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Cited by 292

The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.

Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase

Zheng, Donghai, MacLean, Paul S., Pohnert, Steven C., Knight, John B., Olson, Ann Louise, Winder, William W., Dohm, G. Lynis·2001·Journal of Applied Physiology
DOI 10.1152/jappl.2001.91.3.1073
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Abstract

Skeletal muscle GLUT-4 transcription in response to treatment with 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), a known activator of AMP-activated protein kinase (AMPK), was studied in rats and mice. The increase in GLUT-4 mRNA levels in response to a single subcutaneous injection of AICAR, peaked at 13 h in white and red quadriceps muscles but not in the soleus muscle. The mRNA level of chloramphenicol acyltransferase reporter gene which is driven by 1,154 or 895 bp of the human GLUT-4 proximal promoter was increased in AICAR-treated transgenic mice, demonstrating the transcriptional upregulation of the GLUT-4 gene by AICAR. However, this induction of transcription was not apparent with 730 bp of the promoter. In addition, nuclear extracts from AICAR-treated mice bound to the consensus sequence of myocyte enhancer factor-2 (from −473 to −464) to a greater extent than from saline-injected mice. Thus AMP-activated protein kinase activation by AICAR increases GLUT-4 transcription by a mechanism that requires response elements within 895 bp of human GLUT-4 proximal promoter and that may be cooperatively mediated by myocyte enhancer factor-2.

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Metadata

Authors
Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W., & Dohm, G. L.
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2001-09-01
Volume
91
Issue
3
Pages
1073-1083
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/jappl.2001.91.3.1073
OpenAlex
W1959374451
Cited by
292
References
6
FWCI
6.73
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. https://app.cochat.ai/papers/10.1152/jappl.2001.91.3.1073
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Zheng, D., MacLean, P. S., Pohnert, S. C., Knight, J. B., Olson, A. L., Winder, W. W., & Dohm, G. L. (2001). Regulation of muscle GLUT-4 transcription by AMP-activated protein kinase. Journal of Applied Physiology. https://doi.org/10.1152/jappl.2001.91.3.1073

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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