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Control of the Inflammatory Macrophage Transcriptional Signature by miR-155
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“However, some miRNAs such as miR-155 as pro-inflammatory agents, induced in microglia, promote the inflammatory process (Lippai et al. 2013; Jablonski et al. 2016).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Jablonski et al. 2016
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“MiR-155 is one of the pro-inflammatory agents that is continuously increased in the serum of MS patients (Jablonski et al. 2016).”
From MiR-124 and MiR-155 as Therapeutic Targets in Microglia-Mediated Inflammation in Multiple Sclerosis (2025) · cites this paper as Jablonski et al. 2016
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Citations
Cites
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“Indeed, inflammatory macrophages have been implicated in the pathogenesis of several inflammatory conditions including atherosclerosis, diabetes and glomerulonephritis [8,19,20].”
Backgroundthe Immunological Genome Consortium, Gautier, E. L., Shay, T., Miller, J., Greter, M., Jakubzick, C., Ivanov, S., Helft, J., Chow, A., Elpek, K. G., et al. (2012) · Nature Immunology · doi:10.1038/ni.2419 · Cited by 1,972 · cited 3×
“The classical M1 and alternatively activated M2 phenotypes represent in vitro-derived extremes of a spectrum of in vivomacrophage phenotypes that change as a function of the inflammatory milieu [6,7,64].”
BackgroundRequirement of bic/microRNA-155 for Normal Immune Function
Rodriguez, A., Vigorito, E., Clare, S., Warren, M. V., Couttet, P., Soond, D. R., van Dongen, S., Grocock, R. J., Das, P. P., Miska, E. A., et al. (2007) · Science · doi:10.1126/science.1139253 · Cited by 1,833
Trophic macrophages in development and disease
Pollard, J. W. (2009) · Nature Reviews Immunology · doi:10.1038/nri2528 · Cited by 1,178
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Modulating inflammatory monocytes with a unique microRNA gene signature ameliorates murine ALS
Butovsky, O., Siddiqui, S., Gabriely, G., Lanser, A. J., Dake, B., Murugaiyan, G., Doykan, C. E., Wu, P. M., Gali, R. R., Iyer, L. K., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci62636 · Cited by 481
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Metadata
- Authors
- Jablonski, K. A., Gaudet, A. D., Amici, S. A., Popovich, P. G., & Guerau-de-Arellano, M.
- Venue
- PLOS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2016-07-22
- Volume
- 11
- Issue
- 7
- Pages
- e0159724
- ISSN
- 1932-6203
- PMC
- PMC4957803
- Cited by
- 146
- References
- 13
- Language
- en
- Funders
- International Foundation for Research on Paraplegia (P 129)
- National Institute of Neurological Disorders and Stroke (NIH R21 R21NS081413)
- Ray W. Poppleton Endowment
- Canadian Institutes of Health Research (CA) Postdoctoral Fellowship
- Ohio State University Mayer's Undergraduate Summer Research Fellowship
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