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Cited by 46Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMultisensory perception and integration

Cortical and Collicular Inputs to Cells in the Rat Paralaminar Thalamic Nuclei Adjacent to the Medial Geniculate Body

Smith, Philip H., Bartlett, Edward L., Kowalkowski, Anna·2007·Journal of Neurophysiology
DOI 10.1152/jn.00235.2007
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Abstract

The paralaminar nuclei, including the medial division of the medial geniculate nucleus, surround the auditory thalamus medially and ventrally. This multimodal area receives convergent inputs from auditory, visual, and somatosensory structures and sends divergent outputs to cortical layer 1, amygdala, basal ganglia, and elsewhere. Studies implicate this region in the modulation of cortical 40-Hz oscillations, cortical information binding, and the conditioned fear response. We recently showed that the basic anatomy and intrinsic physiology of paralaminar cells are unlike that of neurons elsewhere in sensory thalamus. Here we evaluate the synaptic inputs to paralaminar cells from the inferior and superior colliculi and the cortex. Combined physiological and anatomical evidence indicates that paralaminar cells receive both excitatory and inhibitory inputs from both colliculi and excitatory cortical inputs. Excitatory inputs from all three sources typically generate small summating EPSPs composed of AMPA and NMDA components and terminate primarily on smaller dendrites and occasionally on dendritic spines. The cortical input shows strong paired-pulse facilitation (PPF), whereas both collicular inputs show weak PPF or paired-pulse depression (PPD). EPSPs of cells with no low-threshold calcium conductance do not evoke a burst response when the cell is hyperpolarized. Longer-latency EPSPs were seen and our evidence indicates that these arise from axon collateral inputs of other synaptically activated paralaminar cells. The inhibitory collicular inputs are GABAergic, activate GABA A receptors, and terminate on dendrites. Their activation can greatly alter EPSP-generated spike number and timing.

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Crossref · 10.1152/jn.00235.2007

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  • Other neurons in the paralaminar thalamus are more efficiently driven by inputs from the IC than from the AuCx.

    “These findings are similar to those in other neurons in the paralaminar thalamus, which are more efficiently driven by inputs from the IC than those from the AuCx26.”

    From Neural circuitry for maternal oxytocin release induced by infant cries (2023) · cites this paper as [26]

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Authors
Smith, P. H., Bartlett, E. L., & Kowalkowski, A.
Affiliations
University of Wisconsin–Madison (US)
ORCID
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
2007-08
Volume
98
Issue
2
Pages
681-695
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.00235.2007
OpenAlex
W2001577583
Cited by
46
References
67
Citations by year
2026: 2 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2019: 1 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 4 · 2012: 1
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Deafness and Other Communication Disorders (R01DC006212)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Multisensory perception and integration
Keywords
medial geniculate body, inferior colliculus, superior colliculus, cortical input, synaptic input, excitatory postsynaptic potentials, paired-pulse facilitation, paired-pulse depression, GABAergic inhibition, GABAA receptor, axon collaterals, burst firing, auditory thalamus, rats
MeSH terms
Animals, Biotin, Cerebral Cortex, Dose-Response Relationship, Radiation, Electric Stimulation, gamma-Aminobutyric Acid, Inferior Colliculi, Membrane Potentials, Neural Pathways, Synaptic Transmission, Neurons, Quinoxalines, Reaction Time, Superior Colliculi, Thalamic Nuclei, Time Factors, Microscopy, Immunoelectron, Excitatory Amino Acid Antagonists, Excitatory Postsynaptic Potentials, Rats, Long-Evans, Rats, Inhibitory Postsynaptic Potentials, In Vitro Techniques

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