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Cited by 32Blood Pressure and Hypertension StudiesHeart Rate Variability and Autonomic ControlHormonal Regulation and Hypertension

Monoaminergic Neuronal Activity in Subcortical Brain Regions in Essential Hypertension

Lambert, Gavin W., Ferrier, Claudia, Kaye, David M., Kalff, Victor, Kelly, Michael J., Cox, Helen S., Turner, Andrea G., Jennings, Garry L. +1 more·1994·Blood Pressure
DOI 10.3109/08037059409101522
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Abstract

In this study we aimed to elucidate the role of central noradrenergic, dopaminergic, adrenergic and serotonergic neuronal systems in the development of essential hypertension. Fifteen untreated essential hypertensive subjects (aged 44 +/- 3 years) and 32 healthy volunteers (aged 38 +/- 3 years) participated in this study. By combining direct blood sampling techniques with cerebral blood flow scans we were able to differentiate between cortical and subcortical venous drainage of the brain. Veno-arterial MHPG, HVA and 5-HIAA plasma concentration gradients combined with internal jugular vein plasma flows were used, according to the Fick Principle, to derive metabolite spillovers which in turn were used as indicators of central noradrenergic, dopaminergic and serotonergic neuronal activity, respectively. These amine systems, in both the brainstem and forebrain, have been implicated in the regulation of sympathetic outflow and blood pressure. Total body noradrenaline spillover to plasma was concurrently measured to assess the relationship between central monoamine turnover and sympathetic activity. Compared to their healthy counterparts the hypertensive subjects had an elevated release of MHPG from subcortical brain regions (1.4 +/- 0.3 v 0.5 +/- 0.2 nmol/min, p < 0.05). An inverse relationship between blood pressure and subcortical HVA overflow existed, with the HVA overflow being significantly lower in the hypertensives (0.5 +/- 0.2 v 2.1 +/- 0.5 nmol/min, p < 0.05). Subcortical 5-HUAA overflow did not differ between the two groups, and adrenaline spillover from the brain was not detected in either group. Subcortical MHPG overflow was significantly correlated with total body NA spillover to plasma (p < 0.05). These results indicate that reciprocal aberrations in subcortical noradrenaline and dopamine turnover exist in essential hypertension. Although the physiological significance of this remains to be unequivocally elucidated we postulate that elevated subcortical noradrenergic activity, presumably in the forebrain where noradrenergic neurons are pressor, may cause sympathoexcitation and play a role in the development of essential hypertension.

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Authors
Lambert, G. W., Ferrier, C., Kaye, D. M., Kalff, V., Kelly, M. J., Cox, H. S., Turner, A. G., Jennings, G. L., & Esler, M. D.
Affiliations
The Alfred Hospital (AU)
ORCID
Venue
Blood Pressure
Publisher
Informa UK Limited
Published
1994-01
Volume
3
Issue
1-2
Pages
55-66
ISSN
  • 0803-7051 (ISSN-L)
  • 1651-1999
DOI
10.3109/08037059409101522
OpenAlex
W2121567908
Cited by
32
References
69
Citations by year
2017: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
2.84
Type
journal article
Language
en
Open access
closed
Locations
  • Blood Pressure (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institutes of Health
Topics
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal Regulation and Hypertension
Keywords
essential hypertension, monoamine neurotransmission, subcortical structures, noradrenaline spillover, MHPG, homovanillic acid, 5-hydroxyindoleacetic acid, cerebral blood flow, venous drainage of the brain, sympathetic nervous system, blood pressure regulation, brainstem, forebrain
MeSH terms
Adult, Brain, Cerebrovascular Circulation, Homovanillic Acid, Humans, Hydroxyindoleacetic Acid, Hypertension, Jugular Veins, Methoxyhydroxyphenylglycol, Middle Aged, Neurons, Reference Values, 3,4-Dihydroxyphenylacetic Acid, Biogenic Monoamines

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