Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs
Open accessAbstract
Endurance training-induced changes in hemodynamic traits are heritable. However, few genes associated with heart rate training responses have been identified. The purpose of our study was to perform a genome-wide association study to uncover DNA sequence variants associated with submaximal exercise heart rate training responses in the HERITAGE Family Study. Heart rate was measured during steady-state exercise at 50 W (HR50) on 2 separate days before and after a 20-wk endurance training program in 483 white subjects from 99 families. Illumina HumanCNV370-Quad v3.0 BeadChips were genotyped using the Illumina BeadStation 500GX platform. After quality control procedures, 320,000 single-nucleotide polymorphisms (SNPs) were available for the genome-wide association study analyses, which were performed using the MERLIN software package (single-SNP analyses and conditional heritability tests) and standard regression models (multivariate analyses). The strongest associations for HR50 training response adjusted for age, sex, body mass index, and baseline HR50 were detected with SNPs at the YWHAQ locus on chromosome 2p25 (P = 8.1 × 10(-7)), the RBPMS locus on chromosome 8p12 (P = 3.8 × 10(-6)), and the CREB1 locus on chromosome 2q34 (P = 1.6 × 10(-5)). In addition, 37 other SNPs showed P values <9.9 × 10(-5). After removal of redundant SNPs, the 10 most significant SNPs explained 35.9% of the ΔHR50 variance in a multivariate regression model. Conditional heritability tests showed that n…
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The genetic component of a response trait can be defined in terms of RNA abundance observed in the sedentary state or by specific genomic variants.
“There are strong indications from a baseline skeletal muscle gene expression profile and from a genome-wide association study performed on the Whites of HERITAGE that the genetic component of a response trait can be defined in terms of RNA abundance observed in the sedentary state or by specific genomic variants [31], [32], [33].”
From Adverse metabolic response to regular exercise: is it a rare or common occurrence? (2012) · cites this paper as [33]
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- Authors
- Rankinen, T., Sung, Y. J., Sarzynski, M. A., Rice, T. K., Rao, D. C., & Bouchard, C.
- Affiliations
- Pennington Biomedical Research Center (US)
- Division of Biostatistics and Department of Psychiatry and
- Washington University in St. Louis (US)
- Corresponding author
- Rankinen, Tuomo
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2012-03-01
- Volume
- 112
- Issue
- 5
- Pages
- 892-897
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC3311659
- OpenAlex
- W2045982298
- Cited by
- 45
- References
- 38
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 5 · 2018: 1 · 2017: 4 · 2016: 7 · 2015: 6 · 2014: 2 · 2013: 6 · 2012: 4
- FWCI
- 2.39
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Journal of Applied Physiology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL 45670, R01HL045670)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Physical Performance
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Keywords
- heritability, single nucleotide polymorphisms, genetic variants, RBPMS, CREB1, cardiac memory, cardiomyocyte function, neuronal function, HERITAGE Family Study
- MeSH terms
- Female, Genotype, Heart Rate, Humans, Male, Neurons, Physical Endurance, Exercise, RNA-Binding Proteins, Cyclic AMP Response Element-Binding Protein, Polymorphism, Single Nucleotide, Myocytes, Cardiac, Genome-Wide Association Study
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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