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Cited by 97

The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.

Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and1H-MR spectroscopy

Howald, Hans, Boesch, Chris, Kreis, Roland, Matter, Sibylle, Billeter, Rudolf, Essen-Gustavsson, Birgitta, Hoppeler, Hans·2002·Journal of Applied Physiology
DOI 10.1152/japplphysiol.01174.2001
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Abstract

Three different methods to determine intramyocellular lipid (IMCL) contents in human skeletal muscle have been compared.1 H-magnetic resonance spectroscopy (MRS) was evaluated against electron microscopic morphometry and biochemical assays of biopsy samples from m. tibialis anterior of 10 healthy subjects. The results of 1 H-MRS and morphometry were strongly correlated, proving the validity of the 1 H-MRS results for the noninvasive determination of IMCL. Biochemical assays yielded results that did not significantly correlate with the results of the other methods. When IMCL levels obtained from the three methods are expressed in common units, it was found that 1 H-MRS yielded IMCL average levels that were 1.8 times lower than those found by morphometry. Potential reasons for the discrepancy are discussed. It is expected that 1 H-MRS will be suitable to replace invasive techniques for IMCL determination, whenever noninvasiveness is crucial, e.g., for repeated investigations in studies of substrate recruitment and recovery in exercise.

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Metadata

Authors
Howald, H., Boesch, C., Kreis, R., Matter, S., Billeter, R., Essen-Gustavsson, B., & Hoppeler, H.
Affiliations
  • Departments of Anatomy and
  • Clinical Research (Magnetic Resonance Spectroscopy and Methodology), University of Bern, CH-3000 Bern, Switzerland; and
  • Unit of Comparative Medicine and Physiology, Department of Large Animal Sciences, Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences, S-750 07 Uppsala, Sweden
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2002-06-01
Volume
92
Issue
6
Pages
2264-2272
ISSN
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.01174.2001
Cited by
97
References
5
Language
en

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CoChat. (2026). Citation check: Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and1H-MR spectroscopy. https://app.cochat.ai/papers/10.1152/japplphysiol.01174.2001
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Howald, H., Boesch, C., Kreis, R., Matter, S., Billeter, R., Essen-Gustavsson, B., & Hoppeler, H. (2002). Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and1H-MR spectroscopy. Journal of Applied Physiology. https://doi.org/10.1152/japplphysiol.01174.2001

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