The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.
Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling
Abstract
Numerous publications have described measurements of breath isoprene in humans, and there has been a hope that breath isoprene analyses could be a noninvasive diagnostic tool to assess blood cholesterol levels or cholesterol synthesis rate. However, significant analytic problems in breath isoprene analysis and variability in isoprene levels with age, exercise, diet, etc., have limited the usefulness of these measurements. Here, we have applied proton transfer reaction-mass spectrometry to this problem, allowing on-line detection of breath isoprene. We show that breath isoprene concentration increases within a few seconds after exercise is started as a result of a rapid increase in heart rate and then reaches a lower steady state when breath rate stabilizes. Additional experiments demonstrated that increases in heart rate associated with standing after reclining or sleeping are associated with increased breath isoprene concentrations. An isoprene gas-exchange model was developed and shows excellent fit to breath isoprene levels measured during exercise. In a preliminary experiment, we demonstrated that atorvastatin therapy leads to a decrease in serum cholesterol and low-density-lipoprotein levels and a parallel decrease in breath isoprene levels. This work suggests that there is constant endogenous production of isoprene during the day and night and reaffirms the possibility that breath isoprene can be a noninvasive marker of cholesterologenesis if care is taken to measure breath isoprene under standard conditions at constant heart rate.
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Cites
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Self-citationAggressive Lipid-Lowering Therapy Compared with Angioplasty in Stable Coronary Artery Disease
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Proton transfer reaction mass spectrometry: on-line trace gas analysis at the ppb level
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A review of the volatiles from the healthy human body
de Lacy Costello, B., Amann, A., Al-Kateb, H., Flynn, C., Filipiak, W., Khalid, T., Osborne, D., & Ratcliffe, N. M. (2014) · Journal of Breath Research · doi:10.1088/1752-7155/8/1/014001 · Cited by 1,042
Proton-Transfer Reaction Mass Spectrometry
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Review—Non-Invasive Monitoring of Human Health by Exhaled Breath Analysis: A Comprehensive Review
Das, S., & Pal, M. (2020) · Journal of The Electrochemical Society · doi:10.1149/1945-7111/ab67a6 · Cited by 466
Breath Analysis in Disease Diagnosis: Methodological Considerations and Applications
Lourenço, C., & Turner, C. (2014) · Metabolites · doi:10.3390/metabo4020465 · Cited by 314
Isoprene and acetone concentration profiles during exercise on an ergometer
King, J., Kupferthaler, A., Unterkofler, K., Koc, H., Teschl, S., Teschl, G., Miekisch, W., Schubert, J., Hinterhuber, H., & Amann, A. (2009) · Journal of Breath Research · doi:10.1088/1752-7155/3/2/027006 · Cited by 278
Metadata
- Authors
- Karl, T., Prazeller, P., Mayr, D., Jordan, A., Rieder, J., Fall, R., & Lindinger, W.
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2001-08-01
- Volume
- 91
- Issue
- 2
- Pages
- 762-770
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2257061691
- Cited by
- 264
- References
- 15
- FWCI
- 5.24
- Type
- journal article
- Language
- en
- Open access
- closed
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- Karl, T., Prazeller, P., Mayr, D., Jordan, A., Rieder, J., Fall, R., & Lindinger, W. (2001). Human breath isoprene and its relation to blood cholesterol levels: new measurements and modeling. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2001.91.2.762
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