Chronic Stress Increases Transcriptomic Indicators of Biological Aging in Mouse Bone Marrow Leukocytes
Open accessAbstract
Research with animals and humans has demonstrated that chronic stress exposure can impact key biological aging pathways such as inflammation and DNA damage, suggesting a mechanism through which stress may increase risk for age-related disease. However, it is less clear whether these effects extend to other hallmarks of the aging process, such as cellular senescence. Male SCID mice were exposed to 14 days of restraint stress, with (n = 6) or without (n = 10) propranolol administration, or a non-stress control condition (n = 10). Normal femoral bone marrow leukocytes were isolated from engrafted leukemia cells that had been injected prior to the stressor, as the mice were also under a cancer challenge. We performed whole genome transcriptional profiling to assess indicators of biological aging: cell stress, DNA damage repair, cellular senescence markers p16INK4a and p21, and the pro-inflammatory senescence-associated secretory phenotype (SASP). ANCOVAs that adjusted for tumor load and Fisher's pairwise comparisons revealed that stressed mice had enhanced p16INK4a (p = .02) and p21 (p = .004), lower DNA damage repair (p < .001), and higher SASP (p = .03) gene expression than control mice. Stressed mice also showed up-regulated beta-adrenergic (CREB) and inflammatory (NF-кB, AP-1) and down-regulated cell stress (Nrf2) transcription factor activity relative to control mice (ps < .01). Propranolol reversed CREB and Nrf2 activity (ps < .03). Findings suggest that chronic stress exposure can impact several key biological aging pathways within bone marrow leukocytes and these effects may be partially mediated by sympathetic beta-adrenergic receptor activation.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Chronic stress can significantly affect biological aging pathways, particularly within bone marrow leukocytes, potentially mediated by sympathetic beta-adrenergic receptor activation.
“The findings suggest that chronic stress can significantly affect biological aging pathways, particularly within bone marrow leukocytes, potentially mediated by sympathetic beta-adrenergic receptor activation.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [16]
In male SCID mice subjected to 14 days of restraint stress, there was increased expression of aging markers p16INK4a and p21, alongside reduced DNA damage repair capabilities.
“In a study involving male SCID mice subjected to 14 days of restraint stress, researchers observed an increased expression of aging markers such as p16INK4a and p21, alongside reduced DNA damage repair capabilities.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [16]
Stressed mice exhibited higher expression of SASP, CREB, NF-κB, and AP-1 genes.
“These stressed mice also exhibited a higher expression of SASP, CREB, NF-κB, and AP-1 genes.”
From Comprehensive review of chronic stress pathways and the efficacy of behavioral stress reduction programs (BSRPs) in managing diseases. (2024) · cites this paper as [16]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Repertoires of Autophagy in the Pathogenesis of Ocular Diseases
Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351 · see citing works
The senescence-associated secretory phenotype: the dark side of tumor suppression
Coppé, J.-P., Desprez, P.-Y., Krtolica, A., & Campisi, J. (2010) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-121808-102144 · Cited by 5,206 · see citing works
Cellular senescence: when bad things happen to good cells
Campisi, J., & d'Adda di Fagagna, F. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2233 · Cited by 4,441 · see citing works
Chronic Inflammation (Inflammaging) and Its Potential Contribution to Age-Associated Diseases
Franceschi, C., & Campisi, J. (2014) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/glu057 · Cited by 3,891 · see citing works
Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders
Baker, D. J., Wijshake, T., Tchkonia, T., LeBrasseur, N. K., Childs, B. G., van de Sluis, B., Kirkland, J. L., & van Deursen, J. M. (2011) · Nature · doi:10.1038/nature10600 · Cited by 3,670 · cited 1× · see citing works
“Importantly, research with mice has demonstrated that removal of p16INK4a-positive cells can prevent or slow the deterioration of several tissues and organs associated with aging (Baker et al., 2011; Demaria et al., 2017).”
BackgroundFour faces of cellular senescence
Rodier, F., & Campisi, J. (2011) · Journal of Cell Biology · doi:10.1083/jcb.201009094 · Cited by 2,016 · see citing works
Cellular senescence in cancer and aging.
Collado, M., Blasco, M. A., & Serrano, M. (2007) · Cell · doi:10.1016/j.cell.2007.07.003 · Cited by 1,708 · see citing works
Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk
Cohen, S., Janicki-Deverts, D., Doyle, W. J., Miller, G. E., Frank, E., Rabin, B. S., & Turner, R. B. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1118355109 · Cited by 1,419 · see citing works
A proteomic atlas of senescence-associated secretomes for aging biomarker development
Basisty, N., Kale, A., Jeon, O. H., Kuehnemann, C., Payne, T., Rao, C., Holtz, A., Shah, S., Sharma, V., Ferrucci, L., et al. (2020) · PLOS Biology · doi:10.1371/journal.pbio.3000599 · Cited by 1,348 · see citing works
Cellular senescence promotes adverse effects of chemotherapy and cancer relapse
Demaria, M., O'Leary, M. N., Chang, J., Shao, L., Liu, S., Alimirah, F., Koenig, K., Le, C., Mitin, N., Deal, A. M., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-0241 · Cited by 1,338 · see citing works
Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma
Thaker, P. H., Han, L. Y., Kamat, A. A., Arevalo, J. M., Takahashi, R., Lu, C., Jennings, N. B., Armaiz-Pena, G., Bankson, J. A., Ravoori, M., et al. (2006) · Nature Medicine · doi:10.1038/nm1447 · Cited by 1,320 · see citing works
The cytoprotective role of the Keap1–Nrf2 pathway
Baird, L., & Dinkova‐Kostova, A. T. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0674-5 · Cited by 1,029 · see citing works
Cellular senescence: a translational perspective
Kirkland, J. L., & Tchkonia, T. (2017) · EBioMedicine · doi:10.1016/j.ebiom.2017.04.013 · Cited by 1,013 · see citing works
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002) · Health Psychology · doi:10.1037//0278-6133.21.6.531 · Cited by 977 · see citing works
An aged immune system drives senescence and ageing of solid organs
Yousefzadeh, M. J., Flores, R. R., Zhu, Y., Schmiechen, Z. C., Brooks, R. W., Trussoni, C. E., Cui, Y., Angelini, L., Lee, K.-A., McGowan, S. J., et al. (2021) · Nature · doi:10.1038/s41586-021-03547-7 · Cited by 972 · see citing works
A mechanism converting psychosocial stress into mononuclear cell activation
Bierhaus, A., Wolf, J., Andrassy, M., Rohleder, N., Humpert, P. M., Petrov, D., Ferstl, R., von Eynatten, M., Wendt, T., Rudofsky, G., et al. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438019100 · Cited by 926 · see citing works
Reciprocal regulation of the neural and innate immune systems
Irwin, M. R., & Cole, S. W. (2011) · Nature Reviews Immunology · doi:10.1038/nri3042 · Cited by 910 · see citing works
Autonomic innervation and regulation of the immune system (1987–2007)
Nance, D. M., & Sanders, V. M. (2007) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.03.008 · Cited by 855 · see citing works
Chronic variable stress activates hematopoietic stem cells
Heidt, T., Sager, H. B., Courties, G., Dutta, P., Iwamoto, Y., Zaltsman, A., von zur Muhlen, C., Bode, C., Fricchione, G. L., Denninger, J., et al. (2014) · Nature Medicine · doi:10.1038/nm.3589 · Cited by 803 · see citing works
Miller, G. E., Cohen, S., & Ritchey, A. K. (2002) · Health Psychology · doi:10.1037/0278-6133.21.6.531 · Cited by 769 · see citing works
Social regulation of gene expression in human leukocytes
Cole, S. W., Hawkley, L. C., Arevalo, J. M., Sung, C. Y., Rose, R. M., & Cacioppo, J. T. (2007) · Genome Biology · doi:10.1186/gb-2007-8-9-r189 · Cited by 745 · see citing works
Hara, E., Smith, R., Parry, D., Tahara, H., Stone, S., & Peters, G. (1996) · Molecular and Cellular Biology · doi:10.1128/mcb.16.3.859 · Cited by 733 · see citing works
Oxygen, Reactive Oxygen Species and Tissue Damage
Bergamini, C. M., Gambetti, S., Dondi, A., & Cervellati, C. (2004) · Current Pharmaceutical Design · doi:10.2174/1381612043384664 · Cited by 661 · see citing works
Powell, N. D., Sloan, E. K., Bailey, M. T., Arevalo, J. M. G., Miller, G. E., Chen, E., Kobor, M. S., Reader, B. F., Sheridan, J. F., & Cole, S. W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1310655110 · Cited by 588 · see citing works
Miller, G. E., Chen, E., Sze, J., Marin, T., Arevalo, J. M. G., Doll, R., Ma, R., & Cole, S. W. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.03.017 · Cited by 552 · see citing works
Good stress, bad stress and oxidative stress: Insights from anticipatory cortisol reactivity
Aschbacher, K., O’Donovan, A., Wolkowitz, O. M., Dhabhar, F. S., Su, Y., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.02.004 · Cited by 459 · see citing works
Psychological and metabolic stress: A recipe for accelerated cellular aging?
Epel, E. S. (2009) · HORMONES · doi:10.14310/horm.2002.1217 · Cited by 422 · see citing works
Cole, S. W. (2014) · PLoS Genetics · doi:10.1371/journal.pgen.1004601 · Cited by 415 · see citing works
Stress and telomere biology: a lifespan perspective
Shalev, I., Entringer, S., Wadhwa, P. D., Wolkowitz, O. M., Puterman, E., Lin, J., & Epel, E. S. (2013) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2013.03.010 · Cited by 400 · see citing works
Li, Y., Nichols, M. A., Shay, J. W., & Xiong, Y. (1994) · PubMed · Cited by 359 · see citing works
The role of CD8<sup>+</sup> T‐cell replicative senescence in human aging
Effros, R. B., Dagarag, M., Spaulding, C., & Man, J. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00259.x · Cited by 336 · see citing works
Social stress induces glucocorticoid resistance in subordinate animals
Avitsur, R., Stark, J. L., & Sheridan, J. F. (2001) · Hormones and Behavior · doi:10.1006/hbeh.2001.1653 · Cited by 321 · see citing works
Social stress induces glucocorticoid resistance in macrophages
Stark, J. L., Avitsur, R., Padgett, D. A., Campbell, K. A., Beck, F. M., & Sheridan, J. F. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.6.r1799 · Cited by 295 · see citing works
Özcan, S., Alessio, N., Acar, M. B., Mert, E., Omerli, F., Peluso, G., & Galderisi, U. (2016) · Aging · doi:10.18632/aging.100971 · Cited by 295 · see citing works
Singh, S., Vrishni, S., Singh, B. K., Rahman, I., & Kakkar, P. (2010) · Free Radical Research · doi:10.3109/10715762.2010.507670 · Cited by 294 · see citing works
Rohleder, N., Marin, T. J., Ma, R., & Miller, G. E. (2009) · Journal of Clinical Oncology · doi:10.1200/jco.2008.18.7435 · Cited by 252 · see citing works
Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression
Bouvier, E., Brouillard, F., Molet, J., Claverie, D., Cabungcal, J.-H., Cresto, N., Doligez, N., Rivat, C., Do, K. Q., Bernard, C., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.144 · Cited by 248 · see citing works
Reber, S. O., Birkeneder, L., Veenema, A. H., Obermeier, F., Falk, W., Straub, R. H., & Neumann, I. (2006) · Endocrinology · doi:10.1210/en.2006-0983 · Cited by 212 · see citing works
Innervation of Lymphoid Tissue
Felten, S. Y., & Felten, D. L. (1991) · Elsevier eBooks · doi:10.1016/b978-0-12-043780-1.50006-3 · Cited by 203 · see citing works
(1991) · Elsevier eBooks · doi:10.1016/c2013-0-10269-3 · Cited by 195 · see citing works
Expression-based monitoring of transcription factor activity: the TELiS database
Cole, S. W., Yan, W., Galic, Z., Arevalo, J., & Zack, J. A. (2005) · Bioinformatics · doi:10.1093/bioinformatics/bti038 · Cited by 185 · see citing works
Miller, G. E., Murphy, M. L. M., Cashman, R., Ma, R., Ma, J., Arevalo, J. M. G., Kobor, M. S., & Cole, S. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.05.016 · Cited by 166 · see citing works
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
Fülöp, G., Kiss, T., Tarantini, S., Balasubramanian, P., Yabluchanskiy, A., Farkas, E., Bari, F., Ungvari, Z. I., & Csiszár, A. (2018) · GeroScience · doi:10.1007/s11357-018-0047-6 · Cited by 157 · see citing works
Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity
Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.02.006 · Cited by 156 · see citing works
The relation between psychological factors and DNA-damage: A critical review
Gidron, Y., Russ, K. M., Tissarchondou, H. S., & Warner, J. A. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2005.11.011 · Cited by 146 · see citing works
Induction of plasma interleukin-6 by circulating adrenaline in the rat
DeRijk, R. H., Boelen, A., Tilders, F. J. H., & BERKENBOSCH, F. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90005-1 · Cited by 139 · see citing works
Niraula, A., Wang, Y., Godbout, J. P., & Sheridan, J. F. (2018) · The Journal of Neuroscience · doi:10.1523/jneurosci.2568-17.2018 · Cited by 137 · see citing works
Chronic stress enhances progression of acute lymphoblastic leukemia via β-adrenergic signaling
Lamkin, D. M., Sloan, E. K., Patel, A. J., Chiang, B. S., Pimentel, M. A., Ma, J. C. Y., Arevalo, J. M. G., Morizono, K., & Cole, S. W. (2012) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2012.01.013 · Cited by 136 · see citing works
Self-citationCat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones
Fleshner, M., Campisi, J., Amiri, L., & Diamond, D. M. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.01.007 · Cited by 117 · see citing works
Social stress shortens lifespan in mice
Razzoli, M., Nyuyki, K. D., Gurney, A., Erickson, C., McCallum, J., Spielman, N., Marzullo, M., Patricelli, J., Kurata, M., Pope, E. A., et al. (2018) · Aging Cell · doi:10.1111/acel.12778 · Cited by 115 · see citing works
Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice
Quan, N. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00042-0 · Cited by 113 · see citing works
Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist
Smagin, G. N., Howell, L. A., Redmann, S. M., Ryan, D. H., & Harris, R. B. S. (1999) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1999.276.5.r1461 · Cited by 111 · see citing works
Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72
Johnson, J. D., Campisi, J., Sharkey, C. M., Kennedy, S. L., Nickerson, M., & Fleshner, M. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00390.2005 · Cited by 108 · see citing works
Abdul-Aziz, A. M., Sun, Y., Hellmich, C., Marlein, C. R., Mistry, J., Forde, E., Piddock, R. E., Shafat, M. S., Morfakis, A., Mehta, T., et al. (2019) · Blood · doi:10.1182/blood-2018-04-845420 · Cited by 105 · see citing works
Tower, J. (2009) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2008.12.005 · Cited by 99 · see citing works
Modern Statistics for the Social and Behavioral Sciences
Wilcox, R. R. (2017) · Chapman & Hall/CRC eBooks · doi:10.1201/9781315154480 · Cited by 94 · see citing works
Hara, M. R., Sachs, B. D., Caron, M. G., & Lefkowitz, R. J. (2013) · Cell Cycle · doi:10.4161/cc.23368 · Cited by 85 · see citing works
Kim, G., Meriin, A. B., Gabai, V. L., Christians, E., Benjamin, I. J., Wilson, A. A., Wolozin, B. L., & Sherman, M. Y. (2012) · Aging Cell · doi:10.1111/j.1474-9726.2012.00827.x · Cited by 76 · see citing works
Schmidt, D., Reber, S. O., Botteron, C., Barth, T. F. E., Peterlik, D., Uschold‐Schmidt, N., Männel, D. N., & Lechner, A. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.04.014 · Cited by 76 · see citing works
Marón, F. J. M., Ferder, L., Saraví, F. D., & Manucha, W. A. (2018) · Stress · doi:10.1080/10253890.2018.1542683 · Cited by 76 · see citing works
Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence
Collin, G., Huna, A., Warnier, M., Flaman, J.-M., & Bernard, D. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0300-z · Cited by 71 · see citing works
Chronic stress exposure and daily stress appraisals relate to biological aging marker p16INK4a
Rentscher, K. E., Carroll, J., Repetti, R. L., Cole, S. W., Reynolds, B. M., & Robles, T. F. (2018) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2018.12.006 · Cited by 69 · see citing works
Self-citationStress-induced remodeling of lymphoid innervation
Sloan, E. K., Capitanio, J. P., & Cole, S. W. (2008) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2007.06.011 · Cited by 62 · see citing works
Hermann, G. E., Beck, F. M., Tovar, C. A., Malarkey, W. B., Allen, C. M., & Sheridan, J. F. (1994) · Journal of Neuroimmunology · doi:10.1016/0165-5728(94)90027-2 · Cited by 52 · see citing works
Restorative Biological Processes and Health
Robles, T. F., & Carroll, J. (2011) · Social and Personality Psychology Compass · doi:10.1111/j.1751-9004.2011.00368.x · Cited by 51 · see citing works
Self-citationOda, T., Sekimoto, T., Kurashima, K., Fujimoto, M., Nakai, A., & Yamashita, T. (2018) · Journal of Cell Science · doi:10.1242/jcs.210724 · Cited by 41 · see citing works
Statistical properties of the quantile normalization method for density curve alignment
Gallón, S., Loubes, J., & Maza, É. (2013) · Mathematical Biosciences · doi:10.1016/j.mbs.2012.12.007 · Cited by 38 · see citing works
Katsuumi, G., Shimizu, I., Yoshida, Y., Hayashi, Y., Ikegami, R., Suda, M., Wakasugi, T., Nakao, M., & Minamino, T. (2018) · International Heart Journal · doi:10.1536/ihj.17-313 · Cited by 36 · see citing works
Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes
Flint, M. S., Carroll, J., Jenkins, F. J., Chambers, W. H., Han, M. L., & Baum, A. E. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.06.012 · Cited by 35 · see citing works
Self-citationMekki, Y., Catallo, R., Bertrand, Y., Manel, A., Ffrench, P., Baghdassarian, N., Duhaut, P., Bryon, P., & Ffrench, M. (1999) · Leukemia · doi:10.1038/sj.leu.2401303 · Cited by 34 · see citing works
DNA brain damage after stress in rats
Consiglio, A. R., Ramos, A. L. L. P., Henriques, J. A. P., & Picada, J. N. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.03.004 · Cited by 32 · see citing works
Walsh, C. P., Ewing, L. J., Cleary, J. L., Vaisleib, A. D., Farrell, C. H., Wright, A. G. C., Gray, K., & Marsland, A. L. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.12.011 · Cited by 32 · see citing works
Manni, L., Fausto, V. D., Fiore, M., & Aloe, L. (2008) · Current Neurovascular Research · doi:10.2174/156720208783565654 · Cited by 30 · see citing works
Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation
Rudqvist, N.-P., Laiakis, E. C., Ghandhi, S. A., Kumar, S., Knotts, J. D., Chowdhury, M., Fornace, A. J., & Amundson, S. A. (2018) · Radiation Research · doi:10.1667/rr14862.1 · Cited by 22 · see citing works
Dynamic regulation of cerebral DNA repair genes by psychological stress
Forsberg, K., Aalling, N., Wörtwein, G., Loft, S. H., Möller, P., Hau, J., Hageman, I., Jørgensen, M. B., & Jørgensen, A. (2014) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2014.12.003 · Cited by 20 · see citing works
Social Stress Induces Oxidative DNA Damage in Mouse Peripheral Blood Cells
Nishio, Y., Nakano, Y., Deguchi, Y., et al. (2007) · Genes and Environment · doi:10.3123/jemsge.29.17 · Cited by 15 · see citing works
Psychological Stress and Oxidative Damage in Lymphocytes of Aerobically Fit and Unfit Individuals1
Knickelbein, K. Z., Flint, M. S., Jenkins, F. J., & Baum, A. E. (2008) · Journal of Applied Biobehavioral Research · doi:10.1111/j.1751-9861.2008.00025.x · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Stress-induced biological aging: A review and guide for research priorities
Polsky, L. R., Rentscher, K. E., & Carroll, J. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.05.016 · Cited by 181 · see citing works
Self-citationShchaslyvyi, A. Y., Antonenko, S. V., & Telegeev, G. D. (2024) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph21081077 · Cited by 73 · see citing works
Lyons, C. E., Razzoli, M., & Bartolomucci, A. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105359 · Cited by 74 · see citing works
To promote healthy aging, focus on the environment
Belsky, D. W., & Baccarelli, A. (2023) · Nature Aging · doi:10.1038/s43587-023-00518-7 · Cited by 58 · see citing works
Proton pump inhibitors display anti‐tumour potential in glioma
Li, B., Liu, Y., & Sun, S. (2022) · Cell Proliferation · doi:10.1111/cpr.13321 · Cited by 24 · see citing works
Mandelblatt, J. S., Antoni, M. H., Bethea, T. N., Cole, S. W., Hudson, B. I., Penedo, F. J., Ramírez, A. G., Rebeck, G. W., Sarkar, S., Schwartz, A. G., et al. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae211 · Cited by 24 · see citing works
Self-citationHansen, J. L., Carroll, J., Seeman, T. E., Cole, S. W., & Rentscher, K. E. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.10.022 · Cited by 21 · see citing works
Self-citationDuarte, M., Pedrosa, S. S., Khusial, P. R., & Madureira, A. R. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111956 · Cited by 20 · see citing works
Transcriptomic markers of biological aging in breast cancer survivors: a longitudinal study
Carroll, J., Crespi, C. M., Cole, S., Ganz, P. A., Petersen, L., & Bower, J. E. (2024) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djae201 · Cited by 15 · see citing works
Self-citationAbreu, T. C., Mackenbach, J. D., Heuvelman, F., Schoonmade, L. J., & Beulens, J. W. J. (2023) · SSM - Population Health · doi:10.1016/j.ssmph.2023.101559 · Cited by 12 · see citing works
Ardestani, S. K., Jamali, T., Taravati, A., Behboudi, H., Mahdavi, M. R. V., Faghihzadeh, E., & Ghazanfari, T. (2022) · Drug and Chemical Toxicology · doi:10.1080/01480545.2022.2150205 · Cited by 11 · see citing works
Tang, N., Zhang, Q., Xiong, X.-F., Liu, X.-W., Wang, G.-E., & Wu, Y. (2025) · Clinical Cosmetic and Investigational Dermatology · doi:10.2147/ccid.s555801 · Cited by 5 · see citing works
Expression and prognosis of cellular senescence genes in head and neck squamous cell carcinoma
Feng, C., Mao, W., Xiao, Q., Liu, Y., Yan, M., Dong, P., Liu, Y., & Chen, X. (2025) · Holistic Integrative Oncology · doi:10.1007/s44178-024-00115-7 · Cited by 4 · see citing works
Ren, J., Wang, X. L., Zhou, X., & Fan, X. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1818021 · Cited by 4 · see citing works
Wakid, M., Almeida, D., Denniston, R., Chawla, A., Aouabed, Z., Davoli, M. A., Ellerbeck, K., Rahimian, R., Yerko, V., Leonova-Erko, E., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03285-6 · Cited by 4 · see citing works
Shcherbinina, V., Bakulevskiy, B. V., Glinin, T. S., & Даев, Е. В. (2023) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093023040154 · Cited by 3 · see citing works
da Silva, J. T., Meira, C. O. S., Nogueira, J. D. S., Lanzetti, M., & Romana‐Souza, B. (2025) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x2025e14472 · Cited by 1 · see citing works
Hansen, J. L., Plotke, R. L., Kanaya, M. R., Webster, S. N., Popok, P., Walsh, E. A., Ream, M. E., Krueger, M. J., Saez-Clarke, E., Perdomo, D. M., et al. (2025) · International Journal of Clinical and Health Psychology · doi:10.1016/j.ijchp.2025.100626 · Cited by 1 · see citing works
Epigenetic biomarkers of mortality risk in mice under chronic social stress
Anderson, S. D., Razzoli, M., Chen, B. H., Pellegrini, M. A., & Bartolomucci, A. (2025) · GeroScience · doi:10.1007/s11357-025-01721-7 · Cited by 1 · see citing works
Effect of DNA damage mediating psychosocial stress on aging
Al-Maeni, M., & Al-Khazraji, S. F. R. (2023) · Iraqi Journal of Cancer and Medical Genetics · doi:10.29409/ijcmg.v16i1.271
Shcherbinina, V., Bakulevskiy, B. V., Glinin, T. S., & Даев, Е. В. (2023) · Российский физиологический журнал им И М Сеченова · doi:10.31857/s0869813923070129
- Authors
- Rentscher, K. E., Carroll, J. E., Polsky, L. R., & Lamkin, D. M.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Rentscher, Kelly E.
- Venue
- Brain, Behavior, & Immunity - Health
- Publisher
- Elsevier BV
- Published
- 2022-07
- Volume
- 22
- Pages
- 100461
- ISSN
- 2666-3546 (ISSN-L)
- PMC
- PMC9035650
- OpenAlex
- W4225252437
- Cited by
- 21
- References
- 77
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 5 · 2023: 6 · 2022: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Behavior & Immunity - Health (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute on Aging (K01AG065485)
- National Cancer Institute (K07CA188237)
- Norman Cousins Center for Psychoneuroimmunology
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- chronic stress, biological aging, bone marrow leukocytes, cellular senescence, propranolol, restraint stress, senescence-associated secretory phenotype, DNA repair, p16INK4a, p21, beta-adrenergic signaling, CREB, Nrf2, NF-kB, AP-1, inflammation, SCID mice, leukemia engraftment
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
