I., Klinger, M., Huang, W. Q., Wotzlaw, C., Hellwig-Bürgel, T., Jelkmann, W., et al. (2003) · Journal of Cell Science · doi:10.1242/jcs.00318 · Cited by 432 · see citing works

Differential Effects of Physiologically Relevant Hypoxic Conditions on T Lymphocyte Development and Effector Functions

Caldwell, C. C., Kojima, H., Lukashev, D., Armstrong, J., Farber, M., Apasov, S. G., & Sitkovsky, M. V. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.167.11.6140 · Cited by 420 · see citing works

Perspectives on Oxygen Sensing

Semenza, G. L. (1999) · Cell · doi:10.1016/s0092-8674(00)81957-1 · Cited by 385 · see citing works

Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by induction of HIF-α-prolyl-4-hydroxylases

MARXSEN, J. H., STENGEL, P., DOEGE, K., HEIKKINEN, P., JOKILEHTO, T., WAGNER, T., JELKMANN, W., JAAKKOLA, P., & METZEN, E. (2004) · Biochemical Journal · doi:10.1042/bj20040620 · Cited by 386 · see citing works

Deficiency in catechol-O-methyltransferase and 2-methoxyoestradiol is associated with pre-eclampsia

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Role of monocarboxylate transporters in human cancers: state of the art

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Role of hypoxia-inducible factor-1 in transcriptional activation of ceruloplasmin by iron deficiency

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Animal performance and stress: responses and tolerance limits at different levels of biological organisation

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Oxygen Regulation of Airway Branching in Drosophila Is Mediated by Branchless FGF

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Hypoxia-Inducible Factor-1α and the Glycolytic Phenotype in Tumors

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Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

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Essential role for prolyl hydroxylase domain protein 2 in oxygen homeostasis of the adult vascular system

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The Role of Inflammation in the Pathogenesis of Glaucoma

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The HIF-1 Hypoxia-Inducible Factor Modulates Lifespan in C. elegans

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