Rat phenome project: the untapped potential of existing rat strains
Abstract
The National Bio Resource Project for the Rat in Japan collects, preserves, and distributes rat strains. More than 250 inbred strains have been deposited thus far into the National Bio Resource Project for the Rat and are maintained as specific pathogen-free rats or cryopreserved embryos. We are now comprehensively characterizing deposited strains as part of the Rat Phenome Project to reevaluate their value as models of human diseases. Phenotypic data are being collected for 7 categories and 109 parameters: functional observational battery (neurobehavior), behavior studies, blood pressure, biochemical blood tests, hematology, urology, and anatomy. Furthermore, genotypes are being determined for 370 simple sequence-length polymorphism markers distributed through the whole rat genome. Here, we report these large-scale, high-throughput screening data that have already been collected for 54 rat strains. This comprehensive, original phenotypic data can be systematically viewed by “strain ranking” for each parameter. This allows investigators to explore the relationship between several rat strains, to identify new rat models, and to select the most suitable strains for specific experiments. The discovery of several potential models for human diseases, such as hypertension, hypotension, renal diseases, hyperlipemia, hematological disorders, and neurological disorders, illustrates the potential of many existing rat strains. All deposited strains and obtained data are freely available for any interested researcher worldwide at http://www.anim.med.kyoto-u.ac.jp/nbr .
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The rat has potential for geroscience research because its aging physiology is closer to humans than mice, especially for onset of certain age-related conditions, and its larger size permits serial sampling and imaging not feasible in mice.
“However, the rat has tremendous potential for use in geroscience research, owning to its aging physiology being closer to humans compared to mice, especially with respect to onset of certain age-related conditions, as well as its larger size, which permits serial sampling and imaging studies not feasible in the mouse [36–41].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [40]
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Self-citation
- Authors
- Mashimo, T., Voigt, B., Kuramoto, T., & Serikawa, T.
- Affiliations
- Kyoto University (JP)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2005-01
- Volume
- 98
- Issue
- 1
- Pages
- 371-379
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2132887552
- Cited by
- 57
- References
- 25
- Citations by year
- 2026: 1 · 2025: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 4 · 2014: 1 · 2013: 2 · 2012: 4
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and phenotypic traits in livestock
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Mapping and Diversity in Plants and Animals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
- Keywords
- inbred rat strains, phenotypic characterization, disease models, functional observational battery, blood pressure, hematologic disorders, kidney disease, hyperlipidemia, neurological disorders
- MeSH terms
- Animals, Behavior, Animal, Chromosome Mapping, Disease Models, Animal, Japan, Men, Phenotype, Rats, Inbred Strains, Species Specificity, Women, Databases, Factual, Proteome, Rats
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