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Cited by 166Nutrition and Health in AgingMuscle Physiology and DisordersMuscle metabolism and nutrition

The DOI matches its Crossref record; 58 of the 60 references it cites were found in a registry or an index.

Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women

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Raue, Ulrika, Slivka, Dustin, Minchev, Kiril, Trappe, Scott·2009·Journal of Applied Physiology
DOI 10.1152/japplphysiol.91587.2008PMC PMC2681332
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Abstract

Advanced sarcopenia is prevalent among octogenarian women; yet little is known about myocellular quality and plasticity in this cohort. The aim of this investigation was to examine single muscle fiber contractile function and whole muscle characteristics before and after 12 wk of high-intensity progressive resistance training (PRT) in very old (85 ± 1 yr) women (OW, n = 6). Young women [YW (21 ± 2 yr old), n = 9] were included as a control group. Whole muscle strength [1 repetition maximum (RM)] and size (CT scans) were assessed before and after PRT. Functional experiments (size, peak force, velocity, and power) were performed on vastus lateralis myosin heavy chain (MHC) I and IIa muscle fibers before and after PRT. With PRT, 1-RM strength increased ( P < 0.05) in YW (36%) and OW (26%). Thigh muscle cross-sectional area increased (5%) in YW ( P < 0.05), but thigh muscle did not hypertrophy in OW. Before PRT, there were no differences in single-fiber parameters between YW and OW. With PRT, MHC IIa fiber size (28%), peak force (31%), and power (28%) improved, but no changes were observed in MHC I fibers, in YW ( P < 0.05). There were no improvements in MHC I or IIa single-fiber function in OW. These data show that the myocellular functional profile in OW is similar to that in YW but that OW have a blunted hypertrophic response to PRT at the whole muscle and myocellular level. The limited myocellular plasticity in OW with PRT contrasts with that in YW and previous PRT studies in elderly women only a decade younger. These data suggest that attempts to greatly enhance skeletal muscle mass and function should begin before 80 yr of age.

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Metadata

Authors
Raue, U., Slivka, D., Minchev, K., & Trappe, S.
Affiliations
Ball State University (US)
ORCID
Venue
Journal of Applied Physiology
Publisher
American Physiological Society
Published
2009-05
Volume
106
Issue
5
Pages
1611-1617
ISSN
  • 0161-7567 (ISSN-L)
  • 8750-7587
  • 1522-1601
DOI
10.1152/japplphysiol.91587.2008
PMC
PMC2681332
OpenAlex
W2090562582
Cited by
166
References
60
Citations by year
2026: 8 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 15
FWCI
10.16
Type
journal article
Language
en
Open access
Locations
  • Journal of Applied Physiology (publishedVersion, public-domain)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG 18409, R01AG018409)
Topics
  • Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
Keywords
high-intensity resistance training, progressive resistance training, sarcopenia, muscle hypertrophy, myosin heavy chain, vastus lateralis, muscle strength, muscle cross-sectional area, muscle power
MeSH terms
Adaptation, Physiological, Aged, 80 and over, Aging, Female, Humans, Isometric Contraction, Male, Sex Factors, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Light Chains, Myosin Heavy Chains, Lower Extremity, Young Adult

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