Posture-Related Oscillations in Human Cerebellar Thalamus in Essential Tremor Are Enabled by Voluntary Motor Circuits
Abstract
The mechanism of essential tremor (ET) is unclear. Animal models of tremor and functional imaging studies in ET predict that the cerebellum and a cerebellar recipient thalamic nucleus (ventral intermediate, Vim) should exhibit oscillatory activity during rest and during tremor due to abnormal olivo-cerebellar activity. Physiologic responses of 152 single neurons were recorded during awake mapping of the ventral thalamus in seven patients with ET prior to thalamotomy. During postural tremor, spectral cross-correlation analysis demonstrated that 51% of the neurons studied exhibited a concentration of power at tremor frequency that was correlated with electromyography, i.e., tremor neurons. During rest, thalamic neurons did not exhibit tremor-frequency activity. Among the three thalamic nuclei surveyed, Vim had a significantly higher proportion of tremor neurons than did the principal somatic sensory nucleus (ventral caudal, Vc) or a pallidal recipient thalamic nucleus (ventral oral posterior, Vop). Neurons related to active movement (voluntary neurons) had significantly greater tremor-related activity than did nonvoluntary neurons. These findings are not consistent with a model of continuous olivo-cerebellar driving of the motor cortex through thalamic connections. Instead ET may be facilitated by motor circuits that enable tremor-related thalamic activity during voluntary movement. Additionally, a subgroup of tremor neurons with proprioceptive inputs were identified that may a…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
During essential tremor, thalamic neurons exhibit firing patterns correlated with tremor, predominantly in the cerebellar input receiving zone, the ventralis intermedius.
“During essential tremor, thalamic neurons exhibit firing patterns correlated with tremor, predominantly in the cerebellar input receiving zone, the ventralis intermedius (Hua and Lenz, 2005).”
From The nature of tremor circuits in parkinsonian and essential tremor (2014) · cites this paper as Hua and Lenz, 2005
Cites
Taussig, M. (1991) · Routledge eBooks · doi:10.4324/9780203397244 · Cited by 2,403 · see citing works
Consensus Statement of the Movement Disorder Society on Tremor
Deuschl, G., Bain, P., & Brin, M. (2008) · Movement Disorders · doi:10.1002/mds.870131303 · Cited by 1,981 · see citing works
Saunders, H. (1974) · The Shock and Vibration Digest · doi:10.1177/058310247400600707 · Cited by 1,145 · see citing works
Cerebrocerebellar communication systems.
Allen, G. I., & Tsukahara, N. (1974) · Physiological Reviews · doi:10.1152/physrev.1974.54.4.957 · Cited by 1,066 · see citing works
A comparison of continuous thalamic stimulation and thalamotomy for suppression of severe tremor.
Schuurman, P., Bosch, D. A., Bossuyt, P., Bonsel, G., van Someren, E. V., de Bie, R. D., Merkus, M., & Speelman, J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200002173420703 · Cited by 1,065 · see citing works
Llinas, R. H., & Yarom, Y. (1981) · The Journal of Physiology · doi:10.1113/jphysiol.1981.sp013763 · Cited by 969 · see citing works
Parkinson’s Disease and Movement Disorders
Tn, M., & Bhattacharyya, K. (2005) · Jaypee Brothers Medical Publishers (P) Ltd. eBooks · doi:10.5005/jp/books/10587 · Cited by 804 · see citing works
Dynamic organization of motor control within the olivocerebellar system
Welsh, J. P., Lang, E. J., Suglhara, I., & Llinás, R. (1995) · Nature · doi:10.1038/374453a0 · Cited by 685 · see citing works
Llinas, R. H., & Yarom, Y. (1986) · The Journal of Physiology · doi:10.1113/jphysiol.1986.sp016147 · Cited by 668 · see citing works
Electrotonic coupling between neurons in cat inferior olive.
Llinas, R. H., Baker, R. G. V., & Sotelo, C. (1974) · Journal of Neurophysiology · doi:10.1152/jn.1974.37.3.560 · Cited by 661 · see citing works
Houk, J. C., & Wise, S. P. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.2.95 · Cited by 594 · see citing works
Principles of Neurobiological Signal Analysis
(1976) · Elsevier eBooks · doi:10.1016/b978-0-12-285950-2.x5001-6 · Cited by 439 · see citing works
Louis, E. D., Ottman, R., & Allen Hauser, W. (1998) · Movement Disorders · doi:10.1002/mds.870130105 · Cited by 424 · see citing works
Theodoridis, S., & Kalouptsidis, N. (1993) · Cited by 399 · see citing works
Animal Models of Action Tremor
Elble, R. J. (2008) · Movement Disorders · doi:10.1002/mds.870131306 · Cited by 381 · see citing works
Lenz, F. A., Kwan, H. C., Martin, R. L., Tasker, R. R., Dostrovsky, J. O., & Lenz, Y. E. (1994) · Brain · doi:10.1093/brain/117.3.531 · Cited by 374 · see citing works
Self-citation(2001) · Elsevier eBooks · doi:10.1016/b978-0-12-305460-9.x5013-8 · Cited by 355 · see citing works
Tactile Functions of Mechanoreceptive Afferents Innervating the Hand
Johnson, K., Yoshioka, T., & Vega‐Bermudez, F. (2000) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-200011000-00002 · Cited by 351 · see citing works
Corticomotoneuronal cells contribute to long‐latency stretch reflexes in the rhesus monkey.
Cheney, P. D., & Fetz, E. E. (1984) · The Journal of Physiology · doi:10.1113/jphysiol.1984.sp015155 · Cited by 311 · see citing works
Outcome after Stereotactic Thalamotomy for Parkinsonian, Essential, and Other Types of Tremor
Jankovic, J. J., Cardoso, F., Grossman, R. G., & Hamilton, W. J. (1995) · Neurosurgery · doi:10.1227/00006123-199510000-00011 · Cited by 309 · see citing works
Jenkins, I. H., Bain, P. G., Colebatch, J. G., Thompson, P. D., Findley, L. J. J., Frackowiak, R. S. J., MARSDEN, C. D., & Brooks, D. J. (1993) · Annals of Neurology · doi:10.1002/ana.410340115 · Cited by 291 · see citing works
Lenz, F., Tasker, R., Kwan, H. C., Schnider, S., Kwong, R. H. S., Murayama, Y., Dostrovsky, J. O., & Murphy, J. T. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-03-00754.1988 · Cited by 289 · see citing works
Self-citationElble, R. J. (1996) · Journal of Clinical Neurophysiology · doi:10.1097/00004691-199603000-00004 · Cited by 269 · see citing works
Thermal and pain sensations evoked by microstimulation in the area of human ventrocaudal nucleus
Lenz, F. A., Seike, M., Richardson, R. T., Lin, Y., Baker, F., Khoja, I., Jaeger, C. J., & Gracely, R. H. (1993) · Journal of Neurophysiology · doi:10.1152/jn.1993.70.1.200 · Cited by 237 · see citing works
Self-citationWills, A. J., Jenkins, I. H., Thompson, P. D., Findley, L. J. J., & Brooks, D. J. (1994) · Annals of Neurology · doi:10.1002/ana.410360413 · Cited by 234 · see citing works
Activation mapping in essential tremor with functional magnetic resonance imaging
Bucher, S., Seelos, K., Dodel, R. C., Reiser, M. F., & Oertel, W. H. (1997) · Annals of Neurology · doi:10.1002/ana.410410108 · Cited by 224 · see citing works
Distributed motor commands in the limb premotor network
Houk, J. C., Keifer, J., & Barto, A. G. (1993) · Trends in Neurosciences · doi:10.1016/0166-2236(93)90049-r · Cited by 215 · see citing works
Findley, L. J. J., & Capildeo, R. (1984) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-06757-2 · Cited by 213 · see citing works
Keating, J. G., & Thach, W. T. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.4.1329 · Cited by 208 · see citing works
Lee, R. G., & Stein, R. B. (1981) · Annals of Neurology · doi:10.1002/ana.410100606 · Cited by 205 · see citing works
The effect of ethanol on alcohol‐responsive essential tremor: A positron emission tomography study
Boecker, H., Wills, A. J., Ceballos-Baumann, A., Samuel, M., Thompson, P. D., Findley, L. J. J., & Brooks, D. J. (1996) · Annals of Neurology · doi:10.1002/ana.410390515 · Cited by 201 · see citing works
Coherence between cerebellar thalamus, cortex and muscle in man: Cerebellar thalamus interactions
Marsden, J. F. (2000) · Brain · doi:10.1093/brain/123.7.1459 · Cited by 197 · see citing works
Welsh, J. P., & Llinás, R. (1997) · Progress in brain research · doi:10.1016/s0079-6123(08)63380-4 · Cited by 196 · see citing works
Estimation of the coherence spectrum and its confidence interval using the fast Fourier transform
Benignus, V. A. (1969) · IEEE Transactions on Audio and Electroacoustics · doi:10.1109/tau.1969.1162046 · Cited by 196 · see citing works
Preliminary report: activation of the cerebellum in essential tremor
Colebatch, J. G. (1990) · The Lancet · doi:10.1016/0140-6736(90)92489-5 · Cited by 189 · see citing works
Cerebral motor control in man : long loop mechanisms
Desmedt, J. E. (1978) · Medical Entomology and Zoology · Cited by 185 · see citing works
Blood flow responses to deep brain stimulation of thalamus
Perlmutter, J. S., Mink, J. W., Bastian, A. J., Zackowski, K. M., Hershey, T. G., Miyawaki, E. K., Koller, W. C., & Videen, T. O. (2002) · Neurology · doi:10.1212/wnl.58.9.1388 · Cited by 175 · see citing works
Pathophysiology of nonparkinsonian tremors
Deuschl, G., & Bergman, H. (2002) · Movement Disorders · doi:10.1002/mds.10141 · Cited by 172 · see citing works
Wilms, H., Sievers, J., & Deuschl, G. (1999) · Movement Disorders · doi:10.1002/1531-8257(199907)14:4 · Cited by 171 · see citing works
(1995) · M. Dekker eBooks · Cited by 171 · see citing works
Glucose metabolism in the brain of patients with essential tremor
Hallett, M., & Dubinsky, R. (1993) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(93)90047-3 · Cited by 157 · see citing works
Epidemiology and Genetics of Essential Tremor
Brin, M. F., & Koller, W. C. (2008) · Movement Disorders · doi:10.1002/mds.870131310 · Cited by 153 · see citing works
Wills, A. J., Jenkins, L. H., Thompson, P. D., Findley, L. J. J., & Brooks, D. J. (1995) · Archives of Neurology · doi:10.1001/archneur.1995.00540270095025 · Cited by 151 · see citing works
The role of spectroscopy in parkinsonism
Davie, C. A. (1998) · Movement Disorders · doi:10.1002/mds.870130104 · Cited by 145 · see citing works
The role of the cerebello-thalamo-cortical pathway in skilled movement
Horne, M. K., & Butler, E. G. (1995) · Progress in Neurobiology · doi:10.1016/0301-0082(95)80011-v · Cited by 144 · see citing works
Muscle Spindles: Their Messages and Their Fusimotor Supply
Matthews, P. B. C. (1981) · Comprehensive physiology · doi:10.1002/cphy.cp010206 · Cited by 141 · see citing works
Homolateral disappearance of essential tremor after cerebellar stroke
Dupuis, M., Delwaide, P. J., Boucquey, D., & Gonsette, R. E. (1989) · Movement Disorders · doi:10.1002/mds.870040210 · Cited by 139 · see citing works
Lenz, F. A., Dostrovsky, J. O., Kwan, H. C., Tasker, R. R., Yamashiro, K., & Murphy, J. T. (1988) · Journal of neurosurgery · doi:10.3171/jns.1988.68.4.0630 · Cited by 128 · see citing works
Self-citationGoldman, M. S., Ahlskog, J. E., & Kelly, P. J. (1992) · Journal of neurosurgery · doi:10.3171/jns.1992.76.6.0924 · Cited by 115 · see citing works
SINGLE UNIT ANALYSIS OF THE HUMAN VENTRAL THALAMIC NUCLEAR GROUP
Lenz, F. A., Kwan, H. C., Dostrovsky, J. O., Tasker, R. R., Murphy, J. T., & Lenz, Y. E. (1990) · Brain · doi:10.1093/brain/113.6.1795 · Cited by 114 · see citing works
Self-citationThe estimation of the frequency response function of a mechanoreceptor
French, A. S., Holden, A. V., & Stein, R. B. (1972) · Kybernetik · doi:10.1007/bf00267761 · Cited by 106 · see citing works
Physiological and pharmacological aids in the differential diagnosis of tremor
Shahani, B. T., & Young, R. R. (1976) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.39.8.772 · Cited by 102 · see citing works
Zirh, A. T., Reich, S. G., Dougherty, P. M., & Lenz, F. A. (1999) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.66.6.772 · Cited by 98 · see citing works
Self-citationVitek, J. L., Ashe, J., DeLong, M. R., & Kaneoke, Y. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.6.2486 · Cited by 82 · see citing works
Milner, T. E., Cadoret, G., Lessard, L., & Smith, A. M. (1995) · Journal of Neurophysiology · doi:10.1152/jn.1995.73.6.2568 · Cited by 76 · see citing works
Boecker, H., & Brooks, D. J. (2008) · Movement Disorders · doi:10.1002/mds.870131311 · Cited by 73 · see citing works
Essential tremor: electrophysiological and pharmacological evidence for a subdivision.
Deuschl, G., Lücking, C. H., & Schenck, E. (1987) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.50.11.1435 · Cited by 71 · see citing works
Animal models of physiological, essential and parkinsonian-like tremors
Lamarre, Y. (1984) · Palgrave Macmillan UK eBooks · doi:10.1007/978-1-349-06757-2_11 · Cited by 62 · see citing works
Lemstra, A. W., Metman, L. V., Lee, J. I., Dougherty, P. M., & Lenz, F. A. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00343-2 · Cited by 62 · see citing works
Self-citationNo Clock Signal in the Discharge of Neurons in the Deep Cerebellar Nuclei
Keating, J. G., & Thach, W. T. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.2232 · Cited by 53 · see citing works
Lenz, F. A., Jaeger, C. J., Seike, M., Lin, Y., & Reich, S. G. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00049.2001 · Cited by 44 · see citing works
Self-citationContralateral abolition of essential tremor following a pontine stroke
Nagaratnam, N., & Kalasabail, G. (1997) · Journal of the Neurological Sciences · doi:10.1016/s0022-510x(97)05397-5 · Cited by 41 · see citing works
Cerebellar guidance of premotor network development and sensorimotor learning.Preprint
Hua, S. E., & Houk, J. C. (1997) · Learning & Memory · doi:10.1101/lm.4.1.63 · Cited by 39 · see citing works
Self-citationPhase resetting and frequency entrainment of essential tremor.
Elble, R., Higgins, C., & Hughes, L. F. (1992) · Experimental Neurology · doi:10.1016/0014-4886(92)90014-h · Cited by 37 · see citing works
Contrasting locations of pallidal-receiving neurons and microexcitable zones in primate thalamus
Buford, J. A., Inase, M., & Anderson, M. E. (1996) · Journal of Neurophysiology · doi:10.1152/jn.1996.75.3.1105 · Cited by 37 · see citing works
Lenz, F., Tatton, W. G., & Tasker, R. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-04-00795.1983 · Cited by 35 · see citing works
Self-citationElectromyographic response to displacement of different forelimb joints in the squirrel monkey
Lenz, F., Tatton, W. G., & Tasker, R. (1983) · Journal of Neuroscience · doi:10.1523/jneurosci.03-04-00783.1983 · Cited by 34 · see citing works
Self-citationFrequency domain analysis of neurophysiological data
French, A. S., & Holden, A. V. (1971) · Computer Programs in Biomedicine · doi:10.1016/0010-468x(71)90013-4 · Cited by 32 · see citing works
Rhythmic activity of spinal interneurons in harmaline-treated cats
Weiss, M. (1982) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(82)90197-6 · Cited by 8 · see citing works
Butler, E. G., Harvey, M. C., Finkelstein, D. I., & Horne, M. K. (1998) · Experimental Brain Research · doi:10.1007/s002210050293 · Cited by 7 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Mechanisms of deep brain stimulation
Herrington, T. M., Cheng, J. J., & Eskandar, E. N. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00281.2015 · Cited by 551 · see citing works
Stimulating at the right time: phase-specific deep brain stimulation
Cagnan, H., Pedrosa, D., Little, S., Pogosyan, A., Cheeran, B., Aziz, T., Green, A., Fitzgerald, J., Foltynie, T., Limousin, P., et al. (2017) · Brain · doi:10.1093/brain/aww286 · Cited by 270 · see citing works
Synchronized brain network associated with essential tremor as revealed by magnetoencephalography
Schnitzler, A., Münks, C., Butz, M., Timmermann, L., & Gross, J. (2009) · Movement Disorders · doi:10.1002/mds.22633 · Cited by 265 · see citing works
Haubenberger, D., & Hallett, M. (2018) · New England Journal of Medicine · doi:10.1056/nejmcp1707928 · Cited by 121 · see citing works
Closed-Loop Control of Deep Brain Stimulation: A Simulation Study
Santaniello, S., Fiengo, G., Glielmo, L., & Grill, W. M. (2010) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2010.2081377 · Cited by 203 · see citing works
The oscillating central network of Essential tremor
Raethjen, J., & Deuschl, G. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.09.024 · Cited by 183 · see citing works
Hallett, M. (2013) · Parkinsonism & Related Disorders · doi:10.1016/s1353-8020(13)70029-4 · Cited by 169 · see citing works
Cortical Involvement in the Generation of Essential Tremor
Raethjen, J., Govindan, R. B., Kopper, F., Muthuraman, M., & Deuschl, G. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00477.2006 · Cited by 152 · see citing works
Opri, E., Cernera, S., Molina, R., Eisinger, R. S., Cagle, J. N., Almeida, L., Denison, T., Okun, M. S., Foote, K. D., & Gunduz, A. (2020) · Science Translational Medicine · doi:10.1126/scitranslmed.aay7680 · Cited by 146 · see citing works
Neuroimaging essentials in essential tremor: A systematic review
Sharifi, S., Nederveen, A. J., Booij, J., & van Rootselaar, A. (2014) · NeuroImage Clinical · doi:10.1016/j.nicl.2014.05.003 · Cited by 141 · see citing works
Human brain connectivity: Clinical applications for clinical neurophysiology
Hallett, M., de Haan, W., Deco, G., Dengler, R., Iorio, R. D., Galléa, C., Gerloff, C. P., Grefkes, C., Helmich, R. C. G., Kringelbach, M. L., et al. (2020) · Clinical Neurophysiology · doi:10.1016/j.clinph.2020.03.031 · Cited by 118 · see citing works
Tremor habituation to deep brain stimulation: Underlying mechanisms and solutions
Fasano, A. A., & Helmich, R. C. G. (2019) · Movement Disorders · doi:10.1002/mds.27821 · Cited by 112 · see citing works
Birdno, M. J., Kuncel, A. M., Dorval, A. D., Turner, D. A., Gross, R. E., & Grill, W. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00906.2010 · Cited by 103 · see citing works
The nature of tremor circuits in parkinsonian and essential tremor
Cagnan, H., Little, S., Foltynie, T., Limousin, P., Zrinzo, L., Hariz, M., Cheeran, B., Fitzgerald, J., Green, A. L., Aziz, T., et al. (2014) · Brain · doi:10.1093/brain/awu250 · Cited by 97 · see citing works
“During essential tremor, thalamic neurons exhibit firing patterns correlated with tremor, predominantly in the cerebellar input receiving zone, the ventralis intermedius (Hua and Lenz, 2005).”
BackgroundNicoletti, V., Cecchi, P. C., Pesaresi, I., Frosini, D., Cosottini, M., & Ceravolo, R. (2020) · Scientific Reports · doi:10.1038/s41598-020-73714-9 · Cited by 98 · see citing works
Phase dependent modulation of tremor amplitude in essential tremor through thalamic stimulation
Cagnan, H., Brittain, J.-S., Little, S., Foltynie, T., Limousin, P., Zrinzo, L., Hariz, M., Joint, C., Fitzgerald, J., Green, A. L., et al. (2013) · Brain · doi:10.1093/brain/awt239 · Cited by 95 · see citing works
Effects of Human Cerebellar Thalamus Disruption on Adaptive Control of Reaching
Chen, H., Hua, S. E., Smith, M. A., Lenz, F. A., & Shadmehr, R. (2005) · Cerebral Cortex · doi:10.1093/cercor/bhj087 · Cited by 88 · see citing works
Self-citationElble, R. (2013) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-013-0353-4 · Cited by 55 · see citing works
Tan, H., Debarros, J., He, S., Pogosyan, A., Aziz, T. Z., Huang, Y., Wang, S., Timmermann, L., Visser-Vandewalle, V., Pedrosa, D. J., et al. (2019) · Brain Stimulation · doi:10.1016/j.brs.2019.02.011 · Cited by 83 · see citing works
Kane, A., Hutchison, W. D., Hodaie, M., Lozano, A. M., & Dostrovsky, J. O. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.02.005 · Cited by 81 · see citing works
Linking Essential Tremor to the Cerebellum: Physiological Evidence
Filip, P., Lungu, O., Manto, M., & Bareš, M. (2015) · The Cerebellum · doi:10.1007/s12311-015-0740-2 · Cited by 81 · see citing works
Dimensionality Reduction in Control and Coordination of the Human Hand
Vinjamuri, R. K., Sun, M., Chang, C.-C., Lee, H.-N., Sclabassi, R. J., & Mao, Z.-H. (2009) · IEEE Transactions on Biomedical Engineering · doi:10.1109/tbme.2009.2032532 · Cited by 80 · see citing works
Toward a network model of dystonia
Hendrix, C. M., & Vitek, J. L. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06692.x · Cited by 78 · see citing works
Nonlinear System Identification of Neural Systems from Neurophysiological Signals
He, F., & Yang, Y. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.12.001 · Cited by 76 · see citing works
Hirschmann, J. V., Schoffelen, J., Schnitzler, A., & van Gerven, M. A. J. (2017) · Clinical Neurophysiology · doi:10.1016/j.clinph.2017.07.419 · Cited by 74 · see citing works
Kuncel, A. M., Cooper, S. E., Wolgamuth, B. R., & Grill, W. M. (2007) · IEEE Transactions on Neural Systems and Rehabilitation Engineering · doi:10.1109/tnsre.2007.897004 · Cited by 73 · see citing works
Mechanical suppression of essential tremor
Rocon, E., Manto, M., Pons, J., Camut, S., & Belda, J. M. (2007) · The Cerebellum · doi:10.1080/14734220601103037 · Cited by 68 · see citing works
Role of cerebellar GABAergic dysfunctions in the origins of essential tremor
Zhang, X., & Santaniello, S. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1817689116 · Cited by 69 · see citing works
Tremor varies as a function of the temporal regularity of deep brain stimulation
Birdno, M. J., Kuncel, A. M., Dorval, A. D., Turner, D. A., & Grill, W. M. (2008) · Neuroreport · doi:10.1097/wnr.0b013e3282f9e45e · Cited by 68 · see citing works
Gallego, J. A., Dideriksen, J. L., Holobar, A., Ibanez, J., Glaser, V., Romero, J. P., Benito-Leon, J., Pons, J. L., Rocon, E., & Farina, D. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0106-15.2015 · Cited by 67 · see citing works
Surgery Insight: deep brain stimulation for movement disorders
Anderson, W. S., & Lenz, F. A. (2006) · Nature Clinical Practice Neurology · doi:10.1038/ncpneuro0193 · Cited by 65 · see citing works
Self-citationSchöberl, F., Feil, K., Xiong, G., Bartenstein, P., la Fougère, C. J., Jahn, K., Brandt, T., Strupp, M. L., Dieterich, M., & Zwergal, A. (2016) · Brain · doi:10.1093/brain/aww268 · Cited by 60 · see citing works
Knowledge gaps and research recommendations for essential tremor
Hopfner, F., Haubenberger, D., Galpern, W. R., Gwinn, K. A., Veer, A. V., White, S., Bhatia, K. P., Adler, C. H., Eidelberg, D., Ondo, W. G., et al. (2016) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2016.10.002 · Cited by 58 · see citing works
Self-citationGibson, W. S., Jo, H. J., Testini, P., Cho, S., Felmlee, J. P., Welker, K. M., Klassen, B. T., Min, H.-K. P., & Lee, K. H. (2016) · Brain · doi:10.1093/brain/aww145 · Cited by 52 · see citing works
Beta oscillatory neurons in the motor thalamus of movement disorder and pain patients
Basha, D., Dostrovsky, J. O., Ríos, A. L. L., Hodaie, M., Lozano, A. M., & Hutchison, W. D. (2014) · Experimental Neurology · doi:10.1016/j.expneurol.2014.08.024 · Cited by 51 · see citing works
Morphometric and functional MRI changes in essential tremor with and without resting tremor
Nicoletti, V., Cecchi, P. C., Frosini, D., Pesaresi, I., Fabbri, S., Diciotti, S., Bonuccelli, U., Cosottini, M., & Ceravolo, R. (2015) · Journal of Neurology · doi:10.1007/s00415-014-7626-y · Cited by 50 · see citing works
Brücke, C., Bock, A., Huebl, J., Krauss, J. K., Schönecker, T., Schneider, G., Brown, P., & Kühn, A. A. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.02.038 · Cited by 49 · see citing works
The effect of inertial loading on wrist postural tremor in essential tremor
Héroux, M. E., Pari, G., & Norman, K. E. (2009) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.03.012 · Cited by 49 · see citing works
Birdno, M. J., Cooper, S. E., Rezai, A. R., & Grill, W. M. (2007) · Journal of Neurophysiology · doi:10.1152/jn.00547.2007 · Cited by 49 · see citing works
Report from a U.S. conference on essential tremor
Elble, R. J. (2006) · Movement Disorders · doi:10.1002/mds.21157 · Cited by 46 · see citing works
Hanson, T., Fuller, A. M., Lebedev, M., Turner, D. A., & Nicolelis, M. A. L. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0750-12.2012 · Cited by 40 · see citing works
Evaluation of a wearable orthosis and an associated algorithm for tremor suppression
Manto, M. U., Rocón, E., Pons, J. L., Lois, J. M. B., & Camut, S. (2007) · Physiological Measurement · doi:10.1088/0967-3334/28/4/007 · Cited by 41 · see citing works
Tremor reduction and modeled neural activity during cycling thalamic deep brain stimulation
Kuncel, A. M., Birdno, M. J., Swan, B. D., & Grill, W. M. (2011) · Clinical Neurophysiology · doi:10.1016/j.clinph.2011.07.052 · Cited by 39 · see citing works
Essential Tremor - a cerebellar driven disorder?
Ibrahim, M. F., Beevis, J. C., & Empson, R. (2020) · Neuroscience · doi:10.1016/j.neuroscience.2020.11.002 · Cited by 27 · see citing works
Acute Cerebellar Inflammation and Related Ataxia: Mechanisms and Pathophysiology
Parvez, M. S. A., & Ohtsuki, G. (2022) · Brain Sciences · doi:10.3390/brainsci12030367 · Cited by 34 · see citing works
Lenz, F. A., Casey, K. L., Jones, E. G., & Willis, W. D. (2010) · Cambridge University Press eBooks · doi:10.1017/cbo9780511770579 · Cited by 47 · see citing works
Self-citationCruz, P. M. R., Vargas, A., Fernández-Carballal, C., Garbizu, J. M., la Casa‐Fages, B. D., & Grandas, F. (2016) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.12337 · Cited by 31 · see citing works
He, F., Sarrigiannis, P. G., Billings, S. A., Wei, H., Rowe, J. G., Romanowski, C. A. J., Hoggard, N., Hadjivassiliou, M., Rao, D. G., Grünewald, R. A., et al. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.03.028 · Cited by 30 · see citing works
Lan, H., Suo, X., Li, W., Li, N., Li, J., Peng, J., Lei, D., Sweeney, J. A., Kemp, G. J., Peng, R., et al. (2021) · Human Brain Mapping · doi:10.1002/hbm.25425 · Cited by 30 · see citing works
T‐type calcium channels as therapeutic targets in essential tremor and Parkinson's disease
Matthews, L. G., Puryear, C. B., Correia, S. S., Srinivasan, S. R., Belfort, G. M., Pan, M., & Kuo, S. (2023) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.51735 · Cited by 30 · see citing works
Short pauses in thalamic deep brain stimulation promote tremor and neuronal bursting
Swan, B. D., Brocker, D. T., Hilliard, J. D., Tatter, S. B., Gross, R. E., Turner, D. A., & Grill, W. M. (2015) · Clinical Neurophysiology · doi:10.1016/j.clinph.2015.07.034 · Cited by 30 · see citing works
Thalamic Deep Brain Stimulation for the Treatment of Action Myoclonus Caused by Perinatal Anoxia
Kobayashi, K., Katayama, Y., Otaka, T., Obuchi, T., Kano, T., Nagaoka, T., Kasai, M., Oshima, H., Fukaya, C., & Yamamoto, T. (2010) · Stereotactic and Functional Neurosurgery · doi:10.1159/000315464 · Cited by 30 · see citing works
Couto, J., & Grill, W. M. (2016) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2016.00022 · Cited by 28 · see citing works
Tuleasca, C., Witjas, T., Ville, D. V. D., Najdenovska, E., Verger, A., Girard, N. J., Champoudry, J., Thiran, J., Cuadra, M. B., Levivier, M., et al. (2017) · Acta Neurochirurgica · doi:10.1007/s00701-017-3391-x · Cited by 28 · see citing works
Deep brain stimulation for vocal tremor: a comprehensive, multidisciplinary methodology
Ho, A. L., Erickson, E., Pendharkar, A. V., Sung, C. K., & Halpern, C. H. (2015) · Neurosurgical FOCUS · doi:10.3171/2015.3.focus1537 · Cited by 28 · see citing works
Ohara, S., Taghva, A. S., Kim, J. H., & Lenz, F. A. (2007) · Experimental Brain Research · doi:10.1007/s00221-007-0856-9 · Cited by 28 · see citing works
Self-citationKim, J. H., Chien, J. H., Liu, C. C., & Lenz, F. A. (2014) · Journal of Neurophysiology · doi:10.1152/jn.00778.2014 · Cited by 25 · see citing works
Self-citationExtraction of Sources of Tremor in Hand Movements of Patients With Movement Disorders
Vinjamuri, R., Crammond, D. J., Kondziolka, D., Lee, H.-N., & Mao, Z.-H. (2009) · IEEE Transactions on Information Technology in Biomedicine · doi:10.1109/titb.2008.2006403 · Cited by 23 · see citing works
Vocal Tremor and Vibrato in the Same Person: Acoustic and Electromyographic Differences
Dromey, C., & Smith (2008) · Journal of Voice · doi:10.1016/j.jvoice.2006.12.001 · Cited by 21 · see citing works
Essential tremor amplitude modulation by median nerve stimulation
Reis, C., Arruda, B. S., Pogosyan, A., Brown, P., & Cagnan, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-96660-6 · Cited by 22 · see citing works
Distinguishing essential tremor from Parkinson’s disease: clinical and experimental tools
Angelini, L., Paparella, G., & Bologna, M. (2024) · Expert Review of Neurotherapeutics · doi:10.1080/14737175.2024.2372339 · Cited by 23 · see citing works
A functional micro-electrode mapping of ventral thalamus in essential tremor
Pedrosa, D., Brown, P., Cagnan, H., Visser-Vandewalle, V., Wirths, J., Timmermann, L., & Brittain, J. (2018) · Brain : a journal of neurology · doi:10.1093/brain/awy192 · Cited by 17 · see citing works
Zakaria, R., Lenz, F. A., Hua, S. E., Avin, B. H., Liu, C. C., & Mari, Z. K. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.011 · Cited by 20 · see citing works
Self-citationThalamic neuronal and EMG activity in psychogenic dystonia compared with organic dystonia
Kobayashi, K., Lang, A. E., Hallett, M., & Lenz, F. A. (2011) · Movement Disorders · doi:10.1002/mds.23565 · Cited by 19 · see citing works
Self-citationYi, G., & Grill, W. M. (2018) · Journal of Neural Engineering · doi:10.1088/1741-2552/aacbff · Cited by 17 · see citing works
Tien, R. N., Tekriwal, A., Calame, D. J., Platt, J. P., Baker, S., Seeberger, L., Kern, D. S., Person, A. L., Ojemann, S. G., Thompson, J. A., et al. (2022) · Frontiers in Signal Processing · doi:10.3389/frsip.2022.884384 · Cited by 17 · see citing works
Subtle changes in central dopaminergic tone underlie bradykinesia in essential tremor
Colella, D., Passaretti, M., Frantellizzi, V., Feo, M. S. D., Cannavacciuolo, A., Angelini, L., Birreci, D., Costa, D. D., Paparella, G., Guerra, A., et al. (2023) · NeuroImage Clinical · doi:10.1016/j.nicl.2023.103526 · Cited by 16 · see citing works
Fanning, A. S., & Kuo, S. (2023) · The Cerebellum · doi:10.1007/s12311-023-01551-3 · Cited by 15 · see citing works
Pretherapeutic functional neuroimaging predicts tremor arrest after thalamotomy
Tuleasca, C., Najdenovska, E., Régis, J. M., Witjas, T., Girard, N. J., Champoudry, J., Faouzi, M., Thiran, J., Cuadra, M. B., Levivier, M., et al. (2018) · Acta Neurologica Scandinavica · doi:10.1111/ane.12891 · Cited by 15 · see citing works
The Bereitschaftspotential in essential tremor.
Lu, M.-K., Jung, P., Bliem, B., Shih, H.-T., Hseu, Y.-T., Yang, Y.-W., Ziemann, U., & Tsai, C.-H. (2010) · Clinical Neurophysiology · doi:10.1016/j.clinph.2009.12.014 · Cited by 15 · see citing works
Mazzocchio, R., Gelli, F., Santo, F. D., Popa, T., & Rossi, A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.05.024 · Cited by 13 · see citing works
Lu, H., Lin, J., Xiong, Y., Deng, L., Wang, X., Zhang, D., Bian, X., Zhou, J., Pan, L., & Lou, X. (2022) · Neurosurgical FOCUS · doi:10.3171/2022.9.focus22228 · Cited by 13 · see citing works
Resting state fMRI reveals the altered synchronization of BOLD signals in essential tremor
Wang, P., Luo, X., Zhong, C., Yang, L., Guo, F., & Yu, N. (2018) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2018.07.008 · Cited by 13 · see citing works
Chahine, L. M., & Ghosh, D. (2009) · Journal of Child Neurology · doi:10.1177/0883073808329528 · Cited by 13 · see citing works
Oscillatory Coupling Between Thalamus, Cerebellum, and Motor Cortex in Essential Tremor
Steina, A., Sure, S., Butz, M., Vesper, J., Schnitzler, A., & Hirschmann, J. (2025) · Movement Disorders · doi:10.1002/mds.30165 · Cited by 14 · see citing works
Tuleasca, C., Régis, J. M., Najdenovska, E., Witjas, T., Girard, N. J., Champoudry, J., Faouzi, M., Thiran, J., Cuadra, M. B., Levivier, M., et al. (2018) · World Neurosurgery · doi:10.1016/j.wneu.2018.01.063 · Cited by 11 · see citing works
Shukla, A. W. (2022) · International review of neurobiology · doi:10.1016/bs.irn.2022.02.008 · Cited by 11 · see citing works
Mechanisms of tremor-modulating effects of primidone and propranolol in essential tremor
Vogelnik, K., Prezelj, N., Kramberger, M. G., & Kojović, M. (2024) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2024.107151 · Cited by 10 · see citing works
Optimizing deep brain stimulation based on isostable amplitude in essential tremor patient models
Duchet, B., Weerasinghe, G., Bick, C., & Bogacz, R. (2021) · Journal of Neural Engineering · doi:10.1088/1741-2552/abd90d · Cited by 9 · see citing works
Cerebello-Thalamo-Cortical Network Dynamics in the Harmaline Rodent Model of Essential Tremor
Woodward, K. M., Apps, R., Goodfellow, M., & Cerminara, N. L. (2022) · Frontiers in Systems Neuroscience · doi:10.3389/fnsys.2022.899446 · Cited by 10 · see citing works
Tuleasca, C., Régis, J. M., Najdenovska, E., Witjas, T., Girard, N. J., Bolton, T. A. W., Delaire, F., Vincent, M., Faouzi, M., Thiran, J., et al. (2018) · Journal of neurosurgery · doi:10.3171/2018.7.gks18752 · Cited by 10 · see citing works
Mapping Subcortico‐Cortical Coupling—A Comparison of Thalamic and Subthalamic Oscillations
Steina, A., Sure, S., Butz, M., Vesper, J., Schnitzler, A., & Hirschmann, J. V. (2024) · Movement Disorders · doi:10.1002/mds.29730 · Cited by 8 · see citing works
Effects of Electrode Implantation Angle on Thalamic Stimulation for Treatment of Tremor
Kobayashi, K., Katayama, Y., Sumi, K., Otaka, T., Obuchi, T., Kano, T., Nagaoka, T., Oshima, H., Fukaya, C., Yamamoto, T., et al. (2009) · Neuromodulation Technology at the Neural Interface · doi:10.1111/j.1525-1403.2009.00235.x · Cited by 9 · see citing works
Bahar, R., Chegeni, M. J., Tahvildari, A., Sani, M., Khakpour, Y., Hashemabady, M., Sagharichi, M., Balaghirad, N., Taghizadeh, M., Mehranpour, M., et al. (2024) · Neuropeptides · doi:10.1016/j.npep.2024.102455 · Cited by 8 · see citing works
Luu, C. P., Ranum, J. N., Youn, Y., Perrault, J. L., Krause, B. M., Banks, M. I., Buyan‐Dent, L., Ludwig, K. A., Lake, W. B., & Suminski, A. J. (2025) · Brain stimulation · doi:10.1016/j.brs.2025.06.004 · Cited by 9 · see citing works
Thalamo-cortical network is associated with harmaline-induced tremor in rodent model
Lee, J., Kim, J., Cortez, J., & Chang, S.-Y. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114210 · Cited by 7 · see citing works
Deep Brain Stimulation for Essential Tremor
Morigaki, R., & Goto, S. (2015) · Springer eBooks · doi:10.1007/978-3-319-08476-3_11 · Cited by 92 · see citing works
Usefulness of thalamic beta activity for closed-loop therapy in essential tremor
Guehl, D., Guillaud, É., Langbour, N., Doat, E., Auzou, N., Courtin, E., Branchard, O., Engelhardt, J., Benazzouz, A., Eusébio, A., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-49511-5 · Cited by 7 · see citing works
Kobayashi, K., Chien, J. H., Kim, J. H., & Lenz, F. A. (2017) · Journal of Alzheimer’s Disease & Parkinsonism · doi:10.4172/2161-0460.1000324 · Cited by 5 · see citing works
Self-citationThalamic post-inhibitory bursting occurs in patients with organic dystonia more often than controls
Kobayashi, K., Liu, C. C., Jensen, A. L., Vitek, J. L., Mari, Z. K., & Lenz, F. A. (2013) · Brain Research · doi:10.1016/j.brainres.2013.10.006 · Cited by 5 · see citing works
Self-citationDifferentiating Postural and Kinetic Tremor Responses to Deep Brain Stimulation in Essential Tremor
Butler, R. D., Brinda, A. K., Blumenfeld, M., Bryants, M. N., Grund, P. M., Pandey, S. R., Cornish, C. K. S., Sullivan, D., Krieg, J. D. S., Umoh, M., et al. (2024) · Movement Disorders Clinical Practice · doi:10.1002/mdc3.14256 · Cited by 4 · see citing works
Vuong, M., Sreenivasan, V., Lee, S., Quinn, B., Keung, M. S., Grundy, M., Ayala, J., Baek, H., & McKeown, M. J. (2026) · Brain stimulation · doi:10.1016/j.brs.2026.103025 · Cited by 4 · see citing works
Decades of delayed diagnosis in 4 levodopa‐responsive young‐onset monogenetic parkinsonism patients
Ling, H., Braschinsky, M., Taba, P., Lüüs, S., Doherty, K. A., Hotter, A., Poewe, W. H., & Lees, A. J. (2011) · Movement Disorders · doi:10.1002/mds.23563 · Cited by 4 · see citing works
Adaptive feedback control in deep brain stimulation: a simulation study
Santaniello, S., Fiengo, G., & Glielmo, L. (2008) · IFAC Proceedings Volumes · doi:10.3182/20080706-5-kr-1001.01970 · Cited by 4 · see citing works
Reis, C., He, S., Pogosyan, A. H., Haliasos, N., Low, H. L., Misbahuddin, A., Aziz, T. Z., FitzGerald, J. J., Green, A. L., Denison, T., et al. (2022) · medRxiv · doi:10.1101/2022.06.16.22276451 · Cited by 4 · see citing works
Zhang, X., Hancock, R., & Santaniello, S. (2025) · Journal of Neural Engineering · doi:10.1088/1741-2552/add76c · Cited by 3 · see citing works
Applying Microelectrode Recordings in Neurosurgery
Anderson, W. S., Winberry, J. E., Liu, C. C., Shi, C., & Lenz, F. A. (2010) · Contemporary Neurosurgery · doi:10.1097/01.cne.0000369792.40458.fa · Cited by 3 · see citing works
Self-citationIntraoperative Microelectrode Recording
Kobayashi, K., & Katayama, Y. (2014) · Springer eBooks · doi:10.1007/978-3-319-08476-3_4 · Cited by 3 · see citing works
Swan, B. D., Brocker, D. T., Gross, R. E., Turner, D. A., & Grill, W. M. (2019) · Clinical Neurophysiology · doi:10.1016/j.clinph.2019.11.060 · Cited by 3 · see citing works
Biophysical modeling of VIM to assess contributions of oscillatory activity to essential tremorPreprint
Lee, S., Segar, D. J., Asaad, W. F., & Jones, S. R. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/339846 · Cited by 3 · see citing works
- Authors
- Hua, S. E., & Lenz, F. A.
- Affiliations
- Johns Hopkins University (US)
- ORCID
- Lenz, Frederick A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2005-01
- Volume
- 93
- Issue
- 1
- Pages
- 117-127
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W2170921456
- Cited by
- 134
- References
- 70
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 8 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 5 · 2019: 4 · 2018: 9 · 2017: 4 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 7 · 2012: 4
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS-38493, NS 40059, R01NS040059)
- Topics
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
- Keywords
- essential tremor, postural tremor, ventral intermediate nucleus, thalamotomy, proprioceptive feedback, single-unit recording
- MeSH terms
- Action Potentials, Adult, Aged, Brain Mapping, Cerebellum, Electromyography, Female, Humans, Functional Laterality, Male, Middle Aged, Motor Activity, Neurons, Periodicity, Posture, Spectrum Analysis, Stereotaxic Techniques, Thalamus, Time Factors, Volition, Muscle, Skeletal, Essential Tremor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
