Cited by 108Heat shock proteins researchStress Responses and CortisolThermoregulation and physiological responses

The DOI matches its Crossref record; 49 of the 51 references it cites were found in a registry or an index.

Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72

Johnson, John D., Campisi, Jay, Sharkey, Craig M., Kennedy, Sarah L., Nickerson, Molly, Fleshner, Monika·2005·Journal of Applied Physiology

DOI 10.1152/japplphysiol.00390.2005

Open this paper in CoChat — free account

Abstract

Heat-shock protein concentrations in the blood increase after exposure to a variety of stressors, including trauma and psychological stress. Although the physiological function of extracellular heat shock protein remains controversial, there is evidence that extracellular heat shock protein 72 (Hsp72) can facilitate immunologic responses. The signal(s) that mediate(s) the in vivo elevation of extracellular Hsp72 in the blood after stressor exposure remain(s) unknown. Here we report that Hsp72 increases in the circulation via an α 1-adrenergic receptor-mediated signaling pathway. Activation of α 1-adrenoceptors results in a rapid increase in circulating Hsp72, and blockade of α 1-adrenoceptors prevents the stress-induced rise in circulating Hsp72. Furthermore, our studies exclude a role for β-adrenoceptors, glucocorticoids, and ACTH in mediating stress-induced elevations in circulating extracellular Hsp72. Understanding the signals involved in elevating extracellular Hsp72 could facilitate the use of extracellular Hsp72 to bolster immunity and perhaps prevent exacerbation of inflammatory diseases during stress.

Integrity signals

Registry

Crossref · 10.1152/japplphysiol.00390.2005

Cites

49 of 49 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

HSP70 stimulates cytokine production through a CD14-dependant pathway, demonstrating its dual role as a chaperone and cytokine
Asea, A. A. A., Kraeft, S., Kurt‐Jones, E. A., Stevenson, M. A., Chen, L. B., Finberg, R. W., Koo, G. C., & Calderwood, S. K. (2000) · Nature Medicine · doi:10.1038/74697 · Cited by 1,642
Novel Signal Transduction Pathway Utilized by Extracellular HSP70
Asea, A., Rehli, M., Kabingu, E., Boch, J. A., Baré, O., Auron, P. E., Stevenson, M. A., & Calderwood, S. K. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m200497200 · Cited by 1,510
Interaction of Heat Shock Proteins with Peptides and Antigen Presenting Cells: Chaperoning of the Innate and Adaptive Immune Responses
Srivastava, P. K. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064801 · Cited by 846
Exosome Release Is Regulated by a Calcium-dependent Mechanism in K562 Cells
Savina, A., Furlán, M., Vidal, M., & Colombo, M. I. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m301642200 · Cited by 835
Overflow of catecholamine neurotransmitters to the circulation: source, fate, and functions
Esler, M., Jennings, G., Lambert, G., Meredith, I., Horne, M., & Eisenhofer, G. (1990) · Physiological Reviews · doi:10.1152/physrev.1990.70.4.963 · Cited by 794 · cited 1×
“Exposure to stressors, including tail-shock stress, stimulates sympathetic postganglionic neurons, resulting in norepinephrine release onto peripheral tissues (spillover can be measured in plasma) and sympathetic preganglionic neurons innervating the adrenal medulla to result in epinephrine release into the blood (14).”
Exosome-dependent Trafficking of HSP70
Lancaster, G. I., & Febbraio, M. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m502017200 · Cited by 547
Endotoxin Contamination in Recombinant Human Heat Shock Protein 70 (Hsp70) Preparation Is Responsible for the Induction of Tumor Necrosis Factor α Release by Murine Macrophages
Gao, B., & Tsan, M.-F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m208742200 · Cited by 396
&cestflwr; The Hsp90 family of proteins in Arabidopsis thaliana
Krishna, P., & Gloor, G. B. (2001) · Cell Stress and Chaperones · doi:10.1379/1466-1268(2001)006 · Cited by 360
Microglial activation and amyloid‐β clearance induced by exogenous heat‐shock proteins
Kakimura, J., Kitamura, Y., Takata, K., Umeki, M., Suzuki, S., Shibagaki, K., Taniguchi, T., Nomura, Y., Gebicke‐Haerter, P. J., Smith, M. A., et al. (2002) · The FASEB Journal · doi:10.1096/fj.01-0530fje · Cited by 333
In vitro studies show that Hsp70 can be released by glia and that exogenous Hsp70 can enhance neuronal stress tolerance
Guzhova, I. V., Kislyakova, K., Moskaliova, O., Fridlanskaya, I., Tytell, M., Cheetham, M. E., & Margulis, B. A. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02774-3 · Cited by 321

Flagged first, then by citations

Show all 51 references

2 of the 51 references couldn’t be matched to a known paper.

Research works printed but not linked: 1

10.1379/1466-1268(2001)006<0386:EISHIH>2.0.CO;2 · DOI

Sorted by citations

The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479
“For example, they increase in the brain during synaptic firing (305) and in the periphery during acute mental (52, 273) or physical stress (13).”
Background
Neural regulation of innate immunity: a coordinated nonspecific host response to pathogens
Sternberg, E. M. (2006) · Nature Reviews Immunology · doi:10.1038/nri1810 · Cited by 1,064
Invited Review: Genes Involved in the Bovine Heat Stress Response
Collier, R. J., Collier, J. L., Rhoads, R. P., & Baumgard, L. H. (2008) · Journal of Dairy Science · doi:10.3168/jds.2007-0540 · Cited by 454
Releasing signals, secretory pathways, and immune function of endogenous extracellular heat shock protein 72
Johnson, J. D., & Fleshner, M. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905523 · Cited by 251
Self-citation
Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders
Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216
Self-citation
Exosomes, DAMPs and miRNA: Features of Stress Physiology and Immune Homeostasis
Fleshner, M., & Crane, C. R. (2017) · Trends in Immunology · doi:10.1016/j.it.2017.08.002 · Cited by 212
Self-citation
The Chaperone Balance Hypothesis: The Importance of the Extracellular to Intracellular HSP70 Ratio to Inflammation‐Driven Type 2 Diabetes, the Effect of Exercise, and the Implications for Clinical Management
Krause, M. D. S., Heck, T. G., Bittencourt, A., Scomazzon, S. P., Newsholme, P., Curi, R., & de Bittencourt, P. I. H. (2015) · Mediators of Inflammation · doi:10.1155/2015/249205 · Cited by 178
Upregulation of Phagocyte-Derived Catecholamines Augments the Acute Inflammatory Response
Flierl, M. A., Rittirsch, D., Nadeau, B. A., Sarma, J. V., Day, D. E., Lentsch, A. B., Huber-Lang, M. S., & Ward, P. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004414 · Cited by 168
Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.07.013 · Cited by 165
The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure
Maslanik, T., Mahaffey, L., Tannura, K., Beninson, L., Greenwood, B. N., & Fleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.10.014 · Cited by 156
Self-citation
Neuroendocrine Regulation of Brain Cytokines After Psychological Stress
Johnson, J. D., Barnard, D. F., Kulp, A. C., & Mehta, D. M. (2019) · Journal of the Endocrine Society · doi:10.1210/js.2019-00053 · Cited by 135
Self-citation
Stress-evoked sterile inflammation, danger associated molecular patterns (DAMPs), microbial associated molecular patterns (MAMPs) and the inflammasome
Fleshner, M. (2013) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2012.08.012 · Cited by 126
Self-citation
Exosomes: An emerging factor in stress-induced immunomodulation
Beninson, L. A., & Fleshner, M. (2014) · Seminars in Immunology · doi:10.1016/j.smim.2013.12.001 · Cited by 125
Self-citation
Exercise Intensity and Duration Affect Blood Soluble HSP72
Fehrenbach, E., Niess, A. M., Voelker, K., Northoff, H., & Mooren, F. C. (2005) · International Journal of Sports Medicine · doi:10.1055/s-2004-830334 · Cited by 118
Effects of chronic heat stress on plasma concentration of secreted heat shock protein 70 in growing feedlot cattle1
Gaughan, J. B., Bonner, S. L., Loxton, I., & Mader, T. L. (2012) · Journal of Animal Science · doi:10.2527/jas.2012-5294 · Cited by 110
HSP70 expression: does it a novel fatigue signalling factor from immune system to the brain?
Heck, T. G., Schöler, C. M., & de Bittencourt, P. I. H. (2011) · Cell Biochemistry and Function · doi:10.1002/cbf.1739 · Cited by 101
Heat shock protein 70 down-regulates the production of toll-like receptor-induced pro-inflammatory cytokines by a heat shock factor-1/constitutive heat shock element-binding factor-dependent mechanism
Ferat-Osorio, E. A., Sánchez-Anaya, A., Gutiérrez-Mendoza, M., Boscó-Gárate, I., Wong‐Baeza, I., Pastelin‐Palacios, R., Pedraza‐Alva, G., Bonifaz, L. C., Cortés‐Reynosa, P., Perez‐Salazar, E., et al. (2014) · Journal of Inflammation · doi:10.1186/1476-9255-11-19 · Cited by 100
Interleukin-1 receptor type 1-deficient mice fail to develop social stress-associated glucocorticoid resistance in the spleen
Engler, H., Bailey, M. T., Engler, A., Stiner-Jones, L. M., Quan, N., & Sheridan, J. F. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2007.10.007 · Cited by 97
Heat-shock proteins: new keys to the development of cytoprotective therapies
Kim, H. P., Morse, D., & Choi, A. M. K. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.5.759 · Cited by 79
Heat shock protein 72 : release and biological significance during exercise
Whitham, M. (2007) · Frontiers in bioscience · doi:10.2741/2765 · Cited by 78
Postischemic Brain Injury Is Attenuated in Mice Lacking the β2-Adrenergic Receptor
Han, R., Ouyang, Y., Xu, L., Agrawal, R., Patterson, A. J., & Giffard, R. G. (2008) · Anesthesia & Analgesia · doi:10.1213/ane.0b013e318187ba6b · Cited by 73
Mechanisms of stress-induced cellular HSP72 release: implications for exercise-induced increases in extracellular HSP72
Lancaster, G. I., & Febbraio, M. A. (2026) · PubMed · doi:10.22029/eir.2005.1614 · Cited by 72
Old Friends, immunoregulation, and stress resilience
Langgartner, D., Lowry, C. A., & Reber, S. O. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2228-7 · Cited by 76
The regulatory roles of NADPH oxidase, intra- and extra-cellular HSP70 in pancreatic islet function, dysfunction and diabetes
Krause, M. D. S., Bock, P. M., Takahashi, H., de Bittencourt, P. I. H., & Newsholme, P. (2015) · Clinical Science · doi:10.1042/cs20140695 · Cited by 71
Cross-Adaptation: Heat and Cold Adaptation to Improve Physiological and Cellular Responses to Hypoxia
Gibson, O. R., Taylor, L. K., Watt, P., & Maxwell, N. (2017) · Sports Medicine · doi:10.1007/s40279-017-0717-z · Cited by 69
The characterization of a concentration-sensitive α-adrenergic-like octopamine receptor found on insect immune cells and its possible role in mediating stress hormone effects on immune function
Huang, J., Wu, S., Li, X., Adamo, S. A., & Yè, G. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.04.007 · Cited by 67
Acute Stressor Exposure Modifies Plasma Exosome-Associated Heat Shock Protein 72 (Hsp72) and microRNA (miR-142-5p and miR-203)
Beninson, L. A., Brown, P. N., Loughridge, A. B., Saludes, J. P., Maslanik, T., Hills, A., Woodworth, T. T., Craig, W. C., Yin, H. H., & Fleshner, M. (2014) · PLoS ONE · doi:10.1371/journal.pone.0108748 · Cited by 65
Self-citation
Acute exercise boosts cell proliferation and the heat shock response in lymphocytes: correlation with cytokine production and extracellular-to-intracellular HSP70 ratio
Heck, T. G., Scomazzon, S. P., Nunes, P. R., Schöler, C. M., da Silva, G. S., Bittencourt, A., Faccioni‐Heuser, M. C., Krause, M. D. S., Bazotte, R. B., Curi, R., et al. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0771-3 · Cited by 63
Heat Shock Protein 72 Response to Exercise in Humans
Yamada, P. M., Amorim, F. T., Moseley, P. L., & Schneider, S. M. (2008) · Sports Medicine · doi:10.2165/00007256-200838090-00002 · Cited by 62
Voluntary wheel running: a useful rodent model for investigating mechanisms of stress robustness and exercise motivation
Greenwood, B. N., & Fleshner, M. (2019) · Current Opinion in Behavioral Sciences · doi:10.1016/j.cobeha.2019.02.001 · Cited by 60
Self-citation
Hepatokines—A novel group of exercise factors
Weigert, C., Hoene, M., & Plomgaard, P. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2216-y · Cited by 57
Heat-Shock Proteins as Endogenous Ligands Building a Bridge Between Innate and Adaptive Immunity
Tamura, Y., Torigoe, T., Kukita, K., Saito, K., Okuya, K., Kutomi, G., Hirata, K., & Sato, N. (2012) · Immunotherapy · doi:10.2217/imt.12.75 · Cited by 58
Impact of Exercise and Metabolic Disorders on Heat Shock Proteins and Vascular Inflammation
Noble, E. G., & Shen, G. X. (2012) · Autoimmune Diseases · doi:10.1155/2012/836519 · Cited by 52
Causal neuro-immune relationships at patients with chronic pyelonephritis and cholecystitis. Correlations between parameters EEG, HRV and white blood cell count
Kul’chyns’kyi, A. B., Kyjenko, V. M., Żukow, W., & Popovych, I. L. (2017) · Open Medicine · doi:10.1515/med-2017-0030 · Cited by 51
Extracellular heat shock proteins (eHSP70) in exercise: Possible targets outside the immune system and their role for neurodegenerative disorders treatment
Krause, M. D. S., & Rodrigues-Krause, J. D. C. (2010) · Medical Hypotheses · doi:10.1016/j.mehy.2010.10.025 · Cited by 45
Role of Hsp72 and norepinephrine in the moderate exercise-induced stimulation of neutrophils’ microbicide capacity
Ortega, E., Giraldo, E., Hinchado, M. D., Martinez, M., Ibáñez, S. J., Cidoncha, A., Collazos, M. E., & García, J. J. (2006) · European Journal of Applied Physiology · doi:10.1007/s00421-006-0269-7 · Cited by 44
Human resting extracellular heat shock protein 72 concentration decreases during the initial adaptation to exercise in a hot, humid environment
Marshall, H. C., Ferguson, R. A., & Nimmo, M. A. (2006) · Cell Stress and Chaperones · doi:10.1379/csc-158r.1 · Cited by 44
Elevation of body temperature is an essential factor for exercise-increased extracellular heat shock protein 72 level in rat plasma
Ogura, Y., Naıto, H., Akın, Ş., Ichinoseki‐Sekine, N., Kurosaka, M., Kakigi, R., Sugiura, T., Powers, S. K., Katamoto, S., & Demirel, H. A. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00581.2007 · Cited by 41
Effect of exercise with and without a thermal clamp on the plasma heat shock protein 72 response
Whitham, M., Laing, S. J., Jackson, A. R., Maassen, N., & Walsh, N. P. (2007) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00484.2007 · Cited by 41
Heat shock response during the resolution of inflammation and its progressive suppression in chronic-degenerative inflammatory diseases
Schroeder, H. T., Muller, C. H. D. L., Heck, T. G., Krause, M. D. S., & de Bittencourt, P. I. H. (2024) · Cell Stress and Chaperones · doi:10.1016/j.cstres.2024.01.002 · Cited by 44
Nitric oxide-heat shock protein axis in menopausal hot flushes: neglected metabolic issues of chronic inflammatory diseases associated with deranged heat shock response
Miragem, A. A., & de Bittencourt, P. I. H. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx020 · Cited by 39
Effect of caffeine supplementation on the extracellular heat shock protein 72 response to exercise
Whitham, M., Walker, G. J., & BISHOP, N. C. (2006) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00409.2006 · Cited by 39
Chaperokine Function of Recombinant Hsp72 Produced in Insect Cells Using a Baculovirus Expression System Is Retained
Zheng, H., Nagaraja, G. M., Kaur, P., Asea, E. E., & Asea, A. A. A. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.024612 · Cited by 37
Adrenergic and glucocorticoid modulation of the sterile inflammatory response
Cox, S. S., Speaker, K. J., Beninson, L. A., Craig, W. C., Paton, M. M., & Fleshner, M. (2014) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2013.11.018 · Cited by 35
Self-citation
Short-term but not long-term hypoglycaemia enhances plasma levels and hepatic expression of HSP72 in insulin-treated rats: an effect associated with increased IL-6 levels but not with IL-10 or TNF–α
Ludwig, M. S., Minguetti‐Câmara, V. C., Heck, T. G., Scomazzon, S. P., Nunes, P. R., Bazotte, R. B., & de Bittencourt, P. I. H. (2014) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-014-2176-2 · Cited by 35
Potential Role of Neurogenic Inflammatory Factors in the Pathogenesis of Vitiligo
Yu, R., Huang, Y., Zhang, X., & Zhou, Y. (2012) · Journal of Cutaneous Medicine and Surgery · doi:10.1177/120347541201600404 · Cited by 32
Expression of HSP70 in Mytilus californianus following exposure to caffeine
del Rey, Z. R., Granek, E. F., & Buckley, B. A. (2011) · Ecotoxicology · doi:10.1007/s10646-011-0649-6 · Cited by 31
Brief maternal separation affects brain α1-adrenoceptors and apoptotic signaling in adult mice
Coccurello, R., Bielawski, A., Zelek-Molik, A., Vetulani, J., Kowalska, M., D'Amato, F. R., & Nalepa, I. (2013) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2013.10.004 · Cited by 29
Noradrenaline increases the expression and release of Hsp72 by human neutrophils
Giraldo, E., Multhoff, G., & Ortega, E. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.02.003 · Cited by 30
Aspirin Enhances the Protection of Hsp90 from Heat-Stressed Injury in Cardiac Microvascular Endothelial Cells Through PI3K-Akt and PKM2 Pathways
Zhang, X., Chen, B., Wu, J., Sha, J., Yang, B., Zhu, J., Sun, J., Hartung, J., & Bao, E. (2020) · Cells · doi:10.3390/cells9010243 · Cited by 30
Hsp72, inflammation, and aging: causes, consequences, and perspectives
Ortega, E., Bote, E., Besedovsky, H. O., & del Rey, A. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06619.x · Cited by 26
Stress-induced facilitation of host response to bacterial challenge in F344 rats is dependent on extracellular heat shock protein 72 and independent of alpha beta T cells
Campisi, J., Sharkey, C. M., Johnson, J. D., Asea, A. A. A., Maslanik, T., Bernstein-Hanley, I., & Fleshner, M. (2012) · Stress · doi:10.3109/10253890.2011.653596 · Cited by 25
Self-citation
Labetalol Prevents Intestinal Dysfunction Induced by Traumatic Brain Injury
Lang, Y., Fu, F., Sun, D., Xi, C.-H., & Chen, F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133215 · Cited by 22
Chronic Stress Increases Transcriptomic Indicators of Biological Aging in Mouse Bone Marrow Leukocytes
Rentscher, K. E., Carroll, J. E., Polsky, L. R., & Lamkin, D. M. (2022) · Brain, Behavior, & Immunity - Health · doi:10.1016/j.bbih.2022.100461 · Cited by 21
Social Stress Increases Vulnerability to High-Fat Diet-Induced Insulin Resistance by Enhancing Neutrophil Elastase Activity in Adipose Tissue
Motoyama, S., Yamada, H., Yamamoto, K., Wakana, N., Terada, K., Kikai, M., Wada, N., Saburi, M., Sugimoto, T., Kubota, H., et al. (2020) · Cells · doi:10.3390/cells9040996 · Cited by 20
Role of alpha- and beta-adrenoreceptors in rat monocyte/macrophage function at rest and acute exercise
Rossato, J. D. S., Krause, M. D. S., Fernandes, A. J. M., Fernandes, J. R., Seibt, I. L., Rech, A., & de Bittencourt, P. I. H. (2014) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-013-0310-3 · Cited by 21
Regulation of bovine pyruvate carboxylase mRNA and promoter expression by thermal stress1
White, H. M., Koser, S. L., & Donkin, S. S. (2012) · Journal of Animal Science · doi:10.2527/jas.2010-3408 · Cited by 18
Heat shock protein 90 relieves heat stress damage of myocardial cells by regulating Akt and PKM2 signaling in�vivo
Zhang, X., Wu, J., Sha, J., Yang, B., Sun, J., & Bao, E. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4560 · Cited by 17
72 kDa Extracellular Heat Shock Protein (eHsp72), Norepinephrine (NE), and the Innate Immune Response Following Moderate Exercise
Ortega, E., Giraldo, E., Hinchado, M. D., Martín-Cordero, L., & García, J. J. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_19 · Cited by 16
Extracellular Hsp 72: A Double-Edged Sword for Host Defense
Fleshner, M., Johnson, J. D., & Friedman, J. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5585-0_15 · Cited by 15
Self-citation
Posttraumatic stress and immune dissonance
Jiang, J. (2008) · Chinese Journal of Traumatology · doi:10.1016/s1008-1275(08)60044-9 · Cited by 15
Adrenoreceptors are involved in the stimulation of neutrophils by exercise‐induced circulating concentrations of Hsp72: cAMP as a potential “intracellular danger signal”
Hinchado, M. D., Giraldo, E., & Ortega, E. (2011) · Journal of Cellular Physiology · doi:10.1002/jcp.22759 · Cited by 15
Estrogen deprivation does not affect vascular heat shock response in female rats: a comparison with oxidative stress markers
Miragem, A. A., Ludwig, M. S., Heck, T. G., Baldissera, F. G., dos Santos, A. B., Frizzo, M. N., & de Bittencourt, P. I. H. (2015) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-015-2472-5 · Cited by 15
The expression of thioredoxin-1 in acute epinephrine stressed mice
Jia, J., Zeng, X., Li, K., Ma, L., Chen, L., & Song, X. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0722-4 · Cited by 13
Hsp70 in the atrial neuroendocrine units of the snail, Achatina fulica
Martynova, M. G., Bystrova, O. A., Shabelnikov, S., Margulis, B. A., & Prokofjeva, D. S. (2007) · Cell Biology International · doi:10.1016/j.cellbi.2007.01.027 · Cited by 12
Salivary Hsp72 does not track exercise stress and caffeine-stimulated plasma Hsp72 responses in humans
Fortes, M. B., & Whitham, M. (2011) · Cell stress & chaperones (Print) · doi:10.1007/s12192-010-0244-4 · Cited by 10
Heat Therapy: Targeting Health, Disease, and Disability
Richey, R. E., Hyldahl, R. D., Kaiser, B. W., Geiger, P. C., Halliwill, J. R., & Minson, C. T. (2026) · Comprehensive physiology · doi:10.1002/cph4.70089 · Cited by 11
Acute isoproterenol induces anxiety-like behavior in rats and increases plasma content of extracellular vesicles
Leo, G., Guescini, M., Genedani, S., Stocchi, V., Carone, C., Filaferro, M., Sisti, D., Marcoli, M., Maura, G., Cortelli, P., et al. (2015) · Physiology & Behavior · doi:10.1016/j.physbeh.2015.02.002 · Cited by 10
Hsp70 response in pigs is affected by their Halothane genotypes after heat stress
Khazzaka, A., Figwer, P., Poirel, M., Serrar, M., & Franck, M. (2006) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2006.08.003 · Cited by 10
Expression Dynamics of Heat Shock Proteins (HSP) in Livestock under Thermal Stress
Dangi, S. S., Bharati, J., Samad, H. A., Bhure, S. K., Singh, G., Maurya, V. P., Sarkar, M., & Kumar, P. (2017) · Heat shock proteins · doi:10.1007/978-3-319-73377-7_2 · Cited by 9
Fatiguing stimulation of one skeletal muscle triggers heat shock proteins activation in several rat organs: the role of muscle innervation
Jammes, Y., Steinberg, J. G., By, Y., Brerro‐Saby, C., Condo, J., Olivier, M., Guieu, R., & Delliaux, S. (2012) · Journal of Experimental Biology · doi:10.1242/jeb.074427 · Cited by 9
Endogenous Extracellular Hsp72 Release Is an Adaptive Feature of the Acute Stress Response
Fleshner, M., Sharkey, C. M., Nickerson, M., & JOHNSON, J. D. (2007) · Elsevier eBooks · doi:10.1016/b978-012088576-3/50055-1 · Cited by 9
Self-citation
Next-Generation Ecological Immunology
Zylberberg, M. (2019) · Physiological and Biochemical Zoology · doi:10.1086/702440 · Cited by 9
Release of Heat Shock Proteins: Passive Versus Active Release Mechanisms
Asea, A. A. A. (2007) · Springer eBooks · doi:10.1007/978-1-4020-5585-0_1 · Cited by 9
Combined activity of post‐exercise concentrations of NA and eHsp72 on human neutrophil function: Role of cAMP
Giraldo, E., Hinchado, M. D., & Ortega, E. (2013) · Journal of Cellular Physiology · doi:10.1002/jcp.24354 · Cited by 8
The effects of heat stress in Jersey, Hungarian Simmental and Holstein-Friesian cows
Jurkovich, V., Somoskői, B., Kovács, L., & Bakony, M. (2022) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/155410/2022 · Cited by 7
Elevated Expression of HSP72 in the Prefrontal Cortex and Hippocampus of Rats Subjected to Chronic Mild Stress and Treated with Imipramine
Bielawski, A., Zelek-Molik, A., Rafa–Zabłocka, K., Kowalska, M., Gruca, P., Papp, M., & Nalepa, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms25010243 · Cited by 9
Role of heat shock proteins in the cardioprotection of regular moderate alcohol consumption
Guisasola, M. C. (2016) · Medicina Clínica (English Edition) · doi:10.1016/j.medcle.2016.05.044 · Cited by 7
Exercise Intensity and Duration Affect Blood-Soluble HSP72
Ogawa, K., & Fehrenbach, E. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_15 · Cited by 7
The mechanisms of the widespread production of phosphorylated HSP25 after fatiguing muscle stimulation
Jammes, Y., Steinberg, J. G., Olivier, M., Brerro‐Saby, C., Condo, J., Ravailhe, S., Guieu, R., & Delliaux, S. (2013) · Journal of Experimental Biology · doi:10.1242/jeb.088898 · Cited by 6
Carbohydrate, but not fat, oxidation is reduced during moderate-intensity exercise performed in 33 vs. 18 °C at matched heart rates
Charoensap, T., Kilding, A. E., & Maunder, E. (2023) · European Journal of Applied Physiology · doi:10.1007/s00421-023-05225-0 · Cited by 7
Cytosolic calcium transients are a determinant of contraction-induced HSP72 transcription in single skeletal muscle fibers
Stary, C. M., & Hogan, M. C. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01060.2015 · Cited by 6
In Vivo Tissue Source and Releasing Signal for Endogenous Extracellular Hsp72
Fleshner, M., Maslanik, T., & Beninson, L. A. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_12 · Cited by 5
Self-citation
Proteínas de choque térmico en la cardioprotección del consumo moderado regular de alcohol
Guisasola, M. C. (2016) · Medicina Clínica · doi:10.1016/j.medcli.2015.12.011 · Cited by 5
Early detection and progression of insulin resistance revealed by impaired organismal anti-inflammatory heat shock response during ex vivo whole-blood heat challenge
Schroeder, H. T., Muller, C. H. D. L., Rodrigues, M. I. L., de Azevedo, M. A., Heck, T. G., Krause, M. D. S., & de Bittencourt, P. I. H. (2024) · Clinical Science · doi:10.1042/cs20243515 · Cited by 4
Increasing heat storage by wearing extra clothing during upper body exercise up-regulates heat shock protein 70 but does not modify the cytokine response
Leicht, C. A., Papanagopoulos, A., Haghighat, S., & Faulkner, S. H. (2016) · Journal of Sports Sciences · doi:10.1080/02640414.2016.1235795 · Cited by 4
Gingko biloba extract EGB761 alleviates heat-stress damage in chicken heart tissue by stimulating Hsp70 expression in vivo in vascular endothelial cells
ZHANG, X., Zhang, M., Wu, J., Li, Y. B., Sun, J. R., Tang, S., & Bao, E. (2019) · British Poultry Science · doi:10.1080/00071668.2019.1697425 · Cited by 4
HSP, Exercise and Skeletal Muscle
Noble, E. G., Melling, C. W. J., & Milne, K. J. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_17 · Cited by 4
Any beneficial effects of mycobacteria on multiple sclerosis and experimental autoimmune encephalitis may include stimulation of the sympathetic nervous system
Shahabi, S., Hassan, Z. M., & Jazani, N. H. (2006) · Medical Hypotheses · doi:10.1016/j.mehy.2006.01.021 · Cited by 3
Release of Heat Shock Proteins and their Effects When in the Extracellular Space in the Nervous System
Tytell, M., Robinson, M., & Milligan, C. E. (2008) · Springer eBooks · doi:10.1007/978-1-4020-8231-3_13 · Cited by 3
Stress-induced Sympathetic Nervous System Activation Contributes to Both Suppressed Acquired Immunity and Potentiated Innate Immunity: The Role of Splenic NE Depletion and Extracellular Hsp72
Fleshner, M. (2006) · Springer eBooks · doi:10.1007/978-0-387-48334-4_3 · Cited by 3
Self-citation
Reaction Kinetics Modeling of eHsp70 Induced by Norepinephrine in Response to Exercise Stress
Lovas, A., Szilágyi, B., Bosnyák, E., Ács, P., Olah, A., Komka, Z., Tóth, M., Merkely, B. P., Németh, E., Gilányi, B., et al. (2020) · International Journal of Sports Medicine · doi:10.1055/a-1224-3792 · Cited by 2
Monocarboxylate transporters and heat shock proteins in domestic pigs in relation to stress and meat quality
Sepponen, K. (2008) · Työväentutkimus Vuosikirja · Cited by 2
Occurrence and Concentrations of Caffeine in Seawater from the Oregon Coast and Potential Effects on the Dominant Mussel, Mytilus californianus
del Rey, Z. R. (2000) · doi:10.15760/etd.722 · Cited by 2
Exercício agudo versus imunossupressão: talvez apenas outro mecanismo homeostático
Nunes, E. A., & Fernandes, L. C. (2009) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) · Cited by 1
„Old Friends“, Immunregulation und Stressresilienz
Langgartner, D., Lowry, C. A., & Reber, S. O. (2020) · Nervenheilkunde · doi:10.1055/a-1037-0710 · Cited by 1
Neuro-inflammatory Response and Immune–Brain Crosstalk in Sleep Regulation
Jha, P. K., & Bouâouda, H. (2024) · Progress in inflammation research · doi:10.1007/978-3-031-74744-1_5 · Cited by 1
Exercise-Induced Chaperokine Activity of Hsp70: Possible Role in Chronic Diseases
Shamsi, M. M., Hassan, Z. M., & Gharakhanlou, R. (2019) · Heat shock proteins · doi:10.1007/978-3-030-02254-9_10 · Cited by 2
Modulation of Extracellular Heat Shock Protein 70 Levels in Rainbow Trout
Faught, L. E. (2013) · UWSpace (University of Waterloo) · Cited by 1
Circulating HSP70 as an Endogenous Cytoprotector?
Pockley, A. G., & Multhoff, G. (2009) · Heat shock proteins · doi:10.1007/978-90-481-3381-9_18 · Cited by 1

Authors: Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., & Fleshner, M.
Affiliations: University of Colorado Boulder (US)
ORCID: Campisi, Jay
Sharkey, Craig M.
Fleshner, Monika
Venue: Journal of Applied Physiology
Publisher: American Physiological Society
Published: 2005-11
Volume: 99
Issue: 5
Pages: 1789-1795
ISSN: 0161-7567 (ISSN-L)
8750-7587
1522-1601
DOI: 10.1152/japplphysiol.00390.2005
OpenAlex: W2121195298
Cited by: 108
References: 51
Citations by year: 2026: 4 · 2024: 3 · 2023: 3 · 2022: 2 · 2020: 5 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 6 · 2015: 6 · 2014: 5 · 2013: 6 · 2012: 12
FWCI: 2.99
Type: journal article
Language: en
Open access: closed
Locations: Journal of Applied Physiology (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Heat shock proteins research
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Health Sciences › Medicine › Physiology (medical) › Thermoregulation and physiological responses
Keywords: HSP72, alpha1-adrenoceptors, stress response, psychological stress, trauma (physical injury), beta-adrenergic receptors, glucocorticoids, ACTH, immunomodulation, inflammatory diseases
MeSH terms: Adrenalectomy, Adrenocorticotropic Hormone, Animals, Catecholamines, Electroshock, Extracellular Space, Glucocorticoids, Hypophysectomy, Immune System, Male, Rats, Inbred F344, Stress, Physiological, Tyrosine, Signal Transduction, Receptors, Adrenergic, alpha-1, HSP72 Heat-Shock Proteins, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks