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A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons
Abstract
1. A long-lasting afterhyperpolarization (AHP) follows current-induced repetitive firing in hippocampal CA1 neurons studied in vitro. A 10-25% increase in membrane slope conductance occurs during the AHP, suggesting that it may be mediated by an increased conductance to either K+ or Cl-. 2. Intracellular Cl- iontophoresis does not alter the AHP but does attenuate the IPSP. In contrast Ba2+, a cation that can decrease K+ conductance, eliminates the AHP but not the IPSP. These findings suggest the AHP is produced by a long-lasting increased conductance to K+, and is distinct from the IPSP. 3. Mn2+, a Ca2+-channel blocker, eliminates the AHP. In comparison, the AHP persists in the presence of the Na+-channel blocker, tetrodotoxin (TTX), and appears to be temporally associated with TTX-resistant "Ca2+ spikes." It is concluded that AHP is probably activated by Ca2+ influx. 4. These observations indicate that the AHP may be produced by a Ca2+ activated K+ current. A balance between cellular depolarization produced by Ca2+ entry and repolarization generated by a Ca2+-activated K+ current appears to operate to control excitability in some mammalian cortical neurons as it does in molluscan neurons. Disruption of this balance by Ba2+ produces spontaneous membrane-potential oscillations and recurrent burst firing in hippocampal neurons. Increases in the magnitude and duration of Ca2+ depolarization and/or decreases in the Ca2+-activated, K+-mediated repolarization may be mechanisms that lead to spontaneous, epileptiform bursting in mammalian cortical neurons.
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“AHP currents are mainly mediated by calcium-dependent potassium channels [77, 78], but also partly by calcium-independent potassium channels [79].”
From Chronic unpredictable stress induces depression-related behaviors by suppressing AgRP neuron activity (2021) · cites this paper as [78]
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Metadata
- Authors
- Hotson, J. R., & Prince, D. A.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1980-02-01
- Volume
- 43
- Issue
- 2
- Pages
- 409-419
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1953088445
- Cited by
- 569
- References
- 0
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 10
- FWCI
- 13.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- afterhyperpolarization, CA1 pyramidal neurons, repetitive firing, calcium-activated potassium current, calcium influx, membrane conductance, barium block, manganese block, tetrodotoxin, calcium spikes, inhibitory postsynaptic potentials, membrane potential oscillations, burst firing, epileptiform bursting, neuronal excitability
- MeSH terms
- Action Potentials, Animals, Barium, Calcium, Chlorides, Electric Stimulation, Guinea Pigs, Hippocampus, Ion Channels, Manganese, Membrane Potentials, Potassium, Tetrodotoxin, In Vitro Techniques
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