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Cited by 571Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

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A calcium-activated hyperpolarization follows repetitive firing in hippocampal neurons

Hotson, J. R., Prince, D. A.·1980·Journal of Neurophysiology
DOI 10.1152/jn.1980.43.2.409
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Abstract

1. A long-lasting afterhyperpolarization (AHP) follows current-induced repetitive firing in hippocampal CA1 neurons studied in vitro. A 10-25% increase in membrane slope conductance occurs during the AHP, suggesting that it may be mediated by an increased conductance to either K+ or Cl-. 2. Intracellular Cl- iontophoresis does not alter the AHP but does attenuate the IPSP. In contrast Ba2+, a cation that can decrease K+ conductance, eliminates the AHP but not the IPSP. These findings suggest the AHP is produced by a long-lasting increased conductance to K+, and is distinct from the IPSP. 3. Mn2+, a Ca2+-channel blocker, eliminates the AHP. In comparison, the AHP persists in the presence of the Na+-channel blocker, tetrodotoxin (TTX), and appears to be temporally associated with TTX-resistant "Ca2+ spikes." It is concluded that AHP is probably activated by Ca2+ influx. 4. These observations indicate that the AHP may be produced by a Ca2+ activated K+ current. A balance between cellular depolarization produced by Ca2+ entry and repolarization generated by a Ca2+-activated K+ current appears to operate to control excitability in some mammalian cortical neurons as it does in molluscan neurons. Disruption of this balance by Ba2+ produces spontaneous membrane-potential oscillations and recurrent burst firing in hippocampal neurons. Increases in the magnitude and duration of Ca2+ depolarization and/or decreases in the Ca2+-activated, K+-mediated repolarization may be mechanisms that lead to spontaneous, epileptiform bursting in mammalian cortical neurons.

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Metadata

Authors
Hotson, J. R., & Prince, D. A.
Venue
Journal of Neurophysiology
Publisher
American Physiological Society
Published
1980-02-01
Volume
43
Issue
2
Pages
409-419
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
DOI
10.1152/jn.1980.43.2.409
OpenAlex
W1953088445
Cited by
569
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 4 · 2023: 3 · 2022: 2 · 2021: 2 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 5 · 2014: 2 · 2013: 8 · 2012: 10
FWCI
13.56
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords
afterhyperpolarization, CA1 pyramidal neurons, repetitive firing, calcium-activated potassium current, calcium influx, membrane conductance, barium block, manganese block, tetrodotoxin, calcium spikes, inhibitory postsynaptic potentials, membrane potential oscillations, burst firing, epileptiform bursting, neuronal excitability
MeSH terms
Action Potentials, Animals, Barium, Calcium, Chlorides, Electric Stimulation, Guinea Pigs, Hippocampus, Ion Channels, Manganese, Membrane Potentials, Potassium, Tetrodotoxin, In Vitro Techniques

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