Network perspectives on the mechanisms of deep brain stimulation
Open accessAbstract
Deep brain stimulation (DBS) is an established medical therapy for the treatment of movement disorders and shows great promise for several other neurological disorders. However, after decades of clinical utility the underlying therapeutic mechanisms remain undefined. Early attempts to explain the mechanisms of DBS focused on hypotheses that mimicked an ablative lesion to the stimulated brain region. More recent scientific efforts have explored the wide-spread changes in neural activity generated throughout the stimulated brain network. In turn, new theories on the mechanisms of DBS have taken a systems-level approach to begin to decipher the network activity. This review provides an introduction to some of the network based theories on the function and pathophysiology of the cortico-basal-ganglia-thalamo-cortical loops commonly targeted by DBS. We then analyze some recent results on the effects of DBS on these networks, with a focus on subthalamic DBS for the treatment of Parkinson's disease. Finally we attempt to summarize how DBS could be achieving its therapeutic effects by overriding pathological network activity.
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Deep brain stimulation can modulate brain networks.
“Furthermore, modulation of networks can be achieved through deep brain stimulation (DBS)180-182.”
From Dysregulation of adult hippocampal neuroplasticity in major depression: Pathogenesis and therapeutic implications (2022) · cites this paper as [181]
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- Authors
- McIntyre, C. C., & Hahn, P. J.
- Affiliations
- Cleveland Clinic (US)
- Corresponding author
- McIntyre, Cameron C.
- ORCID
- McIntyre, Cameron C.
- Venue
- Neurobiology of Disease
- Publisher
- Elsevier BV
- Published
- 2010-06
- Volume
- 38
- Issue
- 3
- Pages
- 329-337
- ISSN
- 0969-9961 (ISSN-L)
- PMC
- PMC2862840
- OpenAlex
- W2057435588
- Cited by
- 439
- References
- 94
- Citations by year
- 2026: 12 · 2025: 17 · 2024: 18 · 2023: 22 · 2022: 24 · 2021: 22 · 2020: 47 · 2019: 27 · 2018: 24 · 2017: 30 · 2016: 32 · 2015: 41 · 2014: 35 · 2013: 36 · 2012: 29
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Neurobiology of Disease (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS059736, R01NS047388)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- deep brain stimulation, therapeutic mechanisms, cortico-basal ganglia-thalamo-cortical loop, subthalamic nucleus, Parkinson's disease, movement disorders, neuronal network activity
- MeSH terms
- Animals, Brain, Humans, Models, Neurological, Neural Pathways, Neurons, Deep Brain Stimulation
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