The DOI matches its Crossref record; 96 of the 96 references it cites were found in a registry or an index.
Mechanism of Deep Brain Stimulation: Inhibition, Excitation, or Disruption?
Open accessAbstract
Deep brain stimulation (DBS), applying high-frequency electrical stimulation to deep brain structures, has now provided an effective therapeutic option for treatment of various neurological and psychiatric disorders. DBS targeting the internal segment of the globus pallidus, subthalamic nucleus, and thalamus is used to treat symptoms of movement disorders, such as Parkinson’s disease, dystonia, and tremor. However, the mechanism underlying the beneficial effects of DBS remains poorly understood and is still under debate: Does DBS inhibit or excite local neuronal elements? In this short review, we would like to introduce our recent work on the physiological mechanism of DBS and propose an alternative explanation: DBS dissociates input and output signals, resulting in the disruption of abnormal information flow through the stimulation site.
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Balestrino, R., & Schapira, A. H. V. (2020) · European Journal of Neurology · doi:10.1111/ene.14108 · Cited by 1,508
Circuit Mechanisms of Parkinson’s Disease
McGregor, M. M., & Nelson, A. B. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.004 · Cited by 624
Hell, F., Palleis, C., Mehrkens, J. H., Koeglsperger, T., & Bötzel, K. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.00314 · Cited by 75
Basu, I., Robertson, M. M., Crocker, B., Peled, N., Farnes, K., Vallejo-Lopez, D. I., Deng, H., Thombs, M., Martinez-Rubio, C., Cheng, J. J., et al. (2019) · Brain Stimulation · doi:10.1016/j.brs.2019.03.007 · Cited by 50
Visual hallucinations in Parkinson’s disease: spotlight on central cholinergic dysfunction
Ignatavicius, A., Matar, E., & Lewis, S. J. G. (2025) · Brain · doi:10.1093/brain/awae289 · Cited by 32
Metadata
- Authors
- Chiken, S., & Nambu, A.
- Venue
- The Neuroscientist
- Publisher
- SAGE Publications
- Published
- 2015-04-17
- Volume
- 22
- Issue
- 3
- Pages
- 313-322
- ISSN
- 1073-8584 (ISSN-L)
- 1089-4098
- OpenAlex
- W2114827170
- Cited by
- 375
- References
- 96
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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