Circadian misalignment increases cardiovascular disease risk factors in humans
Open accessAbstract
Significance: Shift work is a risk factor for hypertension, inflammation, and cardiovascular disease, even after controlling for traditional risk factors. Shift workers frequently undergo circadian misalignment (i.e., misalignment between the endogenous circadian system and 24-h environmental/behavioral cycles). This misalignment has been proposed to explain, in part, why shift work is a risk factor for hypertension, inflammation, and cardiovascular disease. However, the impact of circadian misalignment per se on 24-h blood pressure and inflammatory markers is poorly understood. We show—under highly controlled laboratory conditions—that short-term circadian misalignment increases 24-h blood pressure and inflammatory markers in healthy adults. Our findings may help explain why shift work increases hypertension, inflammation, and cardiovascular disease risk.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
A recent laboratory study of shift workers revealed that circadian misalignment increased 24-hour blood pressure and cardiovascular inflammatory markers including IL-6, C-reactive protein, and TNF-α.
“A recent laboratory study of shift workers revealed that circadian misalignment increased 24-hour BP and CV inflammatory markers including IL-6, C-reactive protein, and TNF-α (142).”
From Role of the circadian system in cardiovascular disease (2018) · cites this paper as [142]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.51.6.1173 · Cited by 91,542 · see citing works
Baron, R. M., & Kenny, D. A. (1986) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.51.6.1173 · Cited by 91,532 · see citing works
Heart Rate Variability: Standards of Measurement, Physiological Interpretation, and Clinical Use
Electrophysiology, T. F. O. T. E. S. O. C. T. N. A. (1996) · Circulation · doi:10.1161/01.cir.93.5.1043 · Cited by 17,159 · see citing works
Heart rate variability: Standards of measurement, physiological interpretation, and clinical use
Malik, M., Bigger, J. T., Camm, A. J., Kleiger, R. E., Malliani, A., Moss, A. J., & Schwartz, P. J. (1996) · European Heart Journal · doi:10.1093/oxfordjournals.eurheartj.a014868 · Cited by 15,289 · see citing works
Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
(2007) · Cited by 6,530 · see citing works
Pearson, T. A., Mensah, G. A., Alexander, R. W., Anderson, J. L., Cannon, R. O., Criqui, M., Fadl, Y. Y., Fortmann, S. P., Hong, Y., Myers, G. L., et al. (2003) · Circulation · doi:10.1161/01.cir.0000052939.59093.45 · Cited by 6,401 · see citing works
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
Adipokines in inflammation and metabolic disease
Ouchi, N., Parker, J. L., Lugus, J. J., & Walsh, K. (2011) · Nature Reviews Immunology · doi:10.1038/nri2921 · Cited by 4,625 · see citing works
Inflammation in Atherosclerosis
Libby, P. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.108.179705 · Cited by 3,748 · see citing works
European Guidelines for Obesity Management in Adults
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., & Toplak, H. (2015) · Obesity Facts · doi:10.1159/000442721 · Cited by 3,432 · see citing works
The pro- and anti-inflammatory properties of the cytokine interleukin-6
Scheller, J., Chalaris, A., Schmidt-Arras, D., & Rose-John, S. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2011.01.034 · Cited by 3,212 · see citing works
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,196 · see citing works
PearsonT, A., MensahG, A., & AlexanderR, W. (2003) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200305000-00016 · Cited by 2,937 · see citing works
Ridker, P. M., Rifai, N., Stampfer, M. J., & Hennekens, C. H. (2000) · Circulation · doi:10.1161/01.cir.101.15.1767 · Cited by 2,429 · see citing works
Adverse metabolic and cardiovascular consequences of circadian misalignment
Scheer, F. A. J. L., Hilton, M. F., Mantzoros, C. S., & Shea, S. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0808180106 · Cited by 2,351 · see citing works
Self-citationCentral and Peripheral Circadian Clocks in Mammals
Mohawk, J. A., Green, C. B., & Takahashi, J. S. (2012) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-060909-153128 · Cited by 2,265 · see citing works
Danesh, J., Collins, R., Appleby, P. N., & Peto, R. (1998) · JAMA · doi:10.1001/jama.279.18.1477 · Cited by 2,027 · see citing works
Low grade inflammation and coronary heart disease: prospective study and updated meta-analyses
Danesh, J. (2000) · BMJ · doi:10.1136/bmj.321.7255.199 · Cited by 1,692 · see citing works
Blood Pressure, Systolic and Diastolic, and Cardiovascular Risks
Stamler, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.153.5.598 · Cited by 1,380 · see citing works
Effect of sleep loss on C-reactive protein, an inflammatory marker of cardiovascular risk
Meier-Ewert, H. K., Ridker, P. M., Rifai, N., Regan, M. M., Price, N. J., Dinges, D. F., & Mullington, J. M. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.07.050 · Cited by 1,195 · see citing works
Inflammation and cardiovascular disease mechanisms
Libby, P. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/83.2.456s · Cited by 1,095 · see citing works
Calculating correlation coefficients with repeated observations: Part 2—correlation between subjects
Bland, J. M., & Altman, D. G. (1995) · BMJ · doi:10.1136/bmj.310.6980.633 · Cited by 1,083 · see citing works
Adverse Effects of Modest Sleep Restriction on Sleepiness, Performance, and Inflammatory Cytokines
Vgontzas, A. N., Zoumakis, E., Bixler, E. O., Lin, H.-M., Follett, H., Kales, A., & Chrousos, G. P. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031562 · Cited by 1,050 · see citing works
Bland, J. M., & Altman, D. G. (1995) · BMJ · doi:10.1136/bmj.310.6977.446 · Cited by 1,036 · see citing works
Blood Pressure, Systolic and Diastolic, and Cardiovascular Risks: US Population Data
Stamler, J. (1993) · Archives of Internal Medicine · doi:10.1001/archinte.1993.00410050036006 · Cited by 1,015 · cited 1× · see citing works
“The circadian misalignmentmediated increase in blood pressure may be clinically important considering that there is an increased risk of cardiovascular disease with progressive elevations in blood pressure, beginning at normal blood pressure levels (32).”
BackgroundRidker, P. M., Rifai, N., Pfeffer, M., Sacks, F., Lepage, S., & Braunwald, E. (2000) · Circulation · doi:10.1161/01.cir.101.18.2149 · Cited by 934 · see citing works
Shift work and vascular events: systematic review and meta-analysis
Vyas, M. V., Garg, A. X., Iansavichus, A. V., Costella, J., Donner, A., Laugsand, L. E., Janszky, I., Mrkobrada, M., Parraga, G., & Hackam, D. G. (2012) · BMJ · doi:10.1136/bmj.e4800 · Cited by 840 · see citing works
Sympathetic Nervous System Overactivity and Its Role in the Development of Cardiovascular Disease
Malpas, S. C. (2010) · Physiological Reviews · doi:10.1152/physrev.00007.2009 · Cited by 696 · see citing works
Haack, M., Sanchez, E., & Mullington, J. M. (2007) · Sleep · doi:10.1093/sleep/30.9.1145 · Cited by 615 · see citing works
Leproult, R., Holmbäck, U., & Van Cauter, E. (2014) · Diabetes · doi:10.2337/db13-1546 · Cited by 607 · see citing works
Predictive Role of the Nighttime Blood Pressure
Hansen, T. W., Li, Y., Boggia, J., Thijs, L., Richart, T., & Staessen, J. A. (2011) · Hypertension · doi:10.1161/hypertensionaha.109.133900 · Cited by 597 · see citing works
Wright, K. P., Drake, A. L., Frey, D. J., Fleshner, M., Desouza, C. A., Gronfier, C., & Czeisler, C. A. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.01.004 · Cited by 567 · see citing works
Treatment allocation by minimisation
Altman, D. G., & Bland, J. M. (2005) · BMJ · doi:10.1136/bmj.330.7495.843 · Cited by 550 · see citing works
Dysregulation of inflammatory responses by chronic circadian disruption
Castanon-Cervantes, O., Wu, M., Ehlen, J. C., Paul, K., Gamble, K. L., Johnson, R. L., Besing, R. C., Menaker, M., Gewirtz, A. T., & Davidson, A. J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001026 · Cited by 542 · see citing works
Circadian clock control of endocrine factors
Gamble, K. L., Berry, R., Frank, S. J., & Young, M. E. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.78 · Cited by 526 · see citing works
Morris, C. J., Yang, J. N., Garcia, J. I., Myers, S., Bozzi, I., Wang, W., Buxton, O. M., Shea, S. A., & Scheer, F. A. J. L. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1418955112 · Cited by 523 · see citing works
Self-citationvan Leeuwen, W. M. A., Lehto, M., Karisola, P., Lindholm, H., Luukkonen, R., Sallinen, M., Härmä, M., Porkka-Heiskanen, T., & Alenius, H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004589 · Cited by 483 · see citing works
Effects of Insufficient Sleep on Blood Pressure Monitored by a New Multibiomedical Recorder
Tochikubo, O., Ikeda, A., Miyajima, E., & Ishii, M. (1996) · Hypertension · doi:10.1161/01.hyp.27.6.1318 · Cited by 470 · see citing works
Daily nighttime melatonin reduces blood pressure in male patients with essential hypertension
Scheer, F. A. J. L., Van Montfrans, G. A., van Someren, E. J. W., Mairuhu, G., & Buijs, R. M. (2004) · Hypertension · doi:10.1161/01.hyp.0000113293.15186.3b · Cited by 451 · see citing works
Doi, M., Takahashi, Y., Komatsu, R., Yamazaki, F., Yamada, H., Haraguchi, S., Emoto, N., Okuno, Y., Tsujimoto, G., Kanematsu, A., et al. (2010) · Nature Medicine · doi:10.1038/nm.2061 · Cited by 431 · see citing works
Circadian system, sleep and endocrinology
Morris, C. J., Aeschbach, D., & Scheer, F. A. J. L. (2012) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.09.003 · Cited by 403 · see citing works
Self-citationCircadian variation of blood pressure and the vascular response to asynchronous stress
Curtis, A. M., Cheng, Y., Kapoor, S. C., Reilly, D. F., Price, T. S., & FitzGerald, G. A. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611680104 · Cited by 401 · see citing works
Impact of the human circadian system, exercise, and their interaction on cardiovascular function
Scheer, F. A. J. L., Hu, K., Evoniuk, H., Kelly, E. E., Malhotra, A., Hilton, M. F., & Shea, S. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1006749107 · Cited by 332 · see citing works
Self-citationEffects of insufficient sleep on blood pressure in hypertensive patients: a 24-h study
Lusardi, P. (1999) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00200-3 · Cited by 331 · see citing works
Effects of rotating shift work on biomarkers of metabolic syndrome and inflammation
Sookoian, S. C., Gemma, C., Gianotti, T. F., Burgueño, A. L., Alvarez, A., González, C. D., & Pirola, C. J. (2007) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2007.01766.x · Cited by 315 · see citing works
The pNNx files: re-examining a widely used heart rate variability measure
Mietus, J. E., Peng, C., Henry, I., Goldsmith, R. L., & Goldberger, A. L. (2002) · Heart · doi:10.1136/heart.88.4.378 · Cited by 263 · see citing works
Tuomisto, K., Jousilahti, P., Sundvall, J., Pajunen, P., & Salomaa, V. V. (2006) · Thrombosis and Haemostasis · doi:10.1160/th05-08-0571 · Cited by 231 · see citing works
Office compared with ambulatory blood pressure in assessing response to antihypertensive treatment
Mancia, G., & Parati, G. (2004) · Journal of Hypertension · doi:10.1097/00004872-200403000-00001 · Cited by 217 · see citing works
The impact of the circadian timing system on cardiovascular and metabolic function
Morris, C. J., Yang, J. N., & Scheer, F. A. J. L. (2012) · Progress in Brain Research · doi:10.1016/b978-0-444-59427-3.00019-8 · Cited by 215 · see citing works
Self-citationYAMAMOTO, K., TAKESHITA, K., KOJIMA, T., TAKAMATSU, J., & SAITO, H. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.11.013 · Cited by 214 · see citing works
Connell, J. M. C., Whitworth, J. A., Davies, D. L., Lever, A. F., Richards, A. M., & Fraser, R. (1987) · Journal of Hypertension · doi:10.1097/00004872-198708000-00007 · Cited by 188 · see citing works
Lusardi, P. (1996) · American Journal of Hypertension · doi:10.1016/0895-7061(95)00389-4 · Cited by 183 · see citing works
Existence of an Endogenous Circadian Blood Pressure Rhythm in Humans That Peaks in the Evening
Shea, S. A., Hilton, M. F., Hu, K., & Scheer, F. A. J. L. (2011) · Circulation Research · doi:10.1161/circresaha.110.233668 · Cited by 179 · see citing works
Self-citationScheer, F. A. J. L., & Shea, S. A. (2014) · Blood · doi:10.1182/blood-2013-07-517060 · Cited by 172 · see citing works
Self-citationMorris, C. J., Garcia, J. I., Myers, S., Yang, J. N., Trienekens, N., & Scheer, F. A. J. L. (2015) · Obesity · doi:10.1002/oby.21189 · Cited by 167 · see citing works
Self-citationEffect of Shiftwork on Systemic Markers of Inflammation
Puttonen, S., Viitasalo, K., & Härmä, M. (2011) · Chronobiology International · doi:10.3109/07420528.2011.580869 · Cited by 165 · see citing works
Modifications of Cardiac Autonomic Profile Associated With a Shift Schedule of Work
Furlan, R., Barbic, F., Piazza, S., Tinelli, M., Seghizzi, P., & Malliani, A. (2000) · Circulation · doi:10.1161/01.cir.102.16.1912 · Cited by 151 · see citing works
Twenty-four-hour ambulatory blood pressure in shift workers.
Chau, N. P., Mallion, J. M., Gaudemaris, R. D., Ruche, E., Siche, J. P., Pelen, O., & Mathern, G. W. (1989) · Circulation · doi:10.1161/01.cir.80.2.341 · Cited by 140 · see citing works
Moore, T. J., Vollmer, W. M., Appel, L. J., Sacks, F. M., Svetkey, L. P., Vogt, T. M., Conlin, P. R., Simons-Morton, D. G., Carter-Edwards, L., & Harsha, D. W. (1999) · Hypertension · doi:10.1161/01.hyp.34.3.472 · Cited by 139 · see citing works
Fonken, L. K., Lieberman, R. A., Weil, Z. M., & Nelson, R. J. (2013) · Endocrinology · doi:10.1210/en.2013-1121 · Cited by 125 · see citing works
Fraden, J., & Neuman, M. R. (1980) · Medical & Biological Engineering & Computing · doi:10.1007/bf02443287 · Cited by 123 · see citing works
Relationship between shift work and onset of hypertension in a cohort of manual workers
Morikawa, Y., Nakagawa, H., Miura, K., Ishizaki, M., Tabata, M., Nishijo, M., 東口, 和., Yoshita, K., Sagara, T., Kido, T., et al. (1999) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.411 · Cited by 122 · see citing works
Shift Work Is a Risk Factor for Increased Blood Pressure in Japanese Men
Suwazono, Y., Dochi, M., Sakata, K., Okubo, Y., Oishi, M., Tanaka, K., Kobayashi, E., & Nogawa, K. (2008) · Hypertension · doi:10.1161/hypertensionaha.108.114553 · Cited by 121 · see citing works
The circadian melatonin and cortisol secretion pattern in permanent night shift workers
Roden, M., Koller, M. M., Pirich, K., Vierhapper, H., & Waldhauser, F. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.265.1.r261 · Cited by 114 · see citing works
Accuracy of the SpaceLabs Medical 90217 ambulatory blood pressure monitor.
Baumgart, P., & Kamp (1998) · PubMed · Cited by 113 · see citing works
The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
Muse, E. D., Feldman, D. I., Blaha, M. J., Dardari, Z., Blumenthal, R. S., Budoff, M. J., Nasir, K., Criqui, M. H., Cushman, M., McClelland, R. L., et al. (2014) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2014.12.044 · Cited by 104 · see citing works
Su, T., Lin, L., Baker, D. B., Schnall, P. L., Chen, M.-F., Hwang, W., Chen, C., & Wang, J. (2008) · Journal of Occupational Health · doi:10.1539/joh.l7056 · Cited by 92 · see citing works
The Relationship Between Shift Work and the Onset of Hypertension in Male Japanese Workers
Sakata, K., Suwazono, Y., Harada, H., Okubo, Y., Kobayashi, E., & Nogawa, K. (2003) · Journal of Occupational and Environmental Medicine · doi:10.1097/01.jom.0000085893.98441.96 · Cited by 91 · see citing works
Serum Resistin Concentrations and Risk of New Onset Heart Failure in Older Persons
Butler, J., Kalogeropoulos, A. P., Georgiopoulou, V. V., de Rekeneire, N., Rodondi, N., Smith, A. L., Hoffmann, U., Kanaya, A. M., Newman, A. B., Kritchevsky, S. B., et al. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.186783 · Cited by 87 · see citing works
Adams, S. L., Roxe, D. M., Weiss, J., Zhang, F., & Rosenthal, J. E. (1998) · Academic Emergency Medicine · doi:10.1111/j.1553-2712.1998.tb02816.x · Cited by 86 · see citing works
Rotating night shift work and disparate hypertension risk in African–Americans
Lieu, S. J., Curhan, G. C., Schernhammer, E. S., & Forman, J. P. (2011) · Journal of Hypertension · doi:10.1097/hjh.0b013e32834e1ea3 · Cited by 84 · see citing works
Kitamura, T., Onishi, K., Dohi, K., 沖中, 務., Ito, M., Isaka, N., & Nakano, T. (2002) · Journal of Human Hypertension · doi:10.1038/sj.jhh.1001328 · Cited by 69 · see citing works
Night work and inflammatory markers
Alireza, S., Sadeghniiat‐Haghighi, K., Omid, A., & Forough, S. (2011) · Indian Journal of Occupational and Environmental Medicine · doi:10.4103/0019-5278.82996 · Cited by 54 · see citing works
Burgueño, A., Gemma, C., Gianotti, T. F., Sookoian, S., & Pirola, C. J. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.12.032 · Cited by 53 · see citing works
Influences of Melatonin on Human Orcadian Rhythms
Cagnacci, A. (1997) · Chronobiology International · doi:10.3109/07420529709001156 · Cited by 48 · see citing works
Fialho, G. L., Cavichio, L. R., Póvoa, R., & PIMENTA, J. (2006) · American Journal of Hypertension · doi:10.1016/j.amjhyper.2006.03.007 · Cited by 47 · see citing works
Effects of photoperiod reduction on rat circadian rhythms of BP, heart rate, and locomotor activity
Zhang, B.-L., Zannou, E. A., & Sannajust, F. (2000) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2000.279.1.r169 · Cited by 27 · see citing works
Oishi, K., & Ohkura, N. (2012) · Blood Coagulation & Fibrinolysis · doi:10.1097/mbc.0b013e32835bfdf3 · Cited by 15 · see citing works
Prior exercise lowers blood pressure during simulated night-work with different meal schedules
Fullick, S., Morris, C., Jones, H., & Atkinson, G. (2009) · American Journal of Hypertension · doi:10.1038/ajh.2009.91 · Cited by 14 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 1
- [72]72. Bland JM, Altman DG (1995) Calculating correlation coefficients with repeated ob- servations: Part 1-Correlation within subjects. BMJ 310(6977):446.
Cited by
Sorted by citations
Touitou, Y., Reinberg, A., & Touitou, D. (2017) · Life Sciences · doi:10.1016/j.lfs.2017.02.008 · Cited by 738 · see citing works
Yin, J., Jin, X., Shan, Z., Li, S., Huang, H., Li, P., Peng, X., Peng, Z., Yu, K., Bao, W., et al. (2017) · Journal of the American Heart Association · doi:10.1161/jaha.117.005947 · Cited by 721 · see citing works
Circadian Rhythm and Sleep Disruption: Causes, Metabolic Consequences, and Countermeasures
Potter, G. D., Skene, D. J., Arendt, J., Cade, J. E., Grant, P. J., & Hardie, L. J. (2016) · Endocrine Reviews · doi:10.1210/er.2016-1083 · Cited by 728 · see citing works
Epigenetic regulation of aging: implications for interventions of aging and diseases
Kang, W., Liu, H., Hu, Q., Wang, L., Liu, J., Zheng, Z., Zhang, W., Ren, J., Zhu, F., & Liu, G. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01211-8 · Cited by 694 · see citing works
Jamshed, H., Beyl, R., Della Manna, D., Yang, E., Ravussin, E., & Peterson, C. (2019) · Nutrients · doi:10.3390/nu11061234 · Cited by 664 · see citing works
The role of insufficient sleep and circadian misalignment in obesity
Chaput, J., McHill, A. W., Cox, R. C., Broussard, J. L., Dutil, C., da Costa, B. G. G., Sampasa‐Kanyinga, H., & Wright, K. P. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00747-7 · Cited by 691 · see citing works
Association between circadian rhythms and neurodegenerative diseases
Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works
Self-citationThe aging clock: circadian rhythms and later life
Hood, S., & Amir, S. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90328 · Cited by 621 · see citing works
Environmental Determinants of Cardiovascular Disease
Bhatnagar, A. (2017) · Circulation Research · doi:10.1161/circresaha.117.306458 · Cited by 610 · see citing works
Bile Acid Metabolism in Liver Pathobiology
Chiang, J. Y. L., & Ferrell, J. M. (2018) · Gene Expression · doi:10.3727/105221618x15156018385515 · Cited by 552 · see citing works
Disturbance of the Circadian System in Shift Work and Its Health Impact
Boivin, D. B., Boudreau, P., & Kosmadopoulos, A. (2021) · Journal of Biological Rhythms · doi:10.1177/07487304211064218 · Cited by 537 · see citing works
Circadian disruption and human health
Fishbein, A. B., Knutson, K. L., & Zee, P. C. (2021) · Journal of Clinical Investigation · doi:10.1172/jci148286 · Cited by 468 · see citing works
Role of the circadian system in cardiovascular disease
Thosar, S. S., Butler, M. P., & Shea, S. A. (2018) · Journal of Clinical Investigation · doi:10.1172/jci80590 · Cited by 443 · see citing works
Later circadian timing of food intake is associated with increased body fat
McHill, A. W., Phillips, A. J., Czeisler, C. A., Keating, L., Yee, K., Barger, L. K., Garaulet, M., Scheer, F. A., & Klerman, E. B. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.117.161588 · Cited by 414 · see citing works
Self-citationCircadian System and Glucose Metabolism: Implications for Physiology and Disease
Qian, J., & Scheer, F. A. J. L. (2016) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2016.03.005 · Cited by 370 · see citing works
Self-citationLifestyle interventions for the prevention and treatment of hypertension
Valenzuela, P. L., Carrera‐Bastos, P., Gálvez, B. G., Ruiz‐Hurtado, G., Ordovás, J. M., Ruilope, L. M., & Lucía, A. (2020) · Nature Reviews Cardiology · doi:10.1038/s41569-020-00437-9 · Cited by 379 · see citing works
Environmental risk factors and cardiovascular diseases: a comprehensive expert review
Münzel, T. F., Hahad, O., Sørensen, M., Lelieveld, J., Duerr, G. D., Nieuwenhuijsen, M. J., & Daiber, A. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab316 · Cited by 381 · see citing works
Impact of Circadian Disruption on Cardiovascular Function and Disease
Chellappa, S. L., Vujović, N., Williams, J. S., & Scheer, F. A. J. L. (2019) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2019.07.008 · Cited by 333 · see citing works
Self-citationExercise Metabolism and Adaptation in Skeletal Muscle
Smith, J. A. B., Murach, K. A., Dyar, K. A., & Zierath, J. R. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00606-x · Cited by 342 · see citing works
Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Eban-Rothschild, A., Appelbaum, L., & de Lecea, L. (2018) · Neuropsychopharmacology · doi:10.1038/npp.2017.294 · Cited by 282 · see citing works
Circadian clock-mediated regulation of blood pressure
Douma, L. G., & Gumz, M. L. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.11.024 · Cited by 267 · see citing works
Effect of night-time temperatures on cause and age-specific mortality in London
Murage, P., Hajat, S., & Kovats, S. R. (2017) · Environmental Epidemiology · doi:10.1097/ee9.0000000000000005 · Cited by 252 · see citing works
Importance of circadian timing for aging and longevity
Acosta-Rodríguez, V. A., Rijo‐Ferreira, F., Green, C. B., & Takahashi, J. S. (2021) · Nature Communications · doi:10.1038/s41467-021-22922-6 · Cited by 249 · see citing works
Soil and water pollution and human health: what should cardiologists worry about?
Münzel, T. F., Hahad, O., Daiber, A., & Landrigan, P. J. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac082 · Cited by 265 · see citing works
The circadian clock and liver function in health and disease
Mukherji, A., Bailey, S. M., Staels, B., & Baumert, T. F. (2019) · Journal of Hepatology · doi:10.1016/j.jhep.2019.03.020 · Cited by 246 · see citing works
Social Jetlag and Related Risks for Human Health: A Timely Review
Caliandro, R., Streng, A. A., van Kerkhof, L. W. M., van der Horst, G. T. J., & Chaves, I. (2021) · Nutrients · doi:10.3390/nu13124543 · Cited by 230 · see citing works
Wang, N., Sun, Y. B., Zhang, H., Wang, B., Chen, C., Wang, Y., Chen, J., Tan, X. W., Zhang, J., Xia, F., et al. (2021) · European Heart Journal · doi:10.1093/eurheartj/ehab505 · Cited by 224 · see citing works
Validation of the Sleep Regularity Index in Older Adults and Associations with Cardiometabolic Risk
Lunsford‐Avery, J. R., Engelhard, M., Návar, A. M., & Kollins, S. H. (2018) · Scientific Reports · doi:10.1038/s41598-018-32402-5 · Cited by 222 · see citing works
Kervezee, L., Kosmadopoulos, A., & Boivin, D. B. (2018) · European Journal of Neuroscience · doi:10.1111/ejn.14216 · Cited by 216 · see citing works
Circadian Misalignment Increases C-Reactive Protein and Blood Pressure in Chronic Shift Workers
Morris, C. J., Purvis, T. E., Mistretta, J., Hu, K., & Scheer, F. A. J. L. (2017) · Journal of Biological Rhythms · doi:10.1177/0748730417697537 · Cited by 209 · see citing works
Self-citationWhen Rhythms Meet the Blues: Circadian Interactions with the Microbiota-Gut-Brain Axis
Teichman, E. M., O’Riordan, K. J., Gahan, C. G. M., Dinan, T. G., & Cryan, J. F. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.02.008 · Cited by 198 · see citing works
Melatonin effects on glucose metabolism: time to unlock the controversy
Garaulet, M., Qian, J., Florez, J. C., Arendt, J., Saxena, R., & Scheer, F. A. J. L. (2020) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2019.11.011 · Cited by 193 · see citing works
Self-citationEvaluation of Sleep Habits and Disturbances Among US Adults, 2017-2020
Di, H., Guo, Y., Daghlas, I., Wang, L., Liu, G., Pan, A., Liu, L., & Shan, Z. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.40788 · Cited by 183 · see citing works
Association Between Residential Greenness and Cardiovascular Disease Risk
Yeager, R. A., Riggs, D. W., DeJarnett, N. K., Tollerud, D. J., Wilson, J. S., Conklin, D. J., O’Toole, T. E., McCracken, J., Lorkiewicz, P. K., Xie, Z., et al. (2018) · Journal of the American Heart Association · doi:10.1161/jaha.118.009117 · Cited by 178 · see citing works
Qian, J., Dalla Man, C., Morris, C. J., Cobelli, C., & Scheer, F. A. J. L. (2018) · Diabetes, Obesity and Metabolism · doi:10.1111/dom.13391 · Cited by 170 · see citing works
Self-citationMisalignment with the external light environment drives metabolic and cardiac dysfunction
West, A. C., Smith, L. C., Ray, D. W., Loudon, A. S. I., Brown, T. M., & Bechtold, D. A. (2017) · Nature Communications · doi:10.1038/s41467-017-00462-2 · Cited by 168 · see citing works
Grimaldi, D., Carter, J. R., Van Cauter, E., & Leproult, R. (2016) · Hypertension · doi:10.1161/hypertensionaha.115.06847 · Cited by 153 · see citing works
“There is, however, a discrepancy between our findings and those of Morris et al. 32 regarding BP and urinary NE responses to CM.”
InfluentialTime‐restricted feeding for prevention and treatment of cardiometabolic disorders
Melkani, G. C., & Panda, S. (2017) · The Journal of Physiology · doi:10.1113/jp273094 · Cited by 155 · see citing works
The role of the circadian clock system in physiology
Pilorz, V., Helfrich‐Förster, C., & Oster, H. (2018) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-2103-y · Cited by 156 · see citing works
McAllister, M. J., Pigg, B., Rentería, L. I., & Waldman, H. S. (2019) · Nutrition Research · doi:10.1016/j.nutres.2019.12.001 · Cited by 152 · see citing works
Circadian rhythmicity of body temperature and metabolism
Refinetti, R. (2020) · Temperature · doi:10.1080/23328940.2020.1743605 · Cited by 155 · see citing works
Neurodegeneration and the Circadian Clock
Hood, S., & Amir, S. (2017) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2017.00170 · Cited by 150 · see citing works
Villanueva, J. E., Livelo, C., Trujillo, A. S., Chandran, S., Woodworth, B., Andrade, L., Le, H. D., Manor, U., Panda, S., & Melkani, G. C. (2019) · Nature Communications · doi:10.1038/s41467-019-10563-9 · Cited by 158 · see citing works
Sleep and circadian regulation of cortisol: A short review
O'Byrne, N. A., Yuen, F., Butt, W. Z., & Liu, P. Y. (2021) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2021.03.011 · Cited by 145 · see citing works
Lananna, B. V., & Musiek, E. S. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104832 · Cited by 145 · see citing works
Li, E., Li, X., Huang, J., Xu, C., Liang, Q., Ren, K., Bai, A., Lü, C., Qian, R., & Sun, N. (2020) · Protein & Cell · doi:10.1007/s13238-020-00713-x · Cited by 142 · see citing works
Off the Clock: From Circadian Disruption to Metabolic Disease
Maury, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071597 · Cited by 142 · see citing works
Sex differences in the circadian misalignment effects on energy regulation
Qian, J., Morris, C. J., Caputo, R., Wang, W., Garaulet, M., & Scheer, F. A. J. L. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1914003116 · Cited by 138 · see citing works
Self-citationvan der Merwe, C., Münch, M. Y., & Kruger, R. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac093 · Cited by 143 · see citing works
Sleep and immunity in times of COVID-19
Silva, E. D. S. M. E., Ono, B. H. V. S., & Souza, J. C. (2020) · Revista da Associação Médica Brasileira · doi:10.1590/1806-9282.66.s2.143 · Cited by 129 · see citing works
BaHammam, A. S., & Pirzada, R. (2023) · Clocks & Sleep · doi:10.3390/clockssleep5030034 · Cited by 138 · see citing works
Gominak, S. C. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.07.007 · Cited by 129 · see citing works
m6A RNA Methylation in Cardiovascular Diseases
Wu, S., Zhang, S., Wu, X., & Zhou, X. (2020) · Molecular Therapy · doi:10.1016/j.ymthe.2020.08.010 · Cited by 125 · see citing works
Timing of food intake: identifying contributing factors to design effective interventions
Dashti, H. S., Scheer, F. A. J. L., Saxena, R., & Garaulet, M. (2019) · Advances in Nutrition · doi:10.1093/advances/nmy131 · Cited by 121 · see citing works
Self-citationCircadian Rhythms, Exercise, and Cardiovascular Health
Hower, I. M., Harper, S. A., & Buford, T. W. (2018) · Journal of Circadian Rhythms · doi:10.5334/jcr.164 · Cited by 121 · see citing works
Daily circadian misalignment impairs human cognitive performance task-dependently
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2018) · Scientific Reports · doi:10.1038/s41598-018-20707-4 · Cited by 120 · see citing works
Self-citationGhrelin is impacted by the endogenous circadian system and by circadian misalignment in humans
Qian, J., Morris, C. J., Caputo, R., Garaulet, M., & Scheer, F. A. J. L. (2019) · International Journal of Obesity · doi:10.1038/s41366-018-0208-9 · Cited by 119 · see citing works
Self-citationKanki, M., Nath, A. P., Xiang, R., Yiallourou, S. R., Fuller, P. J., Cole, T. J., Cánovas, R., & Young, M. J. (2023) · Nature Communications · doi:10.1038/s41467-023-42758-6 · Cited by 118 · see citing works
Circadian rhythm and disease: Relationship, new insights, and future perspectives
Neves, A. R., Albuquerque, T., Quintela, T., & Costa, D. R. B. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30815 · Cited by 120 · see citing works
OSA and Cardiovascular Risk in Pediatrics
Smith, D. F., & Amin, R. S. (2019) · CHEST Journal · doi:10.1016/j.chest.2019.02.011 · Cited by 111 · see citing works
A Pilot Characterization of the Human Chronobiome
Skarke, C., Lahens, N. F., Rhoades, S. D., Campbell, A. E., Bittinger, K. L., Bailey, A., Hoffmann, C., Olson, R. S., Chen, L., Yang, G., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-17362-6 · Cited by 111 · see citing works
Intraindividual variability in sleep and comorbid medical and mental health conditions
Slavish, D. C., Taylor, D. J., & Lichstein, K. L. (2019) · SLEEP · doi:10.1093/sleep/zsz052 · Cited by 109 · see citing works
Islam, Z., Hu, H., Akter, S., Kuwahara, K., Kochi, T., Eguchi, M., Kurotani, K., Nanri, A., Kabe, I., & Mizoue, T. (2019) · SLEEP · doi:10.1093/sleep/zsz204 · Cited by 111 · see citing works
Коростовцева, Л. С., Викторович, Б. М., & Sviryaev, Y. V. (2021) · Sleep Medicine Clinics · doi:10.1016/j.jsmc.2021.05.001 · Cited by 109 · see citing works
Effect of Sleep Disturbances on Blood Pressure
Makarem, N., Alcántara, C., Williams, N., Bello, N. A., & Abdalla, M. (2021) · Hypertension · doi:10.1161/hypertensionaha.120.14479 · Cited by 114 · see citing works
Modifiable Cardiovascular Risk, Hematopoiesis, and Innate Immunity
Schloss, M. J., Świrski, F. K., & Nahrendorf, M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315936 · Cited by 107 · see citing works
Calcineurin signaling in the heart: The importance of time and place
Parra, V., & Rothermel, B. A. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.12.006 · Cited by 103 · see citing works
At the Interface of Lifestyle, Behavior, and Circadian Rhythms: Metabolic Implications
Bae, S.-A., Fang, M., Rustgi, V. K., Zarbl, H., & Androulakis, I. P. (2019) · Frontiers in Nutrition · doi:10.3389/fnut.2019.00132 · Cited by 100 · see citing works
Chronobiological Influence Over Cardiovascular Function
Rana, S., Prabhu, S. D., & Young, M. E. (2020) · Circulation Research · doi:10.1161/circresaha.119.313349 · Cited by 99 · see citing works
Gumz, M. L., Shimbo, D., Abdalla, M., Balijepalli, R. C., Benedict, C., Chen, Y., Earnest, D. J., Gamble, K. L., Garrison, S., Gong, M. C., et al. (2022) · Hypertension · doi:10.1161/hypertensionaha.122.19372 · Cited by 103 · see citing works
Circadian misalignment increases mood vulnerability in simulated shift work
Chellappa, S. L., Morris, C. J., & Scheer, F. A. J. L. (2020) · Scientific Reports · doi:10.1038/s41598-020-75245-9 · Cited by 98 · see citing works
Self-citationAltered mitochondrial metabolism in the insulin‐resistant heart
Makrecka‐Kuka, M., Liepinsh, E., Murray, A. J., Lemieux, H., Dambrova, M., Tepp, K., Puurand, M., Käämbre, T., Han, W. H., de Goede, P., et al. (2019) · Acta Physiologica · doi:10.1111/apha.13430 · Cited by 93 · see citing works
Nikbakhtian, S., Reed, A. B., Obika, B. D., Morelli, D., Cunningham, A. C., Aral, M., & Plans, D. (2021) · European Heart Journal - Digital Health · doi:10.1093/ehjdh/ztab088 · Cited by 96 · see citing works
Time-of-day dependent effects of contractile activity on the phase of the skeletal muscle clock
Kemler, D., Wolff, C. A., & Esser, K. A. (2020) · The Journal of Physiology · doi:10.1113/jp279779 · Cited by 87 · see citing works
Lo, E. H., Albers, G. W., Dichgans, M., Donnan, G. A., Esposito, E., Foster, R., Howells, D. W., Huang, Y.-G., Ji, X., Klerman, E. B., et al. (2021) · Stroke · doi:10.1161/strokeaha.120.031742 · Cited by 93 · see citing works
Self-citationThe Effects of Shift Work on Cardio-Metabolic Diseases and Eating Patterns
Hemmer, A., Mareschal, J., Dibner, C., Pralong, J. A., Dorribo, V., Perrig, S. H., Genton, L., Pichard, C., & Collet, T. (2021) · Nutrients · doi:10.3390/nu13114178 · Cited by 96 · see citing works
Debono, M., Harrison, R. F., Chadarevian, R., Gueroult, C., Abitbol, J.-L., & Newell-Price, J. (2017) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2017-00823 · Cited by 100 · see citing works
Health position paper and redox perspectives - Disease burden by transportation noise
Sørensen, M., Pershagen, G., Thacher, J. D., Lanki, T., Wicki, B., Röösli, M., Vienneau, D., Cantuaria, M. L., Schmidt, J. H., Aasvang, G. M., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102995 · Cited by 91 · see citing works
Circadian Control of Inflammasome Pathways: Implications for Circadian Medicine
Pourcet, B., & Duez, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01630 · Cited by 84 · see citing works
Nuclear Receptors in the Control of the NLRP3 Inflammasome Pathway
Duez, H., & Pourcet, B. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.630536 · Cited by 80 · see citing works
Modified Cortisol Circadian Rhythm: The Hidden Toll of Night-Shift Work
Andreadi, A., Andreadi, S., Todaro, F., Ippoliti, L., Bellia, A., Magrini, A., Chrousos, G. P., & Lauro, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26052090 · Cited by 89 · see citing works
A circadian based inflammatory response – implications for respiratory disease and treatment
Comas, M., Gordon, C. J., Oliver, B. G. G., Stow, N. W., King, G. G., Sharma, P. K., Ammit, A. J., Grunstein, R. R., & Phillips, C. L. (2017) · Sleep Science and Practice · doi:10.1186/s41606-017-0019-2 · Cited by 77 · see citing works
The circadian system, sleep, and the health/disease balance: a conceptual review
Roenneberg, T., Foster, F., & Klerman, E. B. (2022) · Journal of Sleep Research · doi:10.1111/jsr.13621 · Cited by 77 · see citing works
Thompson, R. S., Gaffney, M., Hopkins, S., Kelley, T., González, A., Bowers, S. J., Vitaterna, M. H., Turek, F. W., Foxx, C. L., Lowry, C. A., et al. (2021) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2021.07.006 · Cited by 80 · see citing works
Circadian Clock Model Supports Molecular Link Between PER3 and Human Anxiety
Liberman, A. R., Kwon, S. B., Vu, H., Filipowicz, A., Ay, A. A., & Ingram, K. K. (2017) · Scientific Reports · doi:10.1038/s41598-017-07957-4 · Cited by 72 · see citing works
Sterling, P. (2020) · The MIT Press eBooks · doi:10.7551/mitpress/11472.001.0001 · Cited by 117 · see citing works
Machine learning identifies a compact gene set for monitoring the circadian clock in human blood
Hughey, J. (2017) · Genome Medicine · doi:10.1186/s13073-017-0406-4 · Cited by 72 · see citing works
Mealtime: A circadian disruptor and determinant of energy balance?
Ruddick-Collins, L. C., Morgan, P. J., & Johnstone, A. M. (2020) · Journal of Neuroendocrinology · doi:10.1111/jne.12886 · Cited by 74 · see citing works
Liu, C.-J., Li, Y., Hu, Y., & Zhao, B. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s277377 · Cited by 73 · see citing works
Gabryelska, A., Turkiewicz, S., Karuga, F. F., Sochal, M., Strzelecki, D., & Białasiewicz, P. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23020709 · Cited by 74 · see citing works
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure
Faraci, F. M., & Scheer, F. A. J. L. (2024) · Circulation Research · doi:10.1161/circresaha.124.323515 · Cited by 80 · see citing works
Self-citationMeal timing and its role in obesity and associated diseases
Peters, B., Vahlhaus, J., & Pivovarova-Ramich, O. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1359772 · Cited by 72 · see citing works
“Furthermore, mistimed meal intake resulted in a phase shift in the peripheral clocks of the adipose tissue (30), changes in blood pressure (85), and an increase in in fl ammatory markers (86).”
BackgroundThe impact of glucocorticoids and statins on sleep quality
Szmyd, B., Rogut, M., Białasiewicz, P., & Gabryelska, A. (2021) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2020.101380 · Cited by 66 · see citing works
Phoi, Y. Y., Rogers, M., Bonham, M. P., Dorrian, J., & Coates, A. M. (2021) · Nutrition Research Reviews · doi:10.1017/s0954422421000123 · Cited by 65 · see citing works
Li, H., Kilgallen, A. B., Münzel, T. F., Wolf, E., Lecour, S., Schulz, R., Daiber, A., & Laake, L. W. V. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14949 · Cited by 66 · see citing works
Chrononutrition—When We Eat Is of the Essence in Tackling Obesity
Ahluwalia, M. K. (2022) · Nutrients · doi:10.3390/nu14235080 · Cited by 71 · see citing works
Timing of food intake: Sounding the alarm about metabolic impairments? A systematic review
Beccuti, G., Monagheddu, C., Evangelista, A., Ciccone, G., Broglio, F., Soldati, L., & Bo, S. (2017) · Pharmacological Research · doi:10.1016/j.phrs.2017.09.005 · Cited by 64 · see citing works
Khalyfa, A., Poroyko, V. A., Qiao, Z., Gileles‐Hillel, A., Khalyfa, A. A., Akbarpour, M., Almendros, I., Farré, R., & Gozal, D. (2017) · Frontiers in Physiology · doi:10.3389/fphys.2017.00882 · Cited by 64 · see citing works
Sűdy, Á. R., Ella, K., Bódizs, R., & Káldi, K. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00950 · Cited by 65 · see citing works
Sleep duration in preschool children and impact of screen time
Lan, Q.-Y., Chan, K. C., Yu, K. N., Chan, N. Y., Wing, Y. K., Li, A. M., & Au, C. T. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.09.024 · Cited by 63 · see citing works
- Authors
- Morris, C. J., Purvis, T. E., Hu, K., & Scheer, F. A. J. L.
- Affiliations
- Brigham and Women's Hospital (US)
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 2016-02-08
- Volume
- 113
- Issue
- 10
- Pages
- E1402-11
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC4790999
- OpenAlex
- W2259214365
- Cited by
- 691
- References
- 81
- Citations by year
- 2026: 82 · 2025: 84 · 2024: 69 · 2023: 87 · 2022: 82 · 2021: 74 · 2020: 64 · 2019: 49 · 2018: 43 · 2017: 45 · 2016: 10
- FWCI
- 69.56
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Aeronautics and Space Administration (NCC958)
- Brigham and Women's Hospital (UL1RR025758)
- Harvard University (UL1RR025758)
- National Space Biomedical Research Institute (P01 AG009975, NCC 9‐58)
- National Institute on Aging (R01AG048108, P01AG009975)
- National Heart, Lung, and Blood Institute (R00HL102241, R01HL118601, R01HL094806)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK099512, DK099512)
- National Center for Research Resources (UL1RR025758)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Keywords
- circadian misalignment, shift work, cardiovascular risk, hypertension, blood pressure, sleep blood pressure, cardiac vagal modulation, heart rate variability, urinary epinephrine, urinary norepinephrine, inflammation, interleukin-6, C-reactive protein, resistin, TNF-α
- MeSH terms
- Adult, Blood Pressure, C-Reactive Protein, Cardiovascular Diseases, Circadian Rhythm, Epinephrine, Female, Heart Rate, Humans, Hypertension, Male, Middle Aged, Risk Factors, Time Factors, Tumor Necrosis Factor-alpha, Work Schedule Tolerance, Interleukin-6, Polysomnography, Cross-Over Studies, Sleep Disorders, Circadian Rhythm, Resistin, Young Adult, Actigraphy
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
