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Cited by 230Nausea and vomiting managementVestibular and auditory disordersGastrointestinal motility and disorders

Physiological basis and pharmacology of motion sickness: an update

Yates, B.J, Miller, A.D, Lucot, J.B·1998·Brain Research Bulletin
DOI 10.1016/s0361-9230(98)00092-6
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Abstract

Motion sickness can occur when sensory inputs regarding body position in space are contradictory or are different from those predicted from experience. Signals from the vestibular system are essential for triggering motion sickness. The evolutionary significance of this malady is unclear, although it may simply represent the aberrant activation of vestibuloautonomic pathways that typically subserve homeostasis. The neural pathways that produce nausea and vomiting during motion sickness are presumed to be similar to those that generate illness after ingestion of toxins. The neural substrate of nausea is unknown but may include neurons in the hypothalamus and inferior frontal gyrus of the cerebral cortex. The principal motor act of vomiting is accomplished through the simultaneous contractions of inspiratory and expiratory respiratory muscles and is mediated by neurons in the lateral medullary reticular formation and perhaps by cells near the medullary midline. Cocontraction of the diaphragm and abdominal muscles increases pressure on the stomach, which causes gastric contents to be ejected through the mouth. Effective drugs for combating motion sickness include antihistamines, antimuscarinics, 5-HT1A (serotonergic) receptor agonists and neurokinin type 1 receptor antagonists. However, considerable information concerning the physiological basis and pharmacology of motion sickness is unknown; future research using animal models will be required to understand this condition.

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Crossref · 10.1016/s0361-9230(98)00092-6

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  • Physiological mechanisms underlying the elicitation and expression of motion sickness are complex and still not fully known.

    “The physiological mechanisms underlying the elicitation and expression of motion sickness are complex and still not fully known (Yates et al. 1998).”

    From Motion sickness: more than nausea and vomiting (2014) · cites this paper as Yates et al. 1998

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Authors
Yates, B. J., Miller, A. D., & Lucot, J. B.
Affiliations
  • University of Pittsburgh (US)
  • Rockefeller University (US)
  • Wright State University (US)
Corresponding author
Yates, B.J
ORCID
Yates, B.J
Venue
Brain Research Bulletin
Publisher
Elsevier BV
Published
1998-11
Volume
47
Issue
5
Pages
395-406
ISSN
0361-9230 (ISSN-L)
DOI
10.1016/s0361-9230(98)00092-6
OpenAlex
W2067075667
Cited by
230
References
156
Citations by year
2026: 5 · 2025: 7 · 2024: 6 · 2023: 3 · 2022: 3 · 2021: 11 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 5 · 2016: 13 · 2015: 8 · 2014: 13 · 2013: 8 · 2012: 14
FWCI
2.59
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Brain Research Bulletin (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r01dc002644-03)
  • National Institute on Deafness and Other Communication Disorders (R01DC003732, R01 DC03732, R01DC000693, R01-DC-00693, R01-DC-02644)
Topics
  • Health Sciences › Medicine › Surgery › Nausea and vomiting management
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
Keywords
motion sickness, vestibular system, nausea, vomiting, vomiting reflex, reticular formation, hypothalamus, inferior frontal gyrus, antihistamines, antimuscarinic agents, 5-HT1A receptor agonist, animal models
MeSH terms
Antiemetics, Conflict, Psychological, Cues, Humans, Motion Sickness, Nausea, Spatial Behavior, Stress, Physiological, Vomiting

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