The major limitation to exercise performance in COPD is dynamic hyperinflation

The Respiratory System

Sorokin, S. P. (1983) · doi:10.1007/978-1-349-06859-3_23 · Cited by 1,783

Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076

Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD

O'Donnell, D. E., Flüge, T., Gerken, F., Hamilton, A., Webb, K., Aguilaniu, B., Make, B., & Magnussen, H. (2004) · European Respiratory Journal · doi:10.1183/09031936.04.00116004 · Cited by 859

Measurement of Symptoms, Lung Hyperinflation, and Endurance during Exercise in Chronic Obstructive Pulmonary Disease

O'DONNELL, D. E., LAM, M., & WEBB, K. A. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.158.5.9804004 · Cited by 532

Contractile Properties of the Human Diaphragm during Chronic Hyperinflation

Similowski, T., Yan, S., Gauthier, A. P., Macklem, P. T., & Bellemare, F. (1991) · New England Journal of Medicine · doi:10.1056/nejm199109263251304 · Cited by 473

Qualitative Aspects of Exertional Breathlessness in Chronic Airflow Limitation: Pathophysiologic Mechanisms

O’Donnell, D. E., Bertley, J. C., Chau, L. K. L., & Webb, K. A. (1997) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.155.1.9001298 · Cited by 432

Inhaled Bronchodilators Reduce Dynamic Hyperinflation During Exercise in Patients With Chronic Obstructive Pulmonary Disease

Belman, M. J., Botnick, W. C., & Shin, J. W. (1996) · American journal of respiratory and critical care medicine · doi:10.1164/ajrccm.153.3.8630581 · Cited by 402

Pathophysiology of Dyspnea in Chronic Obstructive Pulmonary Disease: A Roundtable

O'Donnell, D. E., Banzett, R. B., Carrieri‐Kohlman, V., Casaburi, R. H., Davenport, P. W., Gandevia, S. C., Gelb, A. F., Mahler, D. A., & Webb, K. A. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200611-159cc · Cited by 402

Mechanisms of Dyspnea during Cycle Exercise in Symptomatic Patients with GOLD Stage I Chronic Obstructive Pulmonary Disease

Ofir, D., Laveneziana, P., Webb, K. A., Lam, Y.-M., & O'Donnell, D. E. (2008) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200707-1064oc · Cited by 358

Pulmonary mechanics during exercise in subjects with chronic airflow obstruction

Stubbing, D. G., Pengelly, L. D., Morse, J. L., & Jones, N. L. (1980) · Journal of Applied Physiology · doi:10.1152/jappl.1980.49.3.511 · Cited by 314

An official American Thoracic Society/European Respiratory Society statement: key concepts and advances in pulmonary rehabilitation

Spruit, M. A., Singh, S. J., Garvey, C., ZuWallack, R., Nici, L., Rochester, C., Hill, K., Holland, A. E., Lareau, S. C., Man, W. D.-C., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201309-1634st · Cited by 3,938

An Official American Thoracic Society Statement: Update on the Mechanisms, Assessment, and Management of Dyspnea

Parshall, M. B., Schwartzstein, R. M., Adams, L., Banzett, R. B., Manning, H. L., Bourbeau, J., Calverley, P. M., Gift, A. G., Harver, A., Lareau, S. C., et al. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201111-2042st · Cited by 1,844

Pulmonary characteristics in COPD and mechanisms of increased work of breathing

Loring, S. H., Garcia-Jacques, M., & Malhotra, A. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00008.2009 · Cited by 246

Cardiopulmonary Exercise Testing in the Clinical Evaluation of Patients With Heart and Lung Disease

Arena, R. A., & Sietsema, K. E. (2011) · Circulation · doi:10.1161/circulationaha.109.914788 · Cited by 239

Efficacy and safety of NVA237 versus placebo and tiotropium in patients with COPD: the GLOW2 study

Kerwin, E., Hébert, J., Gallagher, N. E., Martin, C., Overend, T., Alagappan, V., Lu, Y., & Banerji, D. D. (2012) · European Respiratory Journal · doi:10.1183/09031936.00040712 · Cited by 208

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation

West, J. B. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.zdg-8100.pcpcomm.2008 · Cited by 17

Last Word on Point:Counterpoint: The major limitation to exercise performance in COPD is 1) inadequate energy supply to the respiratory and locomotor muscles, 2) lower limb muscle dysfunction, 3) dynamic hyperinflation

O’Donnell, D. E., & Webb, K. A. (2008) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90739.2008 · Cited by 8

RESEARCH Open Access

Tzani, P., Aiello, M., Elia, D., Boracchia, L., Marangio, E., Olivieri, D., Clini, E., & Chetta, A. (2013)

Exercise‐induced dynamic hyperinflation in chronic obstructive pulmonary disease

D'Cruz, R. F., Wilkins, D., & Jolley, C. J. (2026) · Experimental Physiology · doi:10.1113/ep091459 · Cited by 3

Dynamic Hyperinflation and Exercise Intolerance in Chronic Obstructive Pulmonary Disease

O'DONNELL, D. E., REVILL, S. M., & WEBB, K. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.5.2012122 · Cited by 1,076

Dyspnea And Exercise Intolerance In COPD: Are Dynamic Hyperinflators Different From Non-Hyperinflators?

Guenette, J. A., Webb, K. A., & O’Donnell, D. E. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a1535

Dynamic hyperinflation on exertion: much remains unknown Hiperinsuflação dinâmica no esforço: ainda muito a ser esclarecido

Luís, A., & de Albuquerque, P. (2012)

The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles vs. lower limb muscle dysfunction vs. dynamic hyperinflation. "In medio stat virtus."

Palange, P. (2008) · IRIS Research product catalog (Sapienza University of Rome)

Dynamic Hyperinflation and Upper Limbs Exercises with Different Work Loads in Patients with COPD.

Colucci, M., Pôrto, E. F., de Castro, A. A. M., Cortopassi, F. F., Colucci, E., Souza, G., Nascimento, O., Iamonti, V. C., & Jardim, J. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm-conference.2009.179.1_meetingabstracts.a2368

Testing for exercise limitation in obstructive lung disease.

Newton, M., Webb, K., & O'Donnell, D. (1999) · Chest · doi:10.1378/chest.115.6.1755-a