Elevated exercise blood pressure in middle-aged women is associated with altered left ventricular and vascular stiffness
Open accessAbstract
Women are at increased risk for heart failure with preserved ejection fraction (HFpEF) largely due to higher prevalence of arterial and cardiac stiffening. We were able to identify several subclinical markers of early (stages A and B) HFpEF pathophysiology largely on the basis of exercise blood pressure (BP) response in otherwise healthy middle-aged women. Exercise BP response may be an inexpensive screening tool to identify women at highest risk for developing future HFpEF.
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Exaggerated exercise blood pressure (EEBP) recorded during clinical exercise testing is independently associated with blood pressure-related cardiovascular disease (CVD) outcomes.
“Exaggerated exercise blood pressure recorded during clinical exercise testing is independently associated with blood pressure -related cardiovascular disease outcomes”
From Cardiorespiratory Fitness, Workload, and the Blood Pressure Response to Exercise Testing (2022) · cites this paper as [15]
EEBP during submaximal exercise is related to increased left ventricular and aortic stiffness in otherwise healthy middle-aged women.
“Sarma et al. also recently reported EEBP during submaximal exercise to be related to increased left ventricular and aortic stiffness in otherwise healthy middle-aged women, proposing that EEBP could serve as a sentinel for heart failure with preserved ejection fraction [38].”
From The Identification and Management of High Blood Pressure Using Exercise Blood Pressure: Current Evidence and Practical Guidance (2022) · cites this paper as [38]
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- Authors
- Sarma, S., Howden, E., Carrick-Ranson, G., Lawley, J., Hearon, C., Samels, M., Everding, B., Livingston, S., Adams-Huet, B., Palmer, M. D., & Levine, B. D.
- Affiliations
- Texas Health Dallas (US)
- Baker Heart and Diabetes Institute (AU)
- School of Health Sciences, University of South Australia, Adelaide, Australia
- Universität Innsbruck (AT)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Sarma, Satyam
- ORCID
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2020-05-01
- Volume
- 128
- Issue
- 5
- Pages
- 1123-1129
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC7272758
- OpenAlex
- W3014413595
- Cited by
- 26
- References
- 43
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 3 · 2020: 1
- FWCI
- 1.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Adelaide Research & Scholarship (AR&S) (University of Adelaide) (submittedVersion)
- Funders
- HHS | National Institutes of Health (RO1 AG17479)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heart failure with preserved ejection fraction, blood pressure response to exercise, left ventricular stiffness, vascular stiffness, middle-aged women, screening, arterial stiffness, cardiac stiffness
- MeSH terms
- Blood Pressure, Female, Heart Failure, Humans, Middle Aged, Stroke Volume, Ventricular Function, Left, Vascular Stiffness
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