Toward exercise as personalized medicine.
Open accessAbstract
The early 21st century has witnessed a steady push by scientists, industry leaders, and government officials to make medicine more personalized. To date, the concept of personalized medicine has referred largely to the field of pharmacogenomics. In contrast, relatively few data exist regarding the application of preventive strategies such as physical exercise in the context of personalized medicine. Within this review, we highlight the extant literature and propose five strategies for scientists that may propel the exercise and sports science fields toward this global goal. Notably, these approaches are in addition to methods to maintain adherence to training - a well-known factor in determining exercise responsiveness. Briefly, these strategies include (1) evaluating participant responses to training at the individual as well as group level; (2) identifying sources of variability in responsiveness to training; (3) optimizing exercise dosing strategies to maximize benefits while minimizing barriers to participation; (4) evaluating the efficacy of multimodal interventions for relevant population subgroups; and (5) increasing the clinical relevance of study populations and outcomes in exercise trials. We look forward to seeing these strategies considered in trials of preventive health interventions such as exercise. Extensive future research in this area is needed for the vision of exercise as a personalized form of medicine to become a reality.
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There is large interindividual heterogeneity in psychophysiological responses to acute physical exercises and in long-term adaptations to physical training.
“Based on the large interindividual heterogeneity (i) in psychophysiological responses to acute physical exercises and (ii) in long-term adaptions to a physical training”
From Dose-Response Matters! - A Perspective on the Exercise Prescription in Exercise-Cognition Research (2019) · cites this paper as Buford et al., 2013
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- Authors
- Buford, T. W., Roberts, M. D., & Church, T. S.
- Affiliations
- University of Florida (US)
- University of Missouri (US)
- Pennington Biomedical Research Center (US)
- Corresponding author
- Buford, Thomas W.
- Venue
- Sports Medicine
- Published
- 2013-02-05
- Volume
- 43
- Issue
- 3
- Pages
- 157-165
- ISSN
- 0112-1642 (ISSN-L)
- 1179-2035
- PMC
- PMC3595541
- OpenAlex
- W2073520427
- Cited by
- 158
- References
- 60
- Citations by year
- 2026: 15 · 2025: 19 · 2024: 14 · 2023: 7 · 2022: 12 · 2021: 14 · 2020: 14 · 2019: 21 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 10 · 2013: 2
- FWCI
- 1.07
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Sports Medicine (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- University of Florida
- National Institutes of Health (KL2TR000065)
- Center for Clinical and Translational Sciences, University of Texas Health Science Center at Houston
- National Institute on Aging (P30AG028740)
- National Center for Advancing Translational Sciences
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Sports Performance and Training
- Keywords
- personalized medicine, physical activity, training responsiveness, exercise adherence, multimodal intervention, subpopulations, preventive health measures, interindividual variability
- MeSH terms
- Exercise Therapy, Humans, Precision Medicine
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