Physiological role of free radicals in skeletal muscles
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A high transmatrix pH gradient appears to contribute more than ΔΨm to O2•− generation with succinate as the substrate.
“Interestingly, a high transmatrix pH gradient appears to contribute more than the ΔΨm to O2•− generation with succinate as the substrate (Fig. 10) (201).”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [201]
Most experimental studies show that even a slight decrease in ΔΨm or transmatrix ΔpH results in marked reduction or cessation of ROS production.
“but most experimental studies show that even a slight decrease in ΔΨm (191, 201, 324) or transmatrix ΔpH (201) results in marked reduction or cessation of ROS production.”
From Mitochondrial reactive oxygen species production in excitable cells: Modulators of mitochondrial and cell function (2009) · cites this paper as [201]
Cites
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855 · see citing works
Peroxisome Proliferator-Activated Receptors: Nuclear Control of Metabolism
Desvergne, B., & Wahli, W. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.5.0380 · Cited by 3,079 · see citing works
Modern thermodynamics: from heat engines to dissipative structures
(1999) · Choice Reviews Online · doi:10.5860/choice.36-4495 · Cited by 1,180 · see citing works
Free Radicals in Biological Materials
Commoner, B., Townsend, J., & Pake, G. E. (1954) · Nature · doi:10.1038/174689a0 · Cited by 743 · see citing works
Oxidative stress and disuse muscle atrophy
Powers, S. K., Kavazis, A. N., & McClung, J. M. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01202.2006 · Cited by 471 · see citing works
Invited Review: Redox modulation of skeletal muscle contraction: what we know and what we don't
Reid, M. B. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.90.2.724 · Cited by 450 · see citing works
Hypoxia-induced reactive oxygen species formation in skeletal muscle
Clanton, T. L. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01298.2006 · Cited by 401 · see citing works
Reactive oxygen in skeletal muscle. II. Extracellular release of free radicals
Reid, M. B., Shoji, T., Moody, M. R., & Entman, M. L. (1992) · Journal of Applied Physiology · doi:10.1152/jappl.1992.73.5.1805 · Cited by 310 · see citing works
Reactive oxygen in skeletal muscle. III. Contractility of unfatigued muscle
Reid, M. B., Khawli, F. A., & Moody, M. R. (1993) · Journal of Applied Physiology · doi:10.1152/jappl.1993.75.3.1081 · Cited by 297 · see citing works
Dual control of relaxation. Its role in the ventricular function in the mammalian heart.
Brutsaert, D. L., Housmans, P. R., & Goethals, M. A. (1980) · Circulation Research · doi:10.1161/01.res.47.5.637 · Cited by 263 · see citing works
The role of free radicals in the pathophysiology of muscular dystrophy
Tidball, J. G., & Wehling‐Henricks, M. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01145.2006 · Cited by 232 · see citing works
The production of reactive oxygen and nitrogen species by skeletal muscle
Jackson, M. J., Pye, D., & Palomero, J. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01102.2006 · Cited by 210 · see citing works
Prediction of amorphous phase stability in the metal–silicon systems
Liu, Y. Q., Shao, G., & Homewood, K. P. (2001) · Journal of Applied Physics · doi:10.1063/1.1381002 · Cited by 174 · see citing works
Classes of Thiols That Influence the Activity of the Skeletal Muscle Calcium Release Channel
Sun, J., Xu, L., Eu, J. P., Stamler, J. S., & Meissner, G. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m100083200 · Cited by 158 · see citing works
Free radical-mediated skeletal muscle dysfunction in inflammatory conditions
Supinski, G. S., & Callahan, L. A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01138.2006 · Cited by 151 · see citing works
Free radical induced respiratory muscle dysfunction
Supinski, G. S. (1998) · Molecular and Cellular Biochemistry · doi:10.1023/a:1006859920875 · Cited by 90 · see citing works
Role of oxidative stress in cardiac dysfunction of PPARα−/−mice
Guellich, A., Damy, T., Lecarpentier, Y., Conti, M., CLAES, V. A., Samuel, J., Quillard, J., Hébert, J., Pineau, T., & Coirault, C. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00037.2007 · Cited by 74 · see citing works
Self-citationModulation of glucose transport in skeletal muscle by reactive oxygen species
Katz, A. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01066.2006 · Cited by 65 · see citing works
Extracellular calcium modulates generation of reactive oxygen species by the contracting diaphragm
Supinski, G. S., Nethery, D. E., Stofan, D. A., & DiMarco, A. F. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.6.2177 · Cited by 40 · see citing works
Tupling, A. R., Vigna, C., Ford, R. J., Tsuchiya, S. C., Graham, D. A., Denniss, S. G., & Rush, J. W. E. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00529.2007 · Cited by 30 · see citing works
Ventilatory muscle activation and inflammation: cytokines, reactive oxygen species, and nitric oxide
Vassilakopoulos, T., & Hussain, S. N. A. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01273.2006 · Cited by 29 · see citing works
Relaxation of the diaphragm muscle: influence of ryanodine and fatigue
Hervé, P., Lecarpentier, Y., Brénot, F., Clergue, M., Chemla, D., & Duroux, P. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.5.1950 · Cited by 28 · see citing works
Self-citationStatistical mechanics of myosin molecular motors in skeletal muscles
Lecarpentier, Y., Blanc, F. –., Quillard, J., Hébert, J., Krokidis, X., & Coirault, C. (2005) · Journal of Theoretical Biology · doi:10.1016/j.jtbi.2005.01.018 · Cited by 24 · see citing works
Self-citationPPARα: essential component to prevent myocardial oxidative stress?
Schulz, R., & Ali, M. A. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00345.2007 · Cited by 4 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Stowe, D. F., & Camara, A. K. S. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2331 · Cited by 471 · see citing works
Bouitbir, J., Charles, A.-L., Echaniz-Laguna, A., Kindo, M., Daussin, F., Auwerx, J., Piquard, F., Geny, B., & Zoll, J. (2012) · European Heart Journal · doi:10.1093/eurheartj/ehr224 · Cited by 256 · see citing works
Barazzoni, R., Zanetti, M., Cappellari, G. G., Semolic, A., Boschelle, M., Codarin, E., Pirulli, A., Cattin, L., & Guarnieri, G. (2011) · Diabetologia · doi:10.1007/s00125-011-2396-x · Cited by 109 · see citing works
Pinheiro, C. H. D. J., de Queiroz, J. C. F., Guimarães‐Ferreira, L., Vitzel, K. F., Nachbar, R. T., de Sousa, L. G. O., de Souza, A. L., Nunes, M. T., & Curi, R. (2011) · Stem Cell Reviews and Reports · doi:10.1007/s12015-011-9304-0 · Cited by 108 · see citing works
Nicastro, H., da Luz, C. R., Chaves, D. F. S., Bechara, L. R. G., Voltarelli, V. A., Rogero, M. M., & Lancha, A. H. (2012) · Journal of Nutrition and Metabolism · doi:10.1155/2012/136937 · Cited by 105 · see citing works
Bouitbir, J., Charles, A.-L., Rasseneur, L., Dufour, S., Piquard, F., Geny, B., & Zoll, J. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00107.2011 · Cited by 86 · see citing works
Miranda‐Vilela, A. L., Pereira, L. C. S., Gonçalves, C. A., & Grisólia, C. K. (2009) · Nutrition Research · doi:10.1016/j.nutres.2009.10.022 · Cited by 75 · see citing works
Miranda‐Vilela, A. L., Akimoto, A. K., Alves, P. C. Z., Pereira, L. C. S., Gonalves, C. A., Klautau-Guimãres, M. N., & Grisólia, C. K. (2009) · Genetics and Molecular Research · doi:10.4238/vol8-4gmr684 · Cited by 55 · see citing works
Evaluation of gene polymorphisms in exercise-induced oxidative stress and damage
Akimoto, A. K., Miranda‐Vilela, A. L., Alves, P. C. Z., Pereira, L. C. D. S., Lordelo, G. S., Hiragi, C. D. O., da Silva, I. C. R., Grisólia, C. K., & Klautau‐Guimarães, M. D. N. (2010) · Free Radical Research · doi:10.3109/10715760903494176 · Cited by 53 · see citing works
Sandiford, S. D. E., Kennedy, K. A., Xie, X., Pickering, J. G., & Li, S. S.-C. (2014) · Cell Communication and Signaling · doi:10.1186/1478-811x-12-5 · Cited by 50 · see citing works
Skeletal and cardiac muscle calcium transport regulation in health and disease
Valentim, M. A., Brahmbhatt, A. N., & Tupling, A. R. (2022) · Bioscience Reports · doi:10.1042/bsr20211997 · Cited by 49 · see citing works
Zhu, Y., Yuyang, H., Li, M., Bingyu, S., Linlin, L., Mingshou, L., Min, Q., Huanan, G., & Xiuqing, Z. (2023) · Food Research International · doi:10.1016/j.foodres.2023.112534 · Cited by 32 · see citing works
Tupling, A. R. (2009) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h09-033 · Cited by 30 · see citing works
Li, D., Lai, Y., Yue, Y., Rabinovitch, P. S., Hakim, C. H., & Duan, D. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006673 · Cited by 29 · see citing works
PPARs, Cardiovascular Metabolism, and Function: Near- or Far-from-Equilibrium Pathways
Lecarpentier, Y., CLAES, V. A., & Hébert, J. (2010) · PPAR Research · doi:10.1155/2010/783273 · Cited by 27 · see citing works
Self-citationMiranda‐Vilela, A. L., Lordelo, G. S., Akimoto, A. K., Alves, P. C. Z., Pereira, L. C. D. S., Klautau‐Guimarães, M. D. N., & Grisólia, C. K. (2011) · Genes & Nutrition · doi:10.1007/s12263-011-0217-y · Cited by 22 · see citing works
Increased oxidative stress in dystrophin deficient (mdx) mice masticatory muscles
SPASSOV, A. W., Gredes, T., Gedrange, T., Pavlović, D., Lupp, A., & Kunert‐Keil, C. (2010) · Experimental and Toxicologic Pathology · doi:10.1016/j.etp.2010.04.006 · Cited by 21 · see citing works
PGC‐1α plays a pivotal role in simvastatin‐induced exercise impairment in mice
Panajatovic, M. V., Singh, F., Roos, N. J., Duthaler, U., Handschin, C., Krähenbühl, S., & Bouitbir, J. (2019) · Acta Physiologica · doi:10.1111/apha.13402 · Cited by 17 · see citing works
Zheng, Z., Yang, X., Liu, J., Qian, P., Hao, L., Wang, Z., & Shun-tang, G. (2017) · RSC Advances · doi:10.1039/c7ra07860a · Cited by 17 · see citing works
Endospanin-2 enhances skeletal muscle energy metabolism and running endurance capacity
Lancel, S., Hesselink, M. K. C., Woldt, E., Rouillé, Y., Dorchies, E., Delhaye, S., Duhem, C., Thorel, Q., Mayeuf-Louchart, A., Pourcet, B., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.98081 · Cited by 16 · see citing works
Ribeiro, I. F., Miranda‐Vilela, A. L., Klautau‐Guimarães, M. D. N., & Grisólia, C. K. (2013) · Lifestyle Genomics · doi:10.1159/000357947 · Cited by 14 · see citing works
Vázquez, P., Tirado-Cortés, A., Álvarez, R., Ronjat, M., Chávez, A. A., & Ortega, A. (2016) · Cell Calcium · doi:10.1016/j.ceca.2016.06.001 · Cited by 10 · see citing works
Ariviani, S., Fauza, G., & Pawestri, C. (2018) · Jurnal Agritech · doi:10.22146/agritech.12739 · Cited by 4 · see citing works
Adenkola, A. Y., Ayo, J. O., Sackey, A. K. B., & Adelaiye, A. B. (2011) · PubMed · Cited by 2 · see citing works
Ação do licopeno nos músculos esquelético e cardíaco sob estresse oxidativo por exercícios
Simões, K., Magosso, R. F., Lagoeiro, C. G., Castellan, V. T., Silva, N. S., Scrivante, B. F., Qualhato, G., Figueiredo, A. C. R., Benetti, E. J., & Rebelo, A. C. S. (2014) · Revista Brasileira de Medicina do Esporte · doi:10.1590/1517-86922014200201518 · Cited by 1 · see citing works
Peters, F. J. (2016) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1 · see citing works
Use of Honey in Sports Medicine
Ooi, F. K., & Chen, C. K. (2023) · doi:10.1002/9781119113324.ch19 · Cited by 1 · see citing works
Fysisk aktivitet och oxidativ stress. En litteraturstudie.
Andersson, A., & Beatrice, M. (2010) · Lund University Publications Student Papers (Lund University)
Zhang, Q., Shuai, Y., Zhang, S., Yi, L., Guanghui, X., Qiang, W., Bao, W., Shiming, Q., Bowei, Z., Yinru, H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.15.676350
Qin, K., & Wu, J. (2026) · Frontiers in Nutrition · doi:10.3389/fnut.2026.1915252
- Authors
- Lecarpentier, Y.
- Corresponding author
- Lecarpentier, Yves
- ORCID
- Lecarpentier, Yves
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-12
- Volume
- 103
- Issue
- 6
- Pages
- 1917-1918
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2081567237
- Cited by
- 32
- References
- 24
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 2 · 2022: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2014: 2 · 2013: 1 · 2012: 1
- FWCI
- 3.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- free radicals, reactive oxygen species, skeletal muscle, oxidative stress, muscle physiology
- MeSH terms
- Animals, Antioxidants, Calcium, Diaphragm, Enzyme Inhibitors, Free Radicals, Glutathione, Humans, Kinetics, Muscle Contraction, Oxidation-Reduction, Sarcoplasmic Reticulum, Signal Transduction, Up-Regulation, Oxidative Stress, Muscle Fatigue, Buthionine Sulfoximine, Sarcoplasmic Reticulum Calcium-Transporting ATPases, Muscle Strength
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review