Rehydration with glycerol: endocrine, cardiovascular, and thermoregulatory responses during exercise in the heat
Abstract
The impact of rehydration with glycerol on cardiovascular and thermoregulatory responses during exercise in the heat was studied in eight highly trained male cyclists. Each subject completed three dehydration-rehydration experimental trials that differed only in the rehydration treatment, each separated by 7 days. Before each experimental day, subjects dehydrated to -4% of their body weight by exercise and water restriction. The experimental treatments were as follows: no fluid (NF), glycerol bolus (1 g/kg body wt) followed by water (G), and water alone (W). Rehydration (3% body weight) was given over an 80-min period. After rehydration, subjects cycled (74% peak O2 uptake) to exhaustion in a hot and wet (37 degrees C and 48% relative humidity) environment. For G, plasma volume was expanded (P < 0.05) during rehydration and remained higher than W (P < 0.05) during exercise. Exercise time to exhaustion during G (33 +/- 4 min) was longer (P < 0.05) compared with both W (27 +/- 3 min) and NF (19 +/- 3 min). Cutaneous vascular conductance was significantly elevated (P < 0.05) during G, but G provided no other thermoregulatory or cardiovascular benefits compared with W and NF. Fluid-regulating hormones (vasopressin, aldosterone, atriopeptin, and plasma renin activity) decreased during rehydration and increased during exercise (except atriopeptin), but there were no differences between G and W. These data indicated that glycerol had little or no major effect on fluid-regulating factors during rehydration or exercise, and the improved exercise capacity in G was likely due to a greater plasma volume during exercise.
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If recovery time is less than 12 h, more aggressive rehydration strategies and moisturizing beverages such as glycerol are required before the next training or competition.
“However, if the recovery time is less than 12 h, more aggressive rehydration strategies and the use of moisturizing beverages (e.g., glycerol) are required before the next training or competition [25].”
From The 4R’s Framework of Nutritional Strategies for Post-Exercise Recovery: A Review with Emphasis on New Generation of Carbohydrates (2020) · cites this paper as [25]
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“, glycerol) are required before the next training or competition [25].”
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- Authors
- Kavouras, S. A., Armstrong, L. E., Maresh, C. M., Casa, D. J., Herrera-Soto, J. A., Scheett, T. P., Stoppani, J., Mack, G. W., & Kraemer, W. J.
- Affiliations
- University of Connecticut (US)
- Yale University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2006-02
- Volume
- 100
- Issue
- 2
- Pages
- 442-450
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W1986122653
- Cited by
- 59
- References
- 49
- Citations by year
- 2025: 2 · 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 4 · 2015: 4 · 2014: 6 · 2013: 2 · 2012: 7
- FWCI
- 1.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Connecticut
- National Heart, Lung, and Blood Institute (HL39818)
- Topics
- Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Rehabilitation › Exercise and Physiological Responses
- Keywords
- exercise in the heat, dehydration, plasma expansion, thermoregulation, cutaneous vascular conductance, vasopressin, aldosterone, atriopeptin, plasma renin activity, time to exhaustion, cyclists
- MeSH terms
- Adult, Body Temperature Regulation, Cardiovascular Physiological Phenomena, Dehydration, Drinking, Endocrine System, Exercise Test, Fluid Therapy, Glycerol, Hot Temperature, Hormones, Humans, Male, Plasma Volume, Regional Blood Flow, Skin, Time Factors, Vascular Resistance, Water-Electrolyte Balance, Exercise, Rehydration Solutions
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