Active hexose correlated compound enhances resistance to Klebsiella pneumoniae infection in mice in the hindlimb-unloading model of spaceflight conditions
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Previous studies have demonstrated that resistance to infection is decreased in Swiss Webster female mice maintained in the hindlimb-unloading model (Aviles H, Belay T, Fountain K, Vance M, and Sonnenfeld G. J Appl Physiol 95: 73-80, 2003; Belay T, Aviles H, Vance M, Fountain K, and Sonnenfeld G. J Allergy Clin Immunol 110: 262-268, 2002). This is a model of some of the aspects of spaceflight conditions, including lack of load bearing on hindlimbs and a fluid shift to the head. Active hexose correlated compound (AHCC), extracted from Basidiomycete mushrooms, has been shown to induce enhancement of immune responses, including enhanced natural killer activity. In the present study, AHCC was orally administered to mice to determine whether the treatment could decrease immunosuppression and mortality of mice maintained in the hindlimb-unloaded model and infected with Klebsiella pneumoniae. The results of the present study showed that administration of AHCC by gavage for 1 wk (1 g/kg body wt) before suspension and throughout the 10-day suspension period yielded significant beneficial effects for the hindlimb-unloaded group, including 1). decreased mortality, 2). increased time to death, and 3). increased ability to clear bacteria. The results suggest that AHCC can decrease the deleterious effects of the hindlimb-unloading model on immunity and resistance to infection.
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Increased susceptibility to infection under space flight conditions has been observed.
“An increased susceptibility to infection under space flight conditions has also been observed [15], [16], [17], [18], [19], [20], [21].”
From Hindlimb suspension and spe-like radiation impairs clearance of bacterial infections (2014) · cites this paper as [15]
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- Authors
- Aviles, H., Belay, T., Fountain, K., Vance, M., Sun, B., & Sonnenfeld, G.
- ORCID
- Belay, Tesfaye
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2003-08
- Volume
- 95
- Issue
- 2
- Pages
- 491-496
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2110501148
- Cited by
- 59
- References
- 49
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 5 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 4 · 2014: 6 · 2013: 3 · 2012: 1
- FWCI
- 1.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Journal of Applied Physiology (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (5G12 RR/AI 03034)
- Topics
- Health Sciences › Medicine › Physiology › Spaceflight effects on biology
- Health Sciences › Medicine › Pharmacology › Fungal Biology and Applications
- Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
- Keywords
- AHCC, Klebsiella pneumoniae infection, hindlimb unloading, immunosuppression, bacterial clearance, mortality, mushroom extracts, immune enhancement, fluid shifts, microgravity
- MeSH terms
- Administration, Oral, Animals, Antibodies, Bacterial, Disease Susceptibility, Female, Hexoses, Immunoglobulin G, Immunosuppression Therapy, Klebsiella Infections, Klebsiella pneumoniae, Lethal Dose 50, Polysaccharides, Space Flight, Colony Count, Microbial, Survival Analysis, Hindlimb Suspension, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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