Inactivity, exercise training and detraining, and plasma lipoproteins. STRRIDE: a randomized, controlled study of exercise intensity and amount
Abstract
Exercise has beneficial effects on lipoproteins. Little is known about how long the effects persist with detraining or whether the duration of benefit is effected by training intensity or amount. Sedentary, overweight subjects (n = 240) were randomized to 6-mo control or one of three exercise groups: 1) high-amount/vigorous-intensity exercise; 2) low-amount/vigorous-intensity exercise; or 3) low-amount/moderate-intensity exercise. Training consisted of a gradual increase in amount of exercise followed by 6 mo of exercise at the prescribed level. Exercise included treadmill, elliptical trainer, and stationary bicycle. The number of minutes necessary to expend the prescribed kilocalories per week (14 kcal x kg body wt(-1) x wk(-1) for both low-amount groups; 23 kcal x kg body wt(-1) x wk(-1) for high-amount group) was calculated for each subject. Average adherence was 83-92% for the three groups; minutes per week were 207, 125, and 203 and sessions per week were 3.6, 2.9, and 3.5 for high-amount/vigorous-intensity, low-amount/vigorous intensity, and low-amount/moderate-intensity groups, respectively. Plasma was obtained at baseline, 24 h, 5 days, and 15 days after exercise cessation. Continued inactivity resulted in significant increases in low-density lipoprotein (LDL) particle number, small dense LDL, and LDL-cholesterol. A modest amount of exercise training prevented this deterioration. Moderate-intensity but not vigorous-intensity exercise resulted in a sustained reduction…
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Lack of aerobic physical activity increases cardiovascular disease risk.
“Lack of aerobic physical activity increases CVD risk [16].”
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Self-citation
- Authors
- Slentz, C. A., Houmard, J. A., Johnson, J. L., Bateman, L. A., Tanner, C. J., McCartney, J. S., Duscha, B. D., & Kraus, W. E.
- Affiliations
- Duke University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2007-08
- Volume
- 103
- Issue
- 2
- Pages
- 432-442
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- OpenAlex
- W2103453276
- Cited by
- 188
- References
- 6
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 7 · 2019: 15 · 2018: 15 · 2017: 11 · 2016: 7 · 2015: 11 · 2014: 12 · 2013: 15 · 2012: 15
- FWCI
- 35.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Applied Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-57354, R01HL057354)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
- Keywords
- exercise training, detraining, physical inactivity, serum lipoproteins, exercise intensity, exercise volume, low-density lipoprotein, small dense LDL, HDL cholesterol, HDL particle size, VLDL triglycerides, lipoprotein metabolism
- MeSH terms
- Adult, Aged, Cardiovascular System, Female, Humans, Insulin Resistance, Lipids, Lipoproteins, Male, Middle Aged, Obesity, Rest, Time Factors, Weight Gain, Exercise, Exercise Tolerance
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