Behavioral triggers of skin conductance responses and their neural correlates in the primate amygdala
Open accessAbstract
The amygdala plays a crucial role in evaluating the emotional significance of stimuli and in transforming the results of this evaluation into appropriate autonomic responses. Lesion and stimulation studies suggest involvement of the amygdala in the generation of the skin conductance response (SCR), which is an indirect measure of autonomic activity that has been associated with both emotion and attention. It is unclear if this involvement marks an emotional reaction to an external stimulus or sympathetic arousal regardless of its origin. We recorded skin conductance in parallel with single-unit activity from the right amygdala of two rhesus monkeys during a rewarded image viewing task and while the monkeys sat alone in a dimly lit room, drifting in and out of sleep. In both experimental conditions, we found similar SCR-related modulation of activity at the single-unit and neural population level. This suggests that the amygdala contributes to the production or modulation of SCRs regardless of the source of sympathetic arousal.
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Amygdala neurons are active in relation to skin conductance responses.
“but also are active in relation to skin conductance responses (114).”
From Localization of Dysfunction in Major Depressive Disorder: Prefrontal Cortex and Amygdala (2011) · cites this paper as [114]
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- Authors
- Laine, C. M., Spitler, K. M., Mosher, C. P., & Gothard, K. M.
- Affiliations
- University of Arizona (US)
- Venue
- Journal of Neurophysiology
- Publisher
- American Physiological Society
- Published
- 2009-04
- Volume
- 101
- Issue
- 4
- Pages
- 1749-1754
- ISSN
- 0022-3077 (ISSN-L)
- 1522-1598
- PMC
- PMC2695635
- OpenAlex
- W2027330320
- Cited by
- 120
- References
- 28
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 19
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Neurophysiology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH 070836, R01MH070836)
- National Institute of General Medical Sciences (R25GM072733, T32 GM-08400, GM-072733, T32GM008400)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- skin conductance response, amygdala, rhesus monkeys, single-unit activity, sympathetic activation, autonomic responses, attention, neural correlates, sleep
- MeSH terms
- Action Potentials, Amygdala, Analysis of Variance, Animals, Behavior, Animal, Brain Mapping, Eye, Galvanic Skin Response, Macaca mulatta, Magnetic Resonance Imaging, Male, Neurons, Rest, Reward
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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