The DOI matches its Crossref record; 214 of the 214 references it cites were found in a registry or an index.
How to Live Long and Prosper: Autophagy, Mitochondria, and Aging
Abstract
Autophagy is a process of cellular self-degradation in which portions of the cytoplasm are sequestered within cytosolic double-membrane vesicles and delivered to the lysosome/vacuole. This process occurs in all eukaryotic cells and is partly a stress response; autophagy is induced during starvation and hypoxia. However, autophagy also plays a role during development and is associated with a range of diseases. Accumulating data also suggest the involvement of autophagy in aging. For example, the role of various hormones and nutrient sensing pathways in life span extension may involve autophagy. Similarly, autophagy is the primary mechanism for removing damaged organelles, such as mitochondria, which may have a direct impact on aging. Here, we review the role of autophagy, with an emphasis on the signaling pathways that are involved in regulation, and the consequences of autophagy induction with regard to aging.
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Citations
Cites
2 retracted
Mitochondrial Autophagy Is an HIF-1-dependent Adaptive Metabolic Response to Hypoxia
Zhang, H., Bosch-Marce, M., Shimoda, L. A., Tan, Y. S., Baek, J. H., Wesley, J. B., Gonzalez, F. J., & Semenza, G. L. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800102200 · Cited by 1,601
RetractedA cytosolic catalase is needed to extend adult lifespan in C. elegans daf-C and clk-1 mutants
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RetractedAutophagy fights disease through cellular self-digestion
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Self-citationResveratrol improves health and survival of mice on a high-calorie diet
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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
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Self-citationAutophagy as a Regulated Pathway of Cellular Degradation
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Self-citationBcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy
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Loss of autophagy in the central nervous system causes neurodegeneration in mice
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Cited by
Regulation mechanisms and signaling pathways of autophagy
He, C., & Klionsky, D. J. (2009) · Annual Review of Genetics · doi:10.1146/annurev-genet-102808-114910 · Cited by 3,609
Self-citationAMP-Activated Protein Kinase (AMPK) Controls the Aging Process via an Integrated Signaling Network
Salminen, A., & Kaarniranta, K. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2011.12.005 · Cited by 860
Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy
Okamoto, K., Kondo-Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 797
Santos, C. X. C., Tanaka, L. Y., Wosniak, J., & Laurindo, F. R. M. (2009) · Antioxidants & Redox Signaling · doi:10.1089/ars.2009.2625 · Cited by 572
Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570
Metadata
- Authors
- Yen, W.-L., & Klionsky, D. J.
- Venue
- Physiology
- Publisher
- American Physiological Society
- Published
- 2008-10
- Volume
- 23
- Issue
- 5
- Pages
- 248-262
- ISSN
- 0886-1714 (ISSN-L)
- 1548-9213
- 1548-9221
- OpenAlex
- W2143542604
- Cited by
- 265
- References
- 214
- FWCI
- 16.20
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yen, W.-L., & Klionsky, D. J. (2008). How to Live Long and Prosper: Autophagy, Mitochondria, and Aging. Physiology. https://doi.org/10.1152/physiol.00013.2008
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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