Atorvastatin treatment reduces exercise capacities in rats: involvement of mitochondrial impairments and oxidative stress

Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data

Ramakers, C. R. B., Ruijter, J. M., Deprez, R. H. L., & Moorman, A. F. M. (2003) · Neuroscience Letters · doi:10.1016/s0304-3940(02)01423-4 · Cited by 3,718 · see citing works

Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c

渡辺, 光., Houten, S. M., Wang, L., Moschetta, A., Mangelsdorf, D. J., Heyman, R. A., Moore, D. D., & Auwerx, J. H. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21025 · Cited by 1,398 · see citing works

Invited Review: Contractile activity-induced mitochondrial biogenesis in skeletal muscle

Hood, D. A. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.3.1137 · Cited by 692 · see citing works

Cerivastatin and Reports of Fatal Rhabdomyolysis

Staffa, J. A., Chang, J. T., & Green, L. (2002) · New England Journal of Medicine · doi:10.1056/nejm200202143460721 · Cited by 627 · see citing works

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

Piantadosi, C. A., Carraway, M. S., Babiker, A., & Suliman, H. B. (2008) · Circulation Research · doi:10.1161/01.res.0000338597.71702.ad · Cited by 580 · see citing works

A New Quantitative Method of Real Time Reverse Transcription Polymerase Chain Reaction Assay Based on Simulation of Polymerase Chain Reaction Kinetics

Liu, W., & Saint, D. A. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5530 · Cited by 521 · see citing works

Glycogen synthase kinase 3: more than a namesake

Rayasam, G. V., Tulasi, V. K., Sodhi, R., Davis, J. A., & Ray, A. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2008.00085.x · Cited by 485 · see citing works

Statins as antioxidant therapy for preventing cardiac myocyte hypertrophy

Takemoto, M., Node, K., Nakagami, H., Liao, Y., Grimm, M. F., Takemoto, Y., Kitakaze, M., & Liao, J. K. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13350 · Cited by 485 · see citing works

Molecular basis of skeletal muscle plasticity-from gene to form and function

Flück, M., & Hoppeler, H. H. (2003) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/s10254-002-0004-7 · Cited by 476 · see citing works

Mitochondrial H + Leak and ROS Generation: An Odd Couple

Brookes, P. S. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.10.016 · Cited by 447 · see citing works

Contractile activity-induced oxidative stress: cellular origin and adaptive responses

McArdle, A., Pattwell, D. M., Vasilaki, A., Griffiths, R. D., & Jackson, M. J. (2001) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2001.280.3.c621 · Cited by 349 · see citing works

Exercise-induced cardioprotection against myocardial ischemia–reperfusion injury

Powers, S. K., Quindry, J. C., & Kavazis, A. N. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2007.02.006 · Cited by 273 · see citing works

Toxicity of statins on rat skeletal muscle mitochondria

Kaufmann, P., Török, M., Zahno, A., Waldhauser, K. M., Brecht, K., & Krähenbühl, S. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-006-6235-z · Cited by 263 · see citing works

Statin-induced apoptosis and skeletal myopathy

Dirks, A. J., & Jones, K. M. (2006) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00226.2006 · Cited by 240 · see citing works

Professional athletes suffering from familial hypercholesterolaemia rarely tolerate statin treatment because of muscular problems

Sinzinger, H. F., & O’Grady, J. (2004) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2003.02044.x · Cited by 223 · see citing works

Effects of HMG-CoA Reductase Inhibitors on Skeletal Muscle

Evans, M., & Rees, A. (2002) · Drug Safety · doi:10.2165/00002018-200225090-00004 · Cited by 211 · see citing works

Simple Enzymatic Determination of Polysaccharide (Glycogen) Content of Animal Tissues

Murat, J. C., & Serfaty, A. (1974) · Clinical Chemistry · doi:10.1093/clinchem/20.12.1576 · Cited by 208 · see citing works

Statins: a new insight into their mechanisms of action and consequent pleiotropic effects.

Jasińska-Stroschein, M., Owczarek, J., & Orszulak–Michalak, D. (2007) · PubMed · Cited by 192 · see citing works

New insights into mechanisms of statin-associated myotoxicity

Sirvent, P., Mercier, J. G., & Lacampagne, A. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.12.010 · Cited by 190 · see citing works

Physical activity changes the regulation of mitochondrial respiration in human skeletal muscle

Zoll, J., Sanchez, H., N’guessan, B. B., Ribera, F., Lampert, E., Bigard, X. A., Serrurier, B., Fortin, D., Gény, B., Veksler, V., et al. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.019661 · Cited by 186 · see citing works

Lovastatin increases exercise-induced skeletal muscle injury

Thompson, P. D., Zmuda, J. M., Domalik, L. J., Zimet, R., Staggers, J. E., & Guyton, J. R. (1997) · Metabolism · doi:10.1016/s0026-0495(97)90218-3 · Cited by 177 · see citing works

Simvastatin triggers mitochondria-induced Ca2+ signaling alteration in skeletal muscle

Sirvent, P., Mercier, J., Vassort, G., & Lacampagne, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.02.070 · Cited by 154 · see citing works

Multiple defects in muscle glycogen synthase activity contribute to reduced glycogen synthesis in non-insulin dependent diabetes mellitus.

Thorburn, A. W., Gumbiner, B., Bulacan, F., Brechtel, G., & Henry, R. R. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115022 · Cited by 152 · see citing works

HMG-CoA reductase inhibitor-induced myopathy in the rat: cyclosporine A interaction and mechanism studies.

Smith, P. F., Eydelloth, R. S., Grossman, S. J., Stubbs, R. J., Schwartz, M. S., Germershausen, J. I., Vyas, K. P., Kari, P. H., & MacDonald, J. S. (1991) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)24759-0 · Cited by 146 · see citing works

Effects of In Vivo Nitroglycerin Treatment on Activity and Expression of the Guanylyl Cyclase and cGMP-Dependent Protein Kinase and Their Downstream Target Vasodilator-Stimulated Phosphoprotein in Aorta

Mülsch, A., Oelze, M. W., Klöss, S., Mollnau, H., Töpfer, A., Smolenski, A., Walter, U., Stasch, J., Warnholtz, A., Hink, U., et al. (2001) · Circulation · doi:10.1161/01.cir.103.17.2188 · Cited by 133 · see citing works

Oxidative capacity of skeletal muscle in heart failure patients versus sedentary or active control subjects

Mettauer, B., Zoll, J., Sanchez, H., Lampert, E., Ribera, F., Veksler, V., Bigard, X. A., Matéo, P., Epailly, É., Lonsdorfer, J., et al. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01460-7 · Cited by 133 · see citing works

Simvastatin induces impairment in skeletal muscle while heart is protected

Sirvent, P., Bordenave, S., Vermaelen, M., Roels, B., Vassort, G., Mercier, J., Raynaud, E., & Lacampagne, A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.10.108 · Cited by 116 · see citing works

Statin‐associated myopathy and its exacerbation with exercise

Meador, B. M., & Huey, K. A. (2010) · Muscle & Nerve · doi:10.1002/mus.21817 · Cited by 98 · see citing works

Effects of Atorvastatin and Pravastatin on Signal Transduction Related to Glucose Uptake in 3T3L1 Adipocytes

Takaguri, A., Satoh, K., Itagaki, M., Tokumitsu, Y., & Ichihara, K. (2008) · Journal of Pharmacological Sciences · doi:10.1254/jphs.fp0072403 · Cited by 87 · see citing works

Anti-inflammatory effect of atorvastatin ameliorates insulin resistance in monosodium glutamate–treated obese mice

Furuya, D. T., Poletto, A. C., Fávaro, R. R., Martins, J. O., Zorn, T. M. T., & Machado, U. F. (2009) · Metabolism · doi:10.1016/j.metabol.2009.08.011 · Cited by 74 · see citing works

Mitochondrial function in human skeletal muscle is not impaired by high intensity exercise

Tonkonogi, M., Walsh, B. J., Tiivel, T., Saks, V. A., & Sahlin, K. (1999) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050818 · Cited by 70 · see citing works

Potential Adverse Effects of Statins on Muscle

Tomlinson, S. S., & Mangione, K. K. (2005) · Physical Therapy · doi:10.1093/ptj/85.5.459 · Cited by 68 · see citing works

Preserved response of mitochondrial function to short-term endurance training in skeletal muscle of heart transplant recipients

Zoll, J., N’guessan, B. B., Ribera, F., Lampert, E., Fortin, D., Veksler, V., Bigard, X. A., Gény, B., Lonsdorfer, J., Ventura‐Clapier, R., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00499-6 · Cited by 66 · see citing works

Activation of Mitochondrial Biogenesis by Hormesis

Sano, M., & Fukuda, K. (2008) · Circulation Research · doi:10.1161/circresaha.108.189092 · Cited by 65 · see citing works

Pleiotropic effects of statins and related pharmacological experimental approaches

Alegret, M., & Silvestre, J. S. (2006) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2006.28.9.1003573 · Cited by 60 · see citing works

Involvement of oxidative stress in simvastatin-induced apoptosis of murine CT26 colon carcinoma cells

Qi, X.-F., Kim, D.-H., Yoon, Y., Kim, S., Cai, D., Teng, Y., Shim, K.-Y., & Lee, K. (2010) · Toxicology Letters · doi:10.1016/j.toxlet.2010.09.010 · Cited by 57 · see citing works

Mitochondrial myopathy developing on treatment with the HMG CoA reductase inhibitors — simvastatin and pravastatin

ENGLAND, J. D. F., WALSH, J. C., STEWART, P. M., BOYD, I., Rohan, A., & Halmagyi, G. M. (1995) · Australian and New Zealand Journal of Medicine · doi:10.1111/j.1445-5994.1995.tb01912.x · Cited by 57 · see citing works

The effects of statins on skeletal muscle strength and exercise performance

Krishnan, G. M., & Thompson, P. D. (2010) · Current Opinion in Lipidology · doi:10.1097/mol.0b013e32833c1edf · Cited by 55 · see citing works

Regulation of GLUT4 Gene Expression during Exercise

Holmes, B. F., & Dohm, G. L. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000132385.34889.fe · Cited by 54 · see citing works

Lovastatin Disrupts Early Events in Insulin Signaling: A Potential Mechanism of Lovastatins Anti-Mitogenic Activity

McGuire, T. F., Xu, X. Q., Corey, S. J., Romero, G. G., & Sebti, S. M. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.2472 · Cited by 51 · see citing works

Effects of exercise and lovastatin on serum creatine kinase activity

Thompson, P. D., Gadaleta, P. A., Yurgalevitch, S. M., Cullinane, E. M., & Herbert, P. N. (1991) · Metabolism · doi:10.1016/0026-0495(91)90039-y · Cited by 37 · see citing works

Pravastatin Reduces Myocardial Infarct Size Via Increasing Protein Kinase C-Dependent Nitric Oxide, Decreasing Oxyradicals and Opening the Mitochondrial Adenosine Triphosphate-Sensitive Potassium Channels in Rabbits

Bao, N., Minatoguchi, S., Kobayashi, H., Yasuda, S., Kawamura, I., Iwasa, M., Yamaki, T., Sumi, S., Misao, Y., Arai, M., et al. (2007) · Circulation Journal · doi:10.1253/circj.71.1622 · Cited by 36 · see citing works

Evaluation of quantitative and qualitative aspects of mitochondrial function in human skeletal and cardiac muscles

N’guessan, B. B., Zoll, J., Ribera, F., Ponsot, E., Lampert, E., Ventura‐Clapier, R., Veksler, V., & Mettauer, B. (2003) · Molecular and Cellular Biochemistry · doi:10.1023/b:mcbi.0000009874.14649.ca · Cited by 33 · see citing works

Physiological role of free radicals in skeletal muscles

Lecarpentier, Y. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01047.2007 · Cited by 32 · see citing works

Simvastatin activates Akt/glycogen synthase kinase-3β signal and inhibits caspase-3 activation after experimental subarachnoid hemorrhage

Cheng, G., Chunlei, W., Pei, W., Liu, Z., & Liu, X. (2009) · Vascular Pharmacology · doi:10.1016/j.vph.2009.12.001 · Cited by 30 · see citing works

The interactions of some commonly consumed drugs with mitochondrial adaptations to exercise

Robinson, M. M., Hamilton, K. L., & Miller, B. F. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00343.2009 · Cited by 28 · see citing works

Simvastatin Impairs Exercise Training Adaptations

Mikus, C. R., Boyle, L. J., Borengasser, S. J., Oberlin, D. J., Naples, S. P., Fletcher, J. A., Meers, G. M.-E., Ruebel, M. L., Laughlin, M. H., Dellsperger, K. C., et al. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2013.02.074 · Cited by 244 · see citing works

Statins: Adverse reactions, oxidative stress and metabolic interactions

Liu, A., Wu, Q., Guo, J., Arés, I., Rodríguez, J.-L., Martínez‐Larrañaga, M., Yuan, Z., Anadón, A., Wang, X., & Martínez, M. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.10.004 · Cited by 168 · see citing works

Simvastatin Effects on Skeletal Muscle

Larsen, S., Stride, N., Hey-Mogensen, M., Hansen, C. N., Bang, L. E., Bundgaard, H., Nielsen, L. B., Helge, J. W., & Dela, F. (2013) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.09.036 · Cited by 165 · see citing works

Antioxidant Effects of Statins by Modulating Nrf2 and Nrf2/HO-1 Signaling in Different Diseases

Mansouri, A., Reiner, Ž., Ruscica, M., Tedeschi-Reiner, E., Radbakhsh, S., Ekta, M. B., & Sahebkar, A. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11051313 · Cited by 164 · see citing works

Mechanisms of statin-associated skeletal muscle-associated symptoms

Bouitbir, J., Sanvee, G. M., Panajatovic, M. V., Singh, F., & Krähenbühl, S. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.03.010 · Cited by 146 · see citing works

Effect of Statins on Skeletal Muscle

Parker, B. A., & Thompson, P. D. (2012) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e31826c169e · Cited by 122 · see citing works

Reductive stress impairs myoblasts mitochondrial function and triggers mitochondrial hormesis

Singh, F., Charles, A., Schlagowski, A.-I., Bouitbir, J., Bonifacio, A., Piquard, F., Krähenbühl, S., Gény, B., & Zoll, J. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.03.006 · Cited by 104 · see citing works

Statins Trigger Mitochondrial Reactive Oxygen Species-Induced Apoptosis in Glycolytic Skeletal Muscle

Bouitbir, J., Singh, F., Charles, A., Schlagowski, A.-I., Bonifacio, A., Echaniz‐Laguna, A., Gény, B., Krähenbühl, S., & Zoll, J. (2015) · Antioxidants and Redox Signaling · doi:10.1089/ars.2014.6190 · Cited by 95 · see citing works

Statin-Associated Muscle Disease: Advances in Diagnosis and Management

Taylor, B. A., & Thompson, P. D. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0670-z · Cited by 85 · see citing works

Efficacy and safety of statins and exercise combination therapy compared to statin monotherapy in patients with dyslipidaemia: A systematic review and meta-analysis

Gui, Y., Liao, C.-X., Liu, Q., Guo, Y., Yang, T., Chen, J., Wang, Y., Hu, J., & Xu, D. (2017) · European Journal of Preventive Cardiology · doi:10.1177/2047487317691874 · Cited by 48 · see citing works

Understanding heterogeneity of responses to, and optimizing clinical efficacy of, exercise training in older adults: NIH NIA Workshop summary

Erickson, M. L., Allen, J. M., Beavers, D. P., Collins, L. M., Davidson, K. W., Erickson, K. I., Esser, K. A., Hesselink, M. K. C., Moreau, K. L., Laber, E. B., et al. (2023) · GeroScience · doi:10.1007/s11357-022-00668-3 · Cited by 47 · see citing works

Statin myalgia is not associated with reduced muscle strength, mass or protein turnover in older male volunteers, but is allied with a slowing of time to peak power output, insulin resistance and differential muscle mRNA expression

Mallinson, J. E., Marimuthu, K., Murton, A. J., Selby, A., Smith, K., Constantin‐Teodosiu, D., Rennie, M. J., & Greenhaff, P. L. (2015) · The Journal of Physiology · doi:10.1113/jphysiol.2014.285577 · Cited by 47 · see citing works

Protective effects of astaxanthin on capillary regression in atrophied soleus muscle of rats

Kanazashi, M., Okumura, Y., Al‐Nassan, S., Murakami, S., Kondo, H., Nagatomo, F., Fujita, N., Ishihara, A., Roy, R. R., & Fujino, H. (2012) · Acta Physiologica · doi:10.1111/apha.12018 · Cited by 44 · see citing works

Treatment of Dyslipidemia with Statins and Physical Exercises: Recent Findings of Skeletal Muscle Responses

Bonfim, M. R., Oliveira, A. S. B., Amaral, S. L., & Monteiro, H. L. (2015) · Arquivos Brasileiros de Cardiologia · doi:10.5935/abc.20150005 · Cited by 43 · see citing works

Amelioration of capillary regression and atrophy of the soleus muscle in hindlimb‐unloaded rats by astaxanthin supplementation and intermittent loading

Kanazashi, M., Tanaka, M., Murakami, S., Kondo, H., Nagatomo, F., Ishihara, A., Roy, R. R., & Fujino, H. (2014) · Experimental Physiology · doi:10.1113/expphysiol.2014.079988 · Cited by 42 · see citing works

Pharmacological activation of the pyruvate dehydrogenase complex reduces statin‐mediated upregulation of FOXO gene targets and protects against statin myopathy in rodents

Mallinson, J. E., Constantin‐Teodosiu, D., Glaves, P. D., Martin, E. A., Davies, W. J., Westwood, F. R., Sidaway, J. E., & Greenhaff, P. L. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2012.238022 · Cited by 40 · see citing works

Skeletal muscle metabolic adaptations to endurance exercise training are attainable in mice with simvastatin treatment

Southern, W. M., Nichenko, A. S., Shill, D. D., Spencer, C. C., Jenkins, N. T., McCully, K. K., & Call, J. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172551 · Cited by 39 · see citing works

Impact of Coenzyme Q-10 on Parameters of Cardiorespiratory Fitness and Muscle Performance in Older Athletes Taking Statins

Deichmann, R. E., Lavie, C. J., & Dornelles, A. C. (2012) · The Physician and Sportsmedicine · doi:10.3810/psm.2012.11.1991 · Cited by 35 · see citing works

The Impact of Exercise on Statin-Associated Skeletal Muscle Myopathy

Chung, H. R., Vakil, M., Munroe, M., Parikh, A., Meador, B. M., Wu, P. T., Jeong, J., Woods, J. A., Wilund, K. R., & Boppart, M. D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0168065 · Cited by 33 · see citing works

Prosarcopenic Effects of Statins May Limit Their Effectiveness in Patients with Heart Failure

Bielecka-Dabrowa, A. M., Fabiś, J., Mikhailidis, D. P., von Haehling, S., Sahebkar, A., Rysz, J., & Banach, M. (2018) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2018.02.003 · Cited by 30 · see citing works

A Reappraisal of the Risks and Benefits of Treating to Target with Cholesterol Lowering Drugs

Alla, V. M., Agrawal, V., DeNazareth, A., Mohiuddin, S., Ravilla, S., & Rendell, M. (2013) · Drugs · doi:10.1007/s40265-013-0072-9 · Cited by 32 · see citing works

Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study

Barrat, E., Zaïr, Y., Sirvent, P., Chauveau, P., Maudet, C., Housez, B., Derbord, E., Lescuyer, J.-F., Bard, J.-M., Cazaubiel, M., et al. (2013) · European Journal of Nutrition · doi:10.1007/s00394-012-0486-2 · Cited by 31 · see citing works

The Effects of Statin Medications on Aerobic Exercise Capacity and Training Adaptations

Murlasits, Z., & Radak, Z. O. (2014) · Sports Medicine · doi:10.1007/s40279-014-0224-4 · Cited by 32 · see citing works

A Peculiar Formula of Essential Amino Acids Prevents Rosuvastatin Myopathy in Mice

D’Antona, G., Tedesco, L., Ruocco, C., Corsetti, G., Ragni, M., Fossati, A., Saba, E., Fenaroli, F., Montinaro, M., Carruba, M. O., et al. (2016) · Antioxidants and Redox Signaling · doi:10.1089/ars.2015.6582 · Cited by 30 · see citing works

Elucidation of the mechanism of atorvastatin-induced myopathy in a rat model

El-Ganainy, S. O., El‐Mallah, A., Abdallah, D., Khattab, M. M., El‐Din, M. M. M., & El-Khatib, A. S. (2016) · Toxicology · doi:10.1016/j.tox.2016.06.015 · Cited by 29 · see citing works

Geranylgeraniol Prevents Statin‐Dependent Myotoxicity in C2C12 Muscle Cells through RAP1 GTPase Prenylation and Cytoprotective Autophagy

Jaśkiewicz, A., Pająk, B., Litwiniuk, A., Urbańska, K., & Orzechowski, A. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/6463807 · Cited by 28 · see citing works

Effect of eccentric versus concentric exercise training on mitochondrial function

Isner-Horobeti, M.-È., Rasseneur, L., Lonsdorfer‐Wolf, E., Dufour, S. P., Doutreleau, S., Bouitbir, J., Zoll, J., Kapchinsky, S., Gény, B., Daussin, F., et al. (2014) · Muscle & Nerve · doi:10.1002/mus.24215 · Cited by 27 · see citing works

Effects of Statin Therapy on Exercise Levels in Participants in the National Runners' and Walkers' Health Study

Williams, P. T., & Thompson, P. D. (2015) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2015.06.019 · Cited by 26 · see citing works

The comparative effects of high dose atorvastatin and proprotein convertase subtilisin/kexin type 9 inhibitor on the mitochondria of oxidative muscle fibers in obese-insulin resistant female rats

Thonusin, C., Apaijai, N., Jaiwongkam, T., Kerdphoo, S., Arunsak, B., Amput, P., Palee, S., Pratchayasakul, W., Chattipakorn, N., & Chattipakorn, S. C. (2019) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2019.114741 · Cited by 26 · see citing works

Respiratory safety pharmacology – Current practice and future directions

Murphy, D. J. (2013) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2013.11.010 · Cited by 24 · see citing works

Statin Therapy, Fitness, and Mortality Risk in Middle-Aged Hypertensive Male Veterans

Kokkinos, P. F., Faselis, C. J., MYERS, J. N., Kokkinos, J., Doumas, M. N., Pittaras, A. E., Kheirbek, R., Manolis, A. J., Panagiotakos, D. B., Papademetriou, V., et al. (2014) · American Journal of Hypertension · doi:10.1093/ajh/hpt241 · Cited by 24 · see citing works

Statin therapy, myopathy and exercise--a case report

Semple, S. (2012) · Lipids in Health and Disease · doi:10.1186/1476-511x-11-40 · Cited by 22 · see citing works

Does Coenzyme Q10 Supplementation Mitigate Statin-Associated Muscle Symptoms? Pharmacological and Methodological Considerations

Taylor, B. A. (2017) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-017-0251-2 · Cited by 22 · see citing works

Skeletal muscle ultrastructure and function in statin-tolerant individuals

Rengo, J. L., Callahan, D. M., Savage, P. D., Ades, P. A., & Toth, M. J. (2015) · Muscle & Nerve · doi:10.1002/mus.24722 · Cited by 21 · see citing works

Effects of astaxanthin supplementation and electrical stimulation on muscle atrophy and decreased oxidative capacity in soleus muscle during hindlimb unloading in rats

Kanazashi, M., Tanaka, M., Nakanishi, R., Maeshige, N., & Fujino, H. (2019) · The Journal of Physiological Sciences · doi:10.1007/s12576-019-00692-7 · Cited by 19 · see citing works

C2C12 myoblasts are more sensitive to the toxic effects of simvastatin than myotubes and show impaired proliferation and myotube formation

Sanvee, G. M., Bouitbir, J., & Krähenbühl, S. (2021) · Biochemical Pharmacology · doi:10.1016/j.bcp.2021.114649 · Cited by 18 · see citing works

Aerobic Exercise Performance and Muscle Strength in Statin Users—The LIFESTAT Study

Morville, T. H., Dohlmann, T. L., Kuhlman, A. B., Sahl, R. E., Kriegbaum, M., Larsen, S., Dela, F., & Helge, J. W. (2019) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000001920 · Cited by 18 · see citing works

PGC‐1α plays a pivotal role in simvastatin‐induced exercise impairment in mice

Panajatovic, M. V., Singh, F., Roos, N. J., Duthaler, U., Handschin, C., Krähenbühl, S., & Bouitbir, J. (2019) · Acta Physiologica · doi:10.1111/apha.13402 · Cited by 17 · see citing works

Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms

Huang, J., Du, J., Lin, W., Long, Z., Zhang, N., Huang, X., Xie, Y., Liu, L., & Ma, W. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.06.003 · Cited by 15 · see citing works

Ubiquinone Supplementation with 300 mg on Glycemic Control and Antioxidant Status in Athletes: A Randomized, Double-Blinded, Placebo-Controlled Trial

Ho, C., Chang, P., Chen, H.-W., Lee, P.-F., Chang, Y.-C., Tseng, C.-Y., & Lin, P. (2020) · Antioxidants · doi:10.3390/antiox9090823 · Cited by 16 · see citing works

Diverse Action of Selected Statins on Skeletal Muscle Cells—An Attempt to Explain the Protective Effect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM)

Jaśkiewicz, A., Pająk, B., Łabieniec-Watała, M., Palma, C. D., & Orzechowski, A. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8050694 · Cited by 13 · see citing works

Validation of a pharmacological model for mitochondrial dysfunction in healthy subjects using simvastatin: A randomized placebo-controlled proof-of-pharmacology study

van Diemen, M. P. J., Berends, C. L., Akram, N., Wezel, J., Teeuwisse, W. M., Mik, B., Kan, H. E., Webb, A., Beenakker, J. M., & Groeneveld, G. J. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.09.031 · Cited by 13 · see citing works

Optimizing the use of methods and measurement endpoints in respiratory safety pharmacology

Murphy, D. J. (2014) · Journal of Pharmacological and Toxicological Methods · doi:10.1016/j.vascn.2014.03.174 · Cited by 12 · see citing works

Statins and Exercise Training Response in Heart Failure Patients

Kelly, J. P., Dunning, A. M., Schulte, P. J., Fiuzat, M., Leifer, E., Fleg, J. L., Cooper, L. S., Keteyian, S. J., Kitzman, D. W., Piña, I. L., et al. (2016) · JACC Heart Failure · doi:10.1016/j.jchf.2016.05.006 · Cited by 11 · see citing works

Rosuvastatin safety: An experimental study of myotoxic effects and mitochondrial alterations in rats

El-Ganainy, S. O., El‐Mallah, A., Abdallah, D., Khattab, M. M., El‐Din, M. M. M., & El-Khatib, A. S. (2016) · Toxicology Letters · doi:10.1016/j.toxlet.2016.10.017 · Cited by 11 · see citing works

Effects of statin therapy on weight loss and diabetes in bariatric patients

Taylor, B. A., Ng, J., Stone, A. M., Thompson, P. D., Papasavas, P. K., & Tishler, D. S. (2016) · Surgery for Obesity and Related Diseases · doi:10.1016/j.soard.2016.11.018 · Cited by 11 · see citing works

Creatine supplementation does not alter the creatine kinase response to eccentric exercise in healthy adults on atorvastatin

Taylor, B. A., Panza, G. A., Ballard, K. D., White, C. M., & Thompson, P. D. (2018) · Journal of clinical lipidology · doi:10.1016/j.jacl.2018.05.018 · Cited by 11 · see citing works

Statin administration activates system xC − in skeletal muscle: a potential mechanism explaining statin-induced muscle pain

Rebalka, I. A., Cao, A. W., May, L. L., Tarnopolsky, M. A., & Hawke, T. J. (2019) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00308.2019 · Cited by 11 · see citing works

Effects of Coenzyme Q10 on Skeletal Muscle Oxidative Metabolism in Statin Users Assessed Using 31P Magnetic Resonance Spectroscopy: a Randomized Controlled Study.

Buettner, C., Greenman, R. L., Ngo, L. H., & Wu, J. S. (2016) · PubMed · Cited by 11 · see citing works

Time course of capillary regression and an expression balance between vascular endothelial growth factor‐A and thrombospondin‐1 in the soleus muscle of hindlimb unloaded rats

Tanaka, M., Kanazashi, M., Kondo, H., & Fujino, H. (2021) · Muscle & Nerve · doi:10.1002/mus.27478 · Cited by 10 · see citing works

Effect of L-carnitine on the skeletal muscle contractility in simvastatin-induced myopathy in rats

Ghalwash, M., Elmasry, A., & El-Adeeb, N. (2018) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp-2017-0156 · Cited by 10 · see citing works

Do statins increase and Mediterranean diet decrease the risk of breast cancer?

de Lorgeril, M., & Salen, P. (2014) · BMC Medicine · doi:10.1186/1741-7015-12-94 · Cited by 10 · see citing works

Rationale for investigating metformin as a protectant against statin-associated muscle symptoms

Elsaid, O., Taylor, B. A., Zaleski, A. L., Panza, G. A., & Thompson, P. D. (2017) · Journal of clinical lipidology · doi:10.1016/j.jacl.2017.06.019 · Cited by 9 · see citing works

The impact of statin therapy and aerobic exercise training on skeletal muscle and whole-body aerobic capacity

Slade, J. M., Abela, G. S., Rozman, M., McClowry, R. J., Hurley, D., Forbes, S. C., & Meyer, R. A. (2021) · American Heart Journal Plus Cardiology Research and Practice · doi:10.1016/j.ahjo.2021.100028 · Cited by 8 · see citing works

Pravastatin improves risk factors but not ischaemic tolerance in obese rats

Oi, M., Donner, D. G., Peart, J. N., Beck, B. R., Wendt, L., Headrick, J. P., & Toit, E. F. D. (2018) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2018.02.050 · Cited by 8 · see citing works

The main side effects of statins in clinical practice

Chaulin, A. M. (2022) · Journal of clinical practice · doi:10.17816/clinpract108076 · Cited by 7 · see citing works

Oxidative Stress-Induced Adverse Effects of Three Statins Following Single or Repetitive Treatments in Mice

Al-Shalchi, R. F., & MOHAMMAD, F. K. (2024) · Cureus · doi:10.7759/cureus.51433 · Cited by 7 · see citing works

Impaired Exercise Performance and Skeletal Muscle Mitochondrial Function in Rats with Secondary Carnitine Deficiency

Bouitbir, J., Haegler, P., Singh, F., Joerin, L., Felser, A., Duthaler, U., & Krähenbühl, S. (2016) · Frontiers in Physiology · doi:10.3389/fphys.2016.00345 · Cited by 7 · see citing works

Acoustic Delivery of Plasma Low-Density Lipoprotein into Liver via ApoB100-Targeted Microbubbles Inhibits Atherosclerotic Plaque Growth

Li, Z., Zhou, Y., Lai, M., Luo, J., & Yan, F. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c00999 · Cited by 6 · see citing works

Skeletal muscle fibre type-dependent effects of atorvastatin on the PI3K/Akt/mTOR signalling pathway and atrophy-related genes in rats

Gawędzka, A., Knapik-Czajka, M. E., Drąg, J., Belczyk, M., Radwańska, E., & Adamek, D. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-10005-w · Cited by 6 · see citing works

Effects of reloading after chronic neuromuscular inactivity on the three-dimensional capillary architecture in rat soleus muscle

Kanazashi, M., Tanaka, M., Maezawa, T., & Fujino, H. (2020) · Acta Histochemica · doi:10.1016/j.acthis.2020.151617 · Cited by 6 · see citing works

Protective effects of chlorogenic acid on capillary regression caused by disuse muscle atrophy

Xing, J., Han, P. A. N., Lin, H., Nakanishi, R., Hirabayashi, T., NAKAYAMA, E., Xiaoqi, M. A., Maeshige, N., Kondo, H., & Fujino, H. (2021) · Biomedical Research · doi:10.2220/biomedres.42.257 · Cited by 6 · see citing works

Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats

Seo, D. Y., Heo, J., No, M., Yoo, S.-Z., Ko, J. R., Park, D., Kang, J., Kim, C., Jung, S., Han, J., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072292 · Cited by 6 · see citing works

Combination of Policosanol (Raydel®) and Atorvastatin Improve High-Density Lipoproteins and Antioxidant Abilities to Protect Vital Organs and Fertility in Hyperlipidemic/Hyperglycemic Zebrafish

Cho, K., Bahuguna, A., Kim, J.-E., Lee, S. H., Lee, Y., Jeon, C., Baek, S. H., & Djayanti, K. (2026) · Pharmaceuticals · doi:10.3390/ph19020237 · Cited by 4 · see citing works

Acute effect of electrical stimulation on muscle protein synthesis and break-down in the soleus muscle of hindlimb unloaded rats

Kanazashi, M., & TANAKA, M. (2023) · Biomedical Research · doi:10.2220/biomedres.44.209 · Cited by 3 · see citing works

Methylglyoxal reduces resistance exercise-induced protein synthesis and anabolic signaling in rat tibialis anterior muscle

Tanaka, M., Kanazashi, M., Kondo, H., & Fujino, H. (2024) · Journal of Muscle Research and Cell Motility · doi:10.1007/s10974-024-09680-w · Cited by 3 · see citing works

A novel investigation of statins myotoxic mechanism: effect of atorvastatin on respiratory muscles in hypoxic environment

El-Ganainy, S. O., El‐Mallah, A., Abdallah, D., Khattab, M. M., El-Khatib, A. S., & El‐Din, M. M. M. (2019) · Toxicology Letters · doi:10.1016/j.toxlet.2019.02.001 · Cited by 3 · see citing works

A call for the better utilization of physical activity and exercise training in the defense against cardiovascular disease

Murlasits, Z. (2015) · The Physician and Sportsmedicine · doi:10.1080/00913847.2015.1095618 · Cited by 2 · see citing works

Evaluation of the toxicity potential of exercise and atorvastatin/metformin combination therapy on STZ-diabetic rats

Tunçyürekli, M., Tülüce, Y., & Lermioǧlu, F. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03663-x · Cited by 2 · see citing works

Evaluation of Trace Elements in Augmentation of Statin-Induced Cytotoxicity in Uremic Serum-Exposed Human Rhabdomyosarcoma Cells

Uchiyama, H., Tsujimoto, M., Shimada, N., Tsutsui, K., Nitta, A., Yoshida, T., Furukubo, T., Izumi, S., Yamakawa, T., Tachiki, H., et al. (2018) · Toxins · doi:10.3390/toxins10020053 · Cited by 2 · see citing works

Changes in propofol anaesthesia and dichlorvos toxicity in mice following repeated dosing with three hypolipidemic statins

Al-Shalchi, R. F., & MOHAMMAD, F. K. (2025) · BULGARIAN JOURNAL OF VETERINARY MEDICINE · doi:10.15547/bjvm.2024-0002 · Cited by 2 · see citing works

Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration

Nonaka, K., Ozaki, Y., Ito, K., Sakita, M., Une, S., & Akiyama, J. (2018) · The Journal of Physiological Sciences · doi:10.1007/s12576-018-0649-x · Cited by 2 · see citing works

Protective Effects of Policosanol and Atorvastatin Co-Supplementation Against High-Cholesterol and High-Galactose Diet-Induced Metabolic and Organ Dysfunction in Zebrafish

Cho, K., Jeon, C., Bahuguna, A., Kim, J.-E., Lee, S. H., Lee, Y., & Baek, S. H. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27177687 · Cited by 1 · see citing works

Effect of Simvastatin on Male Albino Rats, Cytogenetic and Histochemical Studies

Shalaby, R., Rashed, L. A., Foda, F., Kamel, A., & Adel, R. M. (2018) · Journal of Scientific Research in Science /Journal of Scientific Research in Science · doi:10.21608/jsrs.2018.12756 · Cited by 1 · see citing works

Dietary RNA from Torula Yeast Prevents Capillary Regression in Atrophied Skeletal Muscle in Rats

Lin, H., Xing, J., Ma, X., Nakanishi, R., Kondo, H., Fujita, M., Sutoh, K., Maeshige, N., & Fujino, H. (2024) · Life · doi:10.3390/life14121616 · Cited by 1 · see citing works

Investigating the combined effects of statins and exercise on skeletal muscle mitochondrial content and function, cardiorespiratory fitness and quality of life in individuals with dyslipidaemia: protocol for a randomised placebo-controlled trial

Sjúrðarson, T., Larsen, S., Jensen, S. B. K., Bejder, J., Rasmussen, J., Borg, S. Á., Kristiansen, J., Meinhardsson, J. M., Olsen, H. W., Ellingsgaard, H., et al. (2025) · BMJ Open · doi:10.1136/bmjopen-2025-101425 · Cited by 1 · see citing works

Importance of Plasma Membrane Nanodomains in Skeletal Muscle Regeneration

Pająk, B., & Orzechowski, A. (2015) · InTech eBooks · doi:10.5772/60615

The Impact of Physical Activity on Statin-Associated Skeletal Muscle Myopathy

Chung, H. R., Wu, P.-T., Fitschen, P. J., Kistler, B. M., Park, H. W., Jeong, J. H., Wilund, K. R., Woods, J., & Boppart, M. D. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000477291.98365.c0

Dietary/Environmental Factors and Breast Cancer

de Lorgeril, M., & Salen, P. (2015) · Springer eBooks · doi:10.1007/978-3-319-21461-0_17

"ESTATINAS, MIOPATIA E EXERCÍCIO FÍSICO"

Blaj, R. N. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

Measurement of Oxygen MetabolismIn Vivo

van Diemen, M. P. J., Ubbink, R., Münker, F. M., Mik, E. G., & Groeneveld, G. J. (2018) · Wiley eBooks · doi:10.1002/9781119329725.ch20

Über die Rolle der induzierbaren NO-Synthase für die Statinmyotoxizität in einem In vitro-Skelettmuskelmodell

Brandenburg, S.-J. (2017) · doi:10.53846/goediss-6164

Simvastatin impairs myoblast proliferation and myotube formation of C2C12 myoblasts and in mouse skeletal musclePreprint

Sanvee, G. M., Bouitbir, J., & Kraehenbuehl, S. (2021) · Research Square · doi:10.21203/rs.3.rs-348598/v1

Efeito do treinamento físico em pacientes submetidos à angioplastia coronariana eletiva: avaliação dos biomarcadores inflamatórios sanguíneos e fluxo sanguíneo periférico endotélio-dependente

Correia, K. T. S. (2020) · doi:10.11606/t.5.2020.tde-16092021-090909

Statins and myalgia: fact or fiction?

(2015) · British Journal of Cardiology · doi:10.5837/bjc.2015.033

Co-Supplementation of Policosanol and Atorvastatin Attenuates High-Cholesterol and High-Galactose Diet-Induced Ocular and Brain Damage and Improves Cognitive Health in Zebrafish

Cho, K., Bahuguna, A., Baek, S. H., & Yang, C.-E. (2026) · Pharmaceuticals · doi:10.3390/ph19101622

Exercise Training Protects against Atorvastatin-Induced Skeletal Muscle Dysfunction and Mitochondrial Dysfunction in the Skeletal Muscle of Rats

Seo, D. Y., Heo, J., No, M., Yoo, S.-Z., Ko, J. R., Park, D., Kang, J., Kim, C., Jung, S., Han, J., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9072292 · Cited by 6 · see citing works

Mitochondria of trained skeletal muscle are protected from deleterious effects of statins

Bouitbir, J., Daussin, F., Charles, A., Rasseneur, L., Dufour, S. P., Richard, R., Piquard, F., Gény, B., & Zoll, J. (2012) · Muscle & Nerve · doi:10.1002/mus.23309 · Cited by 46 · see citing works

Effects of exercise training on mitochondrial function in atorvastatin-treated rat heart

Heo, J., No, M., Yoo, S.-Z., Park, D., Kang, J., Jung, S., & Kwak, H. (2018)

High-dose atorvastatin therapy progressively decreases skeletal muscle mitochondrial respiratory capacity in humans

RYAN, T. E., Torres, M. J., Lin, C., Clark, A. H., Brophy, P. M., Smith, C. A. S., Smith, C. D., Morris, E. M., Thyfault, J. P., & Neufer, P. D. (2024) · JCI Insight · doi:10.1172/jci.insight.174125 · Cited by 26 · see citing works

Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a ‘mitohormesis’ mechanism involving reactive oxygen species and PGC-1

Bouitbir, J., Charles, A.-L., Echaniz-Laguna, A., Kindo, M., Daussin, F., Auwerx, J., Piquard, F., Geny, B., & Zoll, J. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr224 · Cited by 256 · see citing works