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Electric field suppression of epileptiform activity in hippocampal slices
Abstract
1. The effects of relatively small external DC electric fields on synchronous activity in CA1 and CA3 from transverse and longitudinal type hippocampal slices were studied. 2. To record neuronal activity during significant field changes, differential DC amplification was employed with a reference electrode aligned along an isopotential with the recording electrode. 3. Suppression of epileptiform activity was observed in 31 of 33 slices independent of region studied and type of slice but was highly dependent on field orientation with respect to the apical dendritic-somatic axis. 4. Modulation of neuronal activity in these experiments was readily observed at field strengths < or = 5–10 mV/mm. Suppression was seen with the field oriented (positive to negative potential) from the soma to the apical dentrites. 5. In vivo application of these results may be feasible.
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Cited by
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Merrill, D. R., Bikson, M., & Jefferys, J. G. R. (2005) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.10.020 · Cited by 2,078
Electrical stimulation of the anterior nucleus of thalamus for treatment of refractory epilepsy
Fisher, R., Salanova, V., Witt, T., Worth, R., Henry, T., Gross, R., Oommen, K., Osorio, I., Nazzaro, J., Labar, D., et al. (2010) · Epilepsia · doi:10.1111/j.1528-1167.2010.02536.x · Cited by 1,918
Reato, D., Rahman, A., Bikson, M., & Parra, L. C. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.2059-10.2010 · Cited by 573
Cellular effects of acute direct current stimulation: somatic and synaptic terminal effects
Rahman, A., Reato, D., Arlotti, M., Gasca, F., Datta, A., Parra, L. C., & Bikson, M. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2012.247171 · Cited by 560
Transcranial Electric Stimulation Entrains Cortical Neuronal Populations in Rats
Ozen, S., Sirota, A., Belluscio, M. A., Anastassiou, C. A., Stark, E., Koch, C., & Buzsáki, G. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5252-09.2010 · Cited by 425
Metadata
- Authors
- Gluckman, B. J., Neel, E. J., Netoff, T. I., Ditto, W. L., Spano, M. L., & Schiff, S. J.
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 1996-12-01
- Volume
- 76
- Issue
- 6
- Pages
- 4202-4205
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- OpenAlex
- W1870957045
- Cited by
- 171
- References
- 0
- FWCI
- 2.47
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Electric field suppression of epileptiform activity in hippocampal slices. https://app.cochat.ai/papers/10.1152/jn.1996.76.6.4202
- The paper
- Gluckman, B. J., Neel, E. J., Netoff, T. I., Ditto, W. L., Spano, M. L., & Schiff, S. J. (1996). Electric field suppression of epileptiform activity in hippocampal slices. Journal of Neurophysiology. https://doi.org/10.1152/jn.1996.76.6.4202
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
