Cited by 31Natural Products and Biological ResearchLipoproteins and Cardiovascular HealthComplementary and Alternative Medicine Studies

Effect on LDL-cholesterol of a large dose of a dietary supplement with plant extracts in subjects with untreated moderate hypercholesterolaemia: a randomised, double-blind, placebo-controlled study

Barrat, Emmanuel, Zaïr, Yassine, Sirvent, Pascal, Chauveau, Patrice, Maudet, Corinne, Housez, Béatrice, Derbord, Elodie, Lescuyer, Jean-François +3 more·2013·European Journal of Nutrition

Abstract

Purpose To determine the effect of 4 weeks of supplementation, then, withdrawal of a dietary supplement (DS) containing red yeast rice extract, policosanol and artichoke leaf extract at twice the recommended daily dose (6 tablets, 6-TAB) compared to the usual dose (3-TAB) or to a placebo (PLA), on blood lipid profiles and safety biomarkers.Methods Forty-five healthy subjects (15 per group), with untreated hypercholesterolaemia, were included in this randomised, double-blind, placebo-controlled clinical trial.Results After 4 weeks of supplementation, LDL-C was significantly lower in 6-TAB (-0.21 g/l; 95 % CI -0.38 to -0.03 g/l; p = 0.0217) and 3-TAB (-0.25 g/l; 95 % CI -0.42 to -0.07 g/l; p = 0.0071) compared to PLA, although no difference in LDL-cholesterol was observed between the two groups, while no effect was seen on triacylglycerol and HDL-cholesterol. Four weeks after the end of supplementation, no difference in LDL-C was seen between the PLA group and the DS-treated groups. The muscle breakdown biomarkers, as well as biomarkers of liver and renal function, were altered by neither dose of the DS. Acute application of the DS on permeabilised skeletal muscle fibres of rats did not induce deleterious effects on mitochondrial function.Conclusions Supplementation with twice the recommended dose of the DS was effective in reducing LDL-cholesterol and appeared safe, but according to the present results, no additional benefit could be achieved compared to the recommended dose.

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Crossref · 10.1007/s00394-012-0486-2

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Authors
Barrat, E., Zaïr, Y., Sirvent, P., Chauveau, P., Maudet, C., Housez, B., Derbord, E., Lescuyer, J.-F., Bard, J.-M., Cazaubiel, M., & Peltier, S. L.
Affiliations
  • Centre Hospitalier Universitaire de Nantes (FR)
  • Université Clermont Auvergne (FR)
  • Institut de Cancérologie de l'Ouest (FR)
Venue
European Journal of Nutrition
Published
2012-12-25
Volume
52
Issue
8
Pages
1843-1852
ISSN
  • 1436-6207 (ISSN-L)
  • 1436-6215
OpenAlex
W2077513832
Cited by
31
References
35
Citations by year
2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 4 · 2016: 2 · 2015: 2 · 2014: 2 · 2013: 2
FWCI
1.96
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Nutrition (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Natural Products and Biological Research
  • Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
  • Health Sciences › Medicine › Complementary and alternative medicine › Complementary and Alternative Medicine Studies
Keywords
LDL cholesterol, hypercholesterolemia, dietary supplements, red yeast rice extract, policosanol, artichoke leaf extract, dose-response relationship, lipid profile, safety biomarkers, mitochondrial function, skeletal muscle fibers, plant extracts
MeSH terms
Adolescent, Adult, Aged, Animals, Anticholesteremic Agents, Biological Products, Double-Blind Method, Fatty Alcohols, Female, Humans, Hypercholesterolemia, Life Style, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Mitochondria, Plant Extracts, Triglycerides, Biomarkers, Rats, Wistar, Muscle, Skeletal, Plant Leaves, Dietary Supplements, Endpoint Determination, Cynara scolymus, Rats, Young Adult, Recommended Dietary Allowances

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