Cited by 120Memory and Neural MechanismsNeural and Behavioral Psychology StudiesHeart Rate Variability and Autonomic Control

Behavioral triggers of skin conductance responses and their neural correlates in the primate amygdala

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Laine, Christopher M., Spitler, Kevin M., Mosher, Clayton P., Gothard, Katalin M.·2009·Journal of Neurophysiology

Abstract

The amygdala plays a crucial role in evaluating the emotional significance of stimuli and in transforming the results of this evaluation into appropriate autonomic responses. Lesion and stimulation studies suggest involvement of the amygdala in the generation of the skin conductance response (SCR), which is an indirect measure of autonomic activity that has been associated with both emotion and attention. It is unclear if this involvement marks an emotional reaction to an external stimulus or sympathetic arousal regardless of its origin. We recorded skin conductance in parallel with single-unit activity from the right amygdala of two rhesus monkeys during a rewarded image viewing task and while the monkeys sat alone in a dimly lit room, drifting in and out of sleep. In both experimental conditions, we found similar SCR-related modulation of activity at the single-unit and neural population level. This suggests that the amygdala contributes to the production or modulation of SCRs regardless of the source of sympathetic arousal.

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Crossref · 10.1152/jn.91110.2008

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Authors
Laine, C. M., Spitler, K. M., Mosher, C. P., & Gothard, K. M.
Affiliations
University of Arizona (US)
Venue
Journal of Neurophysiology
Published
2009-04
Volume
101
Issue
4
Pages
1749-1754
ISSN
  • 0022-3077 (ISSN-L)
  • 1522-1598
OpenAlex
W2027330320
Cited by
120
References
28
Citations by year
2026: 8 · 2025: 8 · 2024: 5 · 2023: 6 · 2022: 10 · 2021: 7 · 2020: 10 · 2019: 3 · 2018: 5 · 2017: 2 · 2016: 4 · 2015: 6 · 2014: 3 · 2013: 8 · 2012: 19
FWCI
5.67
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurophysiology (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (MH 070836, R01MH070836)
  • National Institute of General Medical Sciences (R25GM072733, T32 GM-08400, GM-072733, T32GM008400)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
Keywords
skin conductance response, amygdala, rhesus monkeys, single-unit activity, sympathetic activation, autonomic responses, attention, neural correlates, sleep
MeSH terms
Action Potentials, Amygdala, Analysis of Variance, Animals, Behavior, Animal, Brain Mapping, Eye, Galvanic Skin Response, Macaca mulatta, Magnetic Resonance Imaging, Male, Neurons, Rest, Reward

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