Cited by 165Tryptophan and brain disordersStress Responses and CortisolFunctional Brain Connectivity Studies

Functional neuroanatomy of peripheral inflammatory physiology: A meta-analysis of human neuroimaging studies

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Kraynak, Thomas E., Marsland, Anna L., Wager, Tor D., Gianaros, Peter J.·2018·Neuroscience & Biobehavioral Reviews

Abstract

Communication between the brain and peripheral mediators of systemic inflammation is implicated in numerous psychological, behavioral, and physiological processes. Functional neuroimaging studies have identified brain regions that associate with peripheral inflammation in humans, yet there are open questions about the consistency, specificity, and network characteristics of these findings. The present systematic review provides a meta-analysis to address these questions. Multilevel kernel density analysis of 24 studies (37 statistical maps; 264 coordinates; 457 participants) revealed consistent effects in the amygdala, hippocampus, hypothalamus, striatum, insula, midbrain, and brainstem, as well as prefrontal and temporal cortices. Effects in some regions were specific to particular study designs and tasks. Spatial pattern analysis revealed significant overlap of reported effects with limbic, default mode, ventral attention, and corticostriatal networks, and co-activation analyses revealed functional ensembles encompassing the prefrontal cortex, insula, and midbrain/brainstem. Together, these results characterize brain regions and networks associated with peripheral inflammation in humans, and they provide a functional neuroanatomical reference point for future neuroimaging studies on brain-body interactions.

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Crossref · 10.1016/j.neubiorev.2018.07.013

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  • Experimentally induced inflammation in healthy humans and rodents increases pain sensitivity, decreases mood, and changes motivational behaviors.

    “Experimentally induced inflammation in healthy humans and rodents increases pain sensitivity, decreases mood and changes motivational behaviors, see, e.g., [20,21,22,23] for an overview.”

    From Baseline Pro-Inflammatory Cytokine Levels Moderate Psychological Inflexibility in Behavioral Treatment for Chronic Pain (2022) · cites this paper as [21]

    The Introduction (page unavailable) says induced inflammation in humans changes cognitive and affective behavior, including reward processing; the Discussion (page unavailable) reports mood change after typhoid vaccination. The paper also describes inflammation-related sickness behaviors, but the searched passages do not say that experimental inflammation increases pain sensitivity or establish the full set of effects in both healthy humans and rodents. (LLM, conf=0.83)

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  • Peripheral inflammation can perturb brain connectivity, particularly within default mode and salience networks, contributing to downstream effects on behavior.

    “there is emerging evidence that peripheral inflammation can perturb brain connectivity, particularly within default mode and salience networks, 84 , 85 contributing to downstream effects on behavior.”

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Authors
Kraynak, T. E., Marsland, A. L., Wager, T. D., & Gianaros, P. J.
Affiliations
  • University of Pittsburgh (US)
  • University of Colorado Boulder (US)
Corresponding author
Kraynak, Thomas E.
Venue
Neuroscience & Biobehavioral Reviews
Publisher
Elsevier BV
Published
2018-11
Volume
94
Pages
76-92
ISSN
0149-7634 (ISSN-L)
OpenAlex
W2884937801
Cited by
165
References
188
Citations by year
2026: 20 · 2025: 20 · 2024: 11 · 2023: 23 · 2022: 30 · 2021: 23 · 2020: 23 · 2019: 12 · 2018: 3
FWCI
1.33
Type
journal article
Language
en
Open access
Locations
  • Neuroscience & Biobehavioral Reviews (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Heart, Lung, and Blood Institute (R01HL089850, T32HL007560)
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
peripheral inflammation, systemic inflammation, brain-body interaction, neuroinflammation, functional neuroanatomy, amygdala, hippocampus, hypothalamus, insula, midbrain, brainstem, prefrontal cortex, temporal cortex, limbic network, default mode network, ventral attention network, corticostriatal network, CO activation
MeSH terms
Brain, Humans, Inflammation, Neuroimmunomodulation, Neuroimaging

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