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Cited by 699

The DOI matches its Crossref record; 460 of the 460 references it cites were found in a registry or an index.

Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

Malpas, Simon C.·2010·Physiological Reviews
DOI 10.1152/physrev.00007.2009
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Abstract

This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of the topographical organization of the central nervous system and a myriad of afferent inputs. Together this organization produces sympathetic responses tailored to match stimuli. The long-term control of sympathetic nerve activity (SNA) is an area of considerable interest and involves a variety of mediators acting in a quite distinct fashion. These mediators include arterial baroreflexes, angiotensin II, blood volume and osmolarity, and a host of humoral factors. A key feature of many cardiovascular diseases is increased SNA. However, rather than there being a generalized increase in SNA, it is organ specific, in particular to the heart and kidneys. These increases in regional SNA are associated with increased mortality. Understanding the regulation of organ-specific SNA is likely to offer new targets for drug therapy. There is a need for the research community to develop better animal models and technologies that reflect the disease progression seen in humans. A particular focus is required on models in which SNA is chronically elevated.

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Crossref · 10.1152/physrev.00007.2009

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Metadata

Authors
Malpas, S. C.
Venue
Physiological Reviews
Publisher
American Physiological Society
Published
2010-04
Volume
90
Issue
2
Pages
513-557
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
DOI
10.1152/physrev.00007.2009
OpenAlex
W2151429049
Cited by
699
References
460
FWCI
6.28
Type
journal article
Language
en
Open access
closed

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