Hypoxia, HIF-1, and the Pathophysiologi of Common Human Diseases

Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis

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Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

Wang, G. L., Jiang, B. H., Rue, E. A., & Semenza, G. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.12.5510 · Cited by 6,212 · see citing works

The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis

Maxwell, P. H., Wiesener, M. S., Chang, G.-W., Clifford, S. C., Vaux, E. C., Cockman, M. E., Wykoff, C. C., Pugh, C. W., Maher, E. R., & Ratcliffe, P. J. (1999) · Nature · doi:10.1038/20459 · Cited by 5,180 · see citing works

Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation

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Cellular and developmental control of O ₂ homeostasis by hypoxia-inducible factor 1α

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Regulation of hypoxia-inducible factor 1α is mediated by an O ₂ -dependent degradation domain via the ubiquitin-proteasome pathway

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Purification and Characterization of Hypoxia-inducible Factor 1

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Regulation of Mammalian O ₂ Homeostasis by Hypoxia-Inducible Factor 1

Semenza, G. L. (1999) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.15.1.551 · Cited by 1,914 · see citing works

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

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Hypoxia-inducible Factor 1α (HIF-1α) Protein Is Rapidly Degraded by the Ubiquitin-Proteasome System under Normoxic Conditions

Salceda, S., & Caro, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22642 · Cited by 1,674 · see citing works

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997) · Nature Medicine · doi:10.1038/nm0297-177 · Cited by 1,629 · see citing works

HIF‐1α is required for solid tumor formation and embryonic vascularization

Ryan, H. E., Lo, J., & Johnson, R. S. (1998) · The EMBO Journal · doi:10.1093/emboj/17.11.3005 · Cited by 1,579 · see citing works

A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF

Benjamin, L. E., Hemo, I., & Keshet, E. (1998) · Development · doi:10.1242/dev.125.9.1591 · Cited by 1,265 · see citing works

Hypoxia-inducible factor 1 levels vary exponentially over a physiologically relevant range of O2 tension

Jiang, B. H., Semenza, G. L., Bauer, C., & Marti, H. H. (1996) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.1996.271.4.c1172 · Cited by 1,213 · see citing works

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Hypoxia-inducible factor 1: master regulator of O2 homeostasis

Semenza, G. L. (1998) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(98)80016-6 · Cited by 1,092 · see citing works

Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth

Maxwell, P. H., Dachs, G. U., Gleadle, J. M., Nicholls, L. G., Harris, A. L., Stratford, I. J., Hankinson, O., Pugh, C. W., & Ratcliffe, P. J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.15.8104 · Cited by 1,084 · see citing works

Angiogenesis and Tumor Metastasis

Zetter, B. R. (1998) · Annual Review of Medicine · doi:10.1146/annurev.med.49.1.407 · Cited by 1,016 · see citing works

Regulation of the Hypoxia-inducible Transcription Factor 1α by the Ubiquitin-Proteasome Pathway

Kallio, P. J., Wilson, W. J., O’Brien, S. L., Makino, Y., & Poellinger, L. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.10.6519 · Cited by 754 · see citing works

Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α

Yu, A. Y., Shimoda, L. A., Iyer, N. V., Huso, D. L., Sun, X., McWilliams, R. M., Beaty, T. H., Sham, J. S. K., Wiener, C. M., Sylvester, J. T., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5912 · Cited by 645 · see citing works

Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2.

Feldser, D. M., Agani, F. H., Iyer, N. V., Pak, B. J., Ferreira, G., & Semenza, G. L. (1999) · PubMed · Cited by 638 · see citing works

V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression.

Jiang, B., Agani, F. H., Passaniti, A., & Semenza, G. L. (1997) · PubMed · Cited by 532 · see citing works

Defective Vascularization of HIF-1α-Null Embryos Is Not Associated with VEGF Deficiency but with Mesenchymal Cell Death

Kotch, L. E., Iyer, N. V., Laughner, E., & Semenza, G. L. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9253 · Cited by 418 · see citing works

Temporal, spatial, and oxygen-regulated expression of hypoxia-inducible factor-1 in the lung

Yu, A. Y., Frid, M. G., Shimoda, L. A., Wiener, C. M., Stenmark, K. R., & Semenza, G. L. (1998) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1998.275.4.l818 · Cited by 370 · see citing works

Neural Crest Cell Contribution to the Developing Circulatory System

Bergwerff, M., Verberne, M. E., DeRuiter, M. C., Poelmann, R. E., & Groot, A. C. G. (1998) · Circulation Research · doi:10.1161/01.res.82.2.221 · Cited by 293 · see citing works

Cardiac hypertrophy in chronically anemic fetal sheep: Increased vascularization is associated with increased myocardial expression of vascular endothelial growth factor and hypoxia-inducible factor 1

Martin, C., Yu, A. Y., Jiang, B., Davis, L. E., Kimberly, D. J., Hohimer, A. R., & Semenza, G. L. (1998) · American Journal of Obstetrics and Gynecology · doi:10.1016/s0002-9378(98)70433-8 · Cited by 145 · see citing works

Migration of cranial neural crest cells to the pharyngeal arches and heart in rat embryos

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Mechanical loading regulates expression of talin and its mRNA, which are concentrated at myotendinous junctions.

Frenette, J., & Tidball, J. (1998) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.1998.275.3.c818 · Cited by 104 · see citing works

Angiogenesis by gene therapy: a new horizon for myocardial revascularization?

Lewis, B. S. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(97)00170-3 · Cited by 73 · see citing works

Pericyte‐endothelial gap junctions in developing rat cerebral capillaries: A fine structural study

Fujimoto, K. (1995) · The Anatomical Record · doi:10.1002/ar.1092420412 · Cited by 66 · see citing works

Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of <i>ob</i> / <i>ob</i> and dietary obese mice

Ye, J., Gao, Z., Yin, J., & He, Q. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00435.2007 · Cited by 840 · see citing works

Pulmonary Arterial Hypertension

McLaughlin, V. V., & McGoon, M. D. (2006) · Circulation · doi:10.1161/circulationaha.104.503540 · Cited by 662 · see citing works

Identification of a Novel Hypoxia-Inducible Factor 1-Responsive Gene, <i>RTP801</i> , Involved in Apoptosis

Shoshani, T., Faerman, A., Mett, I., Zelin, E., Tenne, T., Gorodin, S., Moshel, Y., Elbaz, S., Budanov, A., Chajut, A., et al. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.7.2283-2293.2002 · Cited by 546 · see citing works

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

Ye, J. (2008) · International Journal of Obesity · doi:10.1038/ijo.2008.229 · Cited by 539 · see citing works

Physiological roles for ecto-5’-nucleotidase (CD73)

Colgan, S. P., Eltzschig, H. K., Eckle, T. D. L. G., & Thompson, L. F. (2006) · Purinergic Signalling · doi:10.1007/s11302-005-5302-5 · Cited by 496 · see citing works

Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function

Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants &amp; Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works

Regulation of HIF-1α Stability through S-Nitrosylation

Li, F., Sonveaux, P., Rabbani, Z. N., Liu, S., Yan, B., Huang, Q., Vujašković, Ž., Dewhirst, M. W., & Li, C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.024 · Cited by 439 · see citing works

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368 · see citing works

Decreased Cardiac Expression of Vascular Endothelial Growth Factor and Its Receptors in Insulin-Resistant and Diabetic States

Chou, E. L., Suzuma, I., Way, K. J., Opland, D. M., Clermont, A. C., Naruse, K., Suzuma, K., Bowling, N. L., Vlahos, C. J., Aiello, L. P., et al. (2002) · Circulation · doi:10.1161/hc0302.102143 · Cited by 337 · see citing works

Hyaluronidase To Enhance Nanoparticle-Based Photodynamic Tumor Therapy

Gong, H., Chao, Y., Xiang, J., Han, X., Song, G., Feng, L., Liu, J., Yang, G., Chen, Q., & Liu, Z. (2016) · Nano Letters · doi:10.1021/acs.nanolett.6b00068 · Cited by 322 · see citing works

The role of low-grade inflammation in the polycystic ovary syndrome

Repaci, A., Gambineri, A., & Pasquali, R. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2010.08.002 · Cited by 300 · see citing works

Cross-talk between Epidermal Growth Factor Receptor and Hypoxia-inducible Factor-1α Signal Pathways Increases Resistance to Apoptosis by Up-regulating Survivin Gene Expression

Peng, X.-H., Karna, P., Cao, Z., Jiang, B., Zhou, M., & Yang, L. P. H. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603414200 · Cited by 298 · see citing works

Hypoxia induces epithelial-mesenchymal transition via activation of SNAI1 by hypoxia-inducible factor -1α in hepatocellular carcinoma

Zhang, L., Huang, G., Li, X., Zhang, Y., Jiang, Y., Shen, J., Liu, J., Wang, Q., Zhu, J., Feng, X., et al. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-108 · Cited by 293 · see citing works

Hypoxia-inducible Factor Prolyl 4-Hydroxylase Inhibition

Siddiq, A., Ayoub, I. A., Chavez, J. C., Aminova, L. R., Shah, S., LaManna, J. C., Patton, S. M., Connor, J. R., Cherny, R. A., Volitakis, I., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504963200 · Cited by 280 · see citing works

Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of β ₂ integrin gene expression

Kong, T., Eltzschig, H. K., Karhausen, J., Colgan, S. P., & Shelley, C. S. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401339101 · Cited by 242 · see citing works

Gene expression profiling of the long-term adaptive response to hypoxia in the gills of adult zebrafish

van der Meer, D. L. M., van den Thillart, G. E. E. J. M., Witte, F., Bakker, M., Besser, J., Richardson, M. K., Spaink, H. P., Leito, J. T. D., & Bagowski, C. P. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00089.2005 · Cited by 238 · see citing works

Serum Levels of Vascular Endothelial Growth Factor Are Elevated in Patients with Obstructive Sleep Apnea and Severe Nighttime Hypoxia

Schulz, R., Hummel, C., Heinemann, S., Seeger, W., & Grimminger, F. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2101062 · Cited by 223 · see citing works

Association of hypoxia‐inducible factors 1α and 2α with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

Sivridis, E., Giatromanolaki, A., Gatter, K. C., Harris, A. L., Koukourakis, M. I., & for the Tumor and Angiogenesis Research Group (2002) · Cancer · doi:10.1002/cncr.10774 · Cited by 218 · see citing works

Mild Hypoxia Enhances Proliferation and Multipotency of Human Neural Stem Cells

Santilli, G., Lamorte, G., Carlessi, L., Ferrari, D., Nodari, L. R., Binda, E., Delia, D., Vescovi, A. L., & Filippis, L. D. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008575 · Cited by 192 · see citing works

Molecular Mechanisms for Early Brain Injury After Subarachnoid Hemorrhage

Ostrowski, R. P., Colohan, A. R. T., & Zhang, J. H. (2006) · Springer eBooks · doi:10.1007/978-0-387-30383-3_13 · Cited by 192 · see citing works

Hypoxia Inducible Factor (HIF)-1 Coordinates Induction of Toll-Like Receptors TLR2 and TLR6 during Hypoxia

Kuhlicke, J., Frick, J.-S., Morote–Garcia, J. C., Rosenberger, P., & Eltzschig, H. K. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001364 · Cited by 190 · see citing works

Endothelial Dysfunction Driven by Hypoxia—The Influence of Oxygen Deficiency on NO Bioavailability

Janaszak‐Jasiecka, A., Siekierzycka, A., Płoska, A., Dobrucki, I. T., & Kalinowski, L. (2021) · Biomolecules · doi:10.3390/biom11070982 · Cited by 189 · see citing works

Divergent effects of hypoxia on dendritic cell functions

Mancino, A., Schioppa, T., Larghi, P., Pasqualini, F., Nebuloni, M., Chen, I., Sozzani, S., Austyn, J. M., Mantovani, A., & Sica, A. (2008) · Blood · doi:10.1182/blood-2008-02-142091 · Cited by 186 · see citing works

Vascular endothelial growth factor and related molecules in acute lung injury

Mura, M., dos Santos, C. C., Stewart, D., & Liu, M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00202.2004 · Cited by 177 · see citing works

Role of hypoxia inducible factor-1 alpha in modulation of apoptosis resistance

Kilic, M., Kasperczyk, H., Fulda, S., & Debatin, K. (2006) · Oncogene · doi:10.1038/sj.onc.1210008 · Cited by 167 · see citing works

Ferroptosis in Neurological Diseases

Ren, J., Sun, X., Yan, X., Guo, Z., & Yang, Y. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2020.00218 · Cited by 158 · see citing works

Dephosphorylation of Cell Cycle–regulated Proteins Correlates with Anoxia-induced Suspended Animation in Caenorhabditis elegans

Padilla, P. A., Nystul, T. G., Zager, R. A., Johnson, A. C. M., & Roth, M. B. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.01-12-0594 · Cited by 153 · see citing works

Glomeruloid Microvascular Proliferation Orchestrated by VPF/VEGF

Brat, D. J., & Meir, E. G. V. (2001) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64025-4 · Cited by 152 · see citing works

Unfolded protein response (UPR) integrated signaling networks determine cell fate during hypoxia

Bartoszewska, S., & Collawn, J. F. (2020) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-020-00212-1 · Cited by 150 · see citing works

Increase of SUMO-1 expression in response to hypoxia: Direct interaction with HIF-1α in adult mouse brain and heart in vivo

Shao, R., Zhang, F.-P., Tian, F., Anders Friberg, P., Wang, X., Sjöland, H., & Billig, H. (2004) · FEBS Letters · doi:10.1016/j.febslet.2004.05.079 · Cited by 149 · see citing works

Mitochondrial Dysfunction in COPD Patients with Low Body Mass Index

Rabinovich, R. A., Bastos, R., Ardite, E., Llinàs, L., Orozco-Levi, M., Gea, J., Vilaró, J., Barberà, J. A., Rodríguez-Roisin, R., Fernández-Checa, J. C., et al. (2007) · European Respiratory Journal · doi:10.1183/09031936.00086306 · Cited by 144 · see citing works

The Role of Hypoxia Inducible Factor 1 in Cobalt Chloride Induced Cell Death in Mouse Embryonic Fibroblasts

Vengellur, A. (2004) · Toxicological Sciences · doi:10.1093/toxsci/kfh278 · Cited by 142 · see citing works

Hypoxia-Inducible Factor-2α Transactivates Abcg2 and Promotes Cytoprotection in Cardiac Side Population Cells

Martin, C. M., Ferdous, A., Gallardo, T., Humphries, C., Sadek, H., Caprioli, A., Garcia, J. A., Szweda, L. I., Garry, M. G., & Garry, D. J. (2008) · Circulation Research · doi:10.1161/circresaha.107.161729 · Cited by 133 · see citing works

Use of Macrophages to Target Therapeutic Adenovirus to Human Prostate Tumors

Muthana, M., Giannoudis, A., Scott, S. D., Fang, H., Coffelt, S. B., Morrow, F. J., Murdoch, C., Burton, J., Cross, N. A., Burke, B., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2349 · Cited by 127 · see citing works

Antitumor activity of pyrvinium pamoate, 6‐(dimethylamino)‐2‐[2‐(2,5‐dimethyl‐1‐phenyl‐1<i>H</i>‐pyrrol‐3‐yl)ethenyl]‐1‐methyl‐quinolinium pamoate salt, showing preferential cytotoxicity during glucose starvation

Esumi, H., Lu, J., Kurashima, Y., & Hanaoka, T. (2004) · Cancer Science · doi:10.1111/j.1349-7006.2004.tb03330.x · Cited by 127 · see citing works

Hypoxia Induces EMT in Low and Highly Aggressive Pancreatic Tumor Cells but Only Cells with Cancer Stem Cell Characteristics Acquire Pronounced Migratory Potential

Salnikov, A. V., Liu, L., Platen, M., Gladkich, J., Salnikova, O. V., Ryschich, E., Mattern, J., Moldenhauer, G., Werner, J., Schemmer, P., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0046391 · Cited by 126 · see citing works

Neuroprotective and neuritogenic activities of novel multimodal iron‐chelating drugs in motor‐neuron‐like NSC‐34 cells and transgenic mouse model of amyotrophic lateral sclerosis

Kupershmidt, L., Weinreb, O., Amit, T., Mandel, S. A., Carrı̀, M. T., & Youdim, M. B. H. (2009) · The FASEB Journal · doi:10.1096/fj.09-130047 · Cited by 123 · see citing works

Enhancement of Hypoxia-Induced Tumor Cell Death <b> <i>In vitro</i> </b> and Radiation Therapy <b> <i>In vivo</i> </b> by Use of Small Interfering RNA Targeted to Hypoxia-Inducible Factor-1α

Zhang, X., Kon, T., Wang, H., Li, F., Huang, Q., Rabbani, Z. N., Kirkpatrick, J. P., Vujaskovic, Z., Dewhirst, M. W., & Li, C.-Y. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-2301 · Cited by 120 · see citing works

Early inhibition of HIF-1α with small interfering RNA reduces ischemic–reperfused brain injury in rats

Chen, C., Hu, Q., Yan, J., Yang, X., Shi, X., Lei, J., Chen, L., Huang, H., Han, J., Zhang, J. H., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.12.010 · Cited by 120 · see citing works

Neutrophils as Sources of Extracellular Nucleotides: Functional Consequences at the Vascular Interface

Eltzschig, H. K., MacManus, C. F., & Colgan, S. P. (2008) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2008.01.006 · Cited by 120 · see citing works

Hypoxia-inducible factor-1α signaling in aquaporin upregulation after traumatic brain injury

Ding, J. Y., Kreipke, C. W., Speirs, S. L., Schafer, P. C., Schafer, S., & Rafols, J. A. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.01.077 · Cited by 103 · see citing works

The Role of Nitric Oxide in Myocardial Repair and Remodeling

Otani, H. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2453 · Cited by 103 · see citing works

JNK1 Mediates Degradation HIF-1α by a VHL-Independent Mechanism that Involves the Chaperones Hsp90/Hsp70

Zhang, D., Li, J., Costa, M., Gao, J., & Huang, C. (2010) · Cancer Research · doi:10.1158/0008-5472.can-09-0448 · Cited by 99 · see citing works

Selective induction of integrin βi by hypoxia‐inducible factor: implications for wound healing

Keely, S., Glover, L. E., MacManus, C. F., Campbell, E. L., Scully, M. M., Furuta, G. T., & Colgan, S. P. (2008) · The FASEB Journal · doi:10.1096/fj.08-125344 · Cited by 97 · see citing works

Genetic and Biologic Progression in Astrocytomas and Their Relation to Angiogenic Dysregulation

Brat, D. J., Castellano-Sanchez, A. A., Kaur, B., & Meir, E. G. V. (2002) · Advances in Anatomic Pathology · doi:10.1097/00125480-200201000-00004 · Cited by 96 · see citing works

Stem cell-based delivery of Hypoxamir-210 to the infarcted heart: implications on stem cell survival and preservation of infarcted heart function

Kim, H. W., Jiang, S., Ashraf, M., & Haider, K. H. (2012) · Journal of Molecular Medicine · doi:10.1007/s00109-012-0920-1 · Cited by 94 · see citing works

Apoptosis-Resistance of Hypoxic Cells

Dong, Z., Wang, J. Z., Yu, F. X., & Venkatachalam, M. A. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63693-0 · Cited by 94 · see citing works

Discovery and Preclinical Characterization of GSK1278863 (Daprodustat), a Small Molecule Hypoxia Inducible Factor–Prolyl Hydroxylase Inhibitor for Anemia

Ariazi, J. L., Duffy, K. J., Adams, D. F., Fitch, D. M., Luo, L., Pappalardi, M. B., Biju, M. P., DiFilippo, E. H., Shaw, T., Wiggall, K., et al. (2017) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.117.242503 · Cited by 93 · see citing works

Expression of Vascular Endothelial Growth Factor (VEGF), Hypoxia Inducible Factor-1α (HIF-1α), and Microvessel Density in Endometrial Tissue in Women With Adenomyosis

Goteri, G., Lucarini, G., Montik, N., Zizzi, A., Stramazzotti, D., Fabris, G., Tranquilli, A. L., & Ciavattini, A. (2009) · International Journal of Gynecological Pathology · doi:10.1097/pgp.0b013e318182c2be · Cited by 88 · see citing works

Obesity, sleep apnea, and cancer

Almendros, I., Martínez‐García, M. Á., Farré, R., & Gozal, D. (2020) · International Journal of Obesity · doi:10.1038/s41366-020-0549-z · Cited by 88 · see citing works

Hypoxia/reoxygenation: A dynamic regulator of lysyl oxidase‐facilitated breast cancer migration

Postovit, L.-M. M., Abbott, D. E., Raimondi, S. L., Wheaton, W. W., Margaryan, N. V., Sullivan, R., Jansen, M. K., Csiszár, K., Hendrix, M. J. C., & Kirschmann, D. A. (2007) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21517 · Cited by 88 · see citing works

Fhl-1, a New Key Protein in Pulmonary Hypertension

Kwapiszewska, G., Wygrecka, M., Marsh, L. M., Schmitt, S., Troesser, R., Wilhelm, J., Helmus, K., Eul, B. G., Zakrzewicz, A., Ghofrani, H. A., et al. (2008) · Circulation · doi:10.1161/circulationaha.107.761916 · Cited by 88 · see citing works

Cardiomyopathy Associated with Microcirculation Dysfunction in Laminin α4 Chain-deficient Mice

Wang, J., Hoshijima, M., Lam, J. T., Zhou, Z., Jokiel, A., Dalton, N. D., Hultenby, K. R., Ruiz‐Lozano, P., ROSS, J. R., Tryggvason, K., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m505061200 · Cited by 87 · see citing works

A Group of Novel HIF‐1α Inhibitors, Glyceollins, Blocks HIF‐1α Synthesis and Decreases Its Stability via Inhibition of the PI3K/AKT/mTOR Pathway and Hsp90 Binding

Lee, S., Jee, J., Bae, J., Liu, K., & Lee, Y. M. (2015) · Journal of Cellular Physiology · doi:10.1002/jcp.24813 · Cited by 86 · see citing works

Hypoxia Selection of Death-resistant Cells

Dong, Z., & Wang, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m312225200 · Cited by 86 · see citing works

Multiple effects of 2ME2 and D609 on the cortical expression of HIF-1α and apoptotic genes in a middle cerebral artery occlusion induced focal ischemia rat model

Chen, C., Hu, Q., Yan, J., Lei, J., Qin, L., Shi, X., Luan, L., Yang, L., Wang, K., Han, J., et al. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.004652.x · Cited by 85 · see citing works

Role of RhoB in the Regulation of Pulmonary Endothelial and Smooth Muscle Cell Responses to Hypoxia

Wójciak‐Stothard, B., Zhao, L., Oliver, E., Dubois, O., Wu, Y., Kardassis, D., Vasilaki, E., Huang, M., Mitchell, J. A., Mackenzie, L. S., et al. (2012) · Circulation Research · doi:10.1161/circresaha.112.264473 · Cited by 84 · see citing works

Identification and function of hypoxia-response genes in Drosophila melanogaster

Liu, G., Roy, J., & Johnson, E. A. (2006) · Physiological Genomics · doi:10.1152/physiolgenomics.00262.2005 · Cited by 82 · see citing works

Single-Dose Gamma-Irradiation Induces Up-Regulation of Chemokine Gene Expression and Recruitment of Granulocytes into the Portal Area but Not into Other Regions of Rat Hepatic Tissue

Malik, I. A., Moriconi, F., Sheikh, N., Naz, N., Khan, S., Dudás, J., Mansuroglu, T., Hess, C. F., Rave‐Fränk, M., Christiansen, H., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090505 · Cited by 81 · see citing works

Effect of hypoxia on Ad5 infection, transgene expression and replication

Shen, B. H., & Hermiston, T. W. (2005) · Gene Therapy · doi:10.1038/sj.gt.3302448 · Cited by 81 · see citing works

Models of Heart Failure Based on the Cardiotoxicity of Anticancer Drugs

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Dexmedetomidine protects against oxygen–glucose deprivation-induced injury through the I2 imidazoline receptor-PI3K/AKT pathway in rat C6 glioma cells

Zhang, F., Ding, T., Yu, L., Zhong, Y., Dai, H., & Yan, M. (2011) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2011.01382.x · Cited by 79 · see citing works

A novel approach of proteomics and transcriptomics to study the mechanism of action of the antioxidant–iron chelator green tea polyphenol (-)-epigallocatechin-3-gallate

Weinreb, O., Amit, T., & Youdim, M. B. H. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.05.011 · Cited by 78 · see citing works

Constitutive and tumor necrosis factor-α-induced activation of nuclear factor-κB in adenomyosis and its inhibition by andrographolide

Li, B., Chen, M., Liu, X., & Guo, S. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.04.028 · Cited by 78 · see citing works

Alterations in TGF-β1 expression in lambs with increased pulmonary blood flow and pulmonary hypertension

Mata‐Greenwood, E., Meyrick, B. O., Steinhorn, R. H., Fineman, J. R., & Black, S. M. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00171.2002 · Cited by 77 · see citing works

Nuclear translocation and activation of YAP by hypoxia contributes to the chemoresistance of SN38 in hepatocellular carcinoma cells

Dai, X.-Y., Zhuang, L., Wang, D., Zhou, T., Chang, L.-L., Gai, R., Zhu, D., Yang, B., Zhu, H., & He, Q. (2016) · Oncotarget · doi:10.18632/oncotarget.6903 · Cited by 73 · see citing works

From mountain to bedside: understanding the clinical relevance of human acclimatisation to high-altitude hypoxia

Martín, D., & Windsor, J. S. (2008) · Postgraduate Medical Journal · doi:10.1136/pgmj.2008.068296 · Cited by 73 · see citing works

Induced Inhibition of Ischemic/Hypoxic Injury by APIP, a Novel Apaf-1-interacting Protein

Cho, D., Hong, Y., Lee, H., Woo, H., Pyo, J.-O., Mak, T. W., & Jung, Y. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405747200 · Cited by 70 · see citing works

Multiple across-strain and within-strain QTLs suggest highly complex genetic architecture for hypoxia tolerance in channel catfish

Wang, X., Liu, S., Jiang, C., Geng, X., Zhou, T., Li, N., Bao, L., Li, Y., Yao, J., Yang, Y., et al. (2016) · Molecular Genetics and Genomics · doi:10.1007/s00438-016-1256-2 · Cited by 68 · see citing works

Cytoprotective Effects of Hypoxia against Cisplatin-Induced Tubular Cell Apoptosis

Wang, J., Biju, M. P., Wang, M.-H., Haase, V. H., & Dong, Z. (2006) · Journal of the American Society of Nephrology · doi:10.1681/asn.2005121371 · Cited by 68 · see citing works

Antioxidant therapeutics: Pandora′s box

Day, B. J. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.05.047 · Cited by 66 · see citing works

Hypoxia induced paclitaxel resistance in human ovarian cancers via hypoxia-inducible factor 1α

Huang, L., Ao, Q., Zhang, Q., Yang, X., Xing, H., Li, F., Chen, G., Zhou, J., Wang, S., Xu, G., et al. (2009) · Journal of Cancer Research and Clinical Oncology · doi:10.1007/s00432-009-0675-4 · Cited by 66 · see citing works

Disparate effects of simvastatin on angiogenesis during hypoxia and inflammation

Zhu, X.-Y., Daghini, E., Chade, A., Lavi, R., Claudio Napoli, A., Lerman, A., & Lerman, L. O. (2008) · Life Sciences · doi:10.1016/j.lfs.2008.09.029 · Cited by 65 · see citing works

Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage

Tulsawani, R., Kelly, L. S., Fatma, N., Chhunchha, B., Kubo, E., Kumar, A., & Singh, D. P. (2010) · BMC Neuroscience · doi:10.1186/1471-2202-11-125 · Cited by 65 · see citing works

Oxygen in the regulation of intestinal epithelial transport

Ward, J. B. J., Keely, S., & Keely, S. J. (2014) · The Journal of Physiology · doi:10.1113/jphysiol.2013.270249 · Cited by 64 · see citing works

COMMD1: A Multifunctional Regulatory Protein

Riera‐Romo, M. (2017) · Journal of Cellular Biochemistry · doi:10.1002/jcb.26151 · Cited by 64 · see citing works

Expression of VEGF and its receptors Flt-1 and Flk-1/KDR is altered in lambs with increased pulmonary blood flow and pulmonary hypertension

Mata‐Greenwood, E., Meyrick, B. O., Soifer, S. J., Fineman, J. R., & Black, S. M. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00388.2002 · Cited by 64 · see citing works

mAKAP Compartmentalizes Oxygen-Dependent Control of HIF-1α

Wong, W., Goehring, A. S., Kapiloff, M. S., Langeberg, L. K., & Scott, J. D. (2008) · Science Signaling · doi:10.1126/scisignal.2000026 · Cited by 63 · see citing works

Suppression of hypoxia‐inducible factor‐1α and its downstream genes reduces acute hyperglycemia‐enhanced hemorrhagic transformation in a rat model of cerebral ischemia

Chen, C., Ostrowski, R. P., Zhou, C., Tang, J., & Zhang, J. H. (2010) · Journal of Neuroscience Research · doi:10.1002/jnr.22361 · Cited by 61 · see citing works

Hypoxia Markers are Expressed in Interneurons Exposed to Recurrent Seizures

Gualtieri, F., Marinelli, C., Longo, D., Pugnaghi, M., Nichelli, P., Meletti, S., & Biagini, G. (2012) · NeuroMolecular Medicine · doi:10.1007/s12017-012-8203-0 · Cited by 58 · see citing works

2-methoxyestradiol reduces cerebral vasospasm after 48 hours of experimental subarachnoid hemorrhage in rats

YAN, J., CHEN, C., Lei, J. N., YANG, L., Wang, K., LIU, J., & ZHOU, C. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.06.009 · Cited by 56 · see citing works

Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation

Goggins, B. J., Chaney, C., Radford‐Smith, G. L., Horvat, J. C., & Keely, S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00272 · Cited by 55 · see citing works

The importin α/β-specific inhibitor Ivermectin affects HIF-dependent hypoxia response pathways

Kosyna, F. K., Nagel, M., Kluxen, L., Kraushaar, K., & Depping, R. (2015) · Biological Chemistry · doi:10.1515/hsz-2015-0171 · Cited by 54 · see citing works

Endotoxaemia leads to major increases in inflammatory adipokine gene expression in white adipose tissue of mice

Leuwer, M., Welters, I. D., Marx, G., Rushton, A., Bao, H., Hunter, L., & Trayhurn, P. (2008) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-008-0564-8 · Cited by 53 · see citing works

miR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha

Liu, L., Li, D., He, Y., Zhou, Y., Gong, S.-H., Wu, L., Zhao, Y., Huang, X. H., Zhao, T., Xu, L., et al. (2017) · Molecular Medicine · doi:10.2119/molmed.2017.00013 · Cited by 53 · see citing works

Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair

Jeewa, A., Manickaraj, A. K., Mertens, L., Manlhiot, C., Kinnear, C., Mondal, T. K., Smythe, J., Rosenberg, H. C., Lougheed, J., McCrindle, B. W., et al. (2012) · Pediatric Research · doi:10.1038/pr.2012.95 · Cited by 52 · see citing works

Involvement of COX‐2/PGE2 signalling in hypoxia‐induced angiogenic response in endothelial cells

Zhao, L., Wu, Y., Xu, Z., Wang, H., Zhao, Z., Li, Y., Yang, P., & Wei, X. C. (2011) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2011.01479.x · Cited by 51 · see citing works

Gene therapy of prostate cancer: current and future directions.

Mabjeesh, N. J., Zhong, H., & Simons, J. W. (2002) · Endocrine Related Cancer · doi:10.1677/erc.0.0090115 · Cited by 51 · see citing works

The hypoxia response pathway promotes PEP carboxykinase and gluconeogenesis in C. elegans

Vora, M., Pyonteck, S. M., Popovitchenko, T., Matlack, T. L., Prashar, A., Kane, N. S., Favate, J. S., Shah, P., & Rongo, C. (2022) · Nature Communications · doi:10.1038/s41467-022-33849-x · Cited by 50 · see citing works

Luteinizing hormone–independent rise of progesterone as the physiological trigger of the ovulatory gonadotropins surge in the human

Dozortsev, D. I., & Diamond, M. P. (2020) · Fertility and Sterility · doi:10.1016/j.fertnstert.2020.06.016 · Cited by 50 · see citing works

Hypoxia adaptation in the cornea: Current animal models and underlying mechanisms

Pang, K., Lennikov, A., & Yang, M. (2021) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12192 · Cited by 49 · see citing works

Hypoxia-specific gene expression for ischemic disease gene therapy

Kim, H., Mahato, R. I., & Lee, M. (2009) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2009.04.009 · Cited by 48 · see citing works

Proteomics reveals lowering oxygen alters cytoskeletal and endoplasmatic stress proteins in human endothelial cells

Østergaard, L., Simonsen, U., Eskildsen-Helmond, Y. E. G., Vorum, H., Uldbjerg, N., Honoré, B., & Mulvany, M. J. (2009) · PROTEOMICS · doi:10.1002/pmic.200800130 · Cited by 48 · see citing works

Hypoxia upregulates PGI-synthase and increases PGI2 release in human vascular cells exposed to inflammatory stimuli

Camacho, M., Rodrı́guez, C., Guadall, A., Alcolea, S., Orriols, M., Escudero, J.-R., Martínez‐González, J., & Vila, L. (2011) · Journal of Lipid Research · doi:10.1194/jlr.m011007 · Cited by 48 · see citing works

Cloning, characterization, hypoxia and heat shock response of hypoxia inducible factor-1 (HIF-1) from the small abalone Haliotis diversicolor

Cai, X., Huang, Y., Zhang, X., Wang, S., Zou, Z., Wang, G., Wang, Y., & Zhang, Z. (2013) · Gene · doi:10.1016/j.gene.2013.10.048 · Cited by 47 · see citing works

HIF-1α is neuroprotective during the early phases of mild hypoxia in rat cortical neurons

López‐Hernández, B., Posadas, I., Podlesniy, P., Abad, M. A., Trullás, R., & Ceña, V. (2011) · Experimental Neurology · doi:10.1016/j.expneurol.2011.11.040 · Cited by 47 · see citing works

Genome-wide analysis of the endothelial transcriptome under short-term chronic hypoxia

Ning, W., Chu, T. J., Li, C., Choi, A. M. K., & Peters, D. G. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00221.2003 · Cited by 47 · see citing works

Targeting hypoxia-inducible factors for breast cancer therapy: A narrative review

Luo, S., Jiang, Y., Zheng, A., Zhao, Y., Wu, X., Li, M., Du, F., Chen, Y., Deng, S., Chen, M., et al. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1064661 · Cited by 45 · see citing works

Inhibiting HIF-1α by 2ME2 ameliorates early brain injury after experimental subarachnoid hemorrhage in rats

Wu, C., Hu, Q., Chen, J., Yan, F., Li, J., Wang, L., Mo, H., Gu, C., Zhang, P., & Chen, G. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.06.107 · Cited by 44 · see citing works

HIF-1: mediator of physiological and pathophysiological responses to hypoxia

Semenza, G. L. (2000) · Journal of Applied Physiology · doi:10.1152/jappl.2000.88.4.1474 · Cited by 1,822 · see citing works

Hypoxia-inducible factor 1: oxygen homeostasis and disease pathophysiology

Semenza, G. L. (2001) · Trends in Molecular Medicine · doi:10.1016/s1471-4914(01)02090-1 · Cited by 930 · see citing works

HIF-1: a key mediator in hypoxia (Review)

Adams, J., DiFazio, L. T., Rolandelli, R. H., Luján, J., Haskó, G., Csóka, B., Selmeczy, Z., & Németh, Z. H. (2009) · Acta Physiologica Hungarica · doi:10.1556/aphysiol.96.2009.1.2 · Cited by 152 · see citing works

Expression of hypoxia-inducible factor 1: mechanisms and consequences

Semenza, G. L. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00292-0 · Cited by 511 · see citing works

Progress in pathophysiology and related drug development of hypoxia-inducible factor-1

Shiji, F. (2014) · The Journal of Pharmaceutical Practice