The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Next-generation sequencing of microRNAs uncovers expression signatures in polarized macrophages
Abstract
microRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at a posttranscriptional level and play a crucial role in the development of cells of the immune system. Macrophages are essential for generating inflammatory reactions upon tissue damage and encountering of invading pathogens, yet modulation of their immune responses is critical for maintaining tissue homeostasis. Macrophages can present different phenotypes, depending on the cytokine environment they encounter in the affected tissues. In this study, we have identified expression signatures of miRNAs that are differentially regulated during maturation of monocytes and polarization of macrophages by cytokines. We present a comprehensive characterization of miRNA expression in human monocytes and M1, M2a, and M2c polarized macrophages, using next-generation sequencing. Furthermore, we show that miRNA expression signatures are closely related to the various immune functions of polarized macrophages and therefore are involved in shaping the diverse phenotypes of these cells. The miRNAs identified here serve as markers for identification of inflammatory macrophages involved in the development of immune responses. Our findings contribute to understanding the role of miRNAs in determining the macrophage function in healthy and diseased tissues.
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In the citing paper
“Expression of miR-34a-5p, miR-106-3p, miR-132-3p, miR-335-5p, miR-362-3p, and miR-424-5p was upregulated in macrophages compared with monocytes.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“miR-500a-5p and miR-502–3p were upregulated in M2a macrophages; miR-21-5p, miR-22-3p, and miR146b-5p were upregulated, and miR-339-3p was downregulated in M2c cells.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“MiR-145-5p was uniquely upregulated in M1, whereas miR-181b-5p was uniquely downregulated in M2a cells, and miR-200a-3p was exclusively downregulated in M2c macrophages.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“MiR-146a-5p, miR-193a-5p, and miR-29b-3p were upregulated, and miR-629-5p was downregulated in M1 cells.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“M1 macrophages present high expression of miR-146a-5p, miR-29b-3p, and miR-147b, and low expression of miR-221-3p.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“M2c macrophages express high levels of miR-125b-5p, miR-125a-5p, and miR-99b and uniquely low levels of miR-200a-3p [196].”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“MiR-221-3p, miR-222-3p, and miR-511 were highly expressed in M2a macrophages.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
In the citing paper
“M2a macrophages display high levels of miR-193b-3p and miR-511, and low expression of miR-181a-5p and miR-181b-5p.”
From MicroRNAs as Regulators of Phagocytosis (2022) · cites this paper as [196]
Citations
Cites
Fast and accurate short read alignment with Burrows-Wheeler transform
Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607
Differential expression analysis for sequence count data
Anders, S., & Huber, W. (2010) · Genome Biology · doi:10.1186/gb-2010-11-10-r106 · Cited by 15,581
Exploring the full spectrum of macrophage activation
Mosser, D. M., & Edwards, J. P. (2008) · Nature Reviews Immunology · doi:10.1038/nri2448 · Cited by 9,144
Macrophage plasticity and polarization: in vivo veritas
Sica, A., & Mantovani, A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci59643 · Cited by 6,335
(2008) · doi:10.1038/nrg2290 · Cited by 5,199
Monocyte and macrophage heterogeneity
Gordon, S., & Taylor, P. R. (2005) · Nature Reviews Immunology · doi:10.1038/nri1733 · Cited by 5,190
TM4: a free, open-source system for microarray data management and analysis
Saeed, A. I., Sharov, V., White, J., Li, J., Liang, W., Bhagabati, N., Braisted, J., Klapa, M., Currier, T., Thiagarajan, M., et al. (2003) · BioTechniques · doi:10.2144/03342mt01 · Cited by 4,837
Taganov, K. D., Boldin, M. P., Chang, K.-J., & Baltimore, D. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0605298103 · Cited by 4,317
Membrane vesicles as conveyors of immune responses
Théry, C., Ostrowski, M., & Segura, É. (2009) · Nature reviews. Immunology · doi:10.1038/nri2567 · Cited by 3,996
Alternative Activation of Macrophages: An Immunologic Functional Perspective
Martinez, F. O., Helming, L., & Gordon, S. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132532 · Cited by 2,745
Research works printed but not linked: 2
- Dalal SR, 2010, Gastroenterol Hepatol, 6, 714
- Li H, Clin Transl Oncol
Cited by
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Essandoh, K., Li, Y., Huo, J., & Fan, G. (2016) · Shock · doi:10.1097/shk.0000000000000604 · Cited by 611
Jung, M., Ma, Y., Iyer, R. P., DeLeon‐Pennell, K. Y., Yabluchanskiy, A., Garrett, M. R., & Lindsey, M. L. (2017) · Basic Research in Cardiology · doi:10.1007/s00395-017-0622-5 · Cited by 453
Molecular and epigenetic basis of macrophage polarized activation
Porta, C., Riboldi, E., Ippolito, A., & Sica, A. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.003 · Cited by 334
Parayath, N. N., Parikh, A. B., & Amiji, M. M. (2018) · Nano Letters · doi:10.1021/acs.nanolett.8b00689 · Cited by 263
Baer, C., Squadrito, M. L., Laoui, D., Thompson, D., Hansen, S. K., Kiialainen, A., Hoves, S., Ries, C. H., Ooi, C.-H., & De Palma, M. (2016) · Nature Cell Biology · doi:10.1038/ncb3371 · Cited by 259
Regulation of pain by neuro-immune interactions between macrophages and nociceptor sensory neurons
Ouyang, C., Donnelly, C. R., & Ji, R. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.11.006 · Cited by 266
Huber, V., Vallacchi, V., Fleming, V., Hu, X., Cova, A., Dugo, M., Shahaj, E., Sulsenti, R., Vergani, E., Filipazzi, P., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci98060 · Cited by 265
Macrophages provide a transient muscle stem cell niche via NAMPT secretion
Ratnayake, D., Nguyen, P. D., Rossello, F. J., Wimmer, V. C., Tan, J. L., Galvis, L. A., Julier, Z., Wood, A. J., Boudier, T., Isiaku, A. I., et al. (2021) · Nature · doi:10.1038/s41586-021-03199-7 · Cited by 239
Molecular Mechanisms Modulating the Phenotype of Macrophages and Microglia
Amici, S. A., Dong, J., & Guerau‐de‐Arellano, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01520 · Cited by 200
Sedighzadeh, S. S., Khoshbin, A. P., Razi, S., Keshavarz‐Fathi, M., & Rezaei, N. (2021) · Translational Lung Cancer Research · doi:10.21037/tlcr-20-1241 · Cited by 190
Tumor-Associated Macrophages as Multifaceted Regulators of Breast Tumor Growth
Munir, M. T., Kay, M., Kang, M.-H., Rahman, M. M., Al‐Harrasi, A., Choudhury, M., Moustaïd‐Moussa, N., Hussain, F., & Rahman, S. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126526 · Cited by 198
Melatonin in macrophage biology: Current understanding and future perspectives
Xia, Y., Chen, S., Zeng, S., Zhao, Y., Zhu, C., Deng, B., Zhu, G., Yin, Y., Wang, W., Hardeland, R., et al. (2018) · Journal of Pineal Research · doi:10.1111/jpi.12547 · Cited by 191
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Curtale, G., Rubino, M., & Locati, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00799 · Cited by 193
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Jablonski, K. A., Gaudet, A. D., Amici, S. A., Popovich, P. G., & Guerau-de-Arellano, M. (2016) · PLOS ONE · doi:10.1371/journal.pone.0159724 · Cited by 146
Paradoxical changes in innate immunity in aging: recent progress and new directions
Montgomery, R. R., & Shaw, A. C. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.5mr0315-104r · Cited by 147
Crooke, S. N., Ovsyannikova, I. G., Poland, G. A., & Kennedy, R. B. (2019) · Experimental Gerontology · doi:10.1016/j.exger.2019.110632 · Cited by 146
Pinto, S., Cunha, C., Barbosa, M., Vaz, A. R., & Brites, D. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00273 · Cited by 135
Transcriptional, Epigenetic and Metabolic Programming of Tumor-Associated Macrophages
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Ma, S., Liu, M., Xu, Z., Li, Y., Guo, H., Ge, Y., Liu, Y., Zheng, D., & Shi, J. (2015) · Oncotarget · doi:10.18632/oncotarget.6284 · Cited by 117
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Peng, X., Wang, Q., Li, W., Ge, G., Peng, J., Xu, Y., Yang, H., Bai, J., & Geng, D. (2023) · Bone Research · doi:10.1038/s41413-023-00244-1 · Cited by 102
Macrophage mediation in normal and diabetic wound healing responses
Ganesh, G. V., & Ramkumar, K. M. (2020) · Inflammation Research · doi:10.1007/s00011-020-01328-y · Cited by 100
Schulert, G. S., Fall, N., Harley, J. B., Shen, N., Lovell, D. J., Thornton, S., & Grom, A. A. (2016) · Arthritis & Rheumatology · doi:10.1002/art.39694 · Cited by 88
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Wallner, S., Schröder, C., Leitão, E., Berulava, T., Haak, C., Beißer, D., Rahmann, S., Richter, A. S., Manke, T., Bönisch, U., et al. (2016) · Epigenetics & Chromatin · doi:10.1186/s13072-016-0079-z · Cited by 84
Lu, L., McCurdy, S., Huang, S., Zhu, X., Peplowska, K., Tiirikainen, M., Boisvert, W. A., & Garmire, L. X. (2016) · Scientific Reports · doi:10.1038/srep37446 · Cited by 84
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Gajos-Michniewicz, A., & Czyż, M. (2019) · Cancers · doi:10.3390/cancers11030326 · Cited by 90
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Goswami, K. K., Bose, A., & Baral, R. (2021) · Clinical Immunology · doi:10.1016/j.clim.2021.108875 · Cited by 88
Wang, H., Wang, L., Pan, H., Wang, Y., Shi, M., Yu, H., Wang, C., Pan, X., & Chen, Z. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.620603 · Cited by 78
Li, D., Duan, M., Feng, Y., Geng, L., Li, X., & Zhang, W. (2016) · Molecular Immunology · doi:10.1016/j.molimm.2016.08.007 · Cited by 73
Xu, S., Hu, H.-T., Li, H. L., & Chang, S. (2019) · Cells · doi:10.3390/cells8101140 · Cited by 73
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Wei, Y., & Schober, A. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2254-6 · Cited by 65
Juknat, A., Gao, F., Coppola, G., Vogel, Z., & Kozela, E. (2019) · PLoS ONE · doi:10.1371/journal.pone.0212039 · Cited by 67
Daseke, M. J., Tenkorang, M. A. A., Ma, Y., Chalise, U., Konfrst, S. R., Garrett, M. R., DeLeon‐Pennell, K. Y., & Lindsey, M. L. (2020) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2020.06.006 · Cited by 59
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Bras, J. P., Silva, A. M., Calin, G. A., Barbosa, M. A., Santos, S. G., & Almeida, M. I. (2017) · PLOS ONE · doi:10.1371/journal.pone.0188530 · Cited by 58
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Khayati, S., Dehnavi, S., Sadeghi, M., Afshari, J. T., Esmaeili, S., & Mohammadi, M. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e21615 · Cited by 60
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Eniafe, J., & Jiang, S. (2020) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1635 · Cited by 51
Wang, X., Huang, R., Lu, Z., Wang, Z., Chen, X., & Huang, D. (2022) · Cancer Science · doi:10.1111/cas.15268 · Cited by 50
Fitzsimons, S., Oggero, S., Bruen, R., McCarthy, C., Strowitzki, M. J., Mahon, N., Ryan, N., Brennan, E. P., Barry, M. C., Perretti, M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.576516 · Cited by 51
Retinal microglia polarization in diabetic retinopathy
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MicroRNAs as Key Players in Melanoma Cell Resistance to MAPK and Immune Checkpoint Inhibitors
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Wang, C., Wang, X., Zhang, D., Sun, X., Wu, Y., Wang, J., Li, Q., & Jiang, G. (2023) · Oncology Reports · doi:10.3892/or.2023.8627 · Cited by 43
Tan, F., Cao, Y., Zheng, L., Wang, T., Zhao, S., Chen, J., Pang, C., Xia, W., Xia, Z., Li, N., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.922614 · Cited by 43
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Melton, D. W., Lei, X., Gelfond, J., & Shireman, P. K. (2016) · Physiological Genomics · doi:10.1152/physiolgenomics.00098.2015 · Cited by 29
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Zhang, M., Xian, H.-C., Dai, L., Tang, Y., & Liang, X. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00630-4 · Cited by 28
Do, T., Tan, R., Bennett, M. F., Medvedovic, M., Grom, A. A., Shen, N., Thornton, S., & Schulert, G. S. (2017) · Journal of Leukocyte Biology · doi:10.1002/jlb.2a0317-107r · Cited by 26
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Gierlikowski, W., & Gierlikowska, B. (2022) · Cells · doi:10.3390/cells11091380 · Cited by 25
Pireaux, V., Sauvage, A., Bihin, B., Steenbrugge, M. V., Rousseau, A., Antwerpen, P. V., Boudjeltia, K. Z., & Raes, M. J. (2016) · Mediators of Inflammation · doi:10.1155/2016/8249476 · Cited by 25
Shahen, M., Guo, Z., Shar, A. H., et al. (2018) · BMC Systems Biology · doi:10.1186/s12918-017-0518-x · Cited by 22
The role of non-coding RNA on macrophage modification in tuberculosis infection
Wang, Z., Xu, H., Wei, Z., Jia, Y., Wu, Y. H., Qi, X., Li, Y., & Gao, X. (2020) · Microbial Pathogenesis · doi:10.1016/j.micpath.2020.104592 · Cited by 21
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Neaga, A., Bagacean, C., Tempescul, A., Jimbu, L., Mesaros, O., Blag, C., Tomuleasa, C., Bocsan, C., Gaman, M., & Zdrenghea, M. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.582915 · Cited by 30
Erdem, J. S., Závodná, T., Ervik, T. K., Skare, Ø., Hron, T., Anmarkrud, K. H., Kuśnierczyk, A., Catalán, J., Ellingsen, D. G., Topinka, J., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1111123 · Cited by 20
Wang, P., Li, G., Zhou, L., Jiang, H.-L., Yang, Y., & Wu, H.-T. (2022) · Neoplasma · doi:10.4149/neo_2022_220426n455 · Cited by 20
Ozone‐induced changes in the murine lung extracellular vesicle small RNA landscape
Smith, G. J., Tovar, A., Kanke, M., Wang, Y., Deshane, J. S., Sethupathy, P., & Kelada, S. N. P. (2021) · Physiological Reports · doi:10.14814/phy2.15054 · Cited by 19
Gheorghe, R., Grosu, A. V., Bica-Popi, M., & Ristoiu, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012389 · Cited by 18
Herkt, C. E., Caffrey, B. E., Surmann, K., Blankenburg, S., Salazar, M. G., Jung, A. L., Herbel, S. M., Hoffmann, K., Schulte, L. N., Chen, W., et al. (2020) · mBio · doi:10.1128/mbio.03155-19 · Cited by 20
Lodge, R., Gilmore, J. C., Barbosa, J. F., Lombard‐Vadnais, F., & Cohen, É. A. (2017) · Viruses · doi:10.3390/v10010013 · Cited by 20
Nemati, M., Akseh, S., Amiri, M., Nejabati, H. R., Jodati, A., Maroufi, N. F., Faridvand, Y., & Nouri, M. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1872616 · Cited by 17
LncRNA AK089514/miR-125b-5p/TRAF6 axis mediates macrophage polarization in allergic asthma
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Hartung, F., Haimerl, P., Schindela, S., Mussack, V., Kirchner, B., Henkel, F. D. R., Bernhardt, U., Zissler, U. M., Santarella‐Mellwig, R., Pfaffl, M. W., et al. (2024) · Allergy · doi:10.1111/all.16117 · Cited by 14
miRNA-Mediated Fine Regulation of TLR-Induced M1 Polarization
Rumpel, N., Riechert, G., & Schumann, J. E. (2024) · Cells · doi:10.3390/cells13080701 · Cited by 13
Research progress on miR-124-3p in the field of kidney disease
Chen, G., Wang, Y., Zhang, L., Yang, K., Wang, X., & Chen, X. (2024) · BMC Nephrology · doi:10.1186/s12882-024-03688-7 · Cited by 13
Next-generation sequencing of microRNAs in primary human polarized macrophages
Jiménez, V. C., Willemsen, A. M., Bradley, E. J., Baas, F., van Kampen, A. H. C., & Kootstra, N. A. (2014) · Genomics Data · doi:10.1016/j.gdata.2014.06.019 · Cited by 13
Self-citationLimited differential expression of miRNAs and other small RNAs in LPS-stimulated human monocytes
Lu, D., Yamawaki, T., Zhou, H., Chou, W.-Y., Chhoa, M., Lamas, E., Escobar, S. M., Arnett, H. A., Ge, H., Juan, T., et al. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214296 · Cited by 13
Biological Response Modifier in Cancer Immunotherapy
Liu, R., Luo, F., Liu, X., Wang, L., Yang, J., Deng, Y., Huang, E., Qian, J., Lu, Z., Jiang, X., et al. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-7555-7_2 · Cited by 12
Montague-Cardoso, K., & Malcangio, M. (2020) · Neuroscience Letters · doi:10.1016/j.neulet.2020.135230 · Cited by 10
Kuno, S., Srinoun, K., & Penglong, T. (2020) · The Journal of Toxicological Sciences · doi:10.2131/jts.45.751 · Cited by 10
Conteduca, G., Rossi, A., Megiorni, F., Parodi, A., Ferrera, F., Tardito, S., Altosole, T., Fausti, V., Occella, C., Kalli, F., et al. (2021) · Skin Health and Disease · doi:10.1002/ski2.34 · Cited by 9
Chang, Y.-P., Tsai, Y., Chen, Y., Huang, K., Lee, C., Hsu, P., Chen, H., Lin, M., & Chen, Y. (2024) · Respiratory Research · doi:10.1186/s12931-024-02703-7 · Cited by 10
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Booiman, T., Jiménez, V. C., van Dort, K. A., Wout, A. B. V. ’., & Kootstra, N. A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0109673 · Cited by 6
Self-citationThe effects of exercise on microRNA expression profiling in adipose tissue macrophages of mice
Qin, F., Huang, W., Qu, C., Zhao, L., Du, Y., Zhao, T., Feng, Y., & Zhao, J. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1412621 · Cited by 5
How Noncoding RNAs Contribute to Macrophage Polarization
Cui, H., & Liu, G. (2014) · Springer eBooks · doi:10.1007/978-3-319-13689-9_4 · Cited by 4
Youn, Y.-J., Shrestha, S., Kim, J.-K., Lee, Y.-B., Lee, J. H., Hur, K., Mali, N. M., Nam, S.-W., Kim, S.-H., Song, D.-K., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/583435 · Cited by 4
Yuan, Z., Chen, R., Fan, R., Yang, Z., Zhu, Q., Qiu, C., Wu, Z., Li, D., He, Y., & Zhang, H. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.124174 · Cited by 2
Hacking macrophages to combat cancer and inflammatory diseases – Current advances and challenges
CHRISTOPOULOS, P. F. (2022) · Scandinavian Journal of Immunology · doi:10.1111/sji.13140 · Cited by 2
EPIGENETIC ALTERATIONS IN GENE EXPRESSION IN THE AGING IMMUNE SYSTEM
Miteva, D., & Velikova, T. V. (2023) · Anti-Aging Eastern Europe · doi:10.56543/aaeeu.2023.2.1.05 · Cited by 1
Using microRNAs to Promote Inflammation Resolution in Cardiovascular Research
Bráz, J. P. H. (2016) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/9tq4-5g41
Tuohy, J. L. (2017) · NCSU Libraries Repository (North Carolina State University Libraries)
Ozone-induced changes in murine lung extracellular vesicle number and small RNA contentPreprint
Smith, G. J., Tovar, A., Kanke, M., Sethupathy, P., & Kelada, S. N. P. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.06.17.157156
Connecting genes to physiology: the first 25 years of Physiological Genomics
Joe, B., Cowley, A. W., Garrett, M. R., Kriegel, A. J., Prokop, J. W., Lee, E. C., Akinola, O. M., & Coller, H. A. (2025) · Physiological Genomics · doi:10.1152/physiolgenomics.00207.2025
Zhu, X., He, L., Li, X., Pei, W., Yang, H., Zhong, M., Zhang, M., Lv, K., & Zhang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22615390
Zhu, X., He, L., Li, X., Pei, W., Yang, H., Zhong, M., Zhang, M., Lv, K., & Zhang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22615393
Zhu, X., He, L., Li, X., Pei, W., Yang, H., Zhong, M., Zhang, M., Lv, K., & Zhang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22615396
Zhu, X., He, L., Li, X., Pei, W., Yang, H., Zhong, M., Zhang, M., Lv, K., & Zhang, Y. (2023) · Figshare · doi:10.6084/m9.figshare.22615399
Diotallevi, A., Buffi, G., Maestrini, S., et al. (2026) · Scientific Reports · doi:10.1038/s41598-026-45026-x
Metadata
- Authors
- Cobos Jiménez, V., Bradley, E. J., Willemsen, A. M., van Kampen, A. H. C., Baas, F., & Kootstra, N. A.
- Affiliations
- Department of Experimental Immunology, Sanquin Research, Landsteiner Laboratory, and Center for Infectious Diseases and Immunity Amsterdam (CINIMA), Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands;
- Amsterdam UMC Location University of Amsterdam (NL)
- Bioinformatics Laboratory, Department of Clinical Epidemiology, Biostatistics and Bioinformatics, Academic Medical Center of the University of Amsterdam, Amsterdam, The Netherlands; and
- Corresponding author
- Kootstra, Neeltje A.
- Venue
- Physiological Genomics
- Publisher
- American Physiological Society
- Published
- 2014-02-01
- Volume
- 46
- Issue
- 3
- Pages
- 91-103
- ISSN
- 1094-8341 (ISSN-L)
- 1531-2267
- OpenAlex
- W2162762911
- Semantic Scholar
- 34af06ad211be134cc169644e3d037e563fc176a
- Cited by
- 103
- References
- 60
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 7 · 2023: 12 · 2022: 7 · 2021: 14 · 2020: 14 · 2019: 11 · 2018: 6 · 2017: 7 · 2016: 13 · 2015: 3 · 2014: 5
- FWCI
- 2.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiological Genomics (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- UvA-DARE (University of Amsterdam) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- microRNA, macrophage polarization, monocyte differentiation, M1 macrophages, M2 macrophages, microRNA signature, cytokine regulation, post-transcriptional regulation, inflammatory macrophages, macrophage phenotype
- MeSH terms
- Cell Differentiation, Gene Expression Regulation, Homeostasis, Humans, Immune System, Inflammation, Macrophages, Monocytes, Phenotype, RNA Processing, Post-Transcriptional, Transcription, Genetic, Cytokines, Sequence Analysis, RNA, Gene Expression Profiling, MicroRNAs, High-Throughput Nucleotide Sequencing
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