The DOI matches its Crossref record; 67 of the 67 references it cites were found in a registry or an index.
Computational Analysis of Subthalamic Nucleus and Lenticular Fasciculus Activation During Therapeutic Deep Brain Stimulation
Abstract
The subthalamic nucleus (STN) is the most common target for the treatment of Parkinson’s disease (PD) with deep brain stimulation (DBS). DBS of the globus pallidus internus (GPi) is also effective in the treatment of PD. The output fibers of the GPi that form the lenticular fasciculus pass in close proximity to STN DBS electrodes. In turn, both STN projection neurons and GPi fibers of passage represent possible therapeutic targets of DBS in the STN region. We built a comprehensive computational model of STN DBS in parkinsonian macaques to study the effects of stimulation in a controlled environment. The model consisted of three fundamental components: 1) a three-dimensional (3D) anatomical model of the macaque basal ganglia, 2) a finite element model of the DBS electrode and electric field transmitted to the tissue medium, and 3) multicompartment biophysical models of STN projection neurons, GPi fibers of passage, and internal capsule fibers of passage. Populations of neurons were positioned within the 3D anatomical model. Neurons were stimulated with electrode positions and stimulation parameters defined as clinically effective in two parkinsonian monkeys. The model predicted axonal activation of STN neurons and GPi fibers during STN DBS. Model predictions regarding the degree of GPi fiber activation matched well with experimental recordings in both monkeys. Only axonal activation of the STN neurons showed a statistically significant increase in both monkeys when comparing clinically effective and ineffective stimulation. Nonetheless, both neural targets may play important roles in the therapeutic mechanisms of STN DBS.
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Cites
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Stimulation of the Subthalamic Nucleus Changes the Firing Pattern of Pallidal Neurons
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Self-citationCellular Effects of Deep Brain Stimulation: Model-Based Analysis of Activation and Inhibition
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Self-citationActivity Patterns in a Model for the Subthalamopallidal Network of the Basal Ganglia
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Lozano, A. M., Lipsman, N., Bergman, H., Brown, P., Chabardes, S., Chang, J. W., Matthews, K., McIntyre, C. C., Schlaepfer, T. E., Schulder, M., et al. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0128-2 · Cited by 1,450
Self-citationPatient-specific analysis of the volume of tissue activated during deep brain stimulation
Butson, C. R., Cooper, S. E., Henderson, J. M., & McIntyre, C. C. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.09.034 · Cited by 489
Self-citationRiva-Posse, P., Choi, K. S., Holtzheimer, P. E., McIntyre, C. C., Gross, R. E., Chaturvedi, A., Crowell, A. L., Garlow, S. J., Rajendra, J. K., & Mayberg, H. S. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2014.03.029 · Cited by 460
Self-citationNetwork perspectives on the mechanisms of deep brain stimulation
McIntyre, C. C., & Hahn, P. J. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.09.022 · Cited by 439
Self-citationMechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?
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Metadata
- Authors
- Miocinovic, S., Parent, M., Butson, C. R., Hahn, P. J., Russo, G. S., Vitek, J. L., & McIntyre, C. C.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2006-09
- Volume
- 96
- Issue
- 3
- Pages
- 1569-1580
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2139526581
- Cited by
- 305
- References
- 67
- FWCI
- 14.85
- Type
- journal article
- Language
- en
- Open access
- closed
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- Miocinovic, S., Parent, M., Butson, C. R., Hahn, P. J., Russo, G. S., Vitek, J. L., & McIntyre, C. C. (2006). Computational Analysis of Subthalamic Nucleus and Lenticular Fasciculus Activation During Therapeutic Deep Brain Stimulation. Journal of Neurophysiology. https://doi.org/10.1152/jn.00305.2006
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