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Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

Malpas, Simon C.·2010·Physiological Reviews

DOI 10.1152/physrev.00007.2009

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Abstract

This review examines how the sympathetic nervous system plays a major role in the regulation of cardiovascular function over multiple time scales. This is achieved through differential regulation of sympathetic outflow to a variety of organs. This differential control is a product of the topographical organization of the central nervous system and a myriad of afferent inputs. Together this organization produces sympathetic responses tailored to match stimuli. The long-term control of sympathetic nerve activity (SNA) is an area of considerable interest and involves a variety of mediators acting in a quite distinct fashion. These mediators include arterial baroreflexes, angiotensin II, blood volume and osmolarity, and a host of humoral factors. A key feature of many cardiovascular diseases is increased SNA. However, rather than there being a generalized increase in SNA, it is organ specific, in particular to the heart and kidneys. These increases in regional SNA are associated with increased mortality. Understanding the regulation of organ-specific SNA is likely to offer new targets for drug therapy. There is a need for the research community to develop better animal models and technologies that reflect the disease progression seen in humans. A particular focus is required on models in which SNA is chronically elevated.

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Neural Control of Renal Function*
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See all 699

Authors: Malpas, S. C.
Venue: Physiological Reviews
Publisher: American Physiological Society
Published: 2010-04
Volume: 90
Issue: 2
Pages: 513-557
ISSN: 0031-9333 (ISSN-L)
1522-1210
DOI: 10.1152/physrev.00007.2009
OpenAlex: W2151429049
Cited by: 699
References: 460
FWCI: 6.28
Type: journal article
Language: en
Open access: closed

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Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease

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