Skeletal Muscle Atrophy: Discovery of Mechanisms and Potential Therapies

The Connectivity Map: Using Gene-Expression Signatures to Connect Small Molecules, Genes, and Disease

Lamb, J., Crawford, E. D., Peck, D., Modell, J. W., Blat, I. C., Wrobel, M. J., Lerner, J., Brunet, J.-P., Subramanian, A., Ross, K. N., et al. (2006) · Science · doi:10.1126/science.1132939 · Cited by 5,257 · see citing works

Identification of ubiquitin ligases required for skeletal muscle atrophy.

Bodine, S. C., Latres, E., Baumhueter, S., Lai, V. K.-M., Nunez, L., Clarke, B. A., Poueymirou, W. T., Panaro, F. J., Na, E., Dharmarajan, K., et al. (2001) · Science · doi:10.1126/science.1065874 · Cited by 3,521 · see citing works

Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy.

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Akt/mTOR pathway is a crucial regulator of skeletal muscle hypertrophy and can prevent muscle atrophy in vivo

Bodine, S. C., Stitt, T. N., Gonzalez, M., Kline, W. O., Stover, G. L., Bauerlein, R., Zlotchenko, E., Scrimgeour, A., Lawrence, J. C., Glass, D. J., et al. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1014 · Cited by 2,752 · see citing works

p21 in cancer: Intricate networks and multiple activities

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The integrated stress response

Pakos‐Zebrucka, K., Koryga, I., Mnich, K., Ljujic, M., Samali, A., & Gorman, A. M. (2016) · The EMBO Reports · doi:10.15252/embr.201642195 · Cited by 2,659 · see citing works

The IGF-1/PI3K/Akt pathway prevents expression of muscle atrophy-induced ubiquitin ligases by inhibiting FOXO transcription factors.

Stitt, T. N., Drujan, D., Clarke, B. A., Panaro, F., Timofeyva, Y., Kline, W. O., Gonzalez, M., Yancopoulos, G. D., & Glass, D. J. (2004) · Molecular Cell · doi:10.1016/s1097-2765(04)00211-4 · Cited by 1,964 · see citing works

Mediation of IGF-1-induced skeletal myotube hypertrophy by PI(3)K/Akt/mTOR and PI(3)K/Akt/GSK3 pathways

Rommel, C., Bodine, S. C., Clarke, B. A., Rossman, R., Nunez, L., Stitt, T. N., Yancopoulos, G. D., & Glass, D. J. (2001) · Nature Cell Biology · doi:10.1038/ncb1101-1009 · Cited by 1,583 · see citing works

CDK inhibitors: Cell cycle regulators and beyond

Besson, A., Dowdy, S. F., & Roberts, J. M. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.01.013 · Cited by 1,152 · see citing works

Skeletal muscle atrophy and the E3 ubiquitin ligases MuRF1 and MAFbx/atrogin-1

Bodine, S. C., & Baehr, L. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00204.2014 · Cited by 1,117 · see citing works

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

Schiaffino, S., & Mammucari, C. (2011) · Skeletal Muscle · doi:10.1186/2044-5040-1-4 · Cited by 816 · cited 1× · see citing works

mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

Ben-Sahra, I., Hoxhaj, G., Ricoult, S. J. H., Asara, J. M., & Manning, B. D. (2016) · Science · doi:10.1126/science.aad0489 · Cited by 795 · see citing works

Regulation of autophagy and the ubiquitin-proteasome system by the FoxO transcriptional network during muscle atrophy

Milan, G., Romanello, V., Pescatore, F., Armani, A., Paik, J.-H., Frasson, L., Seydel, A., Zhao, J., Abraham, R., Goldberg, A. L., et al. (2015) · Nature Communications · doi:10.1038/ncomms7670 · Cited by 709 · see citing works

Rapid disuse and denervation atrophy involve transcriptional changes similar to those of muscle wasting during systemic diseases

Sacheck, J. M., Hyatt, J. K., Raffaello, A., Thomas Jagoe, R., Roy, R. R., Reggie Edgerton, V., Lecker, S. H., & Goldberg, A. L. (2007) · The FASEB Journal · doi:10.1096/fj.06-6604com · Cited by 585 · see citing works

Eukaryotic Initiation Factor 2 Phosphorylation and Translational Control in Metabolism

Baird, T. D., & Wek, R. C. (2012) · Advances in Nutrition · doi:10.3945/an.112.002113 · Cited by 470 · see citing works

The glucocorticoid receptor and FOXO1 synergistically activate the skeletal muscle atrophy-associated MuRF1 gene

Waddell, D. S., Baehr, L. M., van den Brandt, J., Johnsen, S. A., Reichardt, H. M., Furlow, J. D., & Bodine, S. C. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00646.2007 · Cited by 360 · see citing works

Gene expression profile of aging in human muscle

Welle, S. L., Brooks, A. I., Delehanty, J. M., Needler, N. A., & Thornton, C. A. (2003) · Physiological Genomics · doi:10.1152/physiolgenomics.00049.2003 · Cited by 351 · see citing works

mRNA expression signatures of human skeletal muscle atrophy identify a natural compound that increases muscle mass

Kunkel, S. D., Suneja, M., Ebert, S. M., Bongers, K. S., Fox, D. K., Malmberg, S. E., Alipour, F., Shields, R. K., & Adams, C. M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.020 · Cited by 345 · see citing works

Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

Stevenson, E. J., Giresi, P. G., Koncarevic, A., & Kandarian, S. C. (2003) · The Journal of Physiology · doi:10.1111/j.1469-7793.2003.00033.x · Cited by 270 · see citing works

Genomic and proteomic profiling reveals reduced mitochondrial function and disruption of the neuromuscular junction driving rat sarcopenia

Ibebunjo, C., Chick, J. M., Kendall, T., Eash, J. K., Li, C., Zhang, Y., Vickers, C., Wu, Z., Clarke, B. A., Shi, J., et al. (2013) · Molecular and Cellular Biology · doi:10.1128/mcb.01036-12 · Cited by 267 · see citing works

Anticarcinogenic, Cardioprotective, and Other Health Benefits of Tomato Compounds Lycopene, α-Tomatine, and Tomatidine in Pure Form and in Fresh and Processed Tomatoes

Friedman, M. (2013) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf402654e · Cited by 244 · see citing works

Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy

Reed, S. A., Sandesara, P. B., Judge, S. M., & Judge, A. R. (2011) · The FASEB Journal · doi:10.1096/fj.11-189977 · Cited by 224 · see citing works

Stress-induced Skeletal Muscle Gadd45a Expression Reprograms Myonuclei and Causes Muscle Atrophy

Ebert, S. M., Dyle, M. C., Kunkel, S. D., Bullard, S. A., Bongers, K. S., Fox, D. K., Dierdorff, J. M., Foster, E. D., & Adams, C. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.374777 · Cited by 221 · see citing works

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

Kunkel, S. D., Elmore, C., Bongers, K. S., Ebert, S. M., Fox, D. K., Dyle, M. C., Bullard, S. A., & Adams, C. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039332 · Cited by 220 · see citing works

Global analysis of gene expression patterns during disuse atrophy in rat skeletal muscle

Stevenson, E. J., Giresi, P. G., Koncarevic, A., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.044701 · Cited by 212 · see citing works

Skeletal muscle gene expression profiles in 20–29 year old and 65–71 year old women

Welle, S., Brooks, A. I., Delehanty, J. M., Needler, N., Bhatt, K., Shah, B., & Thornton, C. A. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2003.11.011 · Cited by 210 · see citing works

FOXO signaling is required for disuse muscle atrophy and is directly regulated by Hsp70.

Senf, S. M., Dodd, S., & Judge, A. (2010) · American Journal of Physiology - Cell Physiology · doi:10.1152/ajpcell.00315.2009 · Cited by 208 · see citing works

Gene expression profiling of aging reveals activation of a p53-mediated transcriptional program

Edwards, M. G., Anderson, R. M., Yuan, M., Kendziorski, C. M., Weindruch, R., & Prolla, T. A. (2007) · BMC Genomics · doi:10.1186/1471-2164-8-80 · Cited by 174 · see citing works

Role of the Transcription Factor ATF4 in the Anabolic Actions of Insulin and the Anti-anabolic Actions of Glucocorticoids

Adams, C. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m610510200 · Cited by 165 · see citing works

Skeletal muscle denervation causes skeletal muscle atrophy through a pathway that involves both Gadd45a and HDAC4

Bongers, K. S., Fox, D. K., Ebert, S. M., Kunkel, S. D., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., & Adams, C. M. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00380.2013 · Cited by 145 · see citing works

Myostatin blockade with a fully human monoclonal antibody induces muscle hypertrophy and reverses muscle atrophy in young and aged mice

Latres, E., Pangilinan, J., Miloscio, L., Bauerlein, R., Na, E., Potocky, T. B., Huang, Y., Eckersdorff, M., Rafique, A., Mastaitis, J., et al. (2015) · Skeletal Muscle · doi:10.1186/s13395-015-0060-8 · Cited by 143 · see citing works

Systems-Based Discovery of Tomatidine as a Natural Small Molecule Inhibitor of Skeletal Muscle Atrophy

Dyle, M. C., Ebert, S. M., Cook, D. P., Kunkel, S. D., Fox, D. K., Bongers, K. S., Bullard, S. A., Dierdorff, J. M., & Adams, C. M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556241 · Cited by 138 · see citing works

The Transcription Factor ATF4 Promotes Skeletal Myofiber Atrophy during Fasting

Ebert, S. M., Monteys, A. M., Fox, D. K., Bongers, K. S., Shields, B. E., Malmberg, S. E., Davidson, B. L., Suneja, M., & Adams, C. M. (2010) · Molecular Endocrinology · doi:10.1210/me.2009-0345 · Cited by 130 · see citing works

Gene profiling of skeletal muscle in an amyotrophic lateral sclerosis mouse model

de Aguilar, J. G., Niederhauser-Wiederkehr, C., Halter, B., de Tapia, M., Scala, F. D., Demougin, P., Dupuis, L., Primig, M., Meininger, V., & Loeffler, J. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00017.2007 · Cited by 125 · see citing works

Isolation of ursolic acid from apple peels by high speed counter-current chromatography

Frighetto, R. T. S., Welendorf, R. M., Nigro, E. N., Frighetto, N., & Siani, A. C. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.06.003 · Cited by 123 · see citing works

Control of Translation Initiation through Integration of Signals Generated by Hormones, Nutrients, and Exercise*

Kimball, S., & Jefferson, L. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.r110.137208 · Cited by 122 · see citing works

Myostatin inhibition induces muscle fibre hypertrophy prior to satellite cell activation

Wang, Q., & McPherron, A. C. (2012) · The Journal of Physiology · doi:10.1113/jphysiol.2011.226001 · Cited by 122 · see citing works

Identification and Small Molecule Inhibition of an Activating Transcription Factor 4 (ATF4)-dependent Pathway to Age-related Skeletal Muscle Weakness and Atrophy

Ebert, S. M., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Murry, D. J., Fox, D. K., Bongers, K. S., Lira, V. A., Meyerholz, D. K., Talley, J. J., et al. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.681445 · Cited by 120 · see citing works

p53 and ATF4 mediate distinct and additive pathways to skeletal muscle atrophy during limb immobilization

Fox, D. K., Ebert, S. M., Bongers, K. S., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., Kunkel, S. D., & Adams, C. M. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00010.2014 · Cited by 119 · see citing works

In vivo expression patterns of MyoD, p21, and Rb proteins in myonuclei and satellite cells of denervated rat skeletal muscle

Ishido, M., Kami, K., & Masuhara, M. (2004) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00080.2004 · Cited by 95 · see citing works

Altered REDD1, myostatin, and Akt/mTOR/FoxO/MAPK signaling in streptozotocin-induced diabetic muscle atrophy

Hulmi, J. J., Silvennoinen, M., Lehti, M., Kivelä, R., & Kainulainen, H. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00398.2011 · Cited by 81 · see citing works

Cardiac ankyrin repeat protein is a marker of skeletal muscle pathological remodelling

Laure, L., Suel, L., Roudaut, C., Bourg, N., Ouali, A., Bartoli, M., Richard, I., & Danièle, N. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06814.x · Cited by 72 · see citing works

Muscle wasting and the temporal gene expression pattern in a novel rat intensive care unit model

Llano‐Diez, M., Gustafson, A., Olsson, C., Göransson, H., & Larsson, L. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-602 · Cited by 68 · see citing works

Spermine oxidase maintains basal skeletal muscle gene expression and fiber size and is strongly repressed by conditions that cause skeletal muscle atrophy

Bongers, K. S., Fox, D. K., Kunkel, S. D., Stebounova, L. V., Murry, D. J., Pufall, M. A., Ebert, S. M., Dyle, M. C., Bullard, S. A., Dierdorff, J. M., et al. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00472.2014 · Cited by 61 · see citing works

Gene expression and muscle fiber function in a porcine ICU model

Banduseela, V. C., Ochala, J., Chen, Y., Göransson, H., Norman, H. S., Radell, P. J., Eriksson, L. I., Hoffman, E. P., & Larsson, L. (2009) · Physiological Genomics · doi:10.1152/physiolgenomics.00026.2009 · Cited by 59 · see citing works

Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4

Bullard, S. A., Seo, S., Schilling, B., Dyle, M. C., Dierdorff, J. M., Ebert, S. M., DeLau, A. D., Gibson, B. W., & Adams, C. M. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.740308 · Cited by 56 · see citing works

P38α MAPK underlies muscular dystrophy and myofiber death through a Bax-dependent mechanism

Wissing, E. R., Boyer, J. G., Kwong, J. Q., Sargent, M. A., Karch, J. M., McNally, E. M., Otsu, K., & Molkentin, J. D. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu270 · Cited by 53 · see citing works

The Eukaryotic Initiation Factor-2 Kinase Pathway Facilitates Differential GADD45a Expression in Response to Environmental Stress

Jiang, H.-Y., Jiang, L., & Wek, R. C. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m606461200 · Cited by 47 · see citing works

The CDK inhibitor p21 is a novel target gene of ATF 4 and contributes to cell survival under ER stress

Inoue, Y., Kawachi, S., Ohkubo, T., Nagasaka, M., Ito, S., Fukuura, K., Itoh, Y., Ohoka, N., Morishita, D., & Hayashi, H. (2017) · FEBS Letters · doi:10.1002/1873-3468.12869 · Cited by 43 · see citing works

A long‐term comparison of the influence of organic and conventional crop management practices on the content of the glycoalkaloid α‐tomatine in tomatoes

Koh, E., Kaffka, S. R., & Mitchell, A. E. (2012) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.5951 · Cited by 42 · see citing works

Trypanocidal activity and acute toxicity assessment of triterpene acids

Ferreira, D. D. S., Esperandim, V. R., Toldo, M. P. A., Saraiva, J., Cunha, W. R., & de Albuquerque, S. (2010) · Parasitology Research · doi:10.1007/s00436-010-1740-2 · Cited by 40 · see citing works

Insulin Signaling and the General Amino Acid Control Response

Malmberg, S. E., & Adams, C. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801331200 · Cited by 40 · see citing works

Ursolic Acid Induces Allograft Inflammatory Factor-1 Expression via a Nitric Oxide-Related Mechanism and Increases Neovascularization

Lee, A.-W., Chen, T.-L., Shih, C.-M., Huang, C., Tsao, N.-W., Chang, N., Chen, Y., Fong, T.-H., & Lin, F. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf103265x · Cited by 26 · see citing works

Use of mRNA expression signatures to discover small molecule inhibitors of skeletal muscle atrophy

Adams, C. M., Ebert, S. M., & Dyle, M. C. (2015) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000159 · Cited by 20 · see citing works

Metabolic changes in aging humans: current evidence and therapeutic strategies

Palmer, A. K., & Jensen, M. D. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158451 · Cited by 358 · see citing works

The molecular athlete: exercise physiology from mechanisms to medals

Furrer, R., Hawley, J. A., & Handschin, C. (2023) · Physiological Reviews · doi:10.1152/physrev.00017.2022 · Cited by 232 · see citing works

Disuse-induced skeletal muscle atrophy in disease and nondisease states in humans: mechanisms, prevention, and recovery strategies

Nunes, E. A., Stokes, T., McKendry, J., Currier, B. S., & Phillips, S. M. (2022) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00425.2021 · Cited by 183 · see citing works

C2C12 cell model: its role in understanding of insulin resistance at the molecular level and pharmaceutical development at the preclinical stage

Wong, C. Y. J., Al‐Salami, H., & Dass, C. R. (2020) · Journal of Pharmacy and Pharmacology · doi:10.1111/jphp.13359 · Cited by 112 · see citing works

Muscular Atrophy and Sarcopenia in the Elderly: Is There a Role for Creatine Supplementation?

Dolan, E., Artioli, G. G., Pereira, R. M. R., & Gualano, B. (2019) · Biomolecules · doi:10.3390/biom9110642 · Cited by 72 · see citing works

Increased Adenine Nucleotide Degradation in Skeletal Muscle Atrophy

Miller, S. G., Hafen, P. S., & Brault, J. J. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms21010088 · Cited by 65 · see citing works

Skeletal Muscle Recovery from Disuse Atrophy: Protein Turnover Signaling and Strategies for Accelerating Muscle Regrowth

Mirzoev, T. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217940 · Cited by 65 · see citing works

Silencing COX-2 blocks PDK1/TRAF4-induced AKT activation to inhibit fibrogenesis during skeletal muscle atrophy

Chen, H., Qian, Z., Zhang, S., Tang, J. X., Fang, L., Jiang, F., Ge, D., Chang, J., Cao, J., Yang, L., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101774 · Cited by 65 · see citing works

Activating transcription factor 4 (ATF4) promotes skeletal muscle atrophy by forming a heterodimer with the transcriptional regulator C/EBPβ

Ebert, S. M., Bullard, S. A., Basisty, N., Marcotte, G. R., Skopec, Z. P., Dierdorff, J. M., Al‐Zougbi, A., Tomcheck, K. C., DeLau, A. D., Rathmacher, J. A., et al. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.012095 · Cited by 63 · see citing works

Nutraceuticals in the Prevention and Treatment of the Muscle Atrophy

Wang, Y., Liu, Q., Quan, H., Kang, S.-G., Huang, K., & Tong, T. (2021) · Nutrients · doi:10.3390/nu13061914 · Cited by 61 · see citing works

Biology of Activating Transcription Factor 4 (ATF4) and Its Role in Skeletal Muscle Atrophy

Ebert, S. M., Rasmussen, B. B., Judge, A. R., Judge, S. M., Larsson, L., Wek, R. C., Anthony, T. G., Marcotte, G. R., Miller, M. J., Yorek, M. A., et al. (2021) · Journal of Nutrition · doi:10.1093/jn/nxab440 · Cited by 61 · see citing works

Cerebrum, liver, and muscle regulatory networks uncover maternal nutrition effects in developmental programming of beef cattle during early pregnancy

Diniz, W. J. S., Crouse, M. S., Cushman, R. A., McLean, K. J., Caton, J. S. S., Dahlen, C. R., Reynolds, L. P., & Ward, A. K. K. (2021) · Scientific Reports · doi:10.1038/s41598-021-82156-w · Cited by 53 · see citing works

Genome‐wide association studies of preweaning growth and in vivo carcass composition traits in Esme sheep

Yılmaz, O., Kızılaslan, M., Arzık, Y., Behrem, S., Ata, N., Karaca, O., Elmacı, C., & Cemal, İ. (2021) · Journal of Animal Breeding and Genetics · doi:10.1111/jbg.12640 · Cited by 51 · see citing works

Natural products: Potential therapeutic agents to prevent skeletal muscle atrophy.

Yadav, A., Yadav, S., Singh, S., & Dabur, R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.174995 · Cited by 45 · see citing works

Transcriptome Analysis of Immune Receptor Activation and Energy Metabolism Reduction as the Underlying Mechanisms in Interleukin-6-Induced Skeletal Muscle Atrophy

Sun, H., Sun, J., Li, M., Qian, L., Zhang, L., Huang, Z., Shen, Y., Law, B. Y. K., Liu, L., & Gu, X. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.730070 · Cited by 47 · see citing works

Edward F. Adolph Distinguished Lecture. Skeletal muscle atrophy: Multiple pathways leading to a common outcome

Bodine, S. C. (2020) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00381.2020 · Cited by 43 · see citing works

Muscle Proteomic and Transcriptomic Profiling of Healthy Aging and Metabolic Syndrome in Men

Gueugneau, M., Coudy‐Gandilhon, C., Chambon, C., Verney, J., Taillandier, D., Combaret, L., Polge, C., Walrand, S., Roche, F., Barthélemy, J., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084205 · Cited by 37 · see citing works

The Dunkin Hartley Guinea Pig Is a Model of Primary Osteoarthritis That Also Exhibits Early Onset Myofiber Remodeling That Resembles Human Musculoskeletal Aging

Musci, R., Walsh, M., Konopka, A., Wolff, C. A., Peelor, F., Reiser, R., Santangelo, K., & Hamilton, K. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.571372 · Cited by 25 · see citing works

Kaempferol Improves Exercise Performance by Regulating Glucose Uptake, Mitochondrial Biogenesis, and Protein Synthesis via PI3K/AKT and MAPK Signaling Pathways

Ji, X., Zhang, C., Yang, J., Tian, Y., You, L., Yang, H., Li, Y., Liu, H., Pan, D., & Liu, Z. (2024) · Foods · doi:10.3390/foods13071068 · Cited by 37 · see citing works

Advances in research on cell models for skeletal muscle atrophy

Li, L., Huang, C., Pang, J., Huang, Y., Chen, X., & Chen, G. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115517 · Cited by 34 · see citing works

TRIM32: A Multifunctional Protein Involved in Muscle Homeostasis, Glucose Metabolism, and Tumorigenesis

Bawa, S., Piccirillo, R., & Geisbrecht, E. R. (2021) · Biomolecules · doi:10.3390/biom11030408 · Cited by 34 · see citing works

The transcription regulator ATF4 is a mediator of skeletal muscle aging

Miller, M. J., Marcotte, G. R., Basisty, N., Wehrfritz, C., Ryan, Z. C., Strub, M. D., McKeen, A. T., Stern, J. I., Nath, K. A., Rasmussen, B. B., et al. (2023) · GeroScience · doi:10.1007/s11357-023-00772-y · Cited by 37 · see citing works

Quercetin Modulates IGF-I and IGF-II Levels After Eccentric Exercise-Induced Muscle-Damage: A Placebo-Controlled Study

Sgrò, P., Ceci, R., Lista, M., Patrizio, F., Sabatini, S., Felici, F., Sacchetti, M., Bazzucchi, I., Duranti, G., & Luigi, L. D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.745959 · Cited by 33 · see citing works

Tinospora Cordifolia Protects from Skeletal Muscle Atrophy by Alleviating Oxidative Stress and Inflammation Induced by Sciatic Denervation

Sharma, B., Dutt, V., Kaur, N., Mittal, A., & Dabur, R. (2020) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2020.112720 · Cited by 34 · see citing works

Identification and characterization of Fbxl22, a novel skeletal muscle atrophy-promoting E3 ubiquitin ligase

Hughes, D. C., Baehr, L. M., Driscoll, J., Lynch, S. A., Waddell, D. S., & Bodine, S. C. (2020) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00253.2020 · Cited by 29 · see citing works

Aging Aggravates Cachexia in Tumor-Bearing Mice

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GADD45A is a mediator of mitochondrial loss, atrophy, and weakness in skeletal muscle

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