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Improvements in whole muscle and myocellular function are limited with high-intensity resistance training in octogenarian women
Open accessAbstract
Advanced sarcopenia is prevalent among octogenarian women; yet little is known about myocellular quality and plasticity in this cohort. The aim of this investigation was to examine single muscle fiber contractile function and whole muscle characteristics before and after 12 wk of high-intensity progressive resistance training (PRT) in very old (85 ± 1 yr) women (OW, n = 6). Young women [YW (21 ± 2 yr old), n = 9] were included as a control group. Whole muscle strength [1 repetition maximum (RM)] and size (CT scans) were assessed before and after PRT. Functional experiments (size, peak force, velocity, and power) were performed on vastus lateralis myosin heavy chain (MHC) I and IIa muscle fibers before and after PRT. With PRT, 1-RM strength increased ( P < 0.05) in YW (36%) and OW (26%). Thigh muscle cross-sectional area increased (5%) in YW ( P < 0.05), but thigh muscle did not hypertrophy in OW. Before PRT, there were no differences in single-fiber parameters between YW and OW. With PRT, MHC IIa fiber size (28%), peak force (31%), and power (28%) improved, but no changes were observed in MHC I fibers, in YW ( P < 0.05). There were no improvements in MHC I or IIa single-fiber function in OW. These data show that the myocellular functional profile in OW is similar to that in YW but that OW have a blunted hypertrophic response to PRT at the whole muscle and myocellular level. The limited myocellular plasticity in OW with PRT contrasts with that in YW and previous PRT studies in elderly women only a decade younger. These data suggest that attempts to greatly enhance skeletal muscle mass and function should begin before 80 yr of age.
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“observations that the hypertrophic response of aging skeletal muscle may be blunted [40–43]”
From Targeting Intramyocellular Lipids to Improve Aging Muscle Function (2025) · cites this paper as [41]
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“Instead, older women (aged 80 years+) display a blunted anabolic response, as no increase in muscle size was found after 12 weeks of resistive training (Raue et al., 2009).”
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“This indicates that the myocellular response to resistance training is blunted in advanced age (Narici et al., 2004; Slivka et al., 2008; Raue et al., 2009).”
Background
Metadata
- Authors
- Raue, U., Slivka, D., Minchev, K., & Trappe, S.
- Affiliations
- Ball State University (US)
- Venue
- Journal of Applied Physiology
- Publisher
- American Physiological Society
- Published
- 2009-05
- Volume
- 106
- Issue
- 5
- Pages
- 1611-1617
- ISSN
- 0161-7567 (ISSN-L)
- 8750-7587
- 1522-1601
- PMC
- PMC2681332
- OpenAlex
- W2090562582
- Cited by
- 166
- References
- 60
- Citations by year
- 2026: 8 · 2025: 6 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 8 · 2020: 8 · 2019: 15 · 2018: 9 · 2017: 9 · 2016: 11 · 2015: 11 · 2014: 8 · 2013: 6 · 2012: 15
- FWCI
- 10.16
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Applied Physiology (publishedVersion, public-domain)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute on Aging (AG 18409, R01AG018409)
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
- Keywords
- high-intensity resistance training, progressive resistance training, sarcopenia, muscle hypertrophy, myosin heavy chain, vastus lateralis, muscle strength, muscle cross-sectional area, muscle power
- MeSH terms
- Adaptation, Physiological, Aged, 80 and over, Aging, Female, Humans, Isometric Contraction, Male, Sex Factors, Exercise, Muscle, Skeletal, Muscle Fibers, Skeletal, Myosin Light Chains, Myosin Heavy Chains, Lower Extremity, Young Adult
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